Exploration of Bio and Environmental Functions of Aquatic Functional Materials

• Project Area: Aquatic Functional Materials: Creation of New Materials Science for Environment-Friendly and Active Functions
• Project/Area Number: 19H05720
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Kyushu University
• Principal Investigator: 田中 賢 九州大学, 先導物質化学研究所, 教授 (00322850)
• Co-Investigator(Kenkyū-buntansha): 藤井 義久 三重大学, 工学研究科, 准教授 (70578062)
• Project Period (FY): 2019-06-28 – 2024-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥116,480,000 (Direct Cost: ¥89,600,000、Indirect Cost: ¥26,880,000); Fiscal Year 2023: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000); Fiscal Year 2022: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2021: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2020: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2019: ¥46,020,000 (Direct Cost: ¥35,400,000、Indirect Cost: ¥10,620,000)
• Keywords: バイオ界面水 / 生体親和性 / 細胞接着 / 水和界面物性 / 表面ダイナミクス / 中間水 / バイオ界面 / 界面ダイナミクス / 密着性 / 界面レオロジー / 合成高分子 / 水和界面 / 走査プローブ顕微鏡 / 高分子精密合成 / 界面構造・物性解析 / 高分子合成 / タンパク質吸着

Outline of Research at the Start

水圏バイオ・環境機能材料構築を達成するために、材料の化学構造と水和による物理化学的な物性変化により、界面水の構造・運動を制御することで、特定の生体分子や細胞を選択的に認識する生体親和性材料を創製する。界面水の構造・運動を制御するための高分子の精密合成と生体機能評価を行う。また、水中プローブ顕微鏡技術による合成高分子の界面状態の解明・制御を行う。A02（先端計測・シミュレーション班）との連携により水・材料界面の状態を精密解析する技術を確立し、界面水構造・運動制御の基礎学理を構築する。A01（分子・材料構築班）と連携し、生体親和性および金属ステント表面への高接着性を示す材料の設計指針を創出する。

Outline of Annual Research Achievements

生体親和性高分子の金属ステント表面への密着性を向上させるために、無機化合物であるランダム型シルセスキオキサン(SQ)とポリ(2-メトキシエチルアクリレート) (PMEA)のハイブリッドSQ/PMEAを新規に設計した。その結果、Qをコアにもつ擬スター構造と疎水的SQ部位の基材へのアンカー効果により密着安定性が向上し、金属基板表面を完全に被覆することができた。また、SQ/PMEA (Si = 5%)は構造由来の高い運動性から、PMEAの中間水形成能を阻害せず、血小板の粘着を抑制した。また、血管内皮細胞の接着・増殖を促進したことから循環器用のステントの創製に有益であることがわかった。また、アルキル基を介してピロリドン環を側鎖に有するアクリレート高分子(PNARP)を新規に設計・合成した。PNARPは、温度応答性を示すとともにポリ（N-イソプロピルアクリルアミド）よりも血小板の粘着を抑制できた。PNARPは、PMEAと同等の生体親和性を有し、金属表面への密着性はPMEAより優れていることも確認した。生体親和性の異なる水圏材料に対して原子間力顕微鏡、水晶振動子法、軟X線発光分光を用いたマルチプローブ計測を行い、高分子と水の相互作用が水の水和構造に及ぼす影響についても解明した。さらに、精密構造解析の観点から中性子反射率測定に基づき薄膜材料の水和状態と生体親和性との関係について検討行い、これまで水和環境下で安定した薄膜化が困難な高分子種についても評価可能な組み合わせを見出した。走査プローブ顕微鏡による局所的な力学物性解析に基づき、ポリエチレンオキシド薄膜における分子鎖凝集構造と水和状態、水分子の可塑化効果について明らかにした。また、新規な特殊構造高分子だけでなく、汎用高分子を用いて、物理化学的な観点から材料表面の親疎水性と微細な表面形状がタンパク質の吸着特性と関係することを確認した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

A01（分子・材料構築班）と連携し、生体親和性および金属ステント表面への密着性を示す材料の設計・合成に成功した。また、水和環境における高分子の表面物性および水和構造・運動解析を進展させるために、官能基の構造、位置、量、配列が精密に制御された生体親和性合成高分子の合成を計画通りに行った。また、高分子の化学構造と水和による物理化学的な物性変化を精密に評価するために、水和した高分子の物理化学物性について解析を進めた。水和状態における生体親和性材料の分子鎖凝集状態の精密解析に基づきサブマイクロメートルの面内方向およびサブナノメートルの深さ方向における水分子の詳細な分布と状態が材料機能特性に及ぼす影響について検討を行い、水分子の働きについても知見を得ることに成功した。また、走査プローブ顕微鏡を用いて基板の影響を受けることなく薄膜本来の力学物性を評価する方法を確立、さらには、乾燥および水和状態における薄膜表面のガラス転移温度計測にも取り組み、最終年度の物理化学的な材料物性と中間水量の関係解明に繋げる成果が得られた。さらに、A03内だけではなくA02（先端計測・シミュレーション班）との連携、公募研究との共同研究など、領域内連携を推進したことで、24報の原著論文を出版できた。

Strategy for Future Research Activity

水圏バイオ・環境機能材料の設計指針の構築を行うために、官能基の構造、位置、量、配列が制御された合成高分子の生体親和性発現機構を明らかにする。機構解明には、プローブ顕微鏡測定、中性子散乱測定、放射光分光、テラヘルツ分光、シミュレーションなどの手法により水和した高分子および高分子に水和した水の状態を定量化する。本年度は、１．含水時に形成される中間水量を制御した合成高分子の金属ステントへの表面処理特性を評価する。２．乾燥および水和状態における高分子のガラス転移温度、弾性率などの物理化学的な材料物性と中間水量の関係を明らかにする。ポリ（2－メトキシエチルアクリレート）などの重水素化物を用いた中性子計測を行う。３．タンパク質吸着挙動に影響する水和膨潤層の評価を周波数変調型の原子間力顕微鏡により評価する。水和高分子の空間分布変化、水の吸着サイト、水の水素結合ネットワーク構造との関係を考察し、水圏機能材料構築の学理を深める。複数の公募研究と連携して水圏における高分子の表面物性および水和構造・運動性解析とタンパク質の吸着・構造変化、細胞接着との相関解明を行う。また、A02との連携を発展させ含水時の材料物性と細胞接着挙動を予測可能にする機械学習モデルの精度の向上を図る。これにより、生体親和性および金属ステント表面への高接着性を示す材料の設計指針を創出する。

Research Products

• [Int'l Joint Research] University of California, Berkeley(米国)
• [Int'l Joint Research] Glasgow University(英国)
• [Int'l Joint Research] Technical University of Denmark(デンマーク)
• [Int'l Joint Research] National Research Centre, Egypt(エジプト)
• [Int'l Joint Research] National Taiwan University(その他の国・地域)
• [Int'l Joint Research]
• [Int'l Joint Research] デンマーク工科大学(デンマーク)
• [Int'l Joint Research] バイオマテリアル研究所(エジプト)
• [Int'l Joint Research] ケンブリッジ大学(英国)
• [Int'l Joint Research] カリフォルニア大学バークレー校(米国)
• [Int'l Joint Research] ロイトリンゲン大学(ドイツ)
• [Int'l Joint Research] バイオマテリアル研究所(エジプト)
• [Int'l Joint Research] グラスゴー大学(英国)
• [Int'l Joint Research] デンマーク工科大学(デンマーク)
• [Int'l Joint Research] デンマーク工科大学(デンマーク)
• [Journal Article] Interfacial Selective Study on the Gelation Behavior of Aqueous Methylcellulose Solution via a Quartz Crystal Microbalance (2022)
  • Author(s): Kenji Yamaoka, Norifumi L. Yamadam. Koichiro Hori, Yoshihisa Fujii, Naoya Torikai
  • Journal Title: Langmuir Volume: 38 Issue: 15 Pages: 4494-4502
  • DOI: 10.1021/acs.langmuir.1c02728
  • Peer Reviewed
• [Journal Article] Humidity-Induced Self-Assembled Nanostructure via Ion Aggregation in Ionic Linear Polysiloxanes (2022)
  • Author(s): Mitsuo Hara, Atsuki Kodama, Shohei Washiyama, Yoshihisa Fujii, Shusaku Nagano, Takahiro Seki
  • Journal Title: Macromolecules Volume: - Issue: 11 Pages: 4313-4319
  • DOI: 10.1021/acs.macromol.2c00404
  • Peer Reviewed
• [Journal Article] A β-hairpin peptide with pH-controlled affinity for tumor cells (2022)
  • Author(s): Nishimura Shin-nosuke、Nishida Kei、Tanaka Masaru
  • Journal Title: Chemical Communications Volume: 58 Issue: 4 Pages: 505-508
  • DOI: 10.1039/d1cc06218b
  • Peer Reviewed
• [Journal Article] Observing the Repulsion Layers on Blood-compatible Polymer-grafted Interfaces by Frequency Modulation Atomic Force Microscopy (2022)
  • Author(s): D. Murakami, S. Nishimura, Y. Tanaka, M. Tanaka
  • Journal Title: Biomaterials Advances Volume: 133 Pages: 112596-112596
  • DOI: 10.1016/j.msec.2021.112596
  • Peer Reviewed
• [Journal Article] Hydration Mechanism in Blood-Compatible Polymers Undergoing Phase Separation (2022)
  • Author(s): Murakami Daiki、Yamazoe Kosuke、Nishimura Shin-nosuke、Kurahashi Naoya、Ueda Tomoya、Miyawaki Jun、Ikemoto Yuka、Tanaka Masaru、Harada Yoshihisa
  • Journal Title: Langmuir Volume: 38 Issue: 3 Pages: 1090-1098
  • DOI: 10.1021/acs.langmuir.1c02672
  • Peer Reviewed
• [Journal Article] Modulation of Biological Responses of Tumor Cells Adhered to Poly(2-methoxyethyl acrylate) with Increasing Cell Viability under Serum-Free Conditions (2022)
  • Author(s): Nishida Kei、Sekida Shogo、Anada Takahisa、Tanaka Masaru
  • Journal Title: ACS Biomaterials Science & Engineering Volume: 8 Issue: 2 Pages: 672-681
  • DOI: 10.1021/acsbiomaterials.1c01469
  • Peer Reviewed
• [Journal Article] Selective Accumulation to Tumor Cells with Coacervate Droplets Formed from a Water-Insoluble Acrylate Polymer (2022)
  • Author(s): Nishida Kei、Nishimura Shin-nosuke、Tanaka Masaru
  • Journal Title: Biomacromolecules Volume: 23 Issue: 4 Pages: 1569-1580
  • DOI: 10.1021/acs.biomac.1c01343
  • Peer Reviewed
• [Journal Article] Experimental evidences of slow mode water in the vicinity of polyethylene oxide at physiological temperature (2022)
  • Author(s): Taiki Tominaga, Mafumi Hishida, Daiki Murakami, Yoshihisa Fujii, Masaru Tanaka, Hideki Seto
  • Journal Title: Journal of Physical Chemistry B Volume: 126 Issue: 8 Pages: 1758-1767
  • DOI: 10.1021/acs.jpcb.1c09044
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Osmolytes on Water Mobility Correlates with Their Stabilizing Effect on Proteins (2022)
  • Author(s): Mafumi Hishida, Rubaiya Anjum, Takahisa Anada, Daiki Murakami, Masaru Tanaka
  • Journal Title: The Journal of Physical Chemistry B Volume: 126 Issue: 13 Pages: 2466-2475
  • DOI: 10.1021/acs.jpcb.1c10634
  • Peer Reviewed
• [Journal Article] Biocompatible poly(<i>N</i>-(ω-acryloyloxy-<i>n</i>-alkyl)-2-pyrrolidone)s with widely-tunable lower critical solution temperatures (LCSTs): a promising alternative to poly(<i>N</i>-isopropylacrylamide) (2022)
  • Author(s): Nishimura Shin-nosuke、Nishida Kei、Ueda Tomoya、Shiomoto Shohei、Tanaka Masaru
  • Journal Title: Polymer Chemistry Volume: ー Issue: 17 Pages: 2519-2530
  • DOI: 10.1039/d2py00154c
  • Peer Reviewed
• [Journal Article] Nanoscopic analyses of cell-adhesive protein adsorption on poly(2-methoxyethyl acrylate) surfaces (2022)
  • Author(s): Nishida Kei、Baba Koki、Murakami Daiki、Tanaka Masaru
  • Journal Title: Biomaterials Science Volume: 10 Issue: 11 Pages: 2953-2963
  • DOI: 10.1039/d2bm00093h
  • Peer Reviewed
• [Journal Article] Roles of interfacial water states on advanced biomedical material design (2022)
  • Author(s): Nishida Kei、Anada Takahisa、Tanaka Masaru
  • Journal Title: Advanced Drug Delivery Reviews Volume: 186 Pages: 114310-114310
  • DOI: 10.1016/j.addr.2022.114310
  • Peer Reviewed
• [Journal Article] Surfactant-Free Suspension Polymerization of Hydrophilic Monomers with an Oil-in-Water System for the Preparation of Microparticles Toward the Selective Isolation of Tumor Cells (2022)
  • Author(s): Nishimura Shin-nosuke、Nishida Kei、Shiomoto Shohei、Tanaka Masaru
  • Journal Title: Materials Advances Volume: 3 Issue: 12 Pages: 5043-5054
  • DOI: 10.1039/d2ma00129b
  • Peer Reviewed / Open Access
• [Journal Article] Infrared Spectra and Hydrogen-Bond Configurations of Water Molecules at the Interface of Water-Insoluble Polymers under Humidified Conditions (2022)
  • Author(s): Yuka Ikemoto, Yoshihisa Harada, Masaru Tanaka, Daiki Murakami, Shin-nosuke Nishimura, Naoya Kurahashi, Taro Moriwaki, Kosuke Yamazoe, Hitoshi Washizu, Yoshiki Ishii, Hajime Torii
  • Journal Title: Journal of Physical Chemistry B Volume: 126 Issue: 22 Pages: 4143-4151
  • DOI: 10.1021/acs.jpcb.2c01702
  • Peer Reviewed / Open Access
• [Journal Article] Manipulation of Surface Hydration States by Tuning the Oligo(Ethylene Glycol) Moieties on PEDOT to Achieve Platelet-Resistant Bioelectrode Applications (2022)
  • Author(s): J Huang, C.-H. Lin, Y. Tanaka, A. Yamamoto, S.-C Luo, M. Tanaka
  • Journal Title: Advanced Materials Interfaces Volume: 9 Issue: 33 Pages: 2200707-2200707
  • DOI: 10.1002/admi.202200707
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sol-gel silicate glass doped with silver for bone regeneration: Antibacterial activity, intermediate water, and cell death mode (2022)
  • Author(s): M. Mabrouk, H. H. Beherei, Y. Tanaka, M. Tanaka
  • Journal Title: Biomaterials Advances Volume: 138 Pages: 212965-212965
  • DOI: 10.1016/j.bioadv.2022.212965
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Characterization of Hydration Water Bound to Choline Phosphate-Containing Polymers (2022)
  • Author(s): Shiomoto Shohei、Inoue Kaito、Higuchi Hayato、Nishimura Shin-nosuke、Takaba Hiromitsu、Tanaka Masaru、Kobayashi Motoyasu
  • Journal Title: Biomacromolecules Volume: 23 Issue: 7 Pages: 2999-3008
  • DOI: 10.1021/acs.biomac.2c00484
  • Peer Reviewed
• [Journal Article] Poly(2-methoxyethyl acrylate)(PMEA)-coated anti-platelet adhesive surfaces to mimic native blood vessels through HUVECs attachment, migration, and monolayer formation (2022)
  • Author(s): M. A. Haque, D. Murakami, T. Anada, M. Tanaka
  • Journal Title: Coatings Volume: 12 Issue: 6 Pages: 869-869
  • DOI: 10.3390/coatings12060869
  • Peer Reviewed
• [Journal Article] Organic Carboxylate Salt-Enabled Alternative Synthetic Routes for Bio-Functional Cyclic Carbonates and Aliphatic Polycarbonates (2022)
  • Author(s): Watanabe Yuya、Takaoka Shunya、Haga Yuta、Kishi Kohei、Hakozaki Shunta、Narumi Atsushi、Kato Takashi、Tanaka Masaru、Fukushima Kazuki
  • Journal Title: Polymer Chemistry Volume: 13 Issue: 36 Pages: 5193-5199
  • DOI: 10.1039/d2py00705c
  • Peer Reviewed / Open Access
• [Journal Article] Cell Adhesion Strength Indicates the Antithrombogenicity of Poly(2-Methoxyethyl Acrylate) (PMEA): Potential Candidate for Artificial Small-Diameter Blood Vessel (2022)
  • Author(s): M. A. Haque, D. Murakami, M. Tanaka
  • Journal Title: Surfaces Volume: 5 Issue: 3 Pages: 365-382
  • DOI: 10.3390/surfaces5030027
  • Peer Reviewed
• [Journal Article] Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular substrate (2022)
  • Author(s): Junsu Park, Tomoya Ueda, Yusaku Kawai, Kumiko Araki, Makiko Kido, Bunsho Kure, Naomi Takenaka, Yoshinori Takashima, Masaru Tanaka
  • Journal Title: RSC Adv. Volume: 12 Issue: 43 Pages: 27912-27917
  • DOI: 10.1039/d2ra04885j
  • Peer Reviewed / Open Access
• [Journal Article] Enrichment of Cancer Cells Based on Antibody-Free Selective Cell Adhesion (2022)
  • Author(s): Shingo Kobayashi, Atsushi Sugasaki, Yosuke Yamamoto, Yuta Shigenoi, Airi Udaka, Aki Yamamoto, and Masaru Tanaka
  • Journal Title: ACS Biomaterials Science & Engineering Volume: 8 Issue: 10 Pages: 4574-4556
  • DOI: 10.1021/acsbiomaterials.2c00662
  • Peer Reviewed
• [Journal Article] Alkyl chain length-dependent protein nonadsorption and adsorption properties of crystalline alkyl β-celluloside assemblies (2022)
  • Author(s): Serizawa Takeshi、Yamaguchi Saeko、Amitani Moe、Ishii Sawa、Tsuyuki Hiromi、Tanaka Yukiko、Sawada Toshiki、Kawamura Izuru、Watanabe Go、Tanaka Masaru
  • Journal Title: Colloids and Surfaces B: Biointerfaces Volume: 220 Pages: 112898-112898
  • DOI: 10.1016/j.colsurfb.2022.112898
  • Peer Reviewed
• [Journal Article] Comparative Study of PEG and PEGylated Dendrimer in their Eutectic Mixtures of Water Analyzed using X-ray Diffraction and Infrared Spectroscopy (2022)
  • Author(s): Chie Kojima, Yasuhito Suzuki, Yuka Ikemoto, Masaru Tanaka and Akikazu Matsumoto
  • Journal Title: Polymer Journal Volume: 55 Issue: 1 Pages: 63-73
  • DOI: 10.1038/s41428-022-00700-5
  • Peer Reviewed / Open Access
• [Journal Article] 中性子準弾性散乱による水和水の運動状態解析 (2022)
  • Author(s): 瀬戸 秀紀，山田 武，富永 大輝，藤井 義久
  • Journal Title: 熱測定 Volume: 49 Pages: 20-25
  • Peer Reviewed / Open Access
• [Journal Article] Behavior of supramolecular cross-links formed by host-guest interactions in hydrogels responding to water contents (2022)
  • Author(s): Ueda Chiharu、Park Junsu、Hirose Kazuya、Konishi Subaru、Ikemoto Yuka、Osaki Motofumi、Yamaguchi Hiroyasu、Harada Akira、Tanaka Masaru、Watanabe Go、Takashima Yoshinori
  • Journal Title: Supramolecular Materials Volume: 1 Pages: 100001-100001
  • DOI: 10.1016/j.supmat.2021.100001
  • Peer Reviewed / Open Access
• [Journal Article] Fluorine-Containing Bio-Inert Polymers ;Roles of Intermediate Water (2022)
  • Author(s): R. Koguchi, K. Jankova, M. Tanaka
  • Journal Title: Acta Biomaterialia Volume: 138 Pages: 34-56
  • DOI: 10.1016/j.actbio.2021.10.027
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of Local Gelation Behavior of Aqueous Methylcellulose Solution Using Quartz Crystal Microbalance (2021)
  • Author(s): Kenji Yamaoka, Yoshihisa Fujii, Naoya Torikai
  • Journal Title: MATERIALS TRANSACTIONS Volume: 62 Issue: 5 Pages: 647-654
  • DOI: 10.2320/matertrans.MT-M2020392
  • NAID: 130008029710
  • ISSN: 1345-9678, 1347-5320
  • Year and Date: 2021-05-01
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of Local Gelation Behavior of Aqueous Methylcellulose Solution Using Quartz Crystal Microbalance (2021)
  • Author(s): 山岡賢司, 藤井義久, 鳥飼直也
  • Journal Title: Journal of the Japan Institute of Metals and Materials Volume: 85 Issue: 1 Pages: 23-29
  • DOI: 10.2320/jinstmet.JD202007
  • NAID: 130007959981
  • ISSN: 0021-4876, 1880-6880, 2433-7501
  • Year and Date: 2021-01-01
  • Peer Reviewed / Open Access
• [Journal Article] Local Dynamics of the Hydration Water and Poly(methyl methacrylate) (PMMA) Chains in PMMA Networks (2021)
  • Author(s): Y. Fujii, T. Tominaga, D. Murakami, M. Tanaka and H. Seto
  • Journal Title: Frontiers in Chemistry Volume: 9
  • DOI: 10.3389/fchem.2021.728738
  • Peer Reviewed / Open Access
• [Journal Article] Periodically Functionalized Linear Polyethylene with Tertiary Amino Groups via Regioselective Ring-Opening Metathesis Polymerization (2021)
  • Author(s): Sonoda Toshiki、Kobayashi Shingo、Tanaka Masaru
  • Journal Title: Macromolecules Volume: 54 Issue: 6 Pages: 2862-2872
  • DOI: 10.1021/acs.macromol.0c02611
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chain End Effect for Intermediate Water Formation of Poly(2-methoxyethyl acrylate) (2021)
  • Author(s): Nishimura Shin-nosuke、Ueda Tomoya、Murakami Daiki、Tanaka Masaru
  • Journal Title: Organic Materials Volume: - Issue: 02 Pages: 214-202
  • DOI: 10.1055/a-1441-8239
  • Peer Reviewed / Open Access
• [Journal Article] Attachment and Growth of Fibroblast Cells on Poly (2-Methoxyethyl Acrylate) Analog Polymers as Coating Materials (2021)
  • Author(s): Anjum Rubaiya、Nishida Kei、Matsumoto Haruka、Murakami Daiki、Kobayashi Shingo、Anada Takahisa、Tanaka Masaru
  • Journal Title: Coatings Volume: 11 Issue: 4 Pages: 461-461
  • DOI: 10.3390/coatings11040461
  • Peer Reviewed / Open Access
• [Journal Article] Different hydration states and passive tumor targeting ability of polyethylene glycol-modified dendrimers with high and low PEG density (2021)
  • Author(s): Tsujimoto Ayako、Uehara Hiroki、Yoshida Haruna、Nishio Misaki、Furuta Kousuke、Inui Takashi、Matsumoto Akikazu、Morita Shigeaki、Tanaka Masaru、Kojima Chie
  • Journal Title: Materials Science and Engineering: C Volume: - Pages: 112159-112159
  • DOI: 10.1016/j.msec.2021.112159
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Side-Chain Spacing and Length on Hydration States of the Poly(2-methoxyethyl acrylate) Analogs: A Molecular Dynamics Study (2021)
  • Author(s): A. T. Kuo, S. Urata, R. Koguchi, T. Sonoda, S. Kobayashi, M. Tanaka
  • Journal Title: ACS Biomaterials Science & Engineering Volume: 7 Issue: 6 Pages: 2383-2391
  • DOI: 10.1021/acsbiomaterials.1c00388
  • Peer Reviewed / Open Access
• [Journal Article] Poly(tertiary amide acrylate) (Co)polymers Inspired by Poly(2-oxazoline)s: Their Blood Compatibility and Hydration States (2021)
  • Author(s): S. Liu, S. Kobayashi, T. Sonoda, M. Tanaka
  • Journal Title: Biomacromolecules Volume: 22 Pages: 2718-2728
  • Peer Reviewed / Open Access
• [Journal Article] In vitro and In vivo Blood Compatibility of Concentrated Polymer Brushes (2021)
  • Author(s): C. Yoshikawa, S. Hattori, C-F. Huang, H. Kobayashi, M. Tanaka
  • Journal Title: Journal of Materials Chemistry B Volume: 9 Issue: 29 Pages: 5794-5804
  • DOI: 10.1039/d1tb00886b
  • Peer Reviewed / Open Access
• [Journal Article] First Observation of the Hydration Layer around Polymer Chain by Scattering and Its Relationship to Thromboresistance: Dilute Solution Properties of PMEA in THF/Water (2021)
  • Author(s): Kanamaru Takuma、Araki Masataka、Takahashi Rintaro、Fujii Shota、Shikata Toshiyuki、Murakami Daiki、Tanaka Masaru、Sakurai Kazuo
  • Journal Title: The Journal of Physical Chemistry B Volume: 125 Issue: 26 Pages: 7251-7261
  • DOI: 10.1021/acs.jpcb.1c01864
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Branching Degree of Dendritic Polyglycerols on Plasma Protein Adsorption: Relationship Between Hydration States and Surface Morphology (2021)
  • Author(s): M. Yamazaki, Y. Sugimoto, D. Murakami, M. Tanaka, T. Ooya
  • Journal Title: Langmuir Volume: 37 Issue: 28 Pages: 8534-8543
  • DOI: 10.1021/acs.langmuir.1c01003
  • Peer Reviewed / Open Access
• [Journal Article] Protein Stabilization Effect of Zwitterionic Osmolyte-bearing Polymer (2021)
  • Author(s): Anjum Rubaiya、Nishimura Shin-nosuke、Kobayashi Shingo、Nishida Kei、Anada Takahisa、Tanaka Masaru
  • Journal Title: Chemistry Letters Volume: 50 Issue: 9 Pages: 1699-1702
  • DOI: 10.1246/cl.210335
  • NAID: 130008088239
  • Peer Reviewed / Open Access
• [Journal Article] Effect of pendant groups on the blood compatibility and hydration states of poly(2‐oxazoline)s (2021)
  • Author(s): Liu Shichen、Kobayashi Shingo、Nishimura Shin‐nosuke、Ueda Tomoya、Tanaka Masaru
  • Journal Title: Journal of Polymer Science Volume: 59 Issue: 21 Pages: 2559-2570
  • DOI: 10.1002/pol.20210410
  • Peer Reviewed / Open Access
• [Journal Article] Investigating the Intermediate Water Feature of Hydrated Titanium Containing Bioactive Glass (2021)
  • Author(s): M. Mabrouk, H.H. Beherei, Y. Tanaka, M. Tanaka
  • Journal Title: Int. J. Mol. Sci. Volume: 22 Issue: 15 Pages: 8038-8038
  • DOI: 10.3390/ijms22158038
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of bound water content on cell adhesion strength to water-insoluble polymers (2021)
  • Author(s): Nishida Kei、Anada Takahisa、Kobayashi Shingo、Ueda Tomoya、Tanaka Masaru
  • Journal Title: Acta Biomaterialia Volume: 134 Pages: 313-324
  • DOI: 10.1016/j.actbio.2021.07.058
  • Peer Reviewed / Open Access
• [Journal Article] Effect of amount of hydrated water and mobility of hydrated poly(2‐methoxyethyl acrylate) on denaturation of adsorbed fibrinogen (2021)
  • Author(s): Ueda Tomoya、Murakami Daiki、Tanaka Masaru
  • Journal Title: Journal of Polymer Science Volume: 59 Issue: 22 Pages: 2763-2770
  • DOI: 10.1002/pol.20210496
  • Peer Reviewed / Open Access
• [Journal Article] Mechanical Properties with Respect to Water Content of Host-Guest Hydrogels (2021)
  • Author(s): Motofumi Osaki, Shin Yonei, Chiharu Ueda, Ryohei Ikura, Junsu Park, Hiroyasu Yamaguchi, Akira Harada, Masaru Tanaka, Yoshinori Takashima
  • Journal Title: MACROMOLECULES Volume: 54 Issue: 17 Pages: 8067-8076
  • DOI: 10.1021/acs.macromol.1c00970
  • Peer Reviewed / Open Access
• [Journal Article] Protein- and Cell-Resistance of Zwitterionic Peptide-Based Self-Assembled Monolayers: Anti-Biofouling Tests and Surface Force Analysis (2021)
  • Author(s): Ryongsok Chang, Evan Angelo Quimada Mondarte, Debabrata Palai, Taito Sekine, Aki Kashiwazaki, Daiki Murakami, Masaru Tanaka, Tomohiro Hayashi
  • Journal Title: Front Chem. Volume: 9 Pages: 748017-748017
  • DOI: 10.3389/fchem.2021.748017
  • Peer Reviewed / Open Access
• [Journal Article] Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo (2021)
  • Author(s): T. Ishizawa, N. Makino, Y. Kakizaki, A. Matsuda, Y. Toyokawa, S. Ooyama, M. Tanaka, Y. Ueno
  • Journal Title: PLoS ONE Volume: 16 Issue: 9 Pages: e0257828-e0257828
  • DOI: 10.1371/journal.pone.0257828
  • Peer Reviewed / Open Access
• [Journal Article] Carborane as an Alternative Efficient Hydrophobic Tag for Protein Degradation (2021)
  • Author(s): Asawa Yasunobu、Nishida Kei、Kawai Kazuki、Domae Kiyotaka、Ban Hyun Seung、Kitazaki Akihiro、Asami Hiroya、Kohno Jun-Ya、Okada Satoshi、Tokuma Hiraku、Sakano Daisuke、Kume Shoen、Tanaka Masaru、Nakamura Hiroyuki
  • Journal Title: Bioconjugate Chemistry Volume: 32 Issue: 11 Pages: 2377-2385
  • DOI: 10.1021/acs.bioconjchem.1c00431
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of interfacial structure based on grafting density of poly(2-methoxyethyl acrylate) on blood compatibility (2021)
  • Author(s): Tomoya Ueda, Daiki Murakami, Masaru Tanaka
  • Journal Title: Colloids and Surfaces B: Biointerfaces Volume: 199 Pages: 111517-111517
  • DOI: 10.1016/j.colsurfb.2020.111517
  • Peer Reviewed / Open Access
• [Journal Article] A fully covered self-expandable metallic stent coated with poly (2-methoxyethyl acrylate) and its derivative: In vitro evaluation of early-stage biliary sludge formation inhibition (2021)
  • Author(s): Yoshihide Toyokawa, Shingo Kobayashi, Haruka Tsuchiya, Tomokazu Shibuya, Makiko Aoki, Jun Sumiya, Shun Ooyama, Tetsuya Ishizawa, Naohiko Makino, Yoshiyuki Ueno, Masaru Tanaka
  • Journal Title: Materials Science and Engineering: C Volume: 120 Pages: 111386-111386
  • DOI: 10.1016/j.msec.2020.111386
  • Peer Reviewed / Open Access
• [Journal Article] Methoxy-Functionalized Glycerol-Based Aliphatic Polycarbonate: Organocatalytic Synthesis, Blood Compatibility, and Hydrolytic Property (2021)
  • Author(s): Valentina Montagna, Junko Takahashi, Meng-Yu Tsai, Takayuki Ota, Nicolas Zivic, Seigou Kawaguchi, Takashi Kato, Masaru Tanaka, Haritz Sardon, Kazuki Fukushima
  • Journal Title: ACS Biomaterials Science & Engineering Volume: 7 Issue: 2 Pages: 472-481
  • DOI: 10.1021/acsbiomaterials.0c01460
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Elucidating the Feature of Intermediate Water in Hydrated Poly(ω-methoxyalkyl acrylate)s by Molecular Dynamics Simulation and Differential Scanning Calorimetry Measurement (2020)
  • Author(s): An-Tsung Kuo, Toshiki Sonoda, Shingo Urata, Ryohei Koguchi, Shingo Kobayashi, Masaru Tanaka
  • Journal Title: ACS Biomaterials Science & Engineering Volume: 6 Issue: 7 Pages: 3915-3924
  • DOI: 10.1021/acsbiomaterials.0c00746
  • Peer Reviewed / Open Access
• [Journal Article] Elucidating the Feature of Intermediate Water in Hydrated Poly(ω-methoxyalkyl acrylate)s by Molecular Dynamics Simulation and Differential Scanning (2020)
  • Author(s): Shin-nosuke Nishimura, Tomoya Ueda, Shingo Kobayashi, Masaru Tanaka
  • Journal Title: ACS Applied Polymer Materials Volume: 2 Issue: 11 Pages: 4790-4801
  • DOI: 10.1021/acsapm.0c00776
  • Peer Reviewed / Open Access
• [Journal Article] Side-Chain Spacing Control of Derivatives of Poly(2-methoxyethyl acrylate): Impact on Hydration States and Antithrombogenicity (2020)
  • Author(s): Toshiki Sonoda, Shingo Kobayashi, Keisuke Herai, Masaru Tanaka
  • Journal Title: Macromolecules Volume: 53 Issue: 19 Pages: 8570-8580
  • DOI: 10.1021/acs.macromol.0c01144
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Molecular Dynamics Study on the Water Mobility and Side-Chain Flexibility of Hydrated Poly(ω-methoxyalkyl acrylate)s (2020)
  • Author(s): An-Tsung Kuo, Shingo Urata, Ryohei Koguchi, Toshiki Sonoda, Shingo Kobayashi, Masaru Tanaka
  • Journal Title: ACS Biomaterials Science & Engineering Volume: 6 Pages: 6690-6700
  • DOI: 10.1016/j.colsurfb.2020.111449
  • Peer Reviewed / Open Access
• [Journal Article] Blood-Compatible Poly(2-methoxyethyl acrylate) Induces Blebbing-like Phenomenon and Promotes Viability of Tumor Cells in Serum-Free Medium (2020)
  • Author(s): Tsai Meng-Yu、Aratsu Fumihiro、Sekida Shogo、Kobayashi Shingo、Tanaka Masaru
  • Journal Title: ACS Applied Bio Materials Volume: - Issue: 4 Pages: 1858-1864
  • DOI: 10.1021/acsabm.9b00885
  • Peer Reviewed
• [Journal Article] Design of Polymeric Biomaterials: The “Intermediate Water Concept (2019)
  • Author(s): M. Tanaka, S. Kobayashi, D. Murakami, F. Aratsu, A. Kashiwazaki, T. Hoshiba, K. Fukushima
  • Journal Title: Bull. Chem. Soc. Jpn. Volume: 92 Issue: 12 Pages: 2043-2057
  • DOI: 10.1246/bcsj.20190274
  • NAID: 130007761387
  • Peer Reviewed / Open Access
• [Journal Article] Control of interfacial structures and anti-platelet adhesion property of blood-compatible random copolymers (2019)
  • Author(s): Murakami Daiki、Segami Yuto、Ueda Tomoya、Tanaka Masaru
  • Journal Title: Journal of Biomaterials Science, Polymer Edition Volume: 31 Issue: 2 Pages: 207-218
  • DOI: 10.1080/09205063.2019.1680930
  • Peer Reviewed
• [Presentation] 水晶振動子マイクロバランスを用いたソフト界面評価 (2023)
  • Author(s): 山岡賢司, 藤井義久, 鳥飼直也
  • Organizer: CIQuS研究会
  • Invited
• [Presentation] 医療用高分子の基礎・生体親和性の発現機構と表面設計・評価 (2023)
  • Author(s): M. Tanaka
  • Organizer: (株)技術情報協会 2月開催セミナー「生体適合性材料の基礎と表面設計,評価技術」
  • Invited
• [Presentation] Role of Interfacial Water in Determining the Interactions of Proteins and Cells with Hydrated Materials (2023)
  • Author(s): M. Tanaka
  • Organizer: BIOMATFORUM2023
  • Int'l Joint Research / Invited
• [Presentation] 生体親和性高分子の設計と先端医療製品への展開 (2023)
  • Author(s): M. Tanaka
  • Organizer: 三菱ケミカル株式会社特別講演会
  • Invited
• [Presentation] Design of Functional Biomaterials: Intermediate Water Concept for Advanced Medical Devices (2023)
  • Author(s): M. Tanaka
  • Organizer: Nano-seminar at University of California, Berkeley
  • Int'l Joint Research / Invited
• [Presentation] Experimental Evidence of Slow Mode Water in The Vicinity of Poly(ethylene oxide) at Physiological Temperature (2022)
  • Author(s): Taiki Tominaga, Mafumi Hishida, Daiki Murakami, Yoshihisa Fujii, Masaru Tanaka, and Hideki Seto
  • Organizer: QENS/WINS2022
  • Int'l Joint Research / Invited
• [Presentation] ナノインデンターを用いたエポキシ樹脂の不均一構造に由来する物性評価 (2022)
  • Author(s): 大谷瑠奈, 仲川枝里, 大村孝仁, 藤井義久, 鳥飼直也
  • Organizer: 第71回高分子学会年次大会
• [Presentation] 空気雰囲気下のプラズマ処理法により改質した高分子膜表面の性状観察 (2022)
  • Author(s): 安田信太郎, 藤井義久, 鳥飼直也
  • Organizer: 第71回高分子学会年次大会
• [Presentation] 水晶振動子マイクロバランスを用いた水中におけるメチルセルロースの局所運動評価 (2022)
  • Author(s): 山岡賢司, 藤井義久, 鳥飼直也
  • Organizer: 第71回高分子学会年次大会
• [Presentation] (ボトルブラシポリスチレン/線状ポリスチレン)ブレンド膜の表面形態観察 (2022)
  • Author(s): 西村安理,山内祥弘, 佐光貞樹, 藤井義久, 鳥飼直也
  • Organizer: 第71回高分子学会年次大会
• [Presentation] Experimental Evidences of Slow Mode Water in the Vicinity of Polyethylene Oxide at Physiological Temperature (2022)
  • Author(s): Hideki Seto, Taiki Tominaga, Tatsuya Kikuchi, Daiki Murakami, Yoshihisa Fujii, Mafumi Hishida, and Masaru Tanaka
  • Organizer: International Conference on Neutron Scattering 2022
  • Int'l Joint Research
• [Presentation] 急速液/液相分離により作製したマイクロ微粒子の構造解析と形態制御 (2022)
  • Author(s): 藤井義久, 小川凌央, 佐光貞樹, 鳥飼直也
  • Organizer: 第71回高分子討論会
• [Presentation] 2次元マッピングに基づくエポキシ樹脂の力学的不均一性解 (2022)
  • Author(s): 大谷瑠奈, 仲川枝里, 大村孝仁, 藤井義久, 鳥飼直也
  • Organizer: 第71回高分子討論会
• [Presentation] (ボトルブラシ状ポリスチレン/線状ポリスチレン)ブレンド膜の表面偏析挙動と機能特性評価 (2022)
  • Author(s): 西村安理, 山内祥弘, 佐光貞樹, 藤井義久, 鳥飼直也
  • Organizer: 第71回高分子討論会
• [Presentation] 空気プラズマを用いた疎水性高分子膜の形態制御と表面性状解析 (2022)
  • Author(s): 安田信太郎, 藤井義久, 鳥飼直也
  • Organizer: 第71回高分子討論会
• [Presentation] Interfacial Viscoelastic Behavior of Aqueous Methylcellulose Solution in High Frequency Region (2022)
  • Author(s): Kenji Yamaoka, Yoshihisa Fujii, and Naoya Torikai
  • Organizer: 第71回高分子討論会
• [Presentation] ポリスチレン膜および吸着層の摩擦特性に及ぼす浸漬溶媒の効果 (2022)
  • Author(s): 田島慎平, 藤井義久, 鳥飼直也
  • Organizer: 第73回コロイドおよび界面化学討論会
• [Presentation] ソフト材料の界面設計に及ぼす水の効果 (2022)
  • Author(s): 藤井義久, 井上昴紀, 庄村大輝, 鳥飼直也
  • Organizer: 第34回高分子加工技術討論会
  • Invited
• [Presentation] 結晶性高分子薄膜の調湿環境下における構造・物性解析 (2022)
  • Author(s): 小見山夏輝, 藤井義久, 鳥飼直也
  • Organizer: 第53回中部化学関係学協会支部連合秋季大会
• [Presentation] 架橋密度の異なるポリエチレングリコールゲルの水和状態 (2022)
  • Author(s): 原将慶, 藤井義久, 鳥飼直也
  • Organizer: 第60回高分子と水に関する討論会
• [Presentation] Quasi-elastic Neutron Scattering Studies on Hydration Water at Bio-compatible Polymers (2022)
  • Author(s): Hideki Seto, Taiki Tominaga, Daiki Murakami, Yoshihisa Fujii, Shohei Shiomoto, and Masaru Tanaka
  • Organizer: The 32nd Annual Meeting of MRS-J
  • Int'l Joint Research
• [Presentation] 空気プラズマを用いた疎水性高分子膜の表面性状解析とタンパク質吸着の抑制 (2022)
  • Author(s): 安田信太郎, 藤井義久, 鳥飼直也
  • Organizer: 21th産官学接着若手フォーラム
• [Presentation] Design of biocompatible materials for advanced medical devices, (2022)
  • Author(s): M. Tanaka
  • Organizer: 2022 IC-MSE SUZHOU CONFERENCE
  • Int'l Joint Research / Invited
• [Presentation] 生体内には性質の異なる水が存在している？という不思議自由水と不凍水、そして中間水の謎に迫る～ (2022)
  • Author(s): M. Tanaka
  • Organizer: 第一回技術コンソーシアム
  • Invited
• [Presentation] 中間水コンセプトによる生体親和性子分子の設計と医療機器への展開 (2022)
  • Author(s): M. Tanaka
  • Organizer: プラスチック成型加工学会第33回年次大会
  • Invited
• [Presentation] 医療用高分子の基礎・生体親和性の発現機構と表面設計・評価 (2022)
  • Author(s): M. Tanaka
  • Organizer: 株式会社AndTech講演会
  • Invited
• [Presentation] 生体親和性高分子の設計と先端医療機器への展開 (2022)
  • Author(s): M. Tanaka
  • Organizer: 学際統合物質科学研究機構（IRCCS）IRCCS設立シンポジウムおよびキックオフシンポジウム
  • Invited
• [Presentation] ソフトマターとバイオシステムの界面における水和状態と機能 (2022)
  • Author(s): M. Tanaka
  • Organizer: 第73回コロイドおよび界面化学討論会
  • Invited
• [Presentation] Design and Synthesis of Biocompatible Polymers base on the Intermediate Water Concept (2022)
  • Author(s): M. Tanaka
  • Organizer: 2nd Global Summit and Expo on Biotechnology and Bioscience (GSEBB2022)
  • Int'l Joint Research / Invited
• [Presentation] Design of Biocompatible Soft-Materials for Advanced Medical Devices by the Intermediate Water Concept (2022)
  • Author(s): M. Tanaka
  • Organizer: 7th Edition of Applied Science, Engineering and Technology Virtual (V-Applied2022）
  • Int'l Joint Research / Invited
• [Presentation] Design of Biocompatible Polymers for Advanced Medical Devices using the Intermediate Water Concept (2022)
  • Author(s): M. Tanaka
  • Organizer: KYUSHU U.-NTNU JOINT SYMPOSIUM
  • Int'l Joint Research / Invited
• [Presentation] 界面近傍水の役割と機能－バイオ・医療材料を例に－ (2022)
  • Author(s): 田中 賢
  • Organizer: 2021年度アライアンス合同分科会
  • Invited
• [Presentation] 金電極上におけるポリスチレン薄膜の分子鎖熱運動性 (2021)
  • Author(s): 小見山大輝，藤井義久，鳥飼直也
  • Organizer: 第70回高分子学会年次大会
• [Presentation] 基板界面におけるメチルセルロース水溶液の濃度勾配とゲル化挙動 (2021)
  • Author(s): 山岡賢司，山田悟史，藤井義久，鳥飼直也
  • Organizer: 第70回高分子学会年次大会
• [Presentation] 架橋高分子の水和状態と力学物性の関係 (2021)
  • Author(s): 藤井義久，井上昂紀，庄村大輝，菱田理紗，鳥飼直也
  • Organizer: 第70回高分子討論会(依頼講演)
• [Presentation] 固体界面におけるメチルセルロース水溶液のゲル化と濃縮挙動の温度依存性 (2021)
  • Author(s): 山岡賢司，山田悟史，藤井義久，鳥飼直也
  • Organizer: 第70回高分子討論会
• [Presentation] シリコン基板上のポリスチレン吸着鎖の熱安定性と摩擦特性 (2021)
  • Author(s): 田島慎平，藤井義久，鳥飼直也
  • Organizer: 第70回高分子討論会
• [Presentation] 吸湿・乾燥過程におけるポリエチレンオキシド薄膜の結晶状態の観察 (2021)
  • Author(s): 小見山夏輝，藤井義久，鳥飼直也
  • Organizer: 第70回高分子討論会
• [Presentation] Effect of Solution Properties on Polymer Particles in Spray Nanoprecipitation Method (2021)
  • Author(s): Ryo Ogawa, Yoshihisa Fujii, Naoya Torikai
  • Organizer: The 11th International Symposium for Sustainability by Engineering at MIU
  • Int'l Joint Research
• [Presentation] Effect of Polystyrene Adsorbed Layer on Pressure-Sensitive Adhesive Tape Peeling (2021)
  • Author(s): Kohei Koshisuka, Yoshihisa Fujii, Naoya Torikai
  • Organizer: The 11th International Symposium for Sustainability by Engineering at MIU
  • Int'l Joint Research
• [Presentation] Observation of the Crystalline State of Poly(ethylene oxide) Thin Films under Wet and Dry Environments (2021)
  • Author(s): Natsuki Komiyama, Yoshihisa Fujii, Naoya Torikai
  • Organizer: The 11th International Symposium for Sustainability by Engineering at MIU
  • Int'l Joint Research
• [Presentation] Effect of Thermal Stability of Polystyrene Residual Layer on Frictional Properties (2021)
  • Author(s): Shimpei Tajima, Yoshihisa Fujii, Naoya Torikai
  • Organizer: The 11th International Symposium for Sustainability by Engineering at MIU
  • Int'l Joint Research
• [Presentation] Preparation and Characterization of Poly(ethylene glycol) Hydrogels with Different Water Content (2021)
  • Author(s): Masayoshi Hara, Yoshihisa Fujii, Naoya Torikai
  • Organizer: The 11th International Symposium for Sustainability by Engineering at MIU
  • Int'l Joint Research
• [Presentation] 水圏で「はたらく」低含水高分子材料の解析～少ない水の大きな効果～ (2021)
  • Author(s): 藤井義久，富永大輝，村上大樹，田中賢，瀬戸秀紀
  • Organizer: 第11回CSJ化学フェスタ
  • Invited
• [Presentation] 水晶振動子マイクロバランスを用いたメチルセルロース水溶液のゲル化挙動の評価と界面濃縮の効果 (2021)
  • Author(s): 山岡賢司，山田悟史，藤井義久，鳥飼直也
  • Organizer: 第11回CSJ化学フェスタ
• [Presentation] 接合界面における水の振る舞いと接着強度の関係 (2021)
  • Author(s): 藤井義久
  • Organizer: 第52回 中部化学関係学協会支部連合秋季大会(依頼講演)
• [Presentation] 中性子準弾性散乱に基づく水和したポリメタクリル酸メチルの熱運動性 (2021)
  • Author(s): 藤井義久，富永大輝，菊池龍弥，村上大樹，田中賢，瀬戸秀紀
  • Organizer: 第21回日本中性子科学会年会
• [Presentation] 高分子吸着層/粘着剤の界面相の構造評価と剥離強度への影響 (2021)
  • Author(s): 越須賀航平，藤井義久，鳥飼直也
  • Organizer: 第21回日本中性子科学会年会
• [Presentation] NRおよびQCMで評価したメチルセルロースゲルの固体界面における凝集構造と粘弾性 (2021)
  • Author(s): 山岡 賢司，藤井義久，鳥飼直也
  • Organizer: 第21回日本中性子科学会年会
• [Presentation] 急速液/液相分離法を応用したSpray-Precipitationによる微粒子形成と細孔制御 (2021)
  • Author(s): 小川凌央，藤井義久，鳥飼直也
  • Organizer: 2021年度東海高分子研究会学生発表会
• [Presentation] 生体適合性に優れた診断・治療用ソフトバイオマテリアルの設計－中間水コンセプトによる機能材料創出 (2021)
  • Author(s): 田中 賢
  • Organizer: 2021年度 第2回インクジェット研究会（YU-IJWS）セミナー
  • Invited
• [Presentation] 生体親和性材料によるバイオ界面設計－中間水コンセプトによる機能材料創出－ (2021)
  • Author(s): 田中 賢
  • Organizer: Minase Innovation Forum
  • Invited
• [Presentation] Role of intermediate water in determining the interaction of proteins and cells with hydrated materials (2021)
  • Author(s): M. Tanaka
  • Organizer: The International Bioprocessing Association Subject Conference (IBASC-2021)
  • Int'l Joint Research / Invited
• [Presentation] 中間水コンセプトによる生体親和性医療材料の創製 (2021)
  • Author(s): 田中 賢
  • Organizer: 第14回ChemBioハイブリッドレクチャー
  • Invited
• [Presentation] 生体親和性材料の設計─バイオ界面水の役割と機能 (2021)
  • Author(s): 田中 賢
  • Organizer: 第78回日本歯科理工学会学術講演会プログラム
  • Invited
• [Presentation] The Role of Interfacial Water in Materil /Protein/Cell interactions Design of Biocompatible Materials based on the Intermediate Water Concept (2021)
  • Author(s): 田中 賢
  • Organizer: GSBA2021
  • Int'l Joint Research / Invited
• [Presentation] 新たな liquid biopsy による臨床化学の未来図 (2021)
  • Author(s): 田中 賢
  • Organizer: 第61回日本臨床化学会年次学術集会
  • Invited
• [Presentation] 中間水理論による生体親和性高分子の設計と合成 (2021)
  • Author(s): 田中 賢
  • Organizer: 第30回ポリマー材料フォーラム
  • Invited
• [Presentation] Roles of Water in Biocompatible Polymers (2021)
  • Author(s): M. Tanaka
  • Organizer: POLYSOLVAT-13
  • Int'l Joint Research / Invited
• [Presentation] 生体適合性材料における中間水の役割 (2021)
  • Author(s): 田中 賢
  • Organizer: 第59回日本人工臓器学会大会
  • Invited
• [Presentation] 中間水コンセプトによるバイオイナート材料の設計 (2021)
  • Author(s): 田中 賢
  • Organizer: 第43回日本バイオマテリアル学会/第8回アジアバイオマテリアル学会
  • Invited
• [Presentation] Design of Polymeric Biomaterials for Medical Devices and Tissue Engineering: The “Intermediate Water Concept” (2021)
  • Author(s): Masaru Tanaka
  • Organizer: 2021 2nd International Conference on Materials Science and Engineering (IC-MSE 2021)
  • Int'l Joint Research / Invited
• [Presentation] 中間水コンセプトによる多機能生体親和性高分子の設計 (2021)
  • Author(s): 田中 賢
  • Organizer: 2020東海シンポジウム(高分子学会東海支部)
  • Invited
• [Presentation] 生体親和性材料の表面・界面設計とスクリーニング法 (2020)
  • Author(s): 田中 賢
  • Organizer: 生体親和性材料Webセミナー
  • Invited
• [Presentation] 生体親和性材料によるバイオ界面設計 (2020)
  • Author(s): 田中 賢
  • Organizer: 花王株式会社特別講演会
  • Invited
• [Presentation] 生体親和性材料の設計と製品展開 (2020)
  • Author(s): 田中 賢
  • Organizer: 日本学術振興会創造機能化学第116委員会講演会
  • Invited
• [Presentation] Measurement of Peeling Behavior on Interfacial Polystyrene Adsorbed Layer by Using Pressure-Sensitive Adhesive Tape (2020)
  • Author(s): Kohei Koshisuka, Yoshihisa Fujii, Naoya Torikai
  • Organizer: The 10th International Symposium for Sustainability by Engineering at MIU
  • Int'l Joint Research / Invited
• [Presentation] 高分子界面の局所構造・物性解析と接着劣化分析への応用 (2020)
  • Author(s): 藤井義久
  • Organizer: 日本分析化学会中部支部三重地区講演会
  • Invited
• [Presentation] 中性子準弾性散乱法による中間水のダイナミクス解析 (2020)
  • Author(s): 村上大樹, 藤井義久, 富永大輝, 瀬戸秀樹, 田中賢
  • Organizer: 第69回高分子学会年次大会
• [Presentation] 側鎖導入間隔を制御した新規ポリオレフィン系高分子の合成および水和構造の解析 (2020)
  • Author(s): 吉田健人，小林慎吾，田中 賢
  • Organizer: 日本バイオマテリアル学会第9回九州ブロック講演会
• [Presentation] 医用高分子の開発と生体親和性発現機構の解明 (2019)
  • Author(s): Masaru Tanaka
  • Organizer: 市村賞受賞記念フォーラム
  • Invited
• [Presentation] PMEA/水界面の微細構造による細胞接着性制御 (2019)
  • Author(s): 村上大樹，上田智也，瀬上裕斗，田中 賢
  • Organizer: 第68回高分子討論会
• [Presentation] 一次構造を制御したPMEA類自体における水和水の運動性評価 (2019)
  • Author(s): 岡崎恭貴，藤原渉，小林慎吾，田中 賢
  • Organizer: 第68回高分子討論会
• [Presentation] Analysis of Interaction Between Nano-Structures and Fibrinogen at Blood-Compatible (2019)
  • Author(s): Tomoya Ueda，Daiki Murakami，Masaru Tanaka
  • Organizer: The7th Asian Biomaterials Congress
  • Int'l Joint Research
• [Presentation] Control of Interfacial Structures and Protein Adsorption by the Composition of Blood-Compatible Random Copolymers (2019)
  • Author(s): Yuto Segami，Tomoya Ueda，Daiki Murakami，Masaru Tanaka
  • Organizer: The7th Asian Biomaterials Congress
  • Int'l Joint Research
• [Presentation] Effect of Molecular Weight of Poly(2-methoxyethyl acrylate) on Interfacial Structure and Biocompatibility (2019)
  • Author(s): Daiki Murakami，Nami Mawatari，Tosiki Sonoda，Aki Kashiwazaki，Masaru Tanaka
  • Organizer: The7th Asian Biomaterials Congress
  • Int'l Joint Research
• [Presentation] がん検査への応用を目指した血液適合性高分子材料上でのがん細胞生存性評価 (2019)
  • Author(s): 関田将伍，荒津史裕，穴田貴久，田中 賢
  • Organizer: 第9回CSJ化学フェスタ
• [Presentation] カルボニル基の位置を変更したPMEA類似体における水和水の運動性評価 (2019)
  • Author(s): 岡崎恭貴，藤原渉，小林慎吾，田中 賢
  • Organizer: 第9回CSJ化学フェスタ
• [Presentation] Effect of Interfacial Poly(2-methoxyethyl acrylate) Analogue on Cell Attachment (2019)
  • Author(s): Kei Nishida，Shingo Kobayashi，Takahisa Anada，Tomoya Ueda，Masaru Tanaka
  • Organizer: China-Japan Biopolymer Symposium
  • Int'l Joint Research
• [Presentation] Synthesis of Antithrombotic Silsesquioxane/PMEA Hybrid via Thiol-initiated Radical Polymerization for Exceeding the Limitation of Coatability and Stability of PMEA Homopolymer (2019)
  • Author(s): Shin-nosuke Nishimura，Tomoya Ueda，Shingo Kobayashi，Masaru Tanaka
  • Organizer: China-Japan Biopolymer Symposium
  • Int'l Joint Research
• [Presentation] Evaluation of Cellular Uptake Behavior of Water-Solble PMEA Analogs Having Different Hydration State (2019)
  • Author(s): Hiroki Uehara，Kei Nishida，Shingo Kobayashi，Masaru Tanaka
  • Organizer: China-Japan Biopolymer Symposium
  • Int'l Joint Research
• [Presentation] フッ素系合成高分子による低タンパク質吸着表面設計 (2019)
  • Author(s): 小口亮平, 田中 賢
  • Organizer: 第36回医用高分子研究会講座
  • Invited
• [Presentation] HEMA共重合体の水和状態の制御と生体不活性の発現 (2019)
  • Author(s): 小口亮平，Katja Jankova，山本今日子，田中 賢
  • Organizer: 第41回日本バイオマテリアル学会年会
• [Presentation] シルセスキオキサン/ポリ(2-メトキシエチルアクリレート)ハイブリッドの合成とそのコーティング特性および抗血栓性評価 (2019)
  • Author(s): 西村慎之介，上田智也，小林慎吾，田中 賢
  • Organizer: 第41回日本バイオマテリアル学会年会
• [Presentation] Design of Soft-Biomaterials Based on Intermediated Water Contents (2019)
  • Author(s): Masaru Tanaka
  • Organizer: Materials Research Meeting 2019
  • Int'l Joint Research / Invited
• [Presentation] 血中に含まれるがん細胞 (CTC) の選択分離回収技術 (2019)
  • Author(s): Masaru Tanaka
  • Organizer: 九州大学ベンチャーエコシステム連絡会
  • Invited
• [Presentation] Design of Soft-Biomaterials The Intermediate Water Concept (2019)
  • Author(s): Masaru Tanaka
  • Organizer: 2019 International Conference on Materials Science and Engineering
  • Int'l Joint Research / Invited
• [Presentation] High-Frequency Rheometry of Methylcellulose Aqueous Solution using Quartz Crystal Microbalance (2019)
  • Author(s): 山岡賢司，藤井義久，鳥飼直也
  • Organizer: The 9th International Symposium for Sustainability by Engineering at MIU
  • Int'l Joint Research
• [Presentation] Evaluation of Surface Structure of Polystyrene Thin Films Used Various Good Solvents (2019)
  • Author(s): 宮田淳史，藤井義久，鳥飼直也
  • Organizer: The 9th International Symposium for Sustainability by Engineering at MIU
  • Int'l Joint Research
• [Presentation] Effect of Polymer Solution Properties on Membrane Structure and Filtration Performance (2019)
  • Author(s): 板倉圭吾，藤井義久，鳥飼直也
  • Organizer: The 9th International Symposium for Sustainability by Engineering at MIU
  • Int'l Joint Research
• [Presentation] 基板界面近傍におけるメチルセルロース水溶液の粘弾性 (2019)
  • Author(s): 山岡賢司，藤井義久，内藤昌信，鳥飼直也
  • Organizer: 第67回レオロジー討論会
• [Presentation] 高分子薄膜の表面形態に及ぼすスピンコート時の溶液濃縮過程の影響 (2019)
  • Author(s): 宮田淳史，藤井義久，鳥飼直也
  • Organizer: 第67回レオロジー討論会
• [Presentation] 限外ろ過膜の相分離構造と分離性能に及ぼす高分子溶液粘度の効果 (2019)
  • Author(s): 板倉圭吾，藤井義久，鳥飼直也
  • Organizer: 第67回レオロジー討論会
• [Presentation] 水晶振動子を用いた界面近傍の粘弾性評価と基板表面性状の効果 (2019)
  • Author(s): 山岡賢司，藤井義久，鳥飼直也
  • Organizer: 微小領域の力学特性評価とマルチスケールモデリング 研究会
• [Presentation] ロバスト炭素膜の作製と水処理への応用 (2019)
  • Author(s): 藤井義久
  • Organizer: 第93回高分子若手研究会[関西]
  • Invited
• [Remarks] 九州大学田中賢研究室
  • URL: https://www.soft-material.jp/
• [Remarks] 三重大学藤井研究室
  • URL: http://www.oms.chem.mie-u.ac.jp/index.html
• [Remarks] 水圏機能材料領域
  • URL: https://www.aquatic-functional-materials.org/
• [Remarks] 生体親和性の科学を解き明かす
  • URL: https://www.kyushu-u.ac.jp/ja/research/close-up/masaru-tanaka
• [Remarks] 中間水コンセプトとは? “バイオマテリアルサイエンスを極める”
  • URL: https://youtu.be/Bl4eZNkI0x4
• [Remarks] 九州大学田中賢研究室
  • URL: http://www.soft-material.jp
• [Remarks] 研究室HP（田中）
  • URL: http://www.soft-material.jp
• [Remarks] 研究室HP（藤井）
  • URL: http://www.oms.chem.mie-u.ac.jp/index.html
• [Remarks] 領域HP
  • URL: https://www.aquatic-functional-materials.org/
• [Remarks] 研究室HP（田中）
  • URL: http://www.soft-material.jp/