| Budget Amount *help |
¥109,850,000 (Direct Cost: ¥84,500,000、Indirect Cost: ¥25,350,000)
Fiscal Year 2023: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2022: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2021: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2020: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2019: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
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| Outline of Final Research Achievements |
A single fertilized egg has the ability to differentiate into any cell (totipotency). However, it is not well understood how the molecular program establishes and loses totipotency. In this study, we focused on heterochromatin, which is responsible for opening and closing chromatin, and analyzed the dynamics and function of heterochromatin during oocyte formation and fertilization (establishment of totipotency) and preimplantation development (maintenance and loss of totipotency). As a result, we found that totipotent zygotes and early preimplantation embryos have very unique heterochromatin and that they undergo a stepwise transition towards typical heterochromatin during preimplantation development. Thus, we think the atypical heterochromatin state may underlie totipotency.
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