| Budget Amount *help |
¥75,140,000 (Direct Cost: ¥57,800,000、Indirect Cost: ¥17,340,000)
Fiscal Year 2023: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2022: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2021: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2020: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2019: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
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| Outline of Final Research Achievements |
Plant cells are structurally supported by their cell walls and adopt distinct shapes and functions depending on the cell type. Xylem vessel cells, which conduct water, undergo programmed cell death during which cortical microtubules beneath the plasma membrane are locally depolymerized. This localized microtubule disassembly suppresses cell wall deposition in specific regions, resulting in a periodic pattern of secondary wall thickenings. In this study, we discovered a novel mechanism in which the MIDD1 protein forms condensates through liquid-liquid phase separation (LLPS)-like behavior and induces localized microtubule depolymerization, thereby generating the periodic pattern of wall deposition. This work provides new insights into the involvement of LLPS in regulating cell wall architecture and represents a significant advance in our understanding of plant tissue patterning and cell wall formation.
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