| Budget Amount *help |
¥66,820,000 (Direct Cost: ¥51,400,000、Indirect Cost: ¥15,420,000)
Fiscal Year 2023: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2022: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2021: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2020: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2019: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
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| Outline of Final Research Achievements |
To understand the dynamics of bio-metals, it is necessary to obtain information on the distribution and chemical forms of bio-metals under conditions that are as close as possible to the in vivo environment with preserving the microstructure and cellular arrangement of tissues. In this study, we have investigated the intercellular dynamics of bio-metals by chemical imaging using synchrotron radiation and proton beams and bioimaging using autofluorescence and reflected light. Intracellular elemental imaging and quantification at 100 nano-spatial resolution was achieved. Collaboration within the bio-metal science has enabled us to examine measurement samples from plants to human tissues, from hard tissues such as bones and teeth to soft tissues such as kidneys and gastrointestinal tracts, and to advance the analysis of bio-metal distribution from light elements to heavy metals.
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