| Budget Amount *help |
¥80,080,000 (Direct Cost: ¥61,600,000、Indirect Cost: ¥18,480,000)
Fiscal Year 2023: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2022: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2021: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2020: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2019: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
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| Outline of Final Research Achievements |
Eukaryotic DNA has a chromatin structure wrapped around histone proteins. Heterochromatin is defined by methylation of the 9th lysine of histone H3 (H3K9me) and suppresses gene expression, but it tends to form in DNA regions with repetitive sequences. However, the mechanism that connects repeat sequences and heterochromatin remains unclear. In this study, we reproduced this phenomenon in the model organism fission yeast and found that the Epe1 protein, which normally removes H3K9me, promotes H3K9me modification in repetitive DNA sequences via the RNAi mechanism. This proposes a new mechanism that connects heterochromatin and repetitive DNA sequences.
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