| Budget Amount *help |
¥157,820,000 (Direct Cost: ¥121,400,000、Indirect Cost: ¥36,420,000)
Fiscal Year 2023: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2022: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
Fiscal Year 2021: ¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2020: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
Fiscal Year 2019: ¥39,000,000 (Direct Cost: ¥30,000,000、Indirect Cost: ¥9,000,000)
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| Outline of Final Research Achievements |
The regulatory mechanism of epigenomic maintenance is the most important molecular basis for the formation of multicellular organisms, as it generates a diversity of cellular traits. Elucidation of asymmetric division is crucial to understanding the diverse cell types that make up living organisms. By collecting gene expression and chromatin information simultaneously at single-cell resolution, we observed a series of epigenetic changes, including an isoform switch of the lineage-specific transcription factors, which may be involved in the control mechanism for asymmetric division. By analyzing a cancer organoid with bidirectional differentiation and hematopoietic stem cells, we revealed that cell populations are composed of diverse cells with epigenetic difference.
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