| Budget Amount *help |
¥82,800,000 (Direct Cost: ¥82,800,000)
Fiscal Year 2012: ¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2011: ¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2010: ¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2009: ¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2008: ¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2007: ¥13,800,000 (Direct Cost: ¥13,800,000)
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| Research Abstract |
DNA hypomethylation mutation ddm1 (decrease in DNA methylation) induces several types of developmental defects through heritable effects on other loci. One of them, which we named bonsai, was due to transcriptional repression of the responsible gene, which is associated with local increase in DNA methylation. Genetic analyses revealed that the methylation does not depend on RNAi machinery. We also screened mutants inducing BONSAI methylation and identified a novel factor IBM1 (increase in BONSAI methylation). Genome-wide analyses revealed that IBM1 ensures normal plant development by removing heterochromatin marks from transcribed sequences.
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