| Budget Amount *help |
¥75,400,000 (Direct Cost: ¥58,000,000、Indirect Cost: ¥17,400,000)
Fiscal Year 2023: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2022: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2021: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2020: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2019: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Outline of Final Research Achievements |
In this study, we found that the ubiquitin ligase MARC-3 and the ubiquitin-conjugating enzyme LET-70 are involved in the degradation of oocyte plasma membrane proteins that occurs after fertilization in C. elegans. On the other hand, we found that parts of maternal plasma membrane proteins are internalized from the plasma membrane via clathrin-mediated endocytosis and degraded in lysosomes in early mouse embryos. We also revealed that clathrin-mediated endocytosis is essential for early development. These findings indicate that post-fertilization plasma membrane degradation is an essential process for early embryogenesis and is conserved among species.
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