| Budget Amount *help |
¥63,180,000 (Direct Cost: ¥48,600,000、Indirect Cost: ¥14,580,000)
Fiscal Year 2023: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2022: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2021: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2020: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2019: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
|
|---|
| Outline of Final Research Achievements |
This study aimed to elucidate the mechanisms of transport and toxicity of toxic metals in the proximal tubules, as well as the mechanisms of regulation of transport of bio-metals.
In vitro, we used proximal tubule region-specific cultured cells to clarify the transport of Cd and Mn and the mechanism of proximal tubular damage caused by cisplatin and Cd.On the other hand, in vivo, we utilized elemental imaging to examine how administered bio-metals are distributed in various regions of the kidney, focusing on Cd and Mn. We clarified how metal transport is affected by mutations that induce various diseases.
|
