Selective autophagy-mediated cellular regulations

• Project Area: Multimode autophagy: Diverse pathways and selectivity
• Project/Area Number: 19H05706
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Juntendo University
• Principal Investigator: 小松 雅明 順天堂大学, 大学院医学研究科, 教授 (90356254)
• Co-Investigator(Kenkyū-buntansha): 和栗 聡 福島県立医科大学, 医学部, 教授 (30244908) ; 杉浦 悠毅 京都大学, 医学研究科, 特定准教授 (30590202) ; 李 賢哲 順天堂大学, 医学部, 准教授 (30758321)
• Project Period (FY): 2019-06-28 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥255,580,000 (Direct Cost: ¥196,600,000、Indirect Cost: ¥58,980,000); Fiscal Year 2023: ¥58,890,000 (Direct Cost: ¥45,300,000、Indirect Cost: ¥13,590,000); Fiscal Year 2022: ¥57,330,000 (Direct Cost: ¥44,100,000、Indirect Cost: ¥13,230,000); Fiscal Year 2021: ¥56,030,000 (Direct Cost: ¥43,100,000、Indirect Cost: ¥12,930,000); Fiscal Year 2020: ¥55,640,000 (Direct Cost: ¥42,800,000、Indirect Cost: ¥12,840,000); Fiscal Year 2019: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
• Keywords: オートファジー / 選択的オートファジー / p62 / NBR1 / 液ー液相分離 / Vault / KEAP1 / プロテオーム / マクロオートファジー / マルチモードオートファジー / UFM1システム / 液―液相分離 / ユビキチン / 液－液相分離 / NCoR1

Outline of Research at the Start

本研究課題では、選択的マクロオートファジーの普遍的な分子機構に迫る。さらに、オートファジー欠損マウスや選択的オートファジー阻害マウスにおける基質タンパク質群の変動、その結果として起こる細胞生理機能の変化を検証し、個体における選択的マクロオートファジーの生理機能の解明を目指す。

Outline of Annual Research Achievements

オートファジーの対象となるミスフォールドや変性したタンパク質は、ユビキチン化されp62と結合、液―液相分離（LLPS）によってp62 bodyとなる。このp62 bodyはさらに分解性のゲルへと相転移し、オートファジーにより分解される。
p62 bodyの精製方法を確立し、精製p62 bodyの質量分析によりp62 bodyに高度に濃縮されるタンパク質群を同定した。さらに、コントロールと選択的オートファジー不能遺伝子改変マウス肝臓の比較定量プロテオミクスにより選択的オートファジー不能遺伝子改変マウス肝臓に蓄積するタンパク質群を同定した。両者のプロテオームの統合的解析により、p62 bodyに局在し、オートファジーにより分解される新規選択的オートファジー基質として超分子タンパク質複合体vaultを同定した。オートファジーの薬理学的および遺伝学的阻害によりvaultが蓄積することを確認した。さらに、vaultのp62 bodyへの局在化は、選択的オートファジーレセプタータンパク質NBR1依存的であることを見出した。このp62 body介在性選択的オートファジーをvault-phagyと名付け、論文として報告した。p62 bodyにおけるp62の349番目のセリン残基のリン酸化が、KEAP1の細胞質とp62 bodyの平衡をp62 bodyに向けること、その結果KEAP1がp62 bodyに保持され、KEAP1の分解標的である転写因子NRF2が安定、活性化することを明らかし、論文として報告した。

Research Progress Status

令和5年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和5年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Tanta University(エジプト)
• [Int'l Joint Research] Massachusetts General Hospital(米国)
• [Int'l Joint Research] University of Turku(フィンランド)
• [Int'l Joint Research] University of Turku(フィンランド)
• [Int'l Joint Research] University of Helsinki(フィンランド)
• [Int'l Joint Research] Hannam University(韓国)
• [Int'l Joint Research] University of Turku/University of Helsinki(フィンランド)
• [Int'l Joint Research] Hannam University(韓国)
• [Int'l Joint Research] The University of Western Australia(オーストラリア)
• [Journal Article] The UFM1 system: Working principles, cellular functions, and pathophysiology (2024)
  • Author(s): Komatsu Masaaki、Inada Toshifumi、Noda Nobuo N.
  • Journal Title: Molecular Cell Volume: 84 Issue: 1 Pages: 156-169
  • DOI: 10.1016/j.molcel.2023.11.034
  • Peer Reviewed / Open Access
• [Journal Article] Vault-phagy: a phase-separation-mediated selective autophagy of vault, a non-membranous organelle (2023)
  • Author(s): Kurusu Reo、Morishita Hideaki、Komatsu Masaaki
  • Journal Title: Autophagy Volume: 20 Issue: 2 Pages: 441-442
  • DOI: 10.1080/15548627.2023.2266996
  • Peer Reviewed
• [Journal Article] p62 bodies: cytosolic zoning by phase separation (2023)
  • Author(s): Kurusu Reo、Morishita Hideaki、Komatsu Masaaki
  • Journal Title: The Journal of Biochemistry Volume: 175 Issue: 2 Pages: 141-146
  • DOI: 10.1093/jb/mvad089
  • Peer Reviewed / Open Access
• [Journal Article] ATG9A supports Chlamydia trachomatis infection via autophagy-independent mechanisms (2023)
  • Author(s): Michitaka Suzuki, Tomoko Funakoshi, Keigo Kumagai, Masaaki Komatsu, Satoshi Waguri
  • Journal Title: Microbiology Spectrum Volume: 11(5) Issue: 5
  • DOI: 10.1128/spectrum.02774-23
  • Peer Reviewed / Open Access
• [Journal Article] Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control (2023)
  • Author(s): Ishimura Ryosuke、Ito Sota、Mao Gaoxin、Komatsu-Hirota Satoko、Inada Toshifumi、Noda Nobuo N.、Komatsu Masaaki
  • Journal Title: Science Advances Volume: 9 Issue: 33
  • DOI: 10.1126/sciadv.adh3635
  • Peer Reviewed / Open Access
• [Journal Article] Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response (2023)
  • Author(s): Ikeda Ryo、Noshiro Daisuke、Morishita Hideaki、Takada Shuhei、Kageyama Shun、Fujioka Yuko、Funakoshi Tomoko、Komatsu‐Hirota Satoko、Arai Ritsuko、Ryzhii Elena、Abe Manabu、Koga Tomoaki、Motohashi Hozumi、Nakao Mitsuyoshi、Sakimura Kenji、Horii Arata、Waguri Satoshi、Ichimura Yoshinobu、Noda Nobuo N、Komatsu Masaaki
  • Journal Title: The EMBO Journal Volume: 42 Issue: 14
  • DOI: 10.15252/embj.2022113349
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex (2023)
  • Author(s): Kurusu Reo、Fujimoto Yuki、Morishita Hideaki、Noshiro Daisuke、Takada Shuhei、Yamano Koji、Tanaka Hideaki、Arai Ritsuko、Kageyama Shun、Funakoshi Tomoko、Komatsu-Hirota Satoko、Taka Hikari、Kazuno Saiko、Miura Yoshiki、Koike Masato、Wakai Toshifumi、Waguri Satoshi、Noda Nobuo N.、Komatsu Masaaki
  • Journal Title: Developmental Cell Volume: － Issue: 13 Pages: 1189-1205
  • DOI: 10.1016/j.devcel.2023.04.015
  • Peer Reviewed / Open Access
• [Journal Article] Cathelicidin LL-37 activates human keratinocyte autophagy through the P2X7, mechanistic target of rapamycin, and MAPK pathways (2023)
  • Author(s): Ikutama R、Peng G、Tsukamoto S、Umehara Y、Trujillo-Paez JV、Yue H、Nguyen HLT、Takahashi M、Kageyama S、Komatsu M、Okumura K、Ogawa H、Ikeda Sh、Niyonsaba F
  • Journal Title: Journal of Investigative Dermatology Volume: 143 Issue: 5 Pages: 751-761
  • DOI: 10.1016/j.jid.2022.10.020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. (2022)
  • Author(s): Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y, Shindo M, Hatta T, Abe M, Uemura T, Lee-Okada HC, Mohamed TM, Yokomizo T, Ueno T, Sakimura K, Natsume T, Sorimachi H, Inada T, Waguri S, Noda NN, Komatsu M.
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 7857-7857
  • DOI: 10.1038/s41467-022-35501-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] p62 bodies: phase separation, NRF2 activation, and selective autophagic degradation (2022)
  • Author(s): Komatsu M.
  • Journal Title: IUBMB Life Volume: 74(12) Issue: 12 Pages: 1200-1208
  • DOI: 10.1002/iub.2689
  • Peer Reviewed / Open Access
• [Journal Article] Lack of Hepatic Autophagy Promotes Severity of Liver Injury but Not Steatosis (2022)
  • Author(s): Ding WX, Ni HM, Waguri S, Komatsu M.
  • Journal Title: J Hepatol. Volume: 77(5) Issue: 5 Pages: 1458-1459
  • DOI: 10.1016/j.jhep.2022.05.015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Human β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway (2022)
  • Author(s): Peng G、Tsukamoto S、Ikutama R、Nguyen HLT、Umehara Y、Trujillo-Paez JV、Yue H、Takahashi M、Ogawa T、Kishi R、Tominaga M、Takamori K、Kitaura J、Kageyama S、Komatsu M、Okumura K、Ogawa H、Ikeda S、Niyonsaba F
  • Journal Title: Journal of Clinical Investigation Volume: 132 Issue: 17
  • DOI: 10.1172/jci156501
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy (2022)
  • Author(s): Ono Maiko、Komatsu Masaaki、Ji Bin、Takado Yuhei、Shimojo Masafumi、Minamihisamatsu Takeharu、Warabi Eiji、Yanagawa Toru、Matsumoto Gen、Aoki Ichio、Kanaan Nicholas M.、Suhara Tetsuya、Sahara Naruhiko、Higuchi Makoto
  • Journal Title: Aging Cell Volume: 21 Issue: 7
  • DOI: 10.1111/acel.13615
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impaired GATE16-mediated exocytosis in exocrine tissues causes Sj?gren’s syndrome-like exocrinopathy (2022)
  • Author(s): Suzuki Akiko、Iwaya Chihiro、Ogata Kenichi、Yoshioka Hiroki、Shim Junbo、Tanida Isei、Komatsu Masaaki、Tada Norihiro、Iwata Junichi
  • Journal Title: Cellular and Molecular Life Sciences Volume: 79 Issue: 6 Pages: 307-307
  • DOI: 10.1007/s00018-022-04334-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance (2022)
  • Author(s): Sakai Mai、Yu Zhiqian、Hirayama Ryo、Nakasato Masa、Kikuchi Yoshie、Ono Chiaki、Komatsu Hiroshi、Nakanishi Miharu、Yoshii Hatsumi、Stellwagen David、Furuyashiki Tomoyuki、Komatsu Masaaki、Tomita Hiroaki
  • Journal Title: Neural Plasticity Volume: 2022 Pages: 1-13
  • DOI: 10.1155/2022/7503553
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of autophagy in liver diseases (2022)
  • Author(s): Morishita Hideaki, Komatsu Masaaki
  • Journal Title: Current Opinion in Physiology Volume: 30 Pages: 100594-100594
  • Peer Reviewed / Open Access
• [Journal Article] Loss of <i>Atg2b</i> and <i>Gskip</i> Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size (2022)
  • Author(s): Sakai Shun-suke、Hasegawa Atsushi、Ishimura Ryosuke、Tamura Naoki、Kageyama Shun、Komatsu-Hirota Satoko、Abe Manabu、Ling Yiwei、Okuda Shujiro、Funayama Manabu、Kikkawa Mika、Miura Yoshiki、Sakimura Kenji、Narita Ichiei、Waguri Satoshi、Shimizu Ritsuko、Komatsu Masaaki
  • Journal Title: Molecular and Cellular Biology Volume: 42 Issue: 1 Pages: 1-17
  • DOI: 10.1128/mcb.00024-21
  • Peer Reviewed / Open Access
• [Journal Article] USP10 inhibits the dopamine-induced reactive oxygen species-dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity (2022)
  • Author(s): Sango Junya、Kakihana Taichi、Takahashi Masahiko、Katsuragi Yoshinori、Anisimov Sergei、Komatsu Masaaki、Fujii Masahiro
  • Journal Title: Journal of Biological Chemistry Volume: 298 Issue: 1 Pages: 101448-101448
  • DOI: 10.1016/j.jbc.2021.101448
  • Peer Reviewed / Open Access
• [Journal Article] USP10 Inhibits Aberrant Cytoplasmic Aggregation of TDP-43 by Promoting Stress Granule Clearance (2022)
  • Author(s): Takahashi Masahiko、Kitaura Hiroki、Kakita Akiyoshi、Kakihana Taichi、Katsuragi Yoshinori、Onodera Osamu、Iwakura Yuriko、Nawa Hiroyuki、Komatsu Masaaki、Fujii Masahiro
  • Journal Title: Molecular and Cellular Biology Volume: 42 Issue: 3
  • DOI: 10.1128/mcb.00393-21
  • Peer Reviewed / Open Access
• [Journal Article] A Description of Novel Variants and Review of Phenotypic Spectrum in UBA5-related Early Epileptic Encephalopathy (2021)
  • Author(s): Briere LC, Walker MA, High FA, Rogers CA, Callahan C, Cooper C, Ishimura R, Ichimura Y, Caruso PA, Sharma N, Brokamp E, Koziura ME, Mohammad SS, Dale RC, Riley LG, Network UD, Phillips JA, Komatsu M, Sweetser DA.
  • Journal Title: Cold Spring Harb Mol Case Stud. Volume: mcs Issue: 3 Pages: a005827-a005827
  • DOI: 10.1101/mcs.a005827
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control (2021)
  • Author(s): Eskelinen Eeva-Liisa、Kageyama Shun、Komatsu Masaaki
  • Journal Title: Molecular & Cellular Oncology Volume: 8 Issue: 2 Pages: 1890990-1890990
  • DOI: 10.1080/23723556.2021.1890990
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis (2021)
  • Author(s): Maruyama Tatsuro、Alam Jahangir Md.、Fukuda Tomoyuki、Kageyama Shun、Kirisako Hiromi、Ishii Yuki、Shimada Ichio、Ohsumi Yoshinori、Komatsu Masaaki、Kanki Tomotake、Nakatogawa Hitoshi、Noda Nobuo N.
  • Journal Title: Nature Structural &amp; Molecular Biology Volume: 28 Issue: 7 Pages: 583-593
  • DOI: 10.1038/s41594-021-00614-5
  • Peer Reviewed / Open Access
• [Journal Article] Selective autophagy (2021)
  • Author(s): Faruk Mohammad Omar、Ichimura Yoshinobu、Komatsu Masaaki
  • Journal Title: Cancer Science Volume: 112 Issue: 10 Pages: 3972-3978
  • DOI: 10.1111/cas.15112
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes (2021)
  • Author(s): Nishida Mikako、Yamashita Nahoko、Ogawa Taisaku、Koseki Keita、Warabi Eiji、Ohue Tomoyuki、Komatsu Masaaki、Matsushita Hirokazu、Kakimi Kazuhiro、Kawakami Eiryo、Shiroguchi Katsuyuki、Udono Heiichiro
  • Journal Title: Journal for ImmunoTherapy of Cancer Volume: 9 Issue: 9 Pages: e002954-e002954
  • DOI: 10.1136/jitc-2021-002954
  • Peer Reviewed / Open Access
• [Journal Article] Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity (2021)
  • Author(s): Faruk MO, Ichimura Y, Kageyama S, Komatsu-Hirota S, El-Gowily AH, Sou YS, Koike M, Noda NN, Komatsu M.
  • Journal Title: J Biol Chem Volume: 297 Issue: 6 Pages: 101405-101405
  • DOI: 10.1016/j.jbc.2021.101405
  • Peer Reviewed / Open Access
• [Journal Article] 選択的オートファジー：狙われる理由の解明が進む (2021)
  • Author(s): 小松雅明
  • Journal Title: 実験医学 Volume: 39 Pages: 2030-2038
• [Journal Article] Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner (2021)
  • Author(s): Nomura Naho、Ito Chiaki、Ooshio Takako、Tadokoro Yuko、Kohno Susumu、Ueno Masaya、Kobayashi Masahiko、Kasahara Atsuko、Takase Yusuke、Kurayoshi Kenta、Si Sha、Takahashi Chiaki、Komatsu Masaaki、Yanagawa Toru、Hirao Atsushi
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 1666-1679
  • DOI: 10.1038/s41598-021-81076-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response (2021)
  • Author(s): Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M.
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 16-16
  • DOI: 10.1038/s41467-020-20185-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Autophagic receptor p62 protects against glycation‐derived toxicity and enhances viability (2020)
  • Author(s): Gemma Aragones, Kalavathi Dasuri, Opeoluwa Olukorede, Sarah G Francisco, Carol Renneburg, et al.
  • Journal Title: Aging Cell Volume: 19 Issue: 11
  • DOI: 10.1111/acel.13257
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury (2020)
  • Author(s): Shuhei Nakamura et al.,
  • Journal Title: Nature Cell Biology Volume: 22 Issue: 10 Pages: 1252-1263
  • DOI: 10.1038/s41556-020-00583-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Monitoring Autophagy Flux and Activity: Principles and Applications (2020)
  • Author(s): Ueno Takashi、Komatsu Masaaki
  • Journal Title: BioEssays Volume: 42 Issue: 11 Pages: 2000122-2000122
  • DOI: 10.1002/bies.202000122
  • Peer Reviewed / Open Access
• [Journal Article] Inhibitors of the protein-protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line (2020)
  • Author(s): Daisuke Yasuda, Tomoyuki Ohe, Kyoko Takahashi, Riyo Imamura, Hirotatsu Kojima, Takayoshi Okabe, Yoshinobu Ichimura, Masaaki Komatsu, Masayuki Yamamoto, Tetsuo Nagano, Tadahiko Mashino
  • Journal Title: Free Radical Research Volume: Mar 30 Issue: 11-12 Pages: 1-13
  • DOI: 10.1080/10715762.2020.1732955
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ユビキチン介在性選択的オートファジー (2020)
  • Author(s): 一村義信、小松雅明
  • Journal Title: 医学のあゆみ Volume: 272 Pages: 771-781
• [Journal Article] オートファジーとがん (2020)
  • Author(s): 一村義信、小松雅明
  • Journal Title: 医学のあゆみ Volume: 272 Pages: 893-898
• [Journal Article] 飢餓代謝におけるオートファジーの役割の解明へむけて――メタボローム解析によるアプローチ (2020)
  • Author(s): 杉浦悠毅、小松雅明
  • Journal Title: 医学のあゆみ Volume: 272 Pages: 951-957
• [Journal Article] A homozygous UBA5 pathogenic variant causes a fatal congenital neuropathy (2020)
  • Author(s): Cabrera-Serrano Macarena、Coote David Joseph、Azmanov Dimitar、Goullee Hayley、Andersen Erik、McLean Catriona、Davis Mark、Ishimura Ryosuke、Stark Zornitza、Vallat Jean-Michel、Komatsu Masaaki、Kornberg Andrew、Ryan Monique、Laing Nigel G、Ravenscroft Gina
  • Journal Title: Journal of Medical Genetics Volume: - Issue: 12 Pages: 835-842
  • DOI: 10.1136/jmedgenet-2019-106496
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Heparan sulfate and clusterin: Cleaning squad for extracellular protein degradation (2020)
  • Author(s): Sanchez-Martin Pablo、Komatsu Masaaki
  • Journal Title: Journal of Cell Biology Volume: 219 Issue: 3
  • DOI: 10.1083/jcb.202001159
  • Peer Reviewed / Open Access
• [Journal Article] NBR1‐mediated p62‐liquid droplets enhance the Keap1‐Nrf2 system (2020)
  • Author(s): Sanchez-Martin Pablo、Sou Yu‐shin、Kageyama Shun、Koike Masato、Waguri Satoshi、Komatsu Masaaki
  • Journal Title: EMBO reports Volume: 21
  • Peer Reviewed / Open Access
• [Journal Article] Physiological Stress Response by Selective Autophagy (2020)
  • Author(s): Sanchez-Martin Pablo、Komatsu Masaaki
  • Journal Title: Journal of Molecular Biology Volume: 432 Pages: 53-62
  • Peer Reviewed / Open Access
• [Journal Article] 飢餓代謝におけるオートファジーの役割の解明へむけてーメタボローム解析によるアプローチ (2020)
  • Author(s): 杉浦悠毅、小松雅明
  • Journal Title: 医学のあゆみ Volume: 272 Pages: 951-957
• [Journal Article] Intracellular mechanisms regulated by selective macroautophagy (2019)
  • Author(s): 小松 雅明
  • Journal Title: 生化学 Volume: 91 Issue: 5 Pages: 595-601
  • DOI: 10.14952/SEIKAGAKU.2019.910595
  • ISSN: 0037-1017
  • Year and Date: 2019-10-25
• [Journal Article] Loss of autophagy impairs physiological steatosis by accumulation of NCoR1. (2019)
  • Author(s): Takahashi SS, Sou YS, Saito T, Kuma A, Yabe T, Sugiura Y, Lee HC, Suematsu M, Yokomizo T, Koike M, Terai S, Mizushima N, Waguri S, Komatsu M.
  • Journal Title: Life Sci Alliance. Volume: 3 Issue: 1 Pages: 201900513-201900513
  • DOI: 10.26508/lsa.201900513
  • Peer Reviewed / Open Access
• [Journal Article] Hyperosmotic Stress Induces Unconventional Autophagy Independent of the Ulk1 Complex (2019)
  • Author(s): Tamura Naoki、Kageyama Shun、Komatsu Masaaki、Waguri Satoshi
  • Journal Title: Molecular and Cellular Biology Volume: 39 Issue: 16
  • DOI: 10.1128/mcb.00024-19
  • Peer Reviewed / Open Access
• [Journal Article] Loss of autophagy in chondrocytes causes severe growth retardation (2019)
  • Author(s): Horigome Yoji、Ida-Yonemochi Hiroko、Waguri Satoshi、Shibata Shunichi、Endo Naoto、Komatsu Masaaki
  • Journal Title: Autophagy Volume: 16 Issue: 3 Pages: 501-511
  • DOI: 10.1080/15548627.2019.1628541
  • Peer Reviewed / Open Access
• [Journal Article] オートファジーと酸化ストレス (2019)
  • Author(s): 蔭山俊
  • Journal Title: 臨床免疫・アレルギー科 Volume: 72 Pages: 21-28
• [Presentation] p62：液ー液相分離、生理作用、オートファジー分解 (2024)
  • Author(s): 小松雅明
  • Organizer: 東大医科研オートファジーミニシンポジウム
  • Invited
• [Presentation] UFM1システムによる翻訳品質管理機構 (2024)
  • Author(s): 小松雅明
  • Organizer: 第二回タンパク質シンポジウム
• [Presentation] Phase-separation and autophagy co-creating stress response (2023)
  • Author(s): Masaaki Komatsu
  • Organizer: KEYSTONE SYMPOSIA on Molecular and Cellular Biology Autophagy and Disease
  • Int'l Joint Research / Invited
• [Presentation] Phase-separation and autophagy co-creating stress response (2023)
  • Author(s): Masaaki Komatsu
  • Organizer: The Cancer Research Centre of Marseille Seminar
  • Int'l Joint Research / Invited
• [Presentation] Phase-separation and autophagy co-creating stress response (2023)
  • Author(s): Masaaki Komatsu
  • Organizer: 1th Scientific Days on Autophagy (Plenary lecture)
  • Int'l Joint Research / Invited
• [Presentation] Phase-separation and autophagy co-creating stress response (2023)
  • Author(s): Masaaki Komatsu
  • Organizer: Institut NeuroMyoGene Seminar
  • Int'l Joint Research / Invited
• [Presentation] Phase-separation and autophagy co-creating stress response (2023)
  • Author(s): 小松雅明
  • Organizer: 第82回日本癌学会学術総会 特別シンポジウム
  • Invited
• [Presentation] 選択的オートファジーと液ー液相分離 (2023)
  • Author(s): 小松雅明
  • Organizer: ERATO 水島細胞内分解ダイナミクスプロジェクト シンポジウム
  • Invited
• [Presentation] 選択的オートファジーと液ー液相分離 (2023)
  • Author(s): 小松雅明
  • Organizer: 第17回パーキンソン病・運動障害疾患コングレス
  • Invited
• [Presentation] Phase-separated p62 body: formation, biological role and degradation (2023)
  • Author(s): 小松雅明
  • Organizer: 第23回日本蛋白質学会年会
  • Invited
• [Presentation] 選択的オートファジー：p62液滴の形成、生理作用、分解 (2023)
  • Author(s): 小松雅明
  • Organizer: 第89回日本生化学会東北支部例会・特別講演
  • Invited
• [Presentation] Selective autophagy of phase-separated p62: from molecular mechanism to pathophysiology (2023)
  • Author(s): Masaaki Komatsu
  • Organizer: Seoul National University Seminar
  • Int'l Joint Research / Invited
• [Presentation] Selective autophagy of phase-separated p62: from molecular mechanism to pathophysiology (2023)
  • Author(s): Masaaki Komatsu
  • Organizer: KSBMB (Korean Society for Biochemistry and Molecular Biology) International Conference 2023
  • Int'l Joint Research / Invited
• [Presentation] Selective autophagy of phase-separated p62: from molecular mechanism to pathophysiology (2023)
  • Author(s): Masaaki Komatsu
  • Organizer: Chungnam National University School of Medicine Seminar
• [Presentation] 選択的オートファジー 分子から病態まで (2022)
  • Author(s): 小松雅明
  • Organizer: 日本Cell Death学会 特別講演
  • Invited
• [Presentation] Vault-phagy: selective autophagy of large cytoplasmic ribonucleoprotein particles, Vault (2022)
  • Author(s): Masaaki Komatsu
  • Organizer: EMBO Meeting
  • Int'l Joint Research / Invited
• [Presentation] Physiological importance of p62-phosphorylation in NRF2-activation (2022)
  • Author(s): Masaaki Komatsu
  • Organizer: Frankfurt Conference on Quality Control in life Processes
  • Int'l Joint Research / Invited
• [Presentation] UFM1システムによるER&#8210;phagy制御ーその異常と遺伝性脳症ー (2022)
  • Author(s): 石村亮輔、小松雅明
  • Organizer: 第64回日本小児神経学会学術集会
  • Invited
• [Presentation] Proteomic approaches to purified p62-bodies and selective autophagy-deficient mice identify a novel substrate for p62-mediated selective autophagy (2022)
  • Author(s): Hideaki Morishita*, Reo Kurusu*, Yuki Fujimoto*, Shuhei Takada, Masaaki Komatsu
  • Organizer: 10th International Symposium on Autophagy
  • Int'l Joint Research
• [Presentation] Vault-phagy: selective autophagy of large cytoplasmic ribonucleoprotein particles, Vault (2022)
  • Author(s): Masaaki Komatsu
  • Organizer: JSPS 日中韓フォーサイト事業A3 conference
  • Int'l Joint Research / Invited
• [Presentation] 選択的オートファジー：狙われるには理由がある (2022)
  • Author(s): 小松雅明
  • Organizer: 愛知県がんセンター研究所招聘セミナー
  • Invited
• [Presentation] 新局面を迎えるオートファジー研究 (2021)
  • Author(s): 小松雅明
  • Organizer: 第17回日本病理学会カンファレンス特別講演
  • Invited
• [Presentation] p62液滴介在性オートファジーによる超分子複合体の分解機構 (2021)
  • Author(s): 小松雅明
  • Organizer: 第94回日本生化学会シンポジウム
  • Invited
• [Presentation] Autophagy and the Ufm1-system (2020)
  • Author(s): Masaaki Komatsu
  • Organizer: Autophagy India Network webinar lecture series 2020
• [Presentation] ER-phagy Mediated by the Ufm1-System (2020)
  • Author(s): Masaaki Komatsu
  • Organizer: KEYSTONE SYMPOSIA Autophagy: Mechanisms and Disease
• [Presentation] p62/SQSTM1-droplet serves as a platform for autophagosome formation and antioxidative stress response (2020)
  • Author(s): Shun Kageyama, Sigurdur Gudmundsson, Yu-Shin Sou, ..., Masaaki Komatsu
  • Organizer: KEYSTONE SYMPOSIA Autophagy: Mechanisms and Disease
• [Presentation] E3-ligase for the UFM1-system acts as an adaptor for ER-phagy (2020)
  • Author(s): Ryosuke Ishimura, Afnan El-Gowily, Nobuo N Noda , Masaaki Komatsu
  • Organizer: KEYSTONE SYMPOSIA Autophagy: Mechanisms and Disease
• [Presentation] Selective turnover of p62-liquid droplets through autophagy (2020)
  • Author(s): Masaaki Komatsu
  • Organizer: International Conference on Autophagy and Lysosomes
  • Int'l Joint Research / Invited
• [Presentation] 選択的マクロオートファジー：分子から生理機能まで (2019)
  • Author(s): 小松雅明
  • Organizer: Science Pioneers Consortium 2019
  • Invited
• [Presentation] Selective turnover of p62-bodies through autophagy (2019)
  • Author(s): Masaaki Komatsu
  • Organizer: Seoul National University Bioscience Symposium
  • Int'l Joint Research / Invited
• [Presentation] 選択的マクロオートファジー：分子から生理機能まで (2019)
  • Author(s): 小松雅明
  • Organizer: 第4回抗酸菌研究会
  • Invited
• [Presentation] Selective turnover of p62-bodies through autophagy (2019)
  • Author(s): Masaaki Komatsu
  • Organizer: 9th International Symposium on Autophagy
  • Int'l Joint Research / Invited
• [Presentation] Selective turnover of p62-liquid droplets through autophagy (2019)
  • Author(s): Masaaki Komatsu
  • Organizer: Asian Pacific Prion Symposium 2019
  • Int'l Joint Research / Invited
• [Presentation] オートファジー、選択性が生む細胞制御機構 (2019)
  • Author(s): 小松雅明
  • Organizer: 第19回お茶の水眼アレルギー研究会
  • Invited
• [Presentation] オートファジーと癌：両刃の剣 (2019)
  • Author(s): 小松雅明
  • Organizer: 第31回文京脳腫瘍研究会
  • Invited
• [Presentation] 選択的マクロオートファジー：分子から生理機能まで (2019)
  • Author(s): 小松雅明
  • Organizer: 第92回日本生化学会大会
  • Invited
• [Presentation] 選択的オートファジーによる転写制御 (2019)
  • Author(s): 小松雅明
  • Organizer: 第66回日本実験動物学会
  • Invited
• [Remarks] 順天堂大学大学院医学研究科 器官・細胞生理
  • URL: https://www.juntendo.ac.jp/graduate/laboratory/labo/kikan_saibou/
• [Remarks] 文部科学省 新学術領域研究「マルチモードオートファジー」
  • URL: https://proteolysis.jp/multimode_autophagy/
• [Remarks] 順天堂大学大学院医学研究科 器官・細胞生理学（生理学２）
  • URL: https://www.juntendo.ac.jp/graduate/laboratory/labo/kikan_saibou/
• [Remarks] 文部科学省科学研究費助成事業 新学術領域研究 マルチモードオートファジー
  • URL: https://proteolysis.jp/multimode_autophagy/
• [Remarks] 順天堂大学医学部生理学第二講座
  • URL: https://www.juntendo.ac.jp/graduate/laboratory/labo/kikan_saibou/
• [Remarks] 日本学術振興会 日中韓フォーサイト事業 オートファジー、代謝と神経変性疾患
  • URL: https://www.juntendo.ac.jp/graduate/laboratory/labo/kikan_saibou/
• [Remarks] 文部科学省 新学術領域研究 マルチモードオートファジー 多彩な経路と選択性が織り成す自己分解系の理解
  • URL: http://proteolysis.jp/multimode_autophagy/
• [Remarks] 日本学術振興会 日中韓フォーサイト事業 オートファジー、代謝と神経変性疾患
  • URL: https://www.med.niigata-u.ac.jp/bc1/A3/index.html
• [Funded Workshop] 10th International Symposium on Autophagy (2022)