| Budget Amount *help |
¥174,460,000 (Direct Cost: ¥134,200,000、Indirect Cost: ¥40,260,000)
Fiscal Year 2023: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000)
Fiscal Year 2022: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000)
Fiscal Year 2021: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000)
Fiscal Year 2020: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000)
Fiscal Year 2019: ¥43,420,000 (Direct Cost: ¥33,400,000、Indirect Cost: ¥10,020,000)
|
|---|
| Outline of Final Research Achievements |
Using a genome-edited gene knockout mouse approach, we were able to identify a number of factors that govern fertilization, the beginning of life. Furthermore, we have clarified the mechanism of lumicrine system, which controls sperm maturation in the epididymis necessary for the acquisition of fertilization ability. In addition, we revealed that germ line stem cells can be cultured for more than 5 years without losing their ability to differentiate into sperm and produce offspring, while their self-renewal requires a number of factors. Furthermore, we reported that when offspring are obtained by assisted reproduction techniques such as ICSI, malformations and other effects are observed over the generations.
|
