| Budget Amount *help |
¥66,820,000 (Direct Cost: ¥51,400,000、Indirect Cost: ¥15,420,000)
Fiscal Year 2023: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2022: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2021: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2020: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2019: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
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| Outline of Final Research Achievements |
We showed that ATP consumption is required for lysosomal uptake of nucleic acids during RNautophagy/DNautophagy (RDA), but V-ATPase is not required. We found multiple regulatory mechanisms underlying RNautophagy, including an activation mechanism mediated by innate immune receptors and a nucleic acid binding sequence in the cytoplasmic domain of SIDT2. We found a phenomenon in which proteins are directly taken up into lysosomes in an ATP-dependent manner and degraded. We also found that SIDT2 mediates this pathway. Furthermore, we revealed that dysfunction of this degradation mechanism leads to accumulation of proteins within cells, causing neuromuscular diseases.
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