| Budget Amount *help |
¥88,010,000 (Direct Cost: ¥67,700,000、Indirect Cost: ¥20,310,000)
Fiscal Year 2023: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2022: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2021: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2020: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2019: ¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
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| Outline of Final Research Achievements |
We identified a novel factor, MEIOSIN, which acts as a switch from mitosis to meiosis in mouse germ cells, and found that germ cells lacking MEIOSIN fail to initiate meiosis and become infertile with testicular and ovarian atrophy in both males and females. It was also found that many uncharacterized genes were among those directly regulated by MEIOSIN. Analysis of these gene-disrupted mice led to the identification of several novel factors that play essential roles in meiosis.
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