| Budget Amount *help |
¥139,490,000 (Direct Cost: ¥107,300,000、Indirect Cost: ¥32,190,000)
Fiscal Year 2023: ¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Fiscal Year 2022: ¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Fiscal Year 2021: ¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Fiscal Year 2020: ¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Fiscal Year 2019: ¥30,810,000 (Direct Cost: ¥23,700,000、Indirect Cost: ¥7,110,000)
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| Outline of Final Research Achievements |
The structural basis of the core Atg factors responsible for autophagosome formation, a central event in autophagy, and those responsible for selective autophagy were elucidated using X-ray crystallography, cryo-EM, high-speed AFM and NMR. Structure-based functional analyses revealed the autophagy initiation mechanism by phase separation of Atg1 complex, the expansion mechanism of isolation membrane by the lipid scrambling activity of Atg9, the shaping mechanism of isolation membrane by Atg8 and its E1-E2-E3 enzymes, the mitophagy driving mechanism by Atg44, a novel mitochondrial fission factor, and the ERphagy-driven mechanism by Atg40 and TEX264, and the molecular mechanism of droplet-selective autophagy.
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