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Modeling of hyper-adaptability to altered musculoskeletal system

Planned Research

Project AreaHyper-adaptability for overcoming body-brain dysfunction: Integrated empirical and system theoretical approaches
Project/Area Number 19H05728
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionTokyo Institute of Technology

Principal Investigator

Koike Yasuharu  東京工業大学, 科学技術創成研究院, 教授 (10302978)

Co-Investigator(Kenkyū-buntansha) 舩戸 徹郎  電気通信大学, 大学院情報理工学研究科, 准教授 (40512869)
Project Period (FY) 2019-06-28 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥121,030,000 (Direct Cost: ¥93,100,000、Indirect Cost: ¥27,930,000)
Fiscal Year 2023: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2022: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2021: ¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2020: ¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2019: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Keywords腱付け替え / 仮想手術 / 筋骨格系モデル / 筋シナジー / 機械学習 / モデリング
Outline of Research at the Start

仮想手術による長期的な身体変容を生じる実験系を実現し、サルの筋再配置による短期的な身体変容を生じる実験系とあわせて、長期/短期の身体変容後の神経系の変化を調べる。さらに、筋再配置の力学シミュレーション及び脳情報デコーディング技術を確立し、実験で得られた生体データの解析を行うことで、身体変容に対する生体構造の再構成過程を明らかにする。

Outline of Final Research Achievements

In the construction of a musculoskeletal model to simulate muscle rearrangement in monkeys, we analyzed bacterial activity data obtained from monkey experiments and explained the adaptation process that occurred during the recovery process as changes in muscle synergy. In addition, a musculoskeletal model was created for computational simulation, and a model was created to the extent that muscle activity could be explained. In computational modeling research, a musculoskeletal system model was constructed to mathematically reproduce the physical transformation caused by muscle rearrangement, and the modes of learning and control to adapt to the force field were clarified. Furthermore, we developed a theoretical framework to explain the learning rate.

Academic Significance and Societal Importance of the Research Achievements

運動学習・適応過程を筋シナジーを元にして解析する手法を確立した。また、計算機シミュレーションのための筋骨格系モデルを構築し、実際の筋活動や適応過程、その内部構造を明らかにした。さらに、運動学習の速度を説明できる理論的な枠組みを構築した。
これらの結果は、運動学習やリハビリテーションにおいて、適応の難しさの定量化、学習時間の短縮、効率的な学習を促すフィードバック情報の作成などに利用できる。これにより、効果的なリハビリテーション手法の開発などにも応用が可能となる。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (40 results)

All 2024 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (3 results) Journal Article (27 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 24 results,  Open Access: 22 results) Presentation (10 results) (of which Int'l Joint Research: 5 results,  Invited: 3 results)

  • [Int'l Joint Research] University of Southern California(米国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] 西安交通大学(中国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] University Southern California(米国)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Roles of the cerebellar vermis in predictive postural controls against external disturbances2024

    • Author(s)
      Konosu Akira、Matsuki Yuma、Fukuhara Kaito、Funato Tetsuro、Yanagihara Dai
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1 Pages: 3162-3162

    • DOI

      10.1038/s41598-024-53186-x

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Theoretical limits on the speed of learning inverse models explain the rate of adaptation in arm reaching tasks2024

    • Author(s)
      Barradas Victor R.、Koike Yasuharu、Schweighofer Nicolas
    • Journal Title

      Neural Networks

      Volume: 170 Pages: 376-389

    • DOI

      10.1016/j.neunet.2023.10.049

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The control of the arm’s equilibrium position2024

    • Author(s)
      Takagi Atsushi、Burdet Etienne、Koike Yasuharu
    • Journal Title

      Journal of Neurophysiology

      Volume: 131 Issue: 4 Pages: 750-756

    • DOI

      10.1152/jn.00011.2024

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Computational prediction of muscle synergy using a finite element framework for a musculoskeletal model on lower limb2023

    • Author(s)
      Wang Sentong、Hase Kazunori、Funato Tetsuro
    • Journal Title

      Frontiers in Bioengineering and Biotechnology

      Volume: 11 Pages: 1-13

    • DOI

      10.3389/fbioe.2023.1130219

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Partial maximum correntropy regression for robust electrocorticography decoding2023

    • Author(s)
      Li Yuanhao、Chen Badong、Wang Gang、Yoshimura Natsue、Koike Yasuharu
    • Journal Title

      Frontiers in Neuroscience

      Volume: 17

    • DOI

      10.3389/fnins.2023.1213035

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] EMG space similarity feedback promotes learning of expert-like muscle activation patterns in a complex motor skill2023

    • Author(s)
      Barradas Victor R.、Cho Woorim、Koike Yasuharu
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 16 Pages: 805867-805867

    • DOI

      10.3389/fnhum.2022.805867

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Muscle synergy analysis yields an efficient and physiologically relevant method of assessing stroke2022

    • Author(s)
      Funato Tetsuro、Hattori Noriaki、Yozu Arito、An Qi、Oya Tomomichi、Shirafuji Shouhei、Jino Akihiro、Miura Kyoichi、Martino Giovanni、Berger Denise、Miyai Ichiro、Ota Jun、Ivanenko Yury、d’Avella Andrea、Seki Kazuhiko
    • Journal Title

      Brain Communications

      Volume: 4 Issue: 4

    • DOI

      10.1093/braincomms/fcac200

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biomechanical effects of medial meniscus radial tears on the knee joint during gait: A concurrent finite element musculoskeletal framework investigation2022

    • Author(s)
      Sentong Wang, Kazunori Hase, Shunsuke Kita, Shinya Ogaya
    • Journal Title

      Frontiers in Bioengineering and Biotechnology

      Volume: 10 Pages: 957435-957435

    • DOI

      10.3389/fbioe.2022.957435

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Continuous Estimation of Finger and Wrist Joint Angles Using a Muscle Synergy Based Musculoskeletal Model.2022

    • Author(s)
      He Z, Qin Z, Koike Y.
    • Journal Title

      Applied Sciences.

      Volume: 12 Issue: 8 Pages: 3772-3772

    • DOI

      10.3390/app12083772

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Design of an Isometric End-Point Force Control Task for Electromyography Normalization and Muscle Synergy Extraction From the Upper Limb Without Maximum Voluntary Contraction2022

    • Author(s)
      Cho W, Barradas VR, Schweighofer N, Koike Y.
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 16 Pages: 805452-805452

    • DOI

      10.3389/fnhum.2022.805452

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A CW-CNN regression model-based real-time system for virtual hand control2022

    • Author(s)
      Qin Z, He Z, Li Y, Saetia S, Koike Y.
    • Journal Title

      Front Neurorobot

      Volume: 16 Pages: 1072365-1072365

    • DOI

      10.3389/fnbot.2022.1072365

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modulation of wrist stiffness caused by adaptation to stochastic environment2021

    • Author(s)
      H. Kambara, H. Ogawa, A. Takagi, D. Shin, N. Yoshimura, Y. Koike
    • Journal Title

      Advanced Robotics

      Volume: - Issue: 13-14 Pages: 1-17

    • DOI

      10.1080/01691864.2021.1900913

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Computational reproductions of external force field adaption without assuming desired trajectories2021

    • Author(s)
      Hiroyuki Kambara, Atsushi Takagi, Haruka Shimizu, Toshihiro Kawase, Natsue Yoshimura, Nicolas Schweighofer, Yasuharu Koike
    • Journal Title

      Neural Networks

      Volume: 139 Pages: 179-198

    • DOI

      10.1016/j.neunet.2021.01.030

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantitative evaluation of posture control in rats with inferior olive lesions2021

    • Author(s)
      Funato Tetsuro、Sato Yota、Sato Yamato、Fujiki Soichiro、Aoi Shinya、Tsuchiya Kazuo、Yanagihara Dai
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 20362-20362

    • DOI

      10.1038/s41598-021-99785-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Model of Predictive Postural Control Against Floor Tilting in Rats2021

    • Author(s)
      Konosu Akira、Funato Tetsuro、Matsuki Yuma、Fujita Akihiro、Sakai Ryutaro、Yanagihara Dai
    • Journal Title

      Frontiers in Systems Neuroscience

      Volume: 15 Pages: 141-141

    • DOI

      10.3389/fnsys.2021.785366

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multi-Joint Angles Estimation of Forearm Motion using a Regression Model2021

    • Author(s)
      Zixuan Qin, Sorawit Stapornchaisit, Zixun He, Natsue Yoshimura, Yasuharu Koike
    • Journal Title

      Frontiers in Neurorobotics, Frontiers Media SA

      Volume: 1 Pages: 685961-685961

    • DOI

      10.3389/fnbot.2021.685961

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Restricted Minimum Error Entropy Criterion for Robust Classification2021

    • Author(s)
      Y. Li , B. Chen, N. Yoshimura , Y. Koike
    • Journal Title

      IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS

      Volume: 33 Issue: 11 Pages: 6599-6612

    • DOI

      10.1109/tnnls.2021.3082571

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Brain activity reflects subjective response to delayed input when using an electromyography-controlled robot2021

    • Author(s)
      Hyeonseok Kim, Yeongdae Kim, Makoto Miyakoshi, Sorawit Stapornchaisit, Natsue Yoshimura, Yasuharu Koike
    • Journal Title

      Frontiers in Systems Neuroscience, Frontiers

      Volume: 1 Pages: 767477-767477

    • DOI

      10.3389/fnsys.2021.767477

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ラットの直立姿勢制御の構成原理2021

    • Author(s)
      舩戸徹郎, 鴻巣暁, 柳原大
    • Journal Title

      Medical Science Digest

      Volume: 47 Pages: 52-55

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Development of Multi-sensor Array Electrodes for Measurement of Deeper Muscle Activation2020

    • Author(s)
      Koike Yasuharu、Kim Yeongdae、Stapornchaisit Sorawit、Qin Zixuan、Kawase Toshihiro、Yoshimura Natsue
    • Journal Title

      Sensors and Materials

      Volume: 32 Issue: 3 Pages: 959

    • DOI

      10.18494/SAM.2020.2636

    • ISSN
      0914-4935, 2435-0869
    • Year and Date
      2020-03-19
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] When 90% of the variance is not enough: residual EMG from muscle synergy extraction influences task performance2020

    • Author(s)
      Barradas Victor R.、Kutch Jason J.、Kawase Toshihiro、Koike Yasuharu、Schweighofer Nicolas
    • Journal Title

      Journal of Neurophysiology

      Volume: 123 Issue: 6 Pages: 2180-2190

    • DOI

      10.1152/jn.00472.2019

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Independent control of cocontraction and reciprocal activity during goal-directed reaching in muscle space2020

    • Author(s)
      Takagi Atsushi、Kambara Hiroyuki、Koike Yasuharu
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 22333-22333

    • DOI

      10.1038/s41598-020-79526-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Towards a simplified estimation of muscle activation pattern from MRI and EMG using electrical network and graph theory2020

    • Author(s)
      Enrico Piovanelli, Davide Piovesan, Shouhei Shirafuji, Becky Su, Natsue Yoshimura, Yousuke Ogata, Jun Ota
    • Journal Title

      Sensors

      Volume: 20 Issue: 3 Pages: 724-724

    • DOI

      10.3390/s20030724

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Muscle Synergy and Musculoskeletal Model-Based Continuous Multi-Dimensional Estimation of Wrist and Hand Motions2020

    • Author(s)
      Kim Yeongdae、Stapornchaisit Sorawit、Kambara Hiroyuki、Yoshimura Natsue、Koike Yasuharu
    • Journal Title

      Journal of Healthcare Engineering

      Volume: 2020 Pages: 1-13

    • DOI

      10.1155/2020/5451219

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Muscle Synergy Analysis for Rehabilitation2020

    • Author(s)
      Koike Yasuharu
    • Journal Title

      Examines in Physical Medicine & Rehabilitation

      Volume: 2 Issue: 5 Pages: 1-2

    • DOI

      10.31031/epmr.2019.02.000550

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Characteristics of Kinematic Parameters in Decoding Intended Reaching Movements Using Electroencephalography (EEG)2019

    • Author(s)
      Kim Hyeonseok、Yoshimura Natsue、Koike Yasuharu
    • Journal Title

      Frontiers in Neuroscience

      Volume: 13 Pages: 1-13

    • DOI

      10.3389/fnins.2019.01148

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Finger Angle Estimation From Array EMG System Using Linear Regression Model With Independent Component Analysis2019

    • Author(s)
      Stapornchaisit Sorawit、Kim Yeongdae、Takagi Atsushi、Yoshimura Natsue、Koike Yasuharu
    • Journal Title

      Frontiers in Neurorobotics

      Volume: 13 Pages: 1-12

    • DOI

      10.3389/fnbot.2019.00075

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] Theoretical limits on the speed of learning inverse models explain the rate of adaptation in arm reaching tasks2023

    • Author(s)
      Barradas, V.
    • Organizer
      IEEE EMBC2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 表面筋電図の統計的解析2022

    • Author(s)
      小池 康晴
    • Organizer
      第 21 回日本電気生理運動学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 歩行の予期的動作の解明のためのラットのVR実験環境の構築2020

    • Author(s)
      三ツ木 知愛, 舩戸 徹郎, 小松 拓実, 酒井 隆太郎, 鴻巣 暁, 柳原 大
    • Organizer
      第32回自律分散システム・シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 予測可能な傾斜外乱に対するラットの姿勢動作学習の解析2020

    • Author(s)
      藤田 章寛, 鴻巣 暁, 舩戸 徹郎, 柳原 大
    • Organizer
      第32回自律分散システム・シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Design Isometric Force Rotating Task for EMG Normalization of Stroke Patients,2020

    • Author(s)
      Cho Woorim, Nicolas Schweighofer, Barradas Victor, Yasuharu Koike
    • Organizer
      ISEK XXIII Virtual Congress
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Assessment of event-related potential of independent components for intended direction classification2020

    • Author(s)
      Hyeonseok Kim, Natsue Yoshimura, Yasuharu Koike
    • Organizer
      IEEE International Conference on Systems, Man, and Cybernetics
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳波による手の把握動作の識別(Hand grasping / opening classification using EEG)2019

    • Author(s)
      岡田幸樹, 吉村奈津江, 小池康晴,
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Brain machine interface2019

    • Author(s)
      小池康晴
    • Organizer
      ASPIRE Forum 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Non-clinical brain computer interface applications2019

    • Author(s)
      Yasuharu Koike
    • Organizer
      The First UAE Workshop on Clinical and Non-clinical Brain Computer Interface (WBCI2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Motor Learning and Control Mechanism of the Brain2019

    • Author(s)
      Yasuharu Koike
    • Organizer
      2019 Workshop on Brain-inspired Artificial Intelligence
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2019-07-04   Modified: 2025-01-30  

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