| Budget Amount *help |
¥77,480,000 (Direct Cost: ¥59,600,000、Indirect Cost: ¥17,880,000)
Fiscal Year 2023: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2022: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2021: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2020: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2019: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
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| Outline of Final Research Achievements |
The aim of this research was to target various biometal-related proteins of pathogenic microorganisms and to create functional control molecules based on an understanding of the functional expression mechanism of each protein through precise analysis using various physicochemical methods. In microorganisms, biometal-related proteins are utilized, including proteins that function to acquire metals by acting on host metal-binding proteins. By utilizing various cutting-edge technologies through collaboration within the field, we have clarified the molecular mechanism of metal binding selectivity that overturns conventional wisdom, and created functionally inhibiting molecules in various modalities such as antibodies and low-molecular-weight compounds, through evaluation of the antibacterial activity and the drug efficacy in vivo model, and succeeded in achieving comprehensive results from the molecule to the individual.
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