| Budget Amount *help |
¥86,320,000 (Direct Cost: ¥66,400,000、Indirect Cost: ¥19,920,000)
Fiscal Year 2023: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2022: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2021: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2020: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2019: ¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
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| Outline of Final Research Achievements |
Microautophagy is a pathway in which lysosomal or endosomal membranes are directly deformed to engulf cytoplasmic components for degradation. It constitutes one of the diverse autophagy pathways, and still has many unexplored aspects. The choice of whether to use microautophagy or another macroautophagy to degrade intracellular components may be controlled by the cell depending on environmental conditions, but the mechanism remains largely unknown. In this research project, we discovered a group of ESCRT proteins as factors that function specifically in microautophagy, and also revealed the function of the MAP kinase pathway that negatively regulates peroxisome-selective autophagy, and that of a ubiquitin ligase in lipid droplet-specific ｍicroautophagy. We also succeeded in identifying an Atg protein that functions in both macroautophagy and microautophagy in a methanol-utilizing yeast.
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