Elucidation of the hyper-adaptation mechanism by reconstruction of bio-structure and challenges for prevention of decline in latent adaptive capacity

• Project Area: Hyper-adaptability for overcoming body-brain dysfunction: Integrated empirical and system theoretical approaches
• Project/Area Number: 19H05723
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Kyoto University
• Principal Investigator: 伊佐 正 京都大学, 医学研究科, 教授 (20212805)
• Co-Investigator(Kenkyū-buntansha): 内藤 栄一 国立研究開発法人情報通信研究機構, 未来ICT研究所脳情報通信融合研究センター, 室長 (10283293) ; 浅田 稔 大阪大学, 先導的学際研究機構, 特任教授 (60151031) ; 中野 英樹 京都橘大学, 健康科学部, 准教授 (60605559) ; 相澤 秀紀 広島大学, 医系科学研究科(医), 教授 (80391837)
• Project Period (FY): 2019-06-28 – 2024-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥197,990,000 (Direct Cost: ¥152,300,000、Indirect Cost: ¥45,690,000); Fiscal Year 2023: ¥37,830,000 (Direct Cost: ¥29,100,000、Indirect Cost: ¥8,730,000); Fiscal Year 2022: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000); Fiscal Year 2021: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000); Fiscal Year 2020: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000); Fiscal Year 2019: ¥46,280,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥10,680,000)
• Keywords: 機能回復 / 脱抑制 / fMRI / モノアミン / 高齢者 / 霊長類 / ｆMRI / 運動野 / 半球間抑制 / 脊髄損傷

Outline of Research at the Start

大規模脳領域での脱抑制が生体構造の再構成による超適応機構の基盤であるという仮説を検証する。研究代表者伊佐は、脊髄損傷サルにおける脳活動などの縦断的記録により、大規模脳領域で起こる脱抑制のメカニズムを解明する。分担研究者相澤はその脱抑制の基盤と想定されるモノアミン汎性修飾系の関与を検証する。研究分担者内藤は、高齢者および若年成人の安静時および運動中の脳活動を機能的磁気共鳴画像装置(fMRI)で計測し、機能回復と脱抑制回路の操作に伴う皮質脳波の変化と高齢者における安静時の全脳機能結合の特徴との類似点について、B01班と連携してマルチモーダル解析による解釈性のある統合モデルを構築して明らかにする。

Outline of Annual Research Achievements

A01班では，主に超適応機構の「生体構造の再構成」の観点から，大規模脳領域での脱抑制が生体構造の再構成による超適応機構の基盤であるという仮説を，班員それぞれの研究を融合・発展させて検証することを目指している．伊佐のグループのニホンザルを用いて，頚髄 C4/C5 亜半切後の手指の運動機能の回復過程を調べ、損傷前は抑制性であった損傷同側の運動前野から 損傷反対側の一次運動野へ半球間経路が，損傷後は促通に変化することを明らかにした。本年度は，半球間経路を対象として，統計的因果探索手法であるLinear non-Gaussian acyclic model（LiNGAM）を適用し，損傷前後における脳内における興奮性結合のネットワークと抑制性結合のネットワークを調査したところ、α帯域での損傷同側の運動前野から損傷反対側の一次運動野へ半球間結合において，興奮性結合はどの回復時期でも同じような結合強度であった．一方，抑制性結合において，回復早期と後期の結合強度は損傷前に比べると有意に低くなった．これらの結果から，脊髄損傷後の回復過程で，抑制性結合の強度を低くすることで，脱抑制が生じたことが示された．研究分担者内藤と浅田は，機能的MRIを用いて，車椅子レーストップパラリンピアンの脳でみられる超適応現象の解明を行った．通常手の運動中には運動野足領域の抑制がみられるが，この選手では手運動中に足領域の活性化がみられるという超適応現象を突き止めた．研究分担者相澤は，超適応時の大脳皮質における半球間抑制と脱抑制の神経機構を調べるため，光遺伝学と電気生理学を組み合わせたマウス実験を行なった。脳梗塞モデルマウスにおいて，交連線維の光遺伝学的刺激に対する応答を調べたところ，前肢使用の側性化に伴って障害側運動野における抑制成分の減弱が次第に出現することを明らかにした．

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

グループは連携し、ヒトとサルとマウスを用いて、脳卒中や脊髄損傷、さらに高齢者において両側大脳半球間の結合について多角的に研究を行ってきた。その結果、起きている脱抑制とそのメカニズムの解明について、統合的理解が大きく進捗している。

Strategy for Future Research Activity

最終年度に向けて、それぞれの研究をまとめて論文発表するとともに、マウスで得られた結果をサルで検証する実験も行う。そして脳・脊髄障害と加齢による運動機能低下と脱抑制、そしてそのメカニズムについての英文総説の執筆を検討している。

Research Products

• [Int'l Joint Research] リューベンカトリック大学(ベルギー)
• [Int'l Joint Research] チュラロンコン大学(タイ)
• [Int'l Joint Research] カロリンスカ医科大学(スウェーデン)
• [Int'l Joint Research] クイーンズランド大学(オーストラリア)
• [Journal Article] Visualizing advances in the future of primate neuroscience research (2023)
  • Author(s): Janssen Peter、Isa Tadashi、Lanciego Jose、Leech Kirk、Logothetis Nikos、Poo Mu-Ming、Mitchell Anna S.
  • Journal Title: Current Research in Neurobiology Volume: 4 Pages: 100064-100064
  • DOI: 10.1016/j.crneur.2022.100064
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] GENETIC DELETION OF TRANSLOCATOR PROTEIN EXACERBATES POST-SEPSIS SYNDROME WITH ACTIVATION OF THE C1Q PATHWAY IN SEPTIC MOUSE MODEL (2023)
  • Author(s): Kikutani K, Hosokawa K, Giga H, Ota K, Matsumata M, Zhu M, Takemoto H, Ji B, Ohshimo S, Shime N, Aizawa H.
  • Journal Title: SHOCK Volume: 59 Issue: 1 Pages: 82-90
  • DOI: 10.1097/shk.0000000000002030
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Phylogenetic view of the compensatory mechanisms in motor and sensory systems after neuronal injury (2022)
  • Author(s): Isa Tadashi、Tohyama Takamichi、Kinoshita Masaharu
  • Journal Title: Current Research in Neurobiology Volume: 3 Pages: 100058-100058
  • DOI: 10.1016/j.crneur.2022.100058
  • Peer Reviewed / Open Access
• [Journal Article] Temporal dynamics of the sensorimotor convergence underlying voluntary limb movement (2022)
  • Author(s): Umeda Tatsuya、Isa Tadashi、Nishimura Yukio
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 119 Issue: 48
  • DOI: 10.1073/pnas.2208353119
  • Peer Reviewed
• [Journal Article] Protocol for making an animal model of "blindsight" in macaque monkeys. (2022)
  • Author(s): Takakuwa N, Isa K, Yamaguchi R, Onoe H, Takahashi J, Yoshida M, Isa T
  • Journal Title: STAR Protoc Volume: 4(1) Issue: 1 Pages: 101960-101960
  • DOI: 10.1016/j.xpro.2022.101960
  • Peer Reviewed / Open Access
• [Journal Article] Lewy Body Disease Primate Model with α‐Synuclein Propagation from the Olfactory Bulb (2022)
  • Author(s): Sawamura Masanori、Onoe Hirotaka、Tsukada Hideo、Isa Kaoru、Yamakado Hodaka、Okuda Shinya、Ikuno Masashi、Hatanaka Yusuke、Murayama Shigeo、Uemura Norihito、Isa Tadashi、Takahashi Ryosuke
  • Journal Title: Movement Disorders Volume: 37 Issue: 10 Pages: 2033-2044
  • DOI: 10.1002/mds.29161
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hyper-adaptation in the human brain: Functional and structural changes in the foot section of the primary motor cortex in a top wheelchair racing Paralympian. (2022)
  • Author(s): Morita, T., Hirose, S., Kimura, N., Takemura, H., Asada, M. & Naito, E.
  • Journal Title: Frontier in System Neuroscience Volume: 16 Pages: 780652-780652
  • DOI: 10.3389/fnsys.2022.780652
  • Peer Reviewed / Open Access
• [Journal Article] Facilitation of hand proprioceptive processing in paraplegic individuals with long-term wheelchair sports training. (2022)
  • Author(s): Morita, T. & Naito, E.
  • Journal Title: Brain sciences Volume: 12 Issue: 10 Pages: 1295-1295
  • DOI: 10.3390/brainsci12101295
  • Peer Reviewed / Open Access
• [Journal Article] A multisynaptic pathway from the ventral midbrain toward spinal motoneurons in monkeys (2022)
  • Author(s): Suzuki Michiaki、Inoue Ken‐ichi、Nakagawa Hiroshi、Ishida Hiroaki、Kobayashi Kenta、Isa Tadashi、Takada Masahiko、Nishimura Yukio
  • Journal Title: The Journal of Physiology Volume: 600 Issue: 7 Pages: 1731-1752
  • DOI: 10.1113/jp282429
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Amygdala Underlies the Environment Dependency of Defense Responses Induced via Superior Colliculus (2022)
  • Author(s): Isa Kaoru、Tokuoka Kota、Ikeda Sakura、Karimi Sara、Kobayashi Kenta、Sooksawate Thongchai、Isa Tadashi
  • Journal Title: Frontiers in Neural Circuits Volume: 15 Pages: 768647-768647
  • DOI: 10.3389/fncir.2021.768647
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of Light Isoflurane Anesthesia on Organization of Direction and Orientation Selectivity in the Superficial Layer of the Mouse Superior Colliculus (2022)
  • Author(s): Masatoshi KASAI, Tadash ISA
  • Journal Title: J Neurosci Volume: 42 Issue: 4 Pages: 619-630
  • DOI: 10.1523/jneurosci.1196-21.2021
  • Peer Reviewed / Open Access
• [Journal Article] Double viral vector intersectional approaches for pathway-selective manipulation of motor functions and compensatory mechanisms (2022)
  • Author(s): Isa Tadashi
  • Journal Title: Experimental Neurology Volume: 349 Pages: 113959-113959
  • DOI: 10.1016/j.expneurol.2021.113959
  • Peer Reviewed
• [Journal Article] Visual instrumental learning in blindsight monkeys (2021)
  • Author(s): Kato Rikako、Zeghbib Abdelhafid、Redgrave Peter、Isa Tadashi
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 14819-14819
  • DOI: 10.1038/s41598-021-94192-7
  • NAID: 120007147049
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Divergent Whole Brain Projections from the Ventral Midbrain in Macaques (2021)
  • Author(s): Zubair Muhammad、Murris Sjoerd R、Isa Kaoru、Onoe Hirotaka、Koshimizu Yoshinori、Kobayashi Kenta、Vanduffel Wim、Isa Tadashi
  • Journal Title: Cerebral Cortex Volume: 31 Issue: 6 Pages: 2913-2931
  • DOI: 10.1093/cercor/bhaa399
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The posterior parietal cortex contributes to visuomotor processing for saccades in blindsight macaques (2021)
  • Author(s): Kato Rikako、Hayashi Takuya、Onoe Kayo、Yoshida Masatoshi、Tsukada Hideo、Onoe Hirotaka、Isa Tadashi、Ikeda Takuro
  • Journal Title: Communications Biology Volume: online ahead of print Issue: 1 Pages: 278-278
  • DOI: 10.1038/s42003-021-01804-z
  • Peer Reviewed / Open Access
• [Journal Article] Neural Mechanism of Blindsight in a Macaque Model (2021)
  • Author(s): Isa Tadashi、Yoshida Masatoshi
  • Journal Title: Neuroscience Volume: 469 Pages: 138-161
  • DOI: 10.1016/j.neuroscience.2021.06.022
  • Peer Reviewed / Open Access
• [Journal Article] The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action (2021)
  • Author(s): Isa Tadashi、Marquez-Legorreta Emmanuel、Grillner Sten、Scott Ethan K.
  • Journal Title: Current Biology Volume: 31 Issue: 11 Pages: R741-R762
  • DOI: 10.1016/j.cub.2021.04.001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Existence of Interhemispheric Inhibition between Foot Sections of Human Primary Motor Cortices: Evidence from Negative Blood Oxygenation-Level Dependent Signal. (2021)
  • Author(s): Naito, E., Morita, T., Kimura, N. & Asada, M.
  • Journal Title: Brain Sciences Volume: 11 Issue: 8 Pages: 1099-1099
  • DOI: 10.3390/brainsci11081099
  • Peer Reviewed / Open Access
• [Journal Article] Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition (2021)
  • Author(s): Naito, E., Morita, T., Hirose, S., Kimura, N., Okamoto, H., Kamimukai, C., & Asada, M.
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 22696-22696
  • DOI: 10.1038/s41598-021-02173-7
  • Peer Reviewed / Open Access
• [Journal Article] Electrophysiological and pharmacological characterization of spreading depolarization in the adult zebrafish tectum (2021)
  • Author(s): Terai Haruhi、Gwedela Mayeso Naomi Victoria、Kawakami Koichi、Aizawa Hidenori
  • Journal Title: Journal of Neurophysiology Volume: 126 Issue: 6 Pages: 1934-1942
  • DOI: 10.1152/jn.00343.2021
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Novel Microcontroller-Based System for the Wheel-Running Activity in Mice (2021)
  • Author(s): Zhu Meina、Kasaragod Deepa Kamath、Kikutani Kazuya、Taguchi Kei、Aizawa Hidenori
  • Journal Title: eneuro Volume: 8 Issue: 6 Pages: 1-9
  • DOI: 10.1523/eneuro.0260-21.2021
  • Peer Reviewed / Open Access
• [Journal Article] Double viral vector technology for selective manipulation of neural pathways with higher level of efficiency and safety (2021)
  • Author(s): Koshimizu Yoshinori、Isa Kaoru、Kobayashi Kenta、Isa Tadashi
  • Journal Title: Gene Therapy Volume: online ahead of print Issue: 6 Pages: 339-350
  • DOI: 10.1038/s41434-020-00212-y
  • Peer Reviewed / Open Access
• [Journal Article] Repeatability of proton magnetic resonance spectroscopy of the brain at 7 T: effect of scan time on semi-localized by adiabatic selective refocusing and short-echo time stimulated echo acquisition mode scans and their comparison (2021)
  • Author(s): Okada Tomohisa、Kuribayashi Hideto、Kaiser Lana G.、Urushibata Yuta、Salibi Nouha、Seethamraju Ravi Teja、Ahn Sinyeob、Thuy Dinh Ha Duy、Fujimoto Koji、Isa Tadashi
  • Journal Title: Quantitative Imaging in Medicine and Surgery Volume: 11 Issue: 1 Pages: 9-20
  • DOI: 10.21037/qims-20-517
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Properties of visually guided saccadic behavior and bottom-up attention in marmoset, macaque, and human (2021)
  • Author(s): Chen CY, Matrov D, Veale R, Onoe H, Yoshida M, Miura K, Isa T
  • Journal Title: Journal of neurophysiology Volume: 125 Issue: 2 Pages: 437-57
  • DOI: 10.1152/jn.00312.2020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Optimal Model Mapping for Intravoxel Incoherent Motion MRI (2021)
  • Author(s): Liao Yen-Peng、Urayama Shin-ichi、Isa Tadashi、Fukuyama Hidenao
  • Journal Title: Frontiers in Human Neuroscience Volume: 15 Pages: 617152-617152
  • DOI: 10.3389/fnhum.2021.617152
  • Peer Reviewed
• [Journal Article] Contribution of the Pulvinar and Lateral Geniculate Nucleus to the Control of Visually Guided Saccades in Blindsight Monkeys (2020)
  • Author(s): Takakuwa Norihiro、Isa Kaoru、Onoe Hirotaka、Takahashi Jun、Isa Tadashi
  • Journal Title: The Journal of Neuroscience Volume: 41 Issue: 8 Pages: 1755-1768
  • DOI: 10.1523/jneurosci.2293-20.2020
  • Peer Reviewed / Open Access
• [Journal Article] Anatomical and electrophysiological analysis of cholinergic inputs from the parabigeminal nucleus to the superficial superior colliculus (2020)
  • Author(s): Tokuoka Kota、Kasai Masatoshi、Kobayashi Kenta、Isa Tadashi
  • Journal Title: Journal of Neurophysiology Volume: 124 Issue: 6 Pages: 1968-1985
  • DOI: 10.1152/jn.00148.2020
  • Peer Reviewed
• [Journal Article] Dissecting the Tectal Output Channels for Orienting and Defense Responses (2020)
  • Author(s): Isa Kaoru、Sooksawate Thongchai、Kobayashi Kenta、Kobayashi Kazuto、Redgrave Peter、Isa Tadashi
  • Journal Title: eneuro Volume: 7 Issue: 5 Pages: 0271-0271
  • DOI: 10.1523/eneuro.0271-20.2020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dopaminergic signaling in the nucleus accumbens modulates stress-coping strategies during inescapable stress. (2020)
  • Author(s): Cui, W., Aida, T., Ito, H., Kobayashi, K., Wada, Y., Kato, S., Nakano, T., Zhu, M., Isa, K., Kobayashi, K., Isa, T., Tanaka, K. and Aizawa, H.
  • Journal Title: J Neurosci. Volume: 40 Issue: 38 Pages: 7241-7254
  • DOI: 10.1523/jneurosci.0444-20.2020
  • NAID: 120007170786
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Selective Mesoaccumbal Pathway Inactivation Affects Motivation but Not Reinforcement-Based Learning in Macaques (2020)
  • Author(s): Vancraeyenest Pascaline、Arsenault John T.、Li Xiaolian、Zhu Qi、Kobayashi Kenta、Isa Kaoru、Isa Tadashi、Vanduffel Wim
  • Journal Title: Neuron Volume: 108 Issue: 3 Pages: 568-581
  • DOI: 10.1016/j.neuron.2020.07.013
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice (2020)
  • Author(s): Kawamura Atsuki、Katayama Yuta、Nishiyama Masaaki、Shoji Hirotaka、Tokuoka Kota、Ueta Yoshifumi、Miyata Mariko、Isa Tadashi、Miyakawa Tsuyoshi、Hayashi-Takagi Akiko、Nakayama Keiichi I
  • Journal Title: Human Molecular Genetics Volume: - Issue: 8 Pages: 1274-1291
  • DOI: 10.1093/hmg/ddaa036
  • Peer Reviewed
• [Journal Article] Importance of the Primary Motor Cortex in Development of Human Hand/Finger Dexterity (2020)
  • Author(s): Naito Eiichi、Morita Tomoyo、Asada Minoru
  • Journal Title: Cerebral Cortex Communications Volume: online ahead of print Issue: 1 Pages: 1-12
  • DOI: 10.1093/texcom/tgaa085
  • Peer Reviewed / Open Access
• [Journal Article] Pharmacological and Genetic Inhibition of Translocator Protein 18 kDa Ameliorated Neuroinflammation in Murine Endotoxemia Model (2020)
  • Author(s): Giga Hiroshi、Ji Bin、Kikutani Kazuya、Fukuda Shuji、Kitajima Takashi、Katsumata Seishi、Matsumata Miho、Suhara Tetsuya、Yamawaki Shigeto、Shime Nobuaki、Hosokawa Koji、Aizawa Hidenori
  • Journal Title: Shock Volume: Publish Ahead of Print Issue: 1 Pages: 142-149
  • DOI: 10.1097/shk.0000000000001703
  • Peer Reviewed
• [Journal Article] Microglial translocator protein and stressor-related disorder (2020)
  • Author(s): Kikutani Kazuya、Giga Hiroshi、Hosokawa Koji、Shime Nobuaki、Aizawa Hidenori
  • Journal Title: Neurochemistry International Volume: 140 Pages: 104855-104855
  • DOI: 10.1016/j.neuint.2020.104855
  • Peer Reviewed
• [Journal Article] Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix (2020)
  • Author(s): Ito Hikaru、Nozaki Kanako、Sakimura Kenji、Abe Manabu、Yamawaki Shigeto、Aizawa Hidenori
  • Journal Title: Neuropsychopharmacology Volume: 46 Issue: 2 Pages: 442-454
  • DOI: 10.1038/s41386-020-00843-0
  • Peer Reviewed
• [Journal Article] Glial glutamate transporter GLT ‐1 determines susceptibility to spreading depression in the mouse cerebral cortex (2020)
  • Author(s): Aizawa Hidenori、Sun Weinan、Sugiyama Kaori、Itou Yukiko、Aida Tomomi、Cui Wanpeng、Toyoda Saori、Terai Haruhi、Yanagisawa Michiko、Tanaka Kohichi
  • Journal Title: Glia Volume: 68 Issue: 12 Pages: 2631-2642
  • DOI: 10.1002/glia.23874
  • Peer Reviewed
• [Journal Article] The Ventral Striatum is a Key Node for Functional Recovery of Finger Dexterity After Spinal Cord Injury in Monkeys (2019)
  • Author(s): Suzuki Michiaki、Onoe Kayo、Sawada Masahiro、Takahashi Nobuaki、Higo Noriyuki、Murata Yumi、Tsukada Hideo、Isa Tadashi、Onoe Hirotaka、Nishimura Yukio
  • Journal Title: Cerebral Cortex Volume: 30 Issue: 5 Pages: 3259-3270
  • DOI: 10.1093/cercor/bhz307
  • Peer Reviewed / Open Access
• [Journal Article] Alternative routes for recovery of hand functions after corticospinal tract injury in primates and rodents (2019)
  • Author(s): Isa Tadashi、Mitsuhashi Masahiro、Yamaguchi Reona
  • Journal Title: Current Opinion in Neurology Volume: 32 Issue: 6 Pages: 836-843
  • DOI: 10.1097/wco.0000000000000749
  • Peer Reviewed / Open Access
• [Journal Article] Dynamic Interaction between Cortico-Brainstem Pathways during Training-Induced Recovery in Stroke Model Rats (2019)
  • Author(s): Ishida A, Kobayashi K, Ueda Y, Shimizu T, Tajiri N, Isa T, Hida H
  • Journal Title: J Neurosci Volume: 39 Issue: 37 Pages: 7306-7320
  • DOI: 10.1523/jneurosci.0649-19.2019
  • Peer Reviewed / Open Access
• [Journal Article] The somatosensory cortex receives information about motor output (2019)
  • Author(s): Umeda Tatsuya、Isa Tadashi、Nishimura Yukio
  • Journal Title: Science Advances Volume: 5 Issue: 7 Pages: 5388-5388
  • DOI: 10.1126/sciadv.aaw5388
  • Peer Reviewed / Open Access
• [Journal Article] Dexterous Hand Movements and Their Recovery After Central Nervous System Injury (2019)
  • Author(s): Isa Tadashi
  • Journal Title: Annual Review of Neuroscience Volume: 42 Issue: 1 Pages: 315-335
  • DOI: 10.1146/annurev-neuro-070918-050436
  • Peer Reviewed
• [Journal Article] Neuronal and microglial localization of secreted phosphoprotein 1 (osteopontin) in intact and damaged motor cortex of macaques (2019)
  • Author(s): Sugiyama Yoko、Oishi Takao、Yamashita Akiko、Murata Yumi、Yamamoto Tatsuya、Takashima Ichiro、Isa Tadashi、Higo Noriyuki
  • Journal Title: Brain Research Volume: 1714 Pages: 52-64
  • DOI: 10.1016/j.brainres.2019.02.021
  • Peer Reviewed
• [Journal Article] Dynamic Reorganization of Motor Networks During Recovery from Partial Spinal Cord Injury in Monkeys (2018)
  • Author(s): Chao Zenas C、Sawada Masahiro、Isa Tadashi、Nishimura Yukio
  • Journal Title: Cerebral Cortex Volume: in press Issue: 7 Pages: 3059-3073
  • DOI: 10.1093/cercor/bhy172
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Neural circuit mechanism of functional recovery after brain and spinal cord injury (2021)
  • Author(s): Tadashi Isa
  • Organizer: 第９８回日本生理学大会 萩原生長記念レクチャー
• [Presentation] Massive re-routing of corticospinal projection after functional recovery from spinal cord injury in the macaque monkey (2021)
  • Author(s): Satoko Ueno, Reona Yamaguchi, Kaoru Isa, Toshinari Kawasaki, Masahiro Mitsuhashi, Tadashi Isa
  • Organizer: 第９８回日本生理学大会
• [Presentation] アディクションの脳科学 (2021)
  • Author(s): 伊佐 正
  • Organizer: 日本学術会議 公開シンポジウム 「現代社会とアディクション」
• [Presentation] Effexts of isoflurane anesthesia ond direction- and orientation- selective functional structures in mice superior colliculus (2021)
  • Author(s): Masatoshi KASAI, Tadashi ISA
  • Organizer: 第９８回日本生理学大会
• [Presentation] Systems neuroscience of functional recovery after brain and spinal cord Injur (2020)
  • Author(s): Tadashi Isa
  • Organizer: 1st Taiwan Society for Neuroscience Meeting (Plenary Lecture)
  • Int'l Joint Research / Invited
• [Presentation] Massive re-routing of the corticospinal tract fibers accompanying recovery from spinal cord injury in macaque monkey (2020)
  • Author(s): Satoko Ueno, Reona Yamaguchi, Kaoru Isa, Toshinari Kawasaki, Masahiro Mitsuhashi, Tadashi Isa
  • Organizer: 第４３回日本神経科学大会
• [Presentation] Contribution of interhemispheric pathways between the motor-related cortical areas during recovery after the corticospinal tract lesion in macaque monkeys (2020)
  • Author(s): Masahiro Mitsuhashi, Reona Yamaguchi, Toshinari Kawasaki, Satoko Ueno, Tadashi Isa
  • Organizer: 第４３回日本神経科学大会
• [Presentation] Global disinhibition across cortical networks for recovery of hand movements after spinal cord injury (2020)
  • Author(s): Reona Yamaguchi, Toshinari Kawasaki, Zenas C Chao, Masahiro Mitsuhashi, Satoko Ueno, Tadashi Isa
  • Organizer: 第４３回日本神経科学大会
• [Presentation] Resting-state functional connectivity with electrocorticography as a biomarker of motor recovery after spinal cord injury in macaque monkeys (2020)
  • Author(s): Toshinari Kawasaki, Reona Yamaguchi, Zenas C Chao, Masahiro Mitsuhashi, Satoko Ueno, Yukihiro Yamao, Takayuki Kikuchi, Kazumichi Yoshida, Susumu Miyamoto, Tadashi Isa
  • Organizer: 第４３回日本神経科学大会
• [Presentation] Distribution of axon collaterals of ventral tegmental area-cortical motor area projection neurons in rats: a study with double infection of retrograde and anterograde viral vectors (2020)
  • Author(s): Yoshinori Koshimizu, Kaoru Isa, Kenta Kobayashi, Tadashi Isa
  • Organizer: 第４３回日本神経科学大会
• [Presentation] Cortical and subcortical mechanism of reward-based decision making (2020)
  • Author(s): Tadashi Isa
  • Organizer: 第４３回日本神経科学大会（シンポジウム講演）
• [Presentation] Mapping saccadic representation in the frontal cortex (2020)
  • Author(s): Chih-Yang Chen, Denis Matrov, ,Kuan-Ting Ho, Wajd Amly, Hirotaka Onoe, Tadashi Isa
  • Organizer: 第４３回日本神経科学大会
• [Presentation] Mapping saccadic representation in the frontal cortex (2020)
  • Author(s): Chih-Yang Chen, Denis Matrov, ,Kuan-Ting Ho, Wajd Amly, Hirotaka Onoe, Tadashi Isa
  • Organizer: 1st Taiwan Society for Neuroscience Meeting (Symposium)
  • Int'l Joint Research / Invited
• [Presentation] Role of the amygdala for the defense-like responses induced by the stimulation of the deeper layer of superior colliculus in mice (2020)
  • Author(s): Kaoru Isa, Sooksawate Thongchai, Kota Tokuoka, Sakura Ikeda, Sara Karimi, Kenta Kobayashi, Tadashi Isa
  • Organizer: 第４３回日本神経科学大会
  • Invited
• [Presentation] Large-scaled network reorganization after brain and spinal cord injury in nonhuman primate models (2020)
  • Author(s): Tadashi Isa
  • Organizer: Western University Neuroscience Seminar
  • Int'l Joint Research / Invited
• [Presentation] Higher order mechanisms for the recovery from spinal cord injury (2020)
  • Author(s): Tadashi Isa
  • Organizer: Queens University Psychology Seminar
  • Int'l Joint Research / Invited
• [Presentation] Neurobiology of recovery after brain and spinal cord injury in macaque models (2020)
  • Author(s): Tadashi Isa
  • Organizer: NIH Neuroscience Seminar Series
  • Int'l Joint Research / Invited
• [Presentation] How does the non-conscious visuo-motor function emerge after damage to the primary motor cortex? (2020)
  • Author(s): Tadashi Isa
  • Organizer: 1st CU-KU Symposium and 4th CU-NIPS Symposium "Advances in Neuroscience Research"
  • Int'l Joint Research / Invited
• [Presentation] 機能回復の脳科学 (2020)
  • Author(s): 伊佐 正
  • Organizer: 京都大学ELP短期講座
  • Invited
• [Presentation] Effect of light isoflurane anesthesia on orientation selectivity in mouse superior colliculus. (2020)
  • Author(s): KASAI Masatoshi, ISA Tadashi
  • Organizer: 第97回 日本生理学会
• [Presentation] Eye movement tracking in head-fixed common marmosets (2020)
  • Author(s): Chih-Yang Chen, Denis Matrov, Richard Veale, Kuan-Ting Ho, Wajd Amly, Hirotaka Onoe, Kenichi Miura, Tadashi Isa
  • Organizer: 第９回日本マーモセット研究会
• [Presentation] Mapping saccadic representation in the frontal cortex of common marmoset (2020)
  • Author(s): Chih-Yang Chen, Denis Matrov, ,Kuan-Ting Ho, Wajd Amly, Hirotaka Onoe, Tadashi Isa
  • Organizer: 第９回日本マーモセット研究会
• [Presentation] Neural circuits for saccade control in blindsight monkeys (2019)
  • Author(s): Tadashi Isa
  • Organizer: Kyoto Symposium on Eye and Head Movement Control Systems
  • Int'l Joint Research / Invited
• [Presentation] Global disinhibition as a key mechanism for the recovery of hand functions after spinal cord injury (2019)
  • Author(s): Tadashi Isa
  • Organizer: The 29th Annual Meeting of the Society for Neural Control of Movement
  • Int'l Joint Research / Invited
• [Presentation] 機能回復の脳科学 (2019)
  • Author(s): 伊佐 正
  • Organizer: 富山市 市民公開講座「脳科学・リハビリ研究の最前線」
  • Invited
• [Presentation] Evolution of the motor systems (2019)
  • Author(s): Tadashi Isa
  • Organizer: Comparative Neuroanatomy Course
  • Int'l Joint Research / Invited
• [Presentation] Neurobiology of recovery after brain and spinal cord injury in the macaque monkey models (2019)
  • Author(s): Tadashi Isa
  • Organizer: University of California, San Diego, Neuroscience Seminar
  • Int'l Joint Research / Invited
• [Presentation] Large-scaled network reorganization for recovery after spinal cord injury (2019)
  • Author(s): Tadashi Isa
  • Organizer: The Salk Institute Regular Seminar
  • Int'l Joint Research / Invited
• [Presentation] 基礎研究の魅力：日本神経科学学会会長から (2019)
  • Author(s): 伊佐 正
  • Organizer: 第６０回日本神経学会学術集会 シンポジウム
  • Invited
• [Presentation] Desterous motor control in primates, circuits and recovery after injury (2019)
  • Author(s): Tadashi Isa
  • Organizer: IBRO/ICPBR Summer School on Primate Neurobiology
  • Int'l Joint Research / Invited
• [Presentation] Pathway-selective manipulation technique to reveal the copensatory circuits for recovery after brain/spinal cord injury (2019)
  • Author(s): Tadashi Isa
  • Organizer: JANUBET/NRSN/mGate Summer School "Moleular Genetic Tools for the Study of Neural Circuits"
  • Int'l Joint Research / Invited
• [Presentation] Neural mechanisms and functions of blindsight (2019)
  • Author(s): Tadashi Isa
  • Organizer: IBRO2019 Symposium "Novel concepts on visual hierarchy"
  • Int'l Joint Research / Invited
• [Presentation] 機能回復の脳科学 (2019)
  • Author(s): 伊佐 正
  • Organizer: 第3回全国在宅医療医歯薬連合会全国大会シンポジウム
  • Invited
• [Presentation] Neural mechanisms and functional recovery after brain and spinal cord injury in the macaque model (2019)
  • Author(s): Tadashi Isa
  • Organizer: McGovern Institute Neuroscience Seminar、Massachusetts Institute of Technology
  • Int'l Joint Research / Invited
• [Presentation] 盲視の神経メカニズム (2019)
  • Author(s): 伊佐 正
  • Organizer: 神戸大学大学院医学研究先端講義
  • Invited
• [Presentation] Cortical oscillatory network for recovery from spinal cord injury (2019)
  • Author(s): Tadashi Isa
  • Organizer: International Symposium on Neural Oscillation 2019
  • Int'l Joint Research / Invited
• [Presentation] Topographic representation of saccade vector in frontal eye field of common marmoset (2019)
  • Author(s): Chih-Yang Chen, Denis Matrov, Wajd Amly, Kuan-Ting Ho, Tadashi Isa
  • Organizer: 29th NCM Annual Meeting
  • Int'l Joint Research
• [Presentation] Anesthesia alters orientation and direction selective properties in mouse superior colliculus (2019)
  • Author(s): Masatoshi Kasai, Tadashi Isa
  • Organizer: 第４２回日本神経科学大会
• [Presentation] Ventrolateral prefrontal cortex is causally involved in integration of expected value in risky choice (2019)
  • Author(s): Ryo Sasaki, Norihiro Takakuwa, Tadashi Isa
  • Organizer: 第４２回日本神経科学大会
• [Presentation] Dynamic interaction between the cortico-rubral and the cortico-reticular tract in rehabilitation-induced functional recovery in internal capsule hemorrhage rats (2019)
  • Author(s): Akimasa Ishida, Kenta Kobayashi, Yoshitomo Ueda, Takeshi Shimizu, Naoki Tajiri,Tadashi Isa, Hideki Hida
  • Organizer: 第４２回日本神経科学大会
• [Presentation] Brain activity associated with recovery of motor function after spinal cord injury (2019)
  • Author(s): Reona Yamaguchi, Toshinari Kawasaki, Chao C Zenas, Masahiro Mitsuhashi, Satoko Ueno, Tadashi Isa
  • Organizer: 第４２回日本神経科学大会
• [Presentation] Dynamic changes of resting-state motor cortical activity during functional recovery after spinal cord injury assessed by electrocorticography (2019)
  • Author(s): Toshinari Kawasaki, Reona Yamaguchi, Chao C Zenas, Masahiro Mitsuhashi, Satoko Ueno, Yukihiro Yamao, Takayuki Kikuchi, Kazumichi Yoshida, Susumu Miyamoto, Tadashi Isa
  • Organizer: 第４２回日本神経科学大会
• [Presentation] Topographic representation of saccade vector in frontal eye field of common marmoset (2019)
  • Author(s): Chih-Yang Chen, Denis Matrov, Wajd Amly, Kuan-Ting Ho, Hirotaka Onoe, Tadashi Isa
  • Organizer: 第４２回日本神経科学大会
• [Presentation] Circadian oscillation of diurnal primate common marmosets (Callithrix jacchus): III. Electroencephalogram in naturally behaving animals. (2019)
  • Author(s): Iori Murai, Teruaki Fujinaga, Maho Sugawa, Yuka Kono, Teruo Kaneko,Keiko Tominaga, Hirotaka Onoe, Kaoru Isa, Tadashi Isa, Hitoshi Okamura
  • Organizer: 第４２回日本神経科学大会
• [Presentation] Role of the pathway from deeper layer of superior colliculus to amygdala in control of defense-like responses (2019)
  • Author(s): Kaoru Isa, Thongchai Sooksawate, Sakura Ikeda, Kenta Kobayashi, Tadashi Isa
  • Organizer: 第４２回日本神経科学大会
• [Presentation] Multi-Scale Imaging from the Whole Brain Level to the Ultrastructure Level by using a Modified ScaleS Method (2019)
  • Author(s): Takahiro Furuta,Kenta Yamauchi, Shinichiro Okamoto,Yoko Ishida, Aya Takenaka,Jungwon Hwang, Kaoru Isa, Tadashi Isa, Hiroyuki Hioki
  • Organizer: 第４２回日本神経科学大会
• [Presentation] Cholinergic effects on the visual responses in the superficial layer of mouse superior colliculus (2019)
  • Author(s): Kota Tokuoka, Masatoshi Kasai, Tadashi Isa
  • Organizer: 第４２回日本神経科学大会
• [Presentation] Visuomotor transformation in frontal network in blindsight monkey (2019)
  • Author(s): Yusuke Yamamoto, Reona Yamaguchi, Tomohiko Takei, Zenas C. Chao, Tadashi Isa
  • Organizer: IBRO2019
  • Int'l Joint Research
• [Presentation] Activity of frontal network for performance of forced-choice manual response task in blindsight monkey (2019)
  • Author(s): Yusuke Yamamoto, Reona Yamaguchi, Tomohiko Takei, Zenas C. Chao, Tadashi Isa
  • Organizer: Neuroscience 2019 (SfN)
  • Int'l Joint Research
• [Presentation] Changes in brain activity associated with recovery of hand movements after spinal cord injury (2019)
  • Author(s): Reona Yamaguchi, Toshinari Kawasaki, Zenas C. Chao, Masahiro Mitsuhashi, Satoko Ueno, Tadashi Isa
  • Organizer: IBRO2019
  • Int'l Joint Research
• [Presentation] Functional brain network for recovery of hand functions after spinal cord injury (2019)
  • Author(s): Reona Yamaguchi, Toshinari Kawasaki, Zenas C. Chao, Masahiro Mitsuhashi, Satoko Ueno, Tadashi Isa
  • Organizer: Neuroscience 2019 (SfN)
  • Int'l Joint Research
• [Presentation] Analyzing visual instrumental learning in blindsight monkeys with reinforcement learning model. (2019)
  • Author(s): Rikako Kato, Kei Majima, Akira Murakami, Abdelhafid Zeghbib, Peter Redgrave, Yukiyasu Kamitani, Tadashi Isa
  • Organizer: Neuroscience 2019 (SfN)
  • Int'l Joint Research
• [Presentation] Mapping saccade representation in the frontal cortex of common marmoset (2019)
  • Author(s): Chih-Yang Chen, Denis Matrov, Wajd Amly, Kuan-Ting Ho, Hirotaka Onoe, Tadashi Isa
  • Organizer: Neuroscience 2019 (SfN)
  • Int'l Joint Research
• [Presentation] Cortico-tectal projections in marmoset monkeys studied in a brain-wide neurohistological pipeline (2019)
  • Author(s): Denis Matrov, Meng Kuan Lin, Chih-Yang Chen, Bing-Xing Huo, Mitsutoshi Hanada, Jaimi Nagashima, James Nourne, Partha Mitra, Tadashi Isa
  • Organizer: Neuroscience 2019 (SfN)
  • Int'l Joint Research
• [Remarks] 京都大学大学院医学研究科 高次脳科学講座 神経生物学分野
  • URL: https://nscinbiol.med.kyoto-u.ac.jp/
• [Remarks] 脳情報通信融合研究センター 内藤栄一
  • URL: https://cinet.jp/japanese/people/2014899/
• [Remarks] 広島大学 神経生物学研究室へようこそ
  • URL: https://neurobio.hiroshima-u.ac.jp/ja/
• [Remarks] 広島大学神経生物学研究室へようこそ
  • URL: https://neurobio.hiroshima-u.ac.jp/ja/
• [Remarks] researchmap 伊佐 正
  • URL: https://researchmap.jp/tadashiisa/?lang=japanese
• [Remarks] 京都大学医学研究科神経生物学分野
  • URL: https://www.med.kyoto-u.ac.jp/organization-staff/research/doctoral_course/r-019/
• [Remarks] 京都大学ヒト生物学高等研究拠点 伊佐グループ
  • URL: https://ashbi.kyoto-u.ac.jp/ja/groups/isa/