Alteration of brain dynamics as underlying mechanisms of hyper-adaptability in neurotransmitter disorders

• Project Area: Hyper-adaptability for overcoming body-brain dysfunction: Integrated empirical and system theoretical approaches
• Project/Area Number: 19H05726
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Asahikawa Medical College
• Principal Investigator: 高草木 薫 旭川医科大学, 医学部, 教授 (10206732)
• Co-Investigator(Kenkyū-buntansha): 花川 隆 京都大学, 医学研究科, 教授 (30359830)
• Project Period (FY): 2019-06-28 – 2024-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥135,200,000 (Direct Cost: ¥104,000,000、Indirect Cost: ¥31,200,000); Fiscal Year 2023: ¥26,130,000 (Direct Cost: ¥20,100,000、Indirect Cost: ¥6,030,000); Fiscal Year 2022: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000); Fiscal Year 2021: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000); Fiscal Year 2020: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000); Fiscal Year 2019: ¥29,900,000 (Direct Cost: ¥23,000,000、Indirect Cost: ¥6,900,000)
• Keywords: ドーパミン作動系 / コリン作動系 / 遂行機能 / 加齢 / 変性疾患 / アセチルコリン作動系 / 神経伝達物質 / 前頭-頭頂ネットワーク / 脳活動ダイナミクス / 脳変性疾患

Outline of Research at the Start

老化や脳変性疾患における遂行機能障害の背後には脳細胞や神経伝達物質の障害が存在する．本研究では「加齢や脳変性疾患に伴うドーパミン（DA）やアセチルコリン（ACh）の減少に伴う脳活動の変容に対する行動遂行則の変更が超適応を誘発する」という仮説を検証する．臨床研究では加齢やパーキンソン病による中脳DA系の障害と脳活動や遂行機能の低下の因果関係を脳機能画像と脳磁気刺激で証拠立て，加齢に依存する脳活動パラメータを同定する．動物実験ではアルツハイマー病で障害されるACh系にも着目し，ネコのACh系とDA系を分子遺伝学手法で低下させた際の遂行機能障害とその回復過程の脳活動を神経生理学的手法で解析する．

Outline of Annual Research Achievements

動物実験では，中脳から橋外側部に下行するドーパミン（DA）作動系がこの領域に存在する姿勢筋緊張調節領域（脚橋被蓋核；PPN）と歩行調節領域（中脳歩行誘発野；MLR）にどのように作用するのかを解析した．一側のPPNにDAを微量注入すると2分以内に両側下肢の姿勢筋緊張が減弱消失した．一方，DAをMLRに注入すると数分後に自発的な歩行運動を誘発した．除脳ネコの歩容はトレッドミルの速度に対応して変化した．この成績は，① DAがPPNに存在するアセチルコリン（ACh）作動性ニューロンを活動させて脳幹から脊髄に下行する抑制性網様体脊髄路系を賦活することによって筋緊張を消失させること，そして，② MLRのグルタミン酸作動性ニューロンに起始する歩行誘発系を活動させること，の２点を推測させる．以上の結果より，中脳から脳幹に下行するDA系が歩行のみならず姿勢の調節にも関与することを世界に先駆けて証明した．
ヒトの臨床研究では以下の２点の実績を得た．第一点は，これまでの研究期間において構築してきた「脳波と機能的MRIの同時計測法」を用いることにより，大脳基底核の一部である被殻の活動が若年健常者によるbrain-computer interface（BCI）の操作の成否を反映することを示したことである．第二点は，安静時機能結合MRI法を用いて，パーキンソン病（PD）のすくみ足（歩行開始時や歩行転換時に足が地面に吸い付いたように前に出なくなる）の病態において，皮質下運動回路，扁桃体を含む情動回路，認知・注意に関わる前頭頭頂回路の機能障害が関与することを見出すと共に，これらの領域間の結合指標を用いてすくみ足の程度や有無を推定できる可能性を示したことである．
これらの研究成果は，PDにおける姿勢-歩行障害の病態には，大脳半球ならびに脳幹に作用するDA系の機能障害が関与することを推定させる．

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

動物実験においては，分子遺伝学的研究（ウイルスベクター感染実験）において明確に報告できる研究成果は得られていない．その一方で神経薬理学的研究によって，中脳から脳幹に投射するDA作動系が姿勢制御に関与するという結果を得ることができた．この研究成果はPDの病態ならびに治療を考慮する上で極めて重要な知見であるとともに，世界初の成果である．すなわち，動物実験での研究は予想通り進捗していない項目もあれば，予測以上の成果が得られた項目も存在することから，全体としての研究進捗状況は「おおむね順調」であると結論付ける．
一方，臨床研究においては，これまでの研究期間において構築してきた「脳波と機能的MRIの同時計測法」が適切に働いていることを証明することができた．特に，この手法を利用して被殻活動がBCIに利用可能であるという知見を得たことは，脳疾患における運動障害を克服する治療法としてBCIを活用できる可能性を見出した点において極めて重要である．さらに，安静時機能結合MRI法においてPDのすくみ足が「運動系」のみならず「認知系」や「情動系」という，複数の脳情報処理系の機能異常によって誘発されることとを示したことは，これまで想定されていたPDの運動障害の病態生理機構の存在を実際に証明した点において極めて重要な知見である．このように臨床研究では当初の予定通りの研究成果が得られている（おおむね順調）．

Strategy for Future Research Activity

動物実験では，これまで同様にDA系とACh系による行動遂行則原理の解明を推進する．前年度の姿勢-歩行研究（急性実験）に加えて，ネコの姿勢制御-前肢リーチングのマルチタスク課題（慢性実験）を用いてこれを評価する．急性実験においては，中脳-橋におけるDA系とACh系の相互作用が脳幹-脊髄下行路の活動をどのように修飾して「姿勢と歩行の統合的制御」に関与するのかを解明する．慢性実験においては，DREADD法と光遺伝学的手法・神経薬理学手法を組み合わせ，先行性姿勢制御に関与する大脳皮質内ネットワークと皮質-脳幹投射系を同定すると共に，先行性姿勢制御における大脳皮質投射性ACh系の役割の解明を試みる．
ヒトの臨床研究においてもこれまでの研究を継続する．具体的には健常高齢者やPD患者のコホートから取得した MRIやドパミントランスポーター(DAT)SPECTテータを活用し，（昨年度開発に成功したDAT標準化指標とDA機能を反映するMRI解析；ニューロメラニンMRI）に基づいて，年齢依存的なDA減少の個人差を評価する．また，安静時MRIの動的機能結合解析に基づいて，各個人の脳神経回路ダイナミクスを抽出し，これとDA系や認知機能との関係を解析・評価することにより，DA系と認知機能を媒介する脳神経回路ダイナミクスの同定を試みる．加えて，同意済コホート参加者における脳波と機能的MRIの同時計測研究を進め，脳神経回路ダイナミクスの周波数分析，時-空間解像度，機能局在同定能を向上させるための技術開発を推進する．ただし，ニューロメラニンMRIがDA細胞の活動や機能をどの程度反映しているのかは不明確なため，ヒト死後脳や齧歯類の ex vivo MRIと顕微鏡解析を組合せることによって，DA系の機能を反映するニューロメラニンMRIと中脳DA細胞数やDA投射線維などの量的関係についての検討を押し進める．

Research Products

• [Int'l Joint Research] Department of Neuroscience(カナダ)
• [Journal Article] Frontal Lobe Motor Control of Gait (2023)
  • Author(s): Takakusaki K
  • Journal Title: Handbook of Clinical Neurology Volume: -
  • Peer Reviewed
• [Journal Article] Simulating developmental diversity: Impact of neural stochasticity on atypical flexibility and hierarchy (2023)
  • Author(s): Soda Takafumi、Ahmadi Ahmadreza、Tani Jun、Honda Manabu、Hanakawa Takashi、Yamashita Yuichi
  • Journal Title: Frontiers in Psychiatry Volume: 14
  • DOI: 10.3389/fpsyt.2023.1080668
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Interactions across emotional, cognitive and subcortical motor networks underlying freezing of gait (2023)
  • Author(s): Togo Hiroki、Nakamura Tatsuhiro、Wakasugi Noritaka、Takahashi Yuji、Hanakawa Takashi
  • Journal Title: NeuroImage: Clinical Volume: 37 Pages: 103342-103342
  • DOI: 10.1016/j.nicl.2023.103342
  • Peer Reviewed
• [Journal Article] Neurophysiological mechanisms of gait disturbance in advanced Parkinson's disease patients (2022)
  • Author(s): Takakusaki Kaoru、Takahashi Mirai、Noguchi Tomohiro、Chiba Ryosuke
  • Journal Title: Neurology and Clinical Neuroscience Volume: - Issue: 4 Pages: 201-217
  • DOI: 10.1111/ncn3.12683
  • Peer Reviewed / Open Access
• [Journal Article] Reply to: “Letter on Discussion?of Gait Research” (2022)
  • Author(s): Bohnen Nicolaas I.、Costa Rui M.、Dauer William T.、Factor Stewart A.、Giladi Nir、Hallett Mark、Lewis Simon J.G.、Nieuwboer Alice、Nutt John G.、Takakusaki Kaoru、Kang Un Jung、Przedborski Serge、Papa Stella M.
  • Journal Title: Movement Disorders Volume: 37 Issue: 6 Pages: 1328-1328
  • DOI: 10.1002/mds.29049
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Peripheral apelin mediates visceral hypersensitivity and impaired gut barrier in a rat irritable bowel syndrome model (2022)
  • Author(s): Nozu, T. Miyagishi, S. Ishioh, M. Takakusaki, K. Okumura, T.
  • Journal Title: Neuropeptides Volume: 94 Pages: 102248-102248
  • DOI: 10.1016/j.npep.2022.102248
  • Peer Reviewed / Open Access
• [Journal Article] A neural controller model considering the vestibulospinal tract in human postural control (2022)
  • Author(s): Omura,Yuichiro, Kaminishi,Kohei, Chiba,Ryosuke, Takakusaki,Kaoru, & Ota,Jun.
  • Journal Title: Frontiers in Computational Neuroscience Volume: 16
  • DOI: 10.3389/fncom.2022.785099
  • Peer Reviewed / Open Access
• [Journal Article] Knee dynamics during take-off and landing in spike jumps performed by volleyball players with patellar tendinopathy (2022)
  • Author(s): Kazuhiro Obara, Ryosuke Chiba, Mirai Takahashi, Takeo Matsuno, Kaoru Takakusaki
  • Journal Title: Journal of Physical Therapy Science Volume: 34 Issue: 2 Pages: 103-109
  • DOI: 10.1589/jpts.34.103
  • NAID: 130008163064
  • ISSN: 0915-5287, 2187-5626
  • Peer Reviewed / Open Access
• [Journal Article] 大脳基底核による姿勢と歩行の調節機構 (2022)
  • Author(s): 高草木薫，高橋未来，福山秀青，野口智弘，千葉隆介
  • Journal Title: Brain and Nerve Volume: 74 Pages: 1067-1077
  • Peer Reviewed
• [Journal Article] 姿勢の進化・発達と退化 (2022)
  • Author(s): 高草木薫，高橋未来，野口智弘，千葉龍介
  • Journal Title: 計測と制御（特集；身体と脳で生じる超適応のシステム論的理解） Volume: 61 Pages: 294-302
  • Peer Reviewed
• [Journal Article] 姿勢と歩行の大脳皮質-皮質下構造ネットワーク (2022)
  • Author(s): 高草木薫
  • Journal Title: 脊椎脊髄ジャーナル Volume: 35 Pages: 411-417
• [Journal Article] Structural Neuroplasticity in Computer Programming Beginners (2022)
  • Author(s): Takeshi Hongo, Takao Yakou, Kenji Yoshinaga, Toshiharu Kano, Michiko Miyazaki, Takashi Hanakawa
  • Journal Title: Cerebral Cortex Volume: - Issue: 9 Pages: 1-7
  • DOI: 10.1093/cercor/bhac425
  • Peer Reviewed
• [Journal Article] Precise motor rhythmicity relies on motor network responsivity (2022)
  • Author(s): Uehara Kazumasa、Togo Hiroki、Hanakawa Takashi
  • Journal Title: Cerebral Cortex Volume: 33 Issue: 8 Pages: 4432-4447
  • DOI: 10.1093/cercor/bhac353
  • Peer Reviewed
• [Journal Article] Idiopathic rapid eye movement sleep behavior disorder in Japan: An observational study (2022)
  • Author(s): Nishikawa N、Murata M、Hatano T、Mukai Y、Saitoh Y、Sakamoto T、Hanakawa T、Kamei Y、Tachimori H、Hatano K、Matsuda H、Taruno Y、Sawamoto N、Kajiyama Y、Ikenaka K、Kawabata K、Nakamura T、Iwaki H、Kadotani H、Sumi Y、Inoue Y、Hayashi T、Ikeuchi T、Shimo Y、Mochizuki H、Watanabe H、Hattori N、Takahashi Y、Takahashi R
  • Journal Title: Parkinsonism & Related Disorders Volume: 103 Pages: 129
  • DOI: 10.1016/j.parkreldis.2022.08.011
  • Peer Reviewed
• [Journal Article] Detection of deviance in Japanese kanji compound words (2022)
  • Author(s): Egashira Yuka、Kaga Yoshimi、Gunji Atsuko、Kita Yosuke、Kimura Motohiro、Hironaga Naruhito、Takeichi Hiroshige、Hayashi Sayuri、Kaneko Yuu、Takahashi Hidetoshi、Hanakawa Takashi、Okada Takashi、Inagaki Masumi
  • Journal Title: Frontiers in Human Neuroscience Volume: 16 Pages: 913945-913945
  • DOI: 10.3389/fnhum.2022.913945
  • Peer Reviewed / Open Access
• [Journal Article] Basal ganglia-cortical connectivity underlies self-regulation of brain oscillations in humans (2022)
  • Author(s): Kasahara Kazumi、DaSalla Charles S.、Honda Manabu、Hanakawa Takashi
  • Journal Title: Communications Biology Volume: 5 Issue: 1 Pages: 712-712
  • DOI: 10.1038/s42003-022-03665-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A computational model based on corticospinal functional MRI revealed asymmetrically organized motor corticospinal networks in humans (2022)
  • Author(s): Eiji Takasawa †, Mitsunari Abe †*, Hirotaka Chikuda, Takashi Hanakawa †
  • Journal Title: Commutations Biology Volume: 5(1) Issue: 1 Pages: 664-664
  • DOI: 10.1038/s42003-022-03615-2
  • Peer Reviewed / Open Access
• [Journal Article] Increased grey matter volume in visual areas induced by logographic character acquisition in adult alphabetic language speakers (2022)
  • Author(s): Tu L, Zhou F, Omata K, Li W, Huang R, Gao W, Zhu Z, Li Y, Liu C, Mao M, Zhang S, Hanakawa T
  • Journal Title: Front Pychol Volume: online
  • DOI: 10.3389/fpsyg.2022.824219
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] アルツハイマー病における脳機能結合 (2022)
  • Author(s): 花川 隆
  • Journal Title: Clinical Neuroscience Volume: 40 Pages: 765-768
• [Journal Article] Brain-Machine Interfaceによる脳卒中後機能回復の展望 (2022)
  • Author(s): 花川 隆
  • Journal Title: 医学のあゆみ Volume: 280 Pages: 1121-1124
• [Journal Article] Preceding Postural Control in Forelimb Reaching Movements in Cats (2022)
  • Author(s): Takahashi Mirai、Nakajima Toshi、Takakusaki Kaoru
  • Journal Title: Frontiers in Systems Neuroscience Volume: 15 Pages: 792665-792665
  • DOI: 10.3389/fnsys.2021.792665
  • Peer Reviewed / Open Access
• [Journal Article] Implicit and explicit emotional memory recall in anxiety and depression: Role of basolateral amygdala and cortisol-norepinephrine interaction. (2022)
  • Author(s): Hakamata Y, Mizukami S, Izawa S, Okamura H, Mihara K, Marusak H, Moriguchi Y, Hori H, Hanakawa T, Inoue Y, Tagaya H.
  • Journal Title: Psychoneuroendocrinology. Volume: 136 Pages: 105598-105598
  • DOI: 10.1016/j.psyneuen.2021.105598
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Perceptual inference, accuracy, and precision in temporal reproduction in schizophrenia (2022)
  • Author(s): Ueda Natsuki、Tanaka Kanji、Maruo Kazushi、Roach Neil、Sumiyoshi Tomiki、Watanabe Katsumi、Hanakawa Takashi
  • Journal Title: Schizophrenia Research: Cognition Volume: 28 Pages: 100229-100229
  • DOI: 10.1016/j.scog.2021.100229
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 歩行の生理的メカニズム (2022)
  • Author(s): 高草木 薫，野口 智弘，千葉 龍介
  • Journal Title: 日本医師会雑誌 Volume: 150 (11) Pages: 2014-2015
• [Journal Article] 姿勢の進化・発達と退化 (2022)
  • Author(s): 高草木 薫，高橋 未来，野口 智弘，千葉 龍介
  • Journal Title: 計測と制御 Volume: 61 Pages: 294-302
• [Journal Article] Discussion of Research Priorities for Gait Disorders in Parkinson's Disease (2021)
  • Author(s): Bohnen Nicolaas I.、Costa Rui M.、Dauer William T.、Factor Stewart A.、Giladi Nir、Hallett Mark、Lewis Simon J.G.、Nieuwboer Alice、Nutt John G.、Takakusaki Kaoru、Kang Un Jung、Przedborski Serge、Papa Stella M.、The MDS‐Scientific Issues Committee
  • Journal Title: Movement Disorders Volume: 37 Issue: 2 Pages: 253-263
  • DOI: 10.1002/mds.28883
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Evaluation of Postural Sway in Post-stroke Patients by Dynamic Time Warping Clustering (2021)
  • Author(s): Li Dongdong、Kaminishi Kohei、Chiba Ryosuke、Takakusaki Kaoru、Mukaino Masahiko、Ota Jun
  • Journal Title: Frontiers in Human Neuroscience Volume: 15
  • DOI: 10.3389/fnhum.2021.731677
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Increase in muscle tone promotes the use of ankle strategies during perturbed stance (2021)
  • Author(s): Kaminishi Kohei、Chiba Ryosuke、Takakusaki Kaoru、Ota Jun
  • Journal Title: Gait & Posture Volume: 90 Pages: 67-72
  • DOI: 10.1016/j.gaitpost.2021.08.003
  • Peer Reviewed / Open Access
• [Journal Article] EMA401, an angiotensin II type 2 receptor antagonist blocks visceral hypersensitivity and colonic hyperpermeability in rat model of irritable bowel syndrome (2021)
  • Author(s): Nozu, T. Miyagishi, S. Nozu, R. Ishioh, M. Takakusaki, K. Okumura, T.
  • Journal Title: Journal of Pharmacological Sciences Volume: 146 Issue: 3 Pages: 121-124
  • DOI: 10.1016/j.jphs.2021.04.001
  • Peer Reviewed / Open Access
• [Journal Article] Activation of central adenosine A2B receptors mediate brain ghrelin-induced improvement of intestinal barrier function through the vagus nerve in rats (2021)
  • Author(s): Ishioh Masatomo、Nozu Tsukasa、Igarashi Sho、Tanabe Hiroki、Kumei Shima、Ohhira Masumi、Takakusaki Kaoru、Okumura Toshikatsu
  • Journal Title: Experimental Neurology Volume: 341 Pages: 113708-113708
  • DOI: 10.1016/j.expneurol.2021.113708
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Neuroplasticity Caused by Peripheral Proprioceptive Deficits (2021)
  • Author(s): SHITARA HITOSHI、ICHINOSE TSUYOSHI、SHIMOYAMA DAISUKE、SASAKI TSUYOSHI、HAMANO NORITAKA、KAMIYAMA MASATAKA、TAJIKA TSUYOSHI、YAMAMOTO ATSUSHI、KOBAYASHI TSUTOMU、HANAKAWA TAKASHI、TSUSHIMA YOSHITO、TAKAGISHI KENJI、CHIKUDA HIROTAKA
  • Journal Title: Medicine and Science in Sports and Exercise Volume: 54 Issue: 1 Pages: 28-37
  • DOI: 10.1249/mss.0000000000002775
  • Peer Reviewed / Open Access
• [Journal Article] Is Generalized and Segmental Dystonia Accompanied by Impairments in the Dopaminergic System? (2021)
  • Author(s): Ikezawa Jun、Yokochi Fusako、Okiyama Ryoichi、Kumada Satoko、Tojima Maya、Kamiyama Tsutomu、Hanakawa Takashi、Matsuda Hiroshi、Tanaka Fumiaki、Nakata Yasuhiro、Isozaki Eiji
  • Journal Title: Frontiers in Neurology Volume: 12
  • DOI: 10.3389/fneur.2021.751434
  • Peer Reviewed / Open Access
• [Journal Article] Wrist and finger motor representations embedded in the cerebral and cerebellar resting-state activation (2021)
  • Author(s): Kusano Toshiki、Kurashige Hiroki、Nambu Isao、Moriguchi Yoshiya、Hanakawa Takashi、Wada Yasuhiro、Osu Rieko
  • Journal Title: Brain Structure and Function Volume: 226 Issue: 7 Pages: 2307-2319
  • DOI: 10.1007/s00429-021-02330-8
  • Peer Reviewed / Open Access
• [Journal Article] Aberrant Cerebello-Cortical Connectivity in Pianists With Focal Task-Specific Dystonia (2021)
  • Author(s): Kita Kahori、Furuya Shinichi、Osu Rieko、Sakamoto Takashi、Hanakawa Takashi
  • Journal Title: Cerebral Cortex Volume: 31 Issue: 10 Pages: 4853-4863
  • DOI: 10.1093/cercor/bhab127
  • Peer Reviewed
• [Journal Article] Correlation between the brain activity with gait imagery and gait performance in adults with Parkinson's disease: A data set (2021)
  • Author(s): Nishida Daisuke、Mizuno Katsuhiro、Yamada Emi、Tsuji Tetsuya、Hanakawa Takashi、Liu Meigen
  • Journal Title: Data in Brief Volume: 36 Pages: 106993-106993
  • DOI: 10.1016/j.dib.2021.106993
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Childhood trauma affects autobiographical memory deficits through basal cortisol and prefrontal-extrastriate functional connectivity (2021)
  • Author(s): Hakamata Yuko、Mizukami Shinya、Izawa Shuhei、Moriguchi Yoshiya、Hori Hiroaki、Matsumoto Noboru、Hanakawa Takashi、Inoue Yusuke、Tagaya Hirokuni
  • Journal Title: Psychoneuroendocrinology Volume: 127 Pages: 105172-105172
  • DOI: 10.1016/j.psyneuen.2021.105172
  • Peer Reviewed
• [Journal Article] Prefrontal network dysfunctions in rapid eye movement sleep behavior disorder (2021)
  • Author(s): Wakasugi Noritaka、Togo Hiroki、Mukai Yohei、Nishikawa Noriko、Sakamoto Takashi、Murata Miho、Takahashi Yuji、Matsuda Hiroshi、Hanakawa Takashi
  • Journal Title: Parkinsonism & Related Disorders Volume: 85 Pages: 72-77
  • DOI: 10.1016/j.parkreldis.2021.03.005
  • Peer Reviewed
• [Journal Article] It Is Time to Study Overlapping Molecular and Circuit Pathophysiologies in Alzheimer’s and Lewy Body Disease Spectra (2021)
  • Author(s): Wakasugi Noritaka、Hanakawa Takashi
  • Journal Title: Frontiers in Systems Neuroscience Volume: 15
  • DOI: 10.3389/fnsys.2021.777706
  • Peer Reviewed / Open Access
• [Journal Article] Thoughts on vigor in the motor and cognitive domains (2021)
  • Author(s): Hanakawa Takashi
  • Journal Title: Behavioral and Brain Sciences Volume: 44
  • DOI: 10.1017/s0140525x21000133
  • Peer Reviewed / Open Access
• [Journal Article] Q&A-神経科学の素朴な疑問: fMRIで測定されるゆっくりした脳活動の変動による脳領域間機能連関の神経基盤はどこまで解明されているのでしょう？ (2021)
  • Author(s): 花川 隆
  • Journal Title: Clin Neurosci Volume: 39 (8) Pages: 1043-1043
• [Journal Article] 脳を知り、脳を守る (2021)
  • Author(s): 花川 隆
  • Journal Title: 天理医学紀要 Volume: 24 (1) Pages: 1-14
  • NAID: 130008060592
• [Journal Article] The neural correlates of gait improvement by rhythmic sound stimulation in adults with Parkinson's disease ? A functional magnetic resonance imaging study (2021)
  • Author(s): Nishida Daisuke、Mizuno Katsuhiro、Yamada Emi、Hanakawa Takashi、Liu Meigen、Tsuji Tetsuya
  • Journal Title: Parkinsonism & Related Disorders Volume: 84 Pages: 91-97
  • DOI: 10.1016/j.parkreldis.2021.02.010
  • Peer Reviewed
• [Journal Article] Brain/MINDS beyond human brain MRI project: A protocol for multi-level harmonization across brain disorders throughout the lifespan (2021)
  • Author(s): Koike Shinsuke, Tanaka Saori C., Okada Tomohisa, Aso Toshihiko et al.
  • Journal Title: NeuroImage: Clinical Volume: 30 Pages: 102600-102600
  • DOI: 10.1016/j.nicl.2021.102600
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phlorizin attenuates visceral hypersensitivity and colonic hyperpermeability in a rat model of irritable bowel syndrome (2021)
  • Author(s): Nozu, T. Miyagishi, S. Ishioh, M. Takakusaki, K. Okumura, T.
  • Journal Title: Biomed Pharmacother Volume: 139 Pages: 111649-111649
  • DOI: 10.1016/j.biopha.2021.111649
  • Peer Reviewed / Open Access
• [Journal Article] PADNI研究 (2021)
  • Author(s): 花川 隆
  • Journal Title: Dementia Japan Volume: 35 Pages: 39-44
• [Journal Article] Age of Acquisition of Mandarin Modulates Cortical Thickness in High-Proficient Cantonese?Mandarin Bidialectals (2020)
  • Author(s): Tu Liu、Niu Meiqi、Pan Ximin、Hanakawa Takashi、Liu Xiaojin、Lu Zhi、Gao Wei、Ouyang Dan、Zhang Meng、Li Shiya、Wang Junjing、Jiang Bo、Huang Ruiwang
  • Journal Title: Journal of Psycholinguistic Research Volume: NA Issue: 4 Pages: 723-736
  • DOI: 10.1007/s10936-020-09716-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Imipramine improves visceral sensation and gut barrier in rat models of irritable bowel syndrome (2020)
  • Author(s): Nozu, T. Miyagishi, S. Ishioh, M. Takakusaki, K. Okumura, T.
  • Journal Title: Eur J Pharmacol Volume: 887 Pages: 173565-173565
  • DOI: 10.1016/j.ejphar.2020.173565
  • Peer Reviewed / Open Access
• [Journal Article] Losartan improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome (2020)
  • Author(s): Nozu Tsukasa、Miyagishi Saori、Nozu Rintaro、Takakusaki Kaoru、Okumura Toshikatsu
  • Journal Title: Neurogastroenterology & Motility Volume: in press Issue: 6 Pages: 0-0
  • DOI: 10.1111/nmo.13819
  • Peer Reviewed / Open Access
• [Journal Article] Investigation of the effect of tonus on the change in postural control strategy using musculoskeletal simulation (2020)
  • Author(s): Kaminishi Kohei、Chiba Ryosuke、Takakusaki Kaoru、Ota Jun
  • Journal Title: Gait & Posture Volume: 76 Pages: 298-304
  • DOI: 10.1016/j.gaitpost.2019.12.015
  • Peer Reviewed / Open Access
• [Journal Article] Assessment and Rating of Motor Cerebellar Ataxias With the Kinect v2 Depth Sensor: Extending Our Appraisal (2020)
  • Author(s): Honda Takeru、Mitoma Hiroshi、Yoshida Hirotaka、Bando Kyota、Terashi Hiroo、Taguchi Takeshi、Miyata Yohane、Kumada Satoko、Hanakawa Takashi、Aizawa Hitoshi、Yano Shiro、Kondo Toshiyuki、Mizusawa Hidehiro、Manto Mario、Kakei Shinji
  • Journal Title: Frontiers in Neurology Volume: 11 Pages: 1-14
  • DOI: 10.3389/fneur.2020.00179
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Timing of phase-amplitude coupling is essential for neuronal and functional maturation of audiovisual integration in adolescents. (2020)
  • Author(s): Ohki T, Matsuda T, Gunji A, Takei Y, Sakuma R, Kaneko Y, Inagaki M, Hanakawa T, Ueda K, Fukuda M, Hiraki K
  • Journal Title: Brain Behav. Volume: 27 Issue: 6
  • DOI: 10.1002/brb3.1635
  • Peer Reviewed / Open Access
• [Journal Article] Plastic frontal pole cortex structure related to individual persistence for goal achievement (2020)
  • Author(s): Chihiro Hosoda, Satoshi Tsujimoto, Masaru Tatekawa, Manabu Honda, Rieko Osu, Takashi Hanakawa
  • Journal Title: communications biology Volume: 0 Issue: 1 Pages: 0-0
  • DOI: 10.1038/s42003-020-0930-4
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Phase Synchronization Measures for Identifying Stimulus-Induced Functional Connectivity in Human Magnetoencephalographic and Simulated Data (2020)
  • Author(s): Kenji Yoshinaga, Masao Matsuhashi, Tatsuya Mima, Hidenao Fukuyama, Ryosuke Takahashi, Takashi Hanakawa, Akio Ikeda
  • Journal Title: Front Neurosci Volume: 14 Pages: 648-648
  • DOI: 10.3389/fnins.2020.00648
  • Peer Reviewed / Open Access
• [Journal Article] Electrophysiological Effects of Transcranial Direct Current Stimulation on Neural Activity in the Rat Cortex (2020)
  • Author(s): Tomoko Tanaka, Yoshikazu Isomura, Kazuto Kobayashi, Takashi Hanakawa, Satoshi Tanaka, and Manabu Honda
  • Journal Title: Frontiers in Neuroscience Volume: - Pages: 1-10
  • DOI: 10.3389/fnins.2020.00495
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] イメージングバイオマーカーとしての脳機能結合 (2020)
  • Author(s): 花川 隆
  • Journal Title: 脳神経内科 Volume: 92 (2) Pages: 206-210
• [Journal Article] Revealing Relationships Among Cognitive Functions Using Functional Connectivity and a Large-Scale Meta-Analysis Database (2020)
  • Author(s): Kurashige Hiroki、Kaneko Jun、Yamashita Yuichi、Osu Rieko、Otaka Yohei、Hanakawa Takashi、Honda Manabu、Kawabata Hideaki
  • Journal Title: Frontiers in Human Neuroscience Volume: 13 Pages: 457-457
  • DOI: 10.3389/fnhum.2019.00457
  • Peer Reviewed / Open Access
• [Journal Article] イメージングバイオマーカーとしての脳機能結合 (2020)
  • Author(s): 花川 隆
  • Journal Title: 脳神経内科 Volume: 92(2) Pages: 206-210
• [Journal Article] Butyrate inhibits visceral allodynia and colonic hyperpermeability in rat models of irritable bowel syndrome (2019)
  • Author(s): Nozu Tsukasa、Miyagishi Saori、Nozu Rintaro、Takakusaki Kaoru、Okumura Toshikatsu
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 19603-19603
  • DOI: 10.1038/s41598-019-56132-4
  • NAID: 120006775256
  • Peer Reviewed / Open Access
• [Journal Article] The Responsiveness of Triaxial Accelerometer Measurement of Gait Ataxia Is Higher than That of the Scale for the Assessment and Rating of Ataxia in the Early Stages of Spinocerebellar Degeneration. (2019)
  • Author(s): Shirai S, Yabe I, Takahashi-Iwata I, Matsushima M, Ito YM, Takakusaki K, Sasaki H.
  • Journal Title: Cerebellum Volume: 18(4) Issue: 4 Pages: 721-730
  • DOI: 10.1007/s12311-019-01025-5
  • NAID: 120006876276
  • Peer Reviewed
• [Journal Article] Dehydroepiandrosterone sulfate improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome. (2019)
  • Author(s): Nozu T, Miyagishi S, Nozu R, Takakusaki K, Okumura T.
  • Journal Title: Eur J Pharmacol. Volume: 852 Pages: 198-206
  • DOI: 10.1016/j.ejphar.2019.03.037
  • NAID: 120006878173
  • Peer Reviewed
• [Journal Article] Postural control of a musculoskeletal model against multidirectional support surface translations (2019)
  • Author(s): Kaminishi Kohei、Jiang Ping、Chiba Ryosuke、Takakusaki Kaoru、Ota Jun
  • Journal Title: PLOS ONE Volume: 14 Issue: 3 Pages: 1-23
  • DOI: 10.1371/journal.pone.0212613
  • Peer Reviewed / Open Access
• [Journal Article] Visual and Vestibular Inputs Affect Muscle Synergies Responsible for Body Extension and Stabilization in Sit-to-Stand Motion (2019)
  • Author(s): Yoshida Kazunori、An Qi、Yozu Arito、Chiba Ryosuke、Takakusaki Kaoru、Yamakawa Hiroshi、Tamura Yusuke、Yamashita Atsushi、Asama Hajime
  • Journal Title: Frontiers in Neuroscience Volume: 12 Pages: 1042-1042
  • DOI: 10.3389/fnins.2018.01042
  • Peer Reviewed / Open Access
• [Journal Article] Basolateral amygdala connectivity with subgenual anterior cingulate cortex represents enhanced fear-related memory encoding in humans (2019)
  • Author(s): Hakamata Y, Mizukami S, Izawa S, Mizukami S, Moriguchi Y, Hori H, Kim Y, Hanakawa T, Inoue Y, Tagaya H
  • Journal Title: Biol Psychiatry Cogn Neurosci Neuroimaging Volume: 5(3) Issue: 3 Pages: 301-310
  • DOI: 10.1016/j.bpsc.2019.11.008
  • Peer Reviewed / Open Access
• [Journal Article] Cortisol-related hippocampal-extrastriate functional connectivity explains the adverse effect of cortisol on visuospatial retrieval. (2019)
  • Author(s): Hakamata Y, Komi S, Sato E, Izawa S, Mizukami S, Moriguchi Y, Motomura Y, Matsui M, Kim Y, Hanakawa T, Inoue Y, Tagaya H.
  • Journal Title: Psychoneuroendocrinology Volume: 107 Pages: 104310-104310
  • DOI: 10.1016/j.psyneuen.2019.04.013
  • Peer Reviewed / Open Access
• [Journal Article] Impaired adaptive motor learning is correlated with cerebellar gray matter atrophy in spinocerebellar ataxia patients: A voxel-based morphometry study. (2019)
  • Author(s): Bando K, Honda T, Takahashi Y, Ishikawa K, Mizusawa H, Hanakawa T
  • Journal Title: Front Neurol Volume: 10 Pages: 1183-1183
  • DOI: 10.3389/fneur.2019.01183
  • Peer Reviewed / Open Access
• [Journal Article] Sensorimotor connectivity after motor exercise with neurofeedback in post-stroke. (2019)
  • Author(s): Tsuchimoto S, Shindo K, Hotta F, Hanakawa T, Liu M, Ushiba J
  • Journal Title: Neuroscience Volume: 416 Pages: 109-125
  • DOI: 10.1016/j.neuroscience.2019.07.037
  • Peer Reviewed
• [Journal Article] Reciprocal cortical activation patterns during incisal and molar biting correlated with bite force levels: an fMRI study (2019)
  • Author(s): Yoshizawa Hideyuki、Miyamoto Jun J.、Hanakawa Takashi、Shitara Hitoshi、Honda Manabu、Moriyama Keiji
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 8419-8419
  • DOI: 10.1038/s41598-019-44846-4
  • Peer Reviewed / Open Access
• [Journal Article] Phase-Amplitude Coupling of Neural Oscillations Can Be Effectively Probed with Concurrent TMS-EEG (2019)
  • Author(s): Glim Sarah、Okazaki Yuka O.、Nakagawa Yumi、Mizuno Yuji、Hanakawa Takashi、Kitajo Keiichi
  • Journal Title: Neural Plasticity Volume: 2019 Pages: 1-13
  • DOI: 10.1155/2019/6263907
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effective Augmentation of Creativity-Involving Productivity Consequent to Spontaneous Selectivity in Knowledge Acquisition (2019)
  • Author(s): Kurashige Hiroki、Yamashita Yuichi、Hanakawa Takashi、Honda Manabu
  • Journal Title: Frontiers in Psychology Volume: 10 Pages: 600-600
  • DOI: 10.3389/fpsyg.2019.00600
  • Peer Reviewed / Open Access
• [Journal Article] Neural correlates of temporal updating and reasoning in association with neuropsychiatric disorders (2019)
  • Author(s): N, Ueda., T, Hanakawa
  • Journal Title: Behavioral and Brain Sciences Volume: 42
  • DOI: 10.1017/s0140525x19000426
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] アルツハイマー病とdefault mode network (2019)
  • Author(s): 花川 隆
  • Journal Title: Clinical Neuroscience Volume: 37(2) Pages: 189-191
• [Journal Article] Pioglitazone improves visceral sensation and colonic permeability in a rat model of irritable bowel syndrome (2018)
  • Author(s): Nozu, T. Miyagishi, S. Nozu, R. Takakusaki, K. Okumura, T.
  • Journal Title: J Pharmacol Sci Volume: 139 Issue: 1 Pages: 46-49
  • DOI: 10.1016/j.jphs.2018.11.006
  • NAID: 120006643359
  • Peer Reviewed / Open Access
• [Journal Article] Distinct roles of brain activity and somatotopic representation in pathophysiology of focal dystonia (2018)
  • Author(s): Uehara Kazumasa、Furuya Shinichi、Numazawa Hidemi、Kita Kahori、Sakamoto Takashi、Hanakawa Takashi
  • Journal Title: Human Brain Mapping Volume: 40 Issue: 6 Pages: 1738-1749
  • DOI: 10.1002/hbm.24486
  • Peer Reviewed / Open Access
• [Presentation] 視覚関連領域を含む脳領域間の因果的ネットワークの変容がパレイドリア生成に関連する (2023)
  • Author(s): 近藤 毅，吉永 健二，花川 隆
  • Organizer: 日本生理学会第100回記念大会
• [Presentation] 感覚と姿勢制御（シンポジウム；両眼視と姿勢制御における固有感覚の役割） (2022)
  • Author(s): 高草木 薫
  • Organizer: 2022年 日本弱視斜視学会総会
  • Invited
• [Presentation] Posture-gait control by the Basal Ganglia -with reference to Parkinson's disease- (2022)
  • Author(s): Takakusaki K
  • Organizer: Neuro 2022
  • Int'l Joint Research / Invited
• [Presentation] Posture Control Mechanisms by the Central Nervous System (2022)
  • Author(s): Takakusaki K
  • Organizer: Web seminar at International Bobath Instructors Training Association
  • Int'l Joint Research / Invited
• [Presentation] 歩行時の姿勢維持反応はどのように生成されるのか？ (2022)
  • Author(s): 高草木薫
  • Organizer: 第20回日本神経理学療法学会
  • Invited
• [Presentation] Perspectives of Human Connectome Project (HCP)-style MRI analysis in healthy and diseased older population (2022)
  • Author(s): Hanakawa T
  • Organizer: 第52回日本臨床神経生理学会学術大会
  • Invited
• [Presentation] Multimodal measurements of brain structure and functions using MRI as an information hub. (2022)
  • Author(s): Hanakawa T
  • Organizer: 第50回日本磁気共鳴医学会大会
  • Invited
• [Presentation] 脳構造 MRI 画像を用いた神経疾患の年齢予測の検証 (2022)
  • Author(s): 松島 斗真，吉永 健二，高村 恒人，舞草 伯秀，麦倉 俊司，森 菜緒子，布施 昇男，関口 敦，阿部 十也，花川 隆
  • Organizer: 第52回日本臨床神経生理学会学術大会
• [Presentation] 白質病変が健常高齢者の皮質表面解析に及ぼす影響と改善のための新手法. (2022)
  • Author(s): 大井 由貴，廣瀬 正和，東口 大樹，吉永 健二，赤坂 太，岡田 知久，麻生 俊彦，高橋 良輔，林 拓也，花川 隆
  • Organizer: 第45 回日本神経科学大会
• [Presentation] 安静時機能結合fMRIは何を測定しているか？ (2021)
  • Author(s): 花川 隆
  • Organizer: 第51回日本臨床神経生理学会学術大会
• [Presentation] パーキンソン病スペクトラムのコネクトーム解析 (2021)
  • Author(s): 花川 隆
  • Organizer: 第39回日本神経治療学会学術集会
  • Invited
• [Presentation] 画像から読み解く局所性ジストニアの起源―音楽家のジストニアを中心にー (2021)
  • Author(s): 花川 隆
  • Organizer: 第62回日本神経学会学術大会
  • Invited
• [Presentation] Synucleinopathyにおける神経伝達物質の異常と睡眠-覚醒時の行動変容 (2021)
  • Author(s): 高草木 薫
  • Organizer: 第51回日本臨床神経生理学会学術大会
• [Presentation] 前庭脊髄路を考慮した神経系コントローラによるヒトの姿勢制御のモデル化 (2021)
  • Author(s): 尾村優一郎，上西康平，千葉龍介，高草木薫，太田順
  • Organizer: 第33回 自律分散システムシンポジウム
• [Presentation] 二足立位の獲得と退化 (2021)
  • Author(s): 高草木 薫
  • Organizer: 第36回 日本脊髄外科学会
  • Invited
• [Presentation] 脚橋被蓋核に作用する睡眠-覚醒関連神経伝達物質の作用 (2021)
  • Author(s): 高草木 薫，高橋 未来，福山 秀青，野口 智弘，千葉 龍介
  • Organizer: 第101回北海道医学大会生理系分科会
• [Presentation] 脚橋被蓋核への微小電気刺激に対する橋延髄網様体ニューロンおよひ前庭神経核ニューロンの活動様式 (2021)
  • Author(s): 福山秀青，高橋未来，野口智弘，千葉龍介，高草木薫
  • Organizer: 第101回北海道医学大会生理系分科会
• [Presentation] Possible pathophysiological mechanisms of postural disturbances in Parkinson’s disease (2020)
  • Author(s): Takakusaki K, Takahashi M, Fukuyama S, Noguchi T, Chiba R.
  • Organizer: EMBC 2020
  • Int'l Joint Research
• [Presentation] Postural control during movements by an interaction between the reticulospinal tract and flexion reflex afferents (2020)
  • Author(s): Takakusaki K, Takahashi M, Noguchi T, Chiba R.
  • Organizer: Neuro2020
  • Int'l Joint Research
• [Presentation] パーキンソン病の姿勢と歩行 (2020)
  • Author(s): 高草木 薫
  • Organizer: 第61回日本神経学会学術大会
  • Invited
• [Presentation] 基底核の機能と姿勢制御 (2020)
  • Author(s): 高草木 薫
  • Organizer: 第9回 北海道神経難病リハビリテーション研究会
  • Invited
• [Presentation] パーキンソン病の姿勢と歩行 (2020)
  • Author(s): 高草木 薫
  • Organizer: 第3回 神奈川パーキンソン病リハビリテーション研究会
  • Invited
• [Presentation] Challenged person（健康弱者）とポストコロナ (2020)
  • Author(s): 高草木 薫
  • Organizer: 新学術領域研究 超適応 「身体－脳の機能不全を克服する潜在的適応力のシステム論的理解」第1回一般公開シンポジウム
• [Presentation] Neurological mechanisms of bipedal upright posture and gait as see from evolution and degeneration (2020)
  • Author(s): Takakusaki K
  • Organizer: 11th Asia Spine
  • Int'l Joint Research / Invited
• [Presentation] 猫がターゲット位置変化を予測したか否かが到達運動前の姿勢に反映される (2020)
  • Author(s): 中島 敏，高橋 未来，福山 秀青，高草木 薫
  • Organizer: 第67回 中部日本生理学会
• [Presentation] AIとBMIを支える機械学習技術の現状と脳神経内科臨床応用への展望 (2020)
  • Author(s): 花川 隆
  • Organizer: 第61回日本神経学会学術大会
  • Invited
• [Presentation] マルチモーダルイメージングによる神経疾患の病態解明アフタヌーンシンポジウム「ニューロイメージング研究の 基礎から臨床への展開」 (2020)
  • Author(s): 花川 隆
  • Organizer: 第22回日本ヒト脳機能マッピング学会
  • Invited
• [Presentation] スポーツイップスの神経メカニズム シンポジウムII「スポーツイップス」 (2020)
  • Author(s): 花川 隆
  • Organizer: 第11回日本ニューロリハビリテーション学会学術集会
• [Presentation] Parkinson’s Disease and Alzheimer’s Disease Dimensional Neuroimaging Initiative (PADNI). (2020)
  • Author(s): Hanakawa T.
  • Organizer: Neuroscience Network in Kobe
  • Int'l Joint Research / Invited
• [Presentation] Exploring the neural correlates of oscillations in human brain using simultaneous EEG-fMRI recording (2019)
  • Author(s): Hanakawa T, Yoshinaga K
  • Organizer: Neural Oscillation Conference 2019
  • Int'l Joint Research / Invited
• [Presentation] 認知症コホート・レジストリ研究の”あるある”. (2019)
  • Author(s): 花川 隆
  • Organizer: AMEDシンポジウム2019－医療研究が未来を変える－
  • Invited
• [Presentation] 多モダリティ神経画像データベース構築と機械学習（AI）技術開発 (2019)
  • Author(s): 花川 隆
  • Organizer: 九州大学医学部高次脳機能セミナー
  • Invited
• [Presentation] 神経ネットワークのダイナミクス解析により認知症の病態解明を目指すPADNI研究 (2019)
  • Author(s): 花川 隆
  • Organizer: 第38回日本認知症学会学術集会
  • Invited
• [Presentation] パーキンソン病スペクトラムの神経ネットワーク機能異常 (2019)
  • Author(s): 花川 隆
  • Organizer: 第24回東海パーキンソン病研究会
  • Invited
• [Presentation] Roles of the parietal cortex in postural adjustments that accompany forelimb reaching in the cat. (2019)
  • Author(s): Takahashi M, Nakajima T, Miyagishi S, Chiba R, Obara K, Takakusaki K
  • Organizer: Neuro 2019
  • Int'l Joint Research
• [Presentation] Role of parietal cortex involved in postural control during forelimb reaching in the cat. (2019)
  • Author(s): Takahashi M, Nakajima T, Miyagishi S, Obara K, Chiba R, Drew T, Takakusaki K
  • Organizer: Neural Control of Movement Annual Meeting 2019
  • Int'l Joint Research
• [Presentation] Neurotransmitter profiles of spinal interneurons that mediate generalized motor inhibition by the reticulospinal tract (2019)
  • Author(s): Takakusaki K, Takahashi M, Nakajima T, Chiba R, Obara K
  • Organizer: Neuro 2019
  • Int'l Joint Research
• [Presentation] Multi-faced functions of the reticulospinal systems involved in muscle tone regulation with respect to the modulation of neurotransmitters in the brainstem (2019)
  • Author(s): Takakusaki K, Takahashi M, Nakajima T, Chiba R, Obara K
  • Organizer: Soc for Neuroscience 2019
  • Int'l Joint Research
• [Presentation] 運動制御における外側制御系と内側制御系 (2019)
  • Author(s): 高草木 薫
  • Organizer: 第17回ジストニア研究会
  • Invited
• [Presentation] パーキンソン病の姿勢と歩行の制御 (2019)
  • Author(s): 高草木 薫
  • Organizer: 第12回神奈川 Visual Neurology
  • Invited
• [Presentation] 大脳基底核による運動の制御（パーキンソン病の姿勢と歩行） (2019)
  • Author(s): 高草木 薫
  • Organizer: パーキンソン病セミナーin 浜松
  • Invited
• [Presentation] 姿勢と歩行から観た運動障害の病態理解 (2019)
  • Author(s): 高草木 薫
  • Organizer: 大阪理学療法士会研修会2019
  • Invited
• [Presentation] 筋緊張抑制を誘発する脊髄介在細胞の神経伝達物質プロファイル (2019)
  • Author(s): 高草木 薫
  • Organizer: 2019 大脳基底核研究会
• [Presentation] 脳幹内のコリン系とセロトニン系による姿勢筋シナジー調節機構 (2019)
  • Author(s): 高草木 薫, 高橋 未来，中島 敏，千葉 龍介
  • Organizer: 第99回生理系北海道地方会
• [Presentation] ネコ後頭頂皮質へのムシモール微量注入の前肢リーチング運動に随伴する姿勢調節へ及ぼす影響 (2019)
  • Author(s): 高橋 未来・中島 敏・宮岸 沙織・小原 和宏・千葉 龍介・高草木 薫
  • Organizer: 第99回北海道医学大会生理系分科会
• [Presentation] ネコ前肢リーチング動作に随伴する姿勢制御の時空間的定量化 (2019)
  • Author(s): 高橋 未来・中島 敏・宮岸 沙織・小原 和宏・千葉 龍介・高草木 薫
  • Organizer: 次世代脳プロジェクト冬のシンポジウム2019
• [Book] カンデル神経科学 (2022)
  • Author(s): 宮下 保司（翻訳担当 高草木薫）
  • Total Pages: 1704
  • Publisher: メディカル・サイエンス・インターナショナル
  • ISBN: 9784815730550
• [Book] 医用工学ハンドブック（ロボットリハビリテーション） (2022)
  • Author(s): 佐久間 一郎、秋吉 一成、津本 浩平（高草木 薫 他）
  • Total Pages: 544
  • Publisher: エヌ・ティー・エス
  • ISBN: 9784860437350