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Exploration of Bio and Environmental Functions of Aquatic Functional Materials

Planned Research

Project AreaAquatic Functional Materials: Creation of New Materials Science for Environment-Friendly and Active Functions
Project/Area Number 19H05720
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionKyushu University

Principal Investigator

Tanaka Masaru  九州大学, 先導物質化学研究所, 教授 (00322850)

Co-Investigator(Kenkyū-buntansha) 藤井 義久  三重大学, 工学研究科, 准教授 (70578062)
Project Period (FY) 2019-06-28 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥116,480,000 (Direct Cost: ¥89,600,000、Indirect Cost: ¥26,880,000)
Fiscal Year 2023: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2022: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2021: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2020: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2019: ¥46,020,000 (Direct Cost: ¥35,400,000、Indirect Cost: ¥10,620,000)
Keywords生体親和性 / 界面ダイナミクス / 密着性 / 界面レオロジー / 合成高分子 / 細胞接着 / 中間水 / バイオ界面 / バイオ界面水 / 水和界面物性 / 表面ダイナミクス / 水和界面 / 走査プローブ顕微鏡 / 高分子精密合成 / 界面構造・物性解析 / 高分子合成 / タンパク質吸着
Outline of Research at the Start

水圏バイオ・環境機能材料構築を達成するために、材料の化学構造と水和による物理化学的な物性変化により、界面水の構造・運動を制御することで、特定の生体分子や細胞を選択的に認識する生体親和性材料を創製する。界面水の構造・運動を制御するための高分子の精密合成と生体機能評価を行う。また、水中プローブ顕微鏡技術による合成高分子の界面状態の解明・制御を行う。A02(先端計測・シミュレーション班)との連携により水・材料界面の状態を精密解析する技術を確立し、界面水構造・運動制御の基礎学理を構築する。A01(分子・材料構築班)と連携し、生体親和性および金属ステント表面への高接着性を示す材料の設計指針を創出する。

Outline of Final Research Achievements

To achieve our goal for developing bio and environmental functions of aquatic functional materials that are stable in water and have high functionality, we have successfully controlled the hydration water, particularly the intermediate water, which plays a crucial role in aquatic functionality in vivo, with biomaterial synthesis and cell function control based on ring opening metathesis polymerization at the core of our research. Furthermore, we have been making efforts to better understand and control the hydration state at the interface by employing various advanced techniques, including synchrotron infrared spectroscopy, neutron reflectometry, and frequency-modulated atomic force microscopy. Finally, we have established many close collaborations with researchers in this project. Consequently, we elucidated the mechanism by which hydration water forms on the surface of biocompatible materials, which promotes the development of “Aquatic Functional Materials”.

Academic Significance and Societal Importance of the Research Achievements

材料の化学構造制御と含水による物性変化の精密解析により得られた成果は、界面の水和構造と分子運動性、および、特定の生体分子や細胞の選択的認識(はたらく)機構の解明に繋がった。また、水を機能分子として捉えることで、これまで可塑化として巨視的に理解されていた高分子の含水状態を、官能基の局所運動とそれらが誘起する生体親和性と関連付け分子論的に理解が可能になり、高分子基礎科学の発展としても学術的意義が大きい。さらに、中間水量と血小板粘着数の相関解明や生体親和性に優れる材料のスクリーニング技術の確立は、体外式膜型人工肺やステントなどの表面処理材の開発加速にも繋がり、その社会的意義は計り知れない。

Report

(5 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (178 results)

All 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (15 results) Journal Article (58 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 58 results,  Open Access: 38 results) Presentation (95 results) (of which Int'l Joint Research: 30 results,  Invited: 42 results) Remarks (10 results)

  • [Int'l Joint Research] University of California, Berkeley(米国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Glasgow University(英国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Technical University of Denmark(デンマーク)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] National Research Centre, Egypt(エジプト)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] National Taiwan University(その他の国・地域)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] デンマーク工科大学(デンマーク)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] バイオマテリアル研究所(エジプト)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] ケンブリッジ大学(英国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] カリフォルニア大学バークレー校(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] ロイトリンゲン大学(ドイツ)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] バイオマテリアル研究所(エジプト)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] グラスゴー大学(英国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] デンマーク工科大学(デンマーク)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] デンマーク工科大学(デンマーク)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Interfacial Selective Study on the Gelation Behavior of Aqueous Methylcellulose Solution via a Quartz Crystal Microbalance2022

    • Author(s)
      Kenji Yamaoka, Norifumi L. Yamadam. Koichiro Hori, Yoshihisa Fujii, Naoya Torikai
    • Journal Title

      Langmuir

      Volume: 38 Issue: 15 Pages: 4494-4502

    • DOI

      10.1021/acs.langmuir.1c02728

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Humidity-Induced Self-Assembled Nanostructure via Ion Aggregation in Ionic Linear Polysiloxanes2022

    • Author(s)
      Mitsuo Hara, Atsuki Kodama, Shohei Washiyama, Yoshihisa Fujii, Shusaku Nagano, Takahiro Seki
    • Journal Title

      Macromolecules

      Volume: - Issue: 11 Pages: 4313-4319

    • DOI

      10.1021/acs.macromol.2c00404

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A β-hairpin peptide with pH-controlled affinity for tumor cells2022

    • Author(s)
      Nishimura Shin-nosuke、Nishida Kei、Tanaka Masaru
    • Journal Title

      Chemical Communications

      Volume: 58 Issue: 4 Pages: 505-508

    • DOI

      10.1039/d1cc06218b

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Observing the Repulsion Layers on Blood-compatible Polymer-grafted Interfaces by Frequency Modulation Atomic Force Microscopy2022

    • Author(s)
      D. Murakami, S. Nishimura, Y. Tanaka, M. Tanaka
    • Journal Title

      Biomaterials Advances

      Volume: 133 Pages: 112596-112596

    • DOI

      10.1016/j.msec.2021.112596

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydration Mechanism in Blood-Compatible Polymers Undergoing Phase Separation2022

    • Author(s)
      Murakami Daiki、Yamazoe Kosuke、Nishimura Shin-nosuke、Kurahashi Naoya、Ueda Tomoya、Miyawaki Jun、Ikemoto Yuka、Tanaka Masaru、Harada Yoshihisa
    • Journal Title

      Langmuir

      Volume: 38 Issue: 3 Pages: 1090-1098

    • DOI

      10.1021/acs.langmuir.1c02672

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of Biological Responses of Tumor Cells Adhered to Poly(2-methoxyethyl acrylate) with Increasing Cell Viability under Serum-Free Conditions2022

    • Author(s)
      Nishida Kei、Sekida Shogo、Anada Takahisa、Tanaka Masaru
    • Journal Title

      ACS Biomaterials Science & Engineering

      Volume: 8 Issue: 2 Pages: 672-681

    • DOI

      10.1021/acsbiomaterials.1c01469

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective Accumulation to Tumor Cells with Coacervate Droplets Formed from a Water-Insoluble Acrylate Polymer2022

    • Author(s)
      Nishida Kei、Nishimura Shin-nosuke、Tanaka Masaru
    • Journal Title

      Biomacromolecules

      Volume: 23 Issue: 4 Pages: 1569-1580

    • DOI

      10.1021/acs.biomac.1c01343

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Experimental evidences of slow mode water in the vicinity of polyethylene oxide at physiological temperature2022

    • Author(s)
      Taiki Tominaga, Mafumi Hishida, Daiki Murakami, Yoshihisa Fujii, Masaru Tanaka, Hideki Seto
    • Journal Title

      Journal of Physical Chemistry B

      Volume: 126 Issue: 8 Pages: 1758-1767

    • DOI

      10.1021/acs.jpcb.1c09044

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Osmolytes on Water Mobility Correlates with Their Stabilizing Effect on Proteins2022

    • Author(s)
      Mafumi Hishida, Rubaiya Anjum, Takahisa Anada, Daiki Murakami, Masaru Tanaka
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 126 Issue: 13 Pages: 2466-2475

    • DOI

      10.1021/acs.jpcb.1c10634

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biocompatible poly(<i>N</i>-(ω-acryloyloxy-<i>n</i>-alkyl)-2-pyrrolidone)s with widely-tunable lower critical solution temperatures (LCSTs): a promising alternative to poly(<i>N</i>-isopropylacrylamide)2022

    • Author(s)
      Nishimura Shin-nosuke、Nishida Kei、Ueda Tomoya、Shiomoto Shohei、Tanaka Masaru
    • Journal Title

      Polymer Chemistry

      Volume: ー Issue: 17 Pages: 2519-2530

    • DOI

      10.1039/d2py00154c

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanoscopic analyses of cell-adhesive protein adsorption on poly(2-methoxyethyl acrylate) surfaces2022

    • Author(s)
      Nishida Kei、Baba Koki、Murakami Daiki、Tanaka Masaru
    • Journal Title

      Biomaterials Science

      Volume: 10 Issue: 11 Pages: 2953-2963

    • DOI

      10.1039/d2bm00093h

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of interfacial water states on advanced biomedical material design2022

    • Author(s)
      Nishida Kei、Anada Takahisa、Tanaka Masaru
    • Journal Title

      Advanced Drug Delivery Reviews

      Volume: 186 Pages: 114310-114310

    • DOI

      10.1016/j.addr.2022.114310

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surfactant-Free Suspension Polymerization of Hydrophilic Monomers with an Oil-in-Water System for the Preparation of Microparticles Toward the Selective Isolation of Tumor Cells2022

    • Author(s)
      Nishimura Shin-nosuke、Nishida Kei、Shiomoto Shohei、Tanaka Masaru
    • Journal Title

      Materials Advances

      Volume: 3 Issue: 12 Pages: 5043-5054

    • DOI

      10.1039/d2ma00129b

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Infrared Spectra and Hydrogen-Bond Configurations of Water Molecules at the Interface of Water-Insoluble Polymers under Humidified Conditions2022

    • Author(s)
      Yuka Ikemoto, Yoshihisa Harada, Masaru Tanaka, Daiki Murakami, Shin-nosuke Nishimura, Naoya Kurahashi, Taro Moriwaki, Kosuke Yamazoe, Hitoshi Washizu, Yoshiki Ishii, Hajime Torii
    • Journal Title

      Journal of Physical Chemistry B

      Volume: 126 Issue: 22 Pages: 4143-4151

    • DOI

      10.1021/acs.jpcb.2c01702

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Manipulation of Surface Hydration States by Tuning the Oligo(Ethylene Glycol) Moieties on PEDOT to Achieve Platelet-Resistant Bioelectrode Applications2022

    • Author(s)
      J Huang, C.-H. Lin, Y. Tanaka, A. Yamamoto, S.-C Luo, M. Tanaka
    • Journal Title

      Advanced Materials Interfaces

      Volume: 9 Issue: 33 Pages: 2200707-2200707

    • DOI

      10.1002/admi.202200707

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sol-gel silicate glass doped with silver for bone regeneration: Antibacterial activity, intermediate water, and cell death mode2022

    • Author(s)
      M. Mabrouk, H. H. Beherei, Y. Tanaka, M. Tanaka
    • Journal Title

      Biomaterials Advances

      Volume: 138 Pages: 212965-212965

    • DOI

      10.1016/j.bioadv.2022.212965

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characterization of Hydration Water Bound to Choline Phosphate-Containing Polymers2022

    • Author(s)
      Shiomoto Shohei、Inoue Kaito、Higuchi Hayato、Nishimura Shin-nosuke、Takaba Hiromitsu、Tanaka Masaru、Kobayashi Motoyasu
    • Journal Title

      Biomacromolecules

      Volume: 23 Issue: 7 Pages: 2999-3008

    • DOI

      10.1021/acs.biomac.2c00484

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Poly(2-methoxyethyl acrylate)(PMEA)-coated anti-platelet adhesive surfaces to mimic native blood vessels through HUVECs attachment, migration, and monolayer formation2022

    • Author(s)
      M. A. Haque, D. Murakami, T. Anada, M. Tanaka
    • Journal Title

      Coatings

      Volume: 12 Issue: 6 Pages: 869-869

    • DOI

      10.3390/coatings12060869

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organic Carboxylate Salt-Enabled Alternative Synthetic Routes for Bio-Functional Cyclic Carbonates and Aliphatic Polycarbonates2022

    • Author(s)
      Watanabe Yuya、Takaoka Shunya、Haga Yuta、Kishi Kohei、Hakozaki Shunta、Narumi Atsushi、Kato Takashi、Tanaka Masaru、Fukushima Kazuki
    • Journal Title

      Polymer Chemistry

      Volume: 13 Issue: 36 Pages: 5193-5199

    • DOI

      10.1039/d2py00705c

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell Adhesion Strength Indicates the Antithrombogenicity of Poly(2-Methoxyethyl Acrylate) (PMEA): Potential Candidate for Artificial Small-Diameter Blood Vessel2022

    • Author(s)
      M. A. Haque, D. Murakami, M. Tanaka
    • Journal Title

      Surfaces

      Volume: 5 Issue: 3 Pages: 365-382

    • DOI

      10.3390/surfaces5030027

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular substrate2022

    • Author(s)
      Junsu Park, Tomoya Ueda, Yusaku Kawai, Kumiko Araki, Makiko Kido, Bunsho Kure, Naomi Takenaka, Yoshinori Takashima, Masaru Tanaka
    • Journal Title

      RSC Adv.

      Volume: 12 Issue: 43 Pages: 27912-27917

    • DOI

      10.1039/d2ra04885j

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enrichment of Cancer Cells Based on Antibody-Free Selective Cell Adhesion2022

    • Author(s)
      Shingo Kobayashi, Atsushi Sugasaki, Yosuke Yamamoto, Yuta Shigenoi, Airi Udaka, Aki Yamamoto, and Masaru Tanaka
    • Journal Title

      ACS Biomaterials Science & Engineering

      Volume: 8 Issue: 10 Pages: 4574-4556

    • DOI

      10.1021/acsbiomaterials.2c00662

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alkyl chain length-dependent protein nonadsorption and adsorption properties of crystalline alkyl β-celluloside assemblies2022

    • Author(s)
      Serizawa Takeshi、Yamaguchi Saeko、Amitani Moe、Ishii Sawa、Tsuyuki Hiromi、Tanaka Yukiko、Sawada Toshiki、Kawamura Izuru、Watanabe Go、Tanaka Masaru
    • Journal Title

      Colloids and Surfaces B: Biointerfaces

      Volume: 220 Pages: 112898-112898

    • DOI

      10.1016/j.colsurfb.2022.112898

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative Study of PEG and PEGylated Dendrimer in their Eutectic Mixtures of Water Analyzed using X-ray Diffraction and Infrared Spectroscopy2022

    • Author(s)
      Chie Kojima, Yasuhito Suzuki, Yuka Ikemoto, Masaru Tanaka and Akikazu Matsumoto
    • Journal Title

      Polymer Journal

      Volume: 55 Issue: 1 Pages: 63-73

    • DOI

      10.1038/s41428-022-00700-5

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 中性子準弾性散乱による水和水の運動状態解析2022

    • Author(s)
      瀬戸 秀紀,山田 武,富永 大輝,藤井 義久
    • Journal Title

      熱測定

      Volume: 49 Pages: 20-25

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Behavior of supramolecular cross-links formed by host-guest interactions in hydrogels responding to water contents2022

    • Author(s)
      Ueda Chiharu、Park Junsu、Hirose Kazuya、Konishi Subaru、Ikemoto Yuka、Osaki Motofumi、Yamaguchi Hiroyasu、Harada Akira、Tanaka Masaru、Watanabe Go、Takashima Yoshinori
    • Journal Title

      Supramolecular Materials

      Volume: 1 Pages: 100001-100001

    • DOI

      10.1016/j.supmat.2021.100001

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fluorine-Containing Bio-Inert Polymers ;Roles of Intermediate Water2022

    • Author(s)
      R. Koguchi, K. Jankova, M. Tanaka
    • Journal Title

      Acta Biomaterialia

      Volume: 138 Pages: 34-56

    • DOI

      10.1016/j.actbio.2021.10.027

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of Local Gelation Behavior of Aqueous Methylcellulose Solution Using Quartz Crystal Microbalance2021

    • Author(s)
      Kenji Yamaoka, Yoshihisa Fujii, Naoya Torikai
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 62 Issue: 5 Pages: 647-654

    • DOI

      10.2320/matertrans.MT-M2020392

    • NAID

      130008029710

    • ISSN
      1345-9678, 1347-5320
    • Year and Date
      2021-05-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of Local Gelation Behavior of Aqueous Methylcellulose Solution Using Quartz Crystal Microbalance2021

    • Author(s)
      山岡賢司, 藤井義久, 鳥飼直也
    • Journal Title

      Journal of the Japan Institute of Metals and Materials

      Volume: 85 Issue: 1 Pages: 23-29

    • DOI

      10.2320/jinstmet.JD202007

    • NAID

      130007959981

    • ISSN
      0021-4876, 1880-6880, 2433-7501
    • Year and Date
      2021-01-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Local Dynamics of the Hydration Water and Poly(methyl methacrylate) (PMMA) Chains in PMMA Networks2021

    • Author(s)
      Y. Fujii, T. Tominaga, D. Murakami, M. Tanaka and H. Seto
    • Journal Title

      Frontiers in Chemistry

      Volume: 9

    • DOI

      10.3389/fchem.2021.728738

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Periodically Functionalized Linear Polyethylene with Tertiary Amino Groups via Regioselective Ring-Opening Metathesis Polymerization2021

    • Author(s)
      Sonoda Toshiki、Kobayashi Shingo、Tanaka Masaru
    • Journal Title

      Macromolecules

      Volume: 54 Issue: 6 Pages: 2862-2872

    • DOI

      10.1021/acs.macromol.0c02611

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chain End Effect for Intermediate Water Formation of Poly(2-methoxyethyl acrylate)2021

    • Author(s)
      Nishimura Shin-nosuke、Ueda Tomoya、Murakami Daiki、Tanaka Masaru
    • Journal Title

      Organic Materials

      Volume: - Issue: 02 Pages: 214-202

    • DOI

      10.1055/a-1441-8239

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Attachment and Growth of Fibroblast Cells on Poly (2-Methoxyethyl Acrylate) Analog Polymers as Coating Materials2021

    • Author(s)
      Anjum Rubaiya、Nishida Kei、Matsumoto Haruka、Murakami Daiki、Kobayashi Shingo、Anada Takahisa、Tanaka Masaru
    • Journal Title

      Coatings

      Volume: 11 Issue: 4 Pages: 461-461

    • DOI

      10.3390/coatings11040461

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Different hydration states and passive tumor targeting ability of polyethylene glycol-modified dendrimers with high and low PEG density2021

    • Author(s)
      Tsujimoto Ayako、Uehara Hiroki、Yoshida Haruna、Nishio Misaki、Furuta Kousuke、Inui Takashi、Matsumoto Akikazu、Morita Shigeaki、Tanaka Masaru、Kojima Chie
    • Journal Title

      Materials Science and Engineering: C

      Volume: - Pages: 112159-112159

    • DOI

      10.1016/j.msec.2021.112159

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Side-Chain Spacing and Length on Hydration States of the Poly(2-methoxyethyl acrylate) Analogs: A Molecular Dynamics Study2021

    • Author(s)
      A. T. Kuo, S. Urata, R. Koguchi, T. Sonoda, S. Kobayashi, M. Tanaka
    • Journal Title

      ACS Biomaterials Science & Engineering

      Volume: 7 Issue: 6 Pages: 2383-2391

    • DOI

      10.1021/acsbiomaterials.1c00388

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Poly(tertiary amide acrylate) (Co)polymers Inspired by Poly(2-oxazoline)s: Their Blood Compatibility and Hydration States2021

    • Author(s)
      S. Liu, S. Kobayashi, T. Sonoda, M. Tanaka
    • Journal Title

      Biomacromolecules

      Volume: 22 Pages: 2718-2728

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vitro and In vivo Blood Compatibility of Concentrated Polymer Brushes2021

    • Author(s)
      C. Yoshikawa, S. Hattori, C-F. Huang, H. Kobayashi, M. Tanaka
    • Journal Title

      Journal of Materials Chemistry B

      Volume: 9 Issue: 29 Pages: 5794-5804

    • DOI

      10.1039/d1tb00886b

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] First Observation of the Hydration Layer around Polymer Chain by Scattering and Its Relationship to Thromboresistance: Dilute Solution Properties of PMEA in THF/Water2021

    • Author(s)
      Kanamaru Takuma、Araki Masataka、Takahashi Rintaro、Fujii Shota、Shikata Toshiyuki、Murakami Daiki、Tanaka Masaru、Sakurai Kazuo
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 125 Issue: 26 Pages: 7251-7261

    • DOI

      10.1021/acs.jpcb.1c01864

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Branching Degree of Dendritic Polyglycerols on Plasma Protein Adsorption: Relationship Between Hydration States and Surface Morphology2021

    • Author(s)
      M. Yamazaki, Y. Sugimoto, D. Murakami, M. Tanaka, T. Ooya
    • Journal Title

      Langmuir

      Volume: 37 Issue: 28 Pages: 8534-8543

    • DOI

      10.1021/acs.langmuir.1c01003

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protein Stabilization Effect of Zwitterionic Osmolyte-bearing Polymer2021

    • Author(s)
      Anjum Rubaiya、Nishimura Shin-nosuke、Kobayashi Shingo、Nishida Kei、Anada Takahisa、Tanaka Masaru
    • Journal Title

      Chemistry Letters

      Volume: 50 Issue: 9 Pages: 1699-1702

    • DOI

      10.1246/cl.210335

    • NAID

      130008088239

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of pendant groups on the blood compatibility and hydration states of poly(2‐oxazoline)s2021

    • Author(s)
      Liu Shichen、Kobayashi Shingo、Nishimura Shin‐nosuke、Ueda Tomoya、Tanaka Masaru
    • Journal Title

      Journal of Polymer Science

      Volume: 59 Issue: 21 Pages: 2559-2570

    • DOI

      10.1002/pol.20210410

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigating the Intermediate Water Feature of Hydrated Titanium Containing Bioactive Glass2021

    • Author(s)
      M. Mabrouk, H.H. Beherei, Y. Tanaka, M. Tanaka
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 22 Issue: 15 Pages: 8038-8038

    • DOI

      10.3390/ijms22158038

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of bound water content on cell adhesion strength to water-insoluble polymers2021

    • Author(s)
      Nishida Kei、Anada Takahisa、Kobayashi Shingo、Ueda Tomoya、Tanaka Masaru
    • Journal Title

      Acta Biomaterialia

      Volume: 134 Pages: 313-324

    • DOI

      10.1016/j.actbio.2021.07.058

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of amount of hydrated water and mobility of hydrated poly(2‐methoxyethyl acrylate) on denaturation of adsorbed fibrinogen2021

    • Author(s)
      Ueda Tomoya、Murakami Daiki、Tanaka Masaru
    • Journal Title

      Journal of Polymer Science

      Volume: 59 Issue: 22 Pages: 2763-2770

    • DOI

      10.1002/pol.20210496

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanical Properties with Respect to Water Content of Host-Guest Hydrogels2021

    • Author(s)
      Motofumi Osaki, Shin Yonei, Chiharu Ueda, Ryohei Ikura, Junsu Park, Hiroyasu Yamaguchi, Akira Harada, Masaru Tanaka, Yoshinori Takashima
    • Journal Title

      MACROMOLECULES

      Volume: 54 Issue: 17 Pages: 8067-8076

    • DOI

      10.1021/acs.macromol.1c00970

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protein- and Cell-Resistance of Zwitterionic Peptide-Based Self-Assembled Monolayers: Anti-Biofouling Tests and Surface Force Analysis2021

    • Author(s)
      Ryongsok Chang, Evan Angelo Quimada Mondarte, Debabrata Palai, Taito Sekine, Aki Kashiwazaki, Daiki Murakami, Masaru Tanaka, Tomohiro Hayashi
    • Journal Title

      Front Chem.

      Volume: 9 Pages: 748017-748017

    • DOI

      10.3389/fchem.2021.748017

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo2021

    • Author(s)
      T. Ishizawa, N. Makino, Y. Kakizaki, A. Matsuda, Y. Toyokawa, S. Ooyama, M. Tanaka, Y. Ueno
    • Journal Title

      PLoS ONE

      Volume: 16 Issue: 9 Pages: e0257828-e0257828

    • DOI

      10.1371/journal.pone.0257828

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carborane as an Alternative Efficient Hydrophobic Tag for Protein Degradation2021

    • Author(s)
      Asawa Yasunobu、Nishida Kei、Kawai Kazuki、Domae Kiyotaka、Ban Hyun Seung、Kitazaki Akihiro、Asami Hiroya、Kohno Jun-Ya、Okada Satoshi、Tokuma Hiraku、Sakano Daisuke、Kume Shoen、Tanaka Masaru、Nakamura Hiroyuki
    • Journal Title

      Bioconjugate Chemistry

      Volume: 32 Issue: 11 Pages: 2377-2385

    • DOI

      10.1021/acs.bioconjchem.1c00431

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of interfacial structure based on grafting density of poly(2-methoxyethyl acrylate) on blood compatibility2021

    • Author(s)
      Tomoya Ueda, Daiki Murakami, Masaru Tanaka
    • Journal Title

      Colloids and Surfaces B: Biointerfaces

      Volume: 199 Pages: 111517-111517

    • DOI

      10.1016/j.colsurfb.2020.111517

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A fully covered self-expandable metallic stent coated with poly (2-methoxyethyl acrylate) and its derivative: In vitro evaluation of early-stage biliary sludge formation inhibition2021

    • Author(s)
      Yoshihide Toyokawa, Shingo Kobayashi, Haruka Tsuchiya, Tomokazu Shibuya, Makiko Aoki, Jun Sumiya, Shun Ooyama, Tetsuya Ishizawa, Naohiko Makino, Yoshiyuki Ueno, Masaru Tanaka
    • Journal Title

      Materials Science and Engineering: C

      Volume: 120 Pages: 111386-111386

    • DOI

      10.1016/j.msec.2020.111386

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Methoxy-Functionalized Glycerol-Based Aliphatic Polycarbonate: Organocatalytic Synthesis, Blood Compatibility, and Hydrolytic Property2021

    • Author(s)
      Valentina Montagna, Junko Takahashi, Meng-Yu Tsai, Takayuki Ota, Nicolas Zivic, Seigou Kawaguchi, Takashi Kato, Masaru Tanaka, Haritz Sardon, Kazuki Fukushima
    • Journal Title

      ACS Biomaterials Science & Engineering

      Volume: 7 Issue: 2 Pages: 472-481

    • DOI

      10.1021/acsbiomaterials.0c01460

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Elucidating the Feature of Intermediate Water in Hydrated Poly(ω-methoxyalkyl acrylate)s by Molecular Dynamics Simulation and Differential Scanning Calorimetry Measurement2020

    • Author(s)
      An-Tsung Kuo, Toshiki Sonoda, Shingo Urata, Ryohei Koguchi, Shingo Kobayashi, Masaru Tanaka
    • Journal Title

      ACS Biomaterials Science & Engineering

      Volume: 6 Issue: 7 Pages: 3915-3924

    • DOI

      10.1021/acsbiomaterials.0c00746

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elucidating the Feature of Intermediate Water in Hydrated Poly(ω-methoxyalkyl acrylate)s by Molecular Dynamics Simulation and Differential Scanning2020

    • Author(s)
      Shin-nosuke Nishimura, Tomoya Ueda, Shingo Kobayashi, Masaru Tanaka
    • Journal Title

      ACS Applied Polymer Materials

      Volume: 2 Issue: 11 Pages: 4790-4801

    • DOI

      10.1021/acsapm.0c00776

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Side-Chain Spacing Control of Derivatives of Poly(2-methoxyethyl acrylate): Impact on Hydration States and Antithrombogenicity2020

    • Author(s)
      Toshiki Sonoda, Shingo Kobayashi, Keisuke Herai, Masaru Tanaka
    • Journal Title

      Macromolecules

      Volume: 53 Issue: 19 Pages: 8570-8580

    • DOI

      10.1021/acs.macromol.0c01144

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular Dynamics Study on the Water Mobility and Side-Chain Flexibility of Hydrated Poly(ω-methoxyalkyl acrylate)s2020

    • Author(s)
      An-Tsung Kuo, Shingo Urata, Ryohei Koguchi, Toshiki Sonoda, Shingo Kobayashi, Masaru Tanaka
    • Journal Title

      ACS Biomaterials Science & Engineering

      Volume: 6 Pages: 6690-6700

    • DOI

      10.1016/j.colsurfb.2020.111449

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blood-Compatible Poly(2-methoxyethyl acrylate) Induces Blebbing-like Phenomenon and Promotes Viability of Tumor Cells in Serum-Free Medium2020

    • Author(s)
      Tsai Meng-Yu、Aratsu Fumihiro、Sekida Shogo、Kobayashi Shingo、Tanaka Masaru
    • Journal Title

      ACS Applied Bio Materials

      Volume: - Issue: 4 Pages: 1858-1864

    • DOI

      10.1021/acsabm.9b00885

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of Polymeric Biomaterials: The “Intermediate Water Concept2019

    • Author(s)
      M. Tanaka, S. Kobayashi, D. Murakami, F. Aratsu, A. Kashiwazaki, T. Hoshiba, K. Fukushima
    • Journal Title

      Bull. Chem. Soc. Jpn.

      Volume: 92 Issue: 12 Pages: 2043-2057

    • DOI

      10.1246/bcsj.20190274

    • NAID

      130007761387

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Control of interfacial structures and anti-platelet adhesion property of blood-compatible random copolymers2019

    • Author(s)
      Murakami Daiki、Segami Yuto、Ueda Tomoya、Tanaka Masaru
    • Journal Title

      Journal of Biomaterials Science, Polymer Edition

      Volume: 31 Issue: 2 Pages: 207-218

    • DOI

      10.1080/09205063.2019.1680930

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] 水晶振動子マイクロバランスを用いたソフト界面評価2023

    • Author(s)
      山岡賢司, 藤井義久, 鳥飼直也
    • Organizer
      CIQuS研究会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 医療用高分子の基礎・生体親和性の発現機構と表面設計・評価2023

    • Author(s)
      M. Tanaka
    • Organizer
      (株)技術情報協会 2月開催セミナー「生体適合性材料の基礎と表面設計,評価技術」
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Role of Interfacial Water in Determining the Interactions of Proteins and Cells with Hydrated Materials2023

    • Author(s)
      M. Tanaka
    • Organizer
      BIOMATFORUM2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体親和性高分子の設計と先端医療製品への展開2023

    • Author(s)
      M. Tanaka
    • Organizer
      三菱ケミカル株式会社特別講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Design of Functional Biomaterials: Intermediate Water Concept for Advanced Medical Devices2023

    • Author(s)
      M. Tanaka
    • Organizer
      Nano-seminar at University of California, Berkeley
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Experimental Evidence of Slow Mode Water in The Vicinity of Poly(ethylene oxide) at Physiological Temperature2022

    • Author(s)
      Taiki Tominaga, Mafumi Hishida, Daiki Murakami, Yoshihisa Fujii, Masaru Tanaka, and Hideki Seto
    • Organizer
      QENS/WINS2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナノインデンターを用いたエポキシ樹脂の不均一構造に由来する物性評価2022

    • Author(s)
      大谷瑠奈, 仲川枝里, 大村孝仁, 藤井義久, 鳥飼直也
    • Organizer
      第71回高分子学会年次大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 空気雰囲気下のプラズマ処理法により改質した高分子膜表面の性状観察2022

    • Author(s)
      安田信太郎, 藤井義久, 鳥飼直也
    • Organizer
      第71回高分子学会年次大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 水晶振動子マイクロバランスを用いた水中におけるメチルセルロースの局所運動評価2022

    • Author(s)
      山岡賢司, 藤井義久, 鳥飼直也
    • Organizer
      第71回高分子学会年次大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] (ボトルブラシポリスチレン/線状ポリスチレン)ブレンド膜の表面形態観察2022

    • Author(s)
      西村安理,山内祥弘, 佐光貞樹, 藤井義久, 鳥飼直也
    • Organizer
      第71回高分子学会年次大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Experimental Evidences of Slow Mode Water in the Vicinity of Polyethylene Oxide at Physiological Temperature2022

    • Author(s)
      Hideki Seto, Taiki Tominaga, Tatsuya Kikuchi, Daiki Murakami, Yoshihisa Fujii, Mafumi Hishida, and Masaru Tanaka
    • Organizer
      International Conference on Neutron Scattering 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 急速液/液相分離により作製したマイクロ微粒子の構造解析と形態制御2022

    • Author(s)
      藤井義久, 小川凌央, 佐光貞樹, 鳥飼直也
    • Organizer
      第71回高分子討論会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 2次元マッピングに基づくエポキシ樹脂の力学的不均一性解2022

    • Author(s)
      大谷瑠奈, 仲川枝里, 大村孝仁, 藤井義久, 鳥飼直也
    • Organizer
      第71回高分子討論会
    • Related Report
      2022 Annual Research Report
  • [Presentation] (ボトルブラシ状ポリスチレン/線状ポリスチレン)ブレンド膜の表面偏析挙動と機能特性評価2022

    • Author(s)
      西村安理, 山内祥弘, 佐光貞樹, 藤井義久, 鳥飼直也
    • Organizer
      第71回高分子討論会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 空気プラズマを用いた疎水性高分子膜の形態制御と表面性状解析2022

    • Author(s)
      安田信太郎, 藤井義久, 鳥飼直也
    • Organizer
      第71回高分子討論会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Interfacial Viscoelastic Behavior of Aqueous Methylcellulose Solution in High Frequency Region2022

    • Author(s)
      Kenji Yamaoka, Yoshihisa Fujii, and Naoya Torikai
    • Organizer
      第71回高分子討論会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ポリスチレン膜および吸着層の摩擦特性に及ぼす浸漬溶媒の効果2022

    • Author(s)
      田島慎平, 藤井義久, 鳥飼直也
    • Organizer
      第73回コロイドおよび界面化学討論会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ソフト材料の界面設計に及ぼす水の効果2022

    • Author(s)
      藤井義久, 井上昴紀, 庄村大輝, 鳥飼直也
    • Organizer
      第34回高分子加工技術討論会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 結晶性高分子薄膜の調湿環境下における構造・物性解析2022

    • Author(s)
      小見山夏輝, 藤井義久, 鳥飼直也
    • Organizer
      第53回中部化学関係学協会支部連合秋季大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 架橋密度の異なるポリエチレングリコールゲルの水和状態2022

    • Author(s)
      原将慶, 藤井義久, 鳥飼直也
    • Organizer
      第60回高分子と水に関する討論会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Quasi-elastic Neutron Scattering Studies on Hydration Water at Bio-compatible Polymers2022

    • Author(s)
      Hideki Seto, Taiki Tominaga, Daiki Murakami, Yoshihisa Fujii, Shohei Shiomoto, and Masaru Tanaka
    • Organizer
      The 32nd Annual Meeting of MRS-J
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 空気プラズマを用いた疎水性高分子膜の表面性状解析とタンパク質吸着の抑制2022

    • Author(s)
      安田信太郎, 藤井義久, 鳥飼直也
    • Organizer
      21th産官学接着若手フォーラム
    • Related Report
      2022 Annual Research Report
  • [Presentation] Design of biocompatible materials for advanced medical devices,2022

    • Author(s)
      M. Tanaka
    • Organizer
      2022 IC-MSE SUZHOU CONFERENCE
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体内には性質の異なる水が存在している?という不思議自由水と不凍水、そして中間水の謎に迫る~2022

    • Author(s)
      M. Tanaka
    • Organizer
      第一回技術コンソーシアム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 中間水コンセプトによる生体親和性子分子の設計と医療機器への展開2022

    • Author(s)
      M. Tanaka
    • Organizer
      プラスチック成型加工学会第33回年次大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 医療用高分子の基礎・生体親和性の発現機構と表面設計・評価2022

    • Author(s)
      M. Tanaka
    • Organizer
      株式会社AndTech講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 生体親和性高分子の設計と先端医療機器への展開2022

    • Author(s)
      M. Tanaka
    • Organizer
      学際統合物質科学研究機構(IRCCS)IRCCS設立シンポジウムおよびキックオフシンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] ソフトマターとバイオシステムの界面における水和状態と機能2022

    • Author(s)
      M. Tanaka
    • Organizer
      第73回コロイドおよび界面化学討論会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Design and Synthesis of Biocompatible Polymers base on the Intermediate Water Concept2022

    • Author(s)
      M. Tanaka
    • Organizer
      2nd Global Summit and Expo on Biotechnology and Bioscience (GSEBB2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Design of Biocompatible Soft-Materials for Advanced Medical Devices by the Intermediate Water Concept2022

    • Author(s)
      M. Tanaka
    • Organizer
      7th Edition of Applied Science, Engineering and Technology Virtual (V-Applied2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Design of Biocompatible Polymers for Advanced Medical Devices using the Intermediate Water Concept2022

    • Author(s)
      M. Tanaka
    • Organizer
      KYUSHU U.-NTNU JOINT SYMPOSIUM
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 界面近傍水の役割と機能-バイオ・医療材料を例に-2022

    • Author(s)
      田中 賢
    • Organizer
      2021年度アライアンス合同分科会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 金電極上におけるポリスチレン薄膜の分子鎖熱運動性2021

    • Author(s)
      小見山大輝,藤井義久,鳥飼直也
    • Organizer
      第70回高分子学会年次大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 基板界面におけるメチルセルロース水溶液の濃度勾配とゲル化挙動2021

    • Author(s)
      山岡賢司,山田悟史,藤井義久,鳥飼直也
    • Organizer
      第70回高分子学会年次大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 架橋高分子の水和状態と力学物性の関係2021

    • Author(s)
      藤井義久,井上昂紀,庄村大輝,菱田理紗,鳥飼直也
    • Organizer
      第70回高分子討論会(依頼講演)
    • Related Report
      2021 Annual Research Report
  • [Presentation] 固体界面におけるメチルセルロース水溶液のゲル化と濃縮挙動の温度依存性2021

    • Author(s)
      山岡賢司,山田悟史,藤井義久,鳥飼直也
    • Organizer
      第70回高分子討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] シリコン基板上のポリスチレン吸着鎖の熱安定性と摩擦特性2021

    • Author(s)
      田島慎平,藤井義久,鳥飼直也
    • Organizer
      第70回高分子討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 吸湿・乾燥過程におけるポリエチレンオキシド薄膜の結晶状態の観察2021

    • Author(s)
      小見山夏輝,藤井義久,鳥飼直也
    • Organizer
      第70回高分子討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Effect of Solution Properties on Polymer Particles in Spray Nanoprecipitation Method2021

    • Author(s)
      Ryo Ogawa, Yoshihisa Fujii, Naoya Torikai
    • Organizer
      The 11th International Symposium for Sustainability by Engineering at MIU
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Polystyrene Adsorbed Layer on Pressure-Sensitive Adhesive Tape Peeling2021

    • Author(s)
      Kohei Koshisuka, Yoshihisa Fujii, Naoya Torikai
    • Organizer
      The 11th International Symposium for Sustainability by Engineering at MIU
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Observation of the Crystalline State of Poly(ethylene oxide) Thin Films under Wet and Dry Environments2021

    • Author(s)
      Natsuki Komiyama, Yoshihisa Fujii, Naoya Torikai
    • Organizer
      The 11th International Symposium for Sustainability by Engineering at MIU
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Thermal Stability of Polystyrene Residual Layer on Frictional Properties2021

    • Author(s)
      Shimpei Tajima, Yoshihisa Fujii, Naoya Torikai
    • Organizer
      The 11th International Symposium for Sustainability by Engineering at MIU
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation and Characterization of Poly(ethylene glycol) Hydrogels with Different Water Content2021

    • Author(s)
      Masayoshi Hara, Yoshihisa Fujii, Naoya Torikai
    • Organizer
      The 11th International Symposium for Sustainability by Engineering at MIU
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 水圏で「はたらく」低含水高分子材料の解析~少ない水の大きな効果~2021

    • Author(s)
      藤井義久,富永大輝,村上大樹,田中賢,瀬戸秀紀
    • Organizer
      第11回CSJ化学フェスタ
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 水晶振動子マイクロバランスを用いたメチルセルロース水溶液のゲル化挙動の評価と界面濃縮の効果2021

    • Author(s)
      山岡賢司,山田悟史,藤井義久,鳥飼直也
    • Organizer
      第11回CSJ化学フェスタ
    • Related Report
      2021 Annual Research Report
  • [Presentation] 接合界面における水の振る舞いと接着強度の関係2021

    • Author(s)
      藤井義久
    • Organizer
      第52回 中部化学関係学協会支部連合秋季大会(依頼講演)
    • Related Report
      2021 Annual Research Report
  • [Presentation] 中性子準弾性散乱に基づく水和したポリメタクリル酸メチルの熱運動性2021

    • Author(s)
      藤井義久,富永大輝,菊池龍弥,村上大樹,田中賢,瀬戸秀紀
    • Organizer
      第21回日本中性子科学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 高分子吸着層/粘着剤の界面相の構造評価と剥離強度への影響2021

    • Author(s)
      越須賀航平,藤井義久,鳥飼直也
    • Organizer
      第21回日本中性子科学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] NRおよびQCMで評価したメチルセルロースゲルの固体界面における凝集構造と粘弾性2021

    • Author(s)
      山岡 賢司,藤井義久,鳥飼直也
    • Organizer
      第21回日本中性子科学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 急速液/液相分離法を応用したSpray-Precipitationによる微粒子形成と細孔制御2021

    • Author(s)
      小川凌央,藤井義久,鳥飼直也
    • Organizer
      2021年度東海高分子研究会学生発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 生体適合性に優れた診断・治療用ソフトバイオマテリアルの設計-中間水コンセプトによる機能材料創出2021

    • Author(s)
      田中 賢
    • Organizer
      2021年度 第2回インクジェット研究会(YU-IJWS)セミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 生体親和性材料によるバイオ界面設計-中間水コンセプトによる機能材料創出-2021

    • Author(s)
      田中 賢
    • Organizer
      Minase Innovation Forum
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Role of intermediate water in determining the interaction of proteins and cells with hydrated materials2021

    • Author(s)
      M. Tanaka
    • Organizer
      The International Bioprocessing Association Subject Conference (IBASC-2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中間水コンセプトによる生体親和性医療材料の創製2021

    • Author(s)
      田中 賢
    • Organizer
      第14回ChemBioハイブリッドレクチャー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 生体親和性材料の設計─バイオ界面水の役割と機能2021

    • Author(s)
      田中 賢
    • Organizer
      第78回日本歯科理工学会学術講演会プログラム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] The Role of Interfacial Water in Materil /Protein/Cell interactions Design of Biocompatible Materials based on the Intermediate Water Concept2021

    • Author(s)
      田中 賢
    • Organizer
      GSBA2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新たな liquid biopsy による臨床化学の未来図2021

    • Author(s)
      田中 賢
    • Organizer
      第61回日本臨床化学会年次学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 中間水理論による生体親和性高分子の設計と合成2021

    • Author(s)
      田中 賢
    • Organizer
      第30回ポリマー材料フォーラム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Roles of Water in Biocompatible Polymers2021

    • Author(s)
      M. Tanaka
    • Organizer
      POLYSOLVAT-13
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体適合性材料における中間水の役割2021

    • Author(s)
      田中 賢
    • Organizer
      第59回日本人工臓器学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 中間水コンセプトによるバイオイナート材料の設計2021

    • Author(s)
      田中 賢
    • Organizer
      第43回日本バイオマテリアル学会/第8回アジアバイオマテリアル学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Design of Polymeric Biomaterials for Medical Devices and Tissue Engineering: The “Intermediate Water Concept”2021

    • Author(s)
      Masaru Tanaka
    • Organizer
      2021 2nd International Conference on Materials Science and Engineering (IC-MSE 2021)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中間水コンセプトによる多機能生体親和性高分子の設計2021

    • Author(s)
      田中 賢
    • Organizer
      2020東海シンポジウム(高分子学会東海支部)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 生体親和性材料の表面・界面設計とスクリーニング法2020

    • Author(s)
      田中 賢
    • Organizer
      生体親和性材料Webセミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 生体親和性材料によるバイオ界面設計2020

    • Author(s)
      田中 賢
    • Organizer
      花王株式会社特別講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 生体親和性材料の設計と製品展開2020

    • Author(s)
      田中 賢
    • Organizer
      日本学術振興会創造機能化学第116委員会講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Measurement of Peeling Behavior on Interfacial Polystyrene Adsorbed Layer by Using Pressure-Sensitive Adhesive Tape2020

    • Author(s)
      Kohei Koshisuka, Yoshihisa Fujii, Naoya Torikai
    • Organizer
      The 10th International Symposium for Sustainability by Engineering at MIU
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高分子界面の局所構造・物性解析と接着劣化分析への応用2020

    • Author(s)
      藤井義久
    • Organizer
      日本分析化学会中部支部三重地区講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 中性子準弾性散乱法による中間水のダイナミクス解析2020

    • Author(s)
      村上大樹, 藤井義久, 富永大輝, 瀬戸秀樹, 田中賢
    • Organizer
      第69回高分子学会年次大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 側鎖導入間隔を制御した新規ポリオレフィン系高分子の合成および水和構造の解析2020

    • Author(s)
      吉田健人,小林慎吾,田中 賢
    • Organizer
      日本バイオマテリアル学会第9回九州ブロック講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 医用高分子の開発と生体親和性発現機構の解明2019

    • Author(s)
      Masaru Tanaka
    • Organizer
      市村賞受賞記念フォーラム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] PMEA/水界面の微細構造による細胞接着性制御2019

    • Author(s)
      村上大樹,上田智也,瀬上裕斗,田中 賢
    • Organizer
      第68回高分子討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 一次構造を制御したPMEA類自体における水和水の運動性評価2019

    • Author(s)
      岡崎恭貴,藤原渉,小林慎吾,田中 賢
    • Organizer
      第68回高分子討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Analysis of Interaction Between Nano-Structures and Fibrinogen at Blood-Compatible2019

    • Author(s)
      Tomoya Ueda,Daiki Murakami,Masaru Tanaka
    • Organizer
      The7th Asian Biomaterials Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Control of Interfacial Structures and Protein Adsorption by the Composition of Blood-Compatible Random Copolymers2019

    • Author(s)
      Yuto Segami,Tomoya Ueda,Daiki Murakami,Masaru Tanaka
    • Organizer
      The7th Asian Biomaterials Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Molecular Weight of Poly(2-methoxyethyl acrylate) on Interfacial Structure and Biocompatibility2019

    • Author(s)
      Daiki Murakami,Nami Mawatari,Tosiki Sonoda,Aki Kashiwazaki,Masaru Tanaka
    • Organizer
      The7th Asian Biomaterials Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] がん検査への応用を目指した血液適合性高分子材料上でのがん細胞生存性評価2019

    • Author(s)
      関田将伍,荒津史裕,穴田貴久,田中 賢
    • Organizer
      第9回CSJ化学フェスタ
    • Related Report
      2019 Annual Research Report
  • [Presentation] カルボニル基の位置を変更したPMEA類似体における水和水の運動性評価2019

    • Author(s)
      岡崎恭貴,藤原渉,小林慎吾,田中 賢
    • Organizer
      第9回CSJ化学フェスタ
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effect of Interfacial Poly(2-methoxyethyl acrylate) Analogue on Cell Attachment2019

    • Author(s)
      Kei Nishida,Shingo Kobayashi,Takahisa Anada,Tomoya Ueda,Masaru Tanaka
    • Organizer
      China-Japan Biopolymer Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of Antithrombotic Silsesquioxane/PMEA Hybrid via Thiol-initiated Radical Polymerization for Exceeding the Limitation of Coatability and Stability of PMEA Homopolymer2019

    • Author(s)
      Shin-nosuke Nishimura,Tomoya Ueda,Shingo Kobayashi,Masaru Tanaka
    • Organizer
      China-Japan Biopolymer Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of Cellular Uptake Behavior of Water-Solble PMEA Analogs Having Different Hydration State2019

    • Author(s)
      Hiroki Uehara,Kei Nishida,Shingo Kobayashi,Masaru Tanaka
    • Organizer
      China-Japan Biopolymer Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フッ素系合成高分子による低タンパク質吸着表面設計2019

    • Author(s)
      小口亮平, 田中 賢
    • Organizer
      第36回医用高分子研究会講座
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] HEMA共重合体の水和状態の制御と生体不活性の発現2019

    • Author(s)
      小口亮平,Katja Jankova,山本今日子,田中 賢
    • Organizer
      第41回日本バイオマテリアル学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] シルセスキオキサン/ポリ(2-メトキシエチルアクリレート)ハイブリッドの合成とそのコーティング特性および抗血栓性評価2019

    • Author(s)
      西村慎之介,上田智也,小林慎吾,田中 賢
    • Organizer
      第41回日本バイオマテリアル学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Design of Soft-Biomaterials Based on Intermediated Water Contents2019

    • Author(s)
      Masaru Tanaka
    • Organizer
      Materials Research Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 血中に含まれるがん細胞 (CTC) の選択分離回収技術2019

    • Author(s)
      Masaru Tanaka
    • Organizer
      九州大学ベンチャーエコシステム連絡会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Design of Soft-Biomaterials The Intermediate Water Concept2019

    • Author(s)
      Masaru Tanaka
    • Organizer
      2019 International Conference on Materials Science and Engineering
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] High-Frequency Rheometry of Methylcellulose Aqueous Solution using Quartz Crystal Microbalance2019

    • Author(s)
      山岡賢司,藤井義久,鳥飼直也
    • Organizer
      The 9th International Symposium for Sustainability by Engineering at MIU
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of Surface Structure of Polystyrene Thin Films Used Various Good Solvents2019

    • Author(s)
      宮田淳史,藤井義久,鳥飼直也
    • Organizer
      The 9th International Symposium for Sustainability by Engineering at MIU
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Polymer Solution Properties on Membrane Structure and Filtration Performance2019

    • Author(s)
      板倉圭吾,藤井義久,鳥飼直也
    • Organizer
      The 9th International Symposium for Sustainability by Engineering at MIU
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 基板界面近傍におけるメチルセルロース水溶液の粘弾性2019

    • Author(s)
      山岡賢司,藤井義久,内藤昌信,鳥飼直也
    • Organizer
      第67回レオロジー討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高分子薄膜の表面形態に及ぼすスピンコート時の溶液濃縮過程の影響2019

    • Author(s)
      宮田淳史,藤井義久,鳥飼直也
    • Organizer
      第67回レオロジー討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 限外ろ過膜の相分離構造と分離性能に及ぼす高分子溶液粘度の効果2019

    • Author(s)
      板倉圭吾,藤井義久,鳥飼直也
    • Organizer
      第67回レオロジー討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 水晶振動子を用いた界面近傍の粘弾性評価と基板表面性状の効果2019

    • Author(s)
      山岡賢司,藤井義久,鳥飼直也
    • Organizer
      微小領域の力学特性評価とマルチスケールモデリング 研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ロバスト炭素膜の作製と水処理への応用2019

    • Author(s)
      藤井義久
    • Organizer
      第93回高分子若手研究会[関西]
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Remarks] 九州大学田中賢研究室

    • URL

      https://www.soft-material.jp/

    • Related Report
      2022 Annual Research Report
  • [Remarks] 三重大学藤井研究室

    • URL

      http://www.oms.chem.mie-u.ac.jp/index.html

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
  • [Remarks] 水圏機能材料領域

    • URL

      https://www.aquatic-functional-materials.org/

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
  • [Remarks] 生体親和性の科学を解き明かす

    • URL

      https://www.kyushu-u.ac.jp/ja/research/close-up/masaru-tanaka

    • Related Report
      2022 Annual Research Report
  • [Remarks] 中間水コンセプトとは? “バイオマテリアルサイエンスを極める”

    • URL

      https://youtu.be/Bl4eZNkI0x4

    • Related Report
      2022 Annual Research Report
  • [Remarks] 九州大学田中賢研究室

    • URL

      http://www.soft-material.jp

    • Related Report
      2021 Annual Research Report
  • [Remarks] 研究室HP(田中)

    • URL

      http://www.soft-material.jp

    • Related Report
      2020 Annual Research Report
  • [Remarks] 研究室HP(藤井)

    • URL

      http://www.oms.chem.mie-u.ac.jp/index.html

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] 領域HP

    • URL

      https://www.aquatic-functional-materials.org/

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] 研究室HP(田中)

    • URL

      http://www.soft-material.jp/

    • Related Report
      2019 Annual Research Report

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Published: 2019-07-04   Modified: 2025-01-30  

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