| Budget Amount *help |
¥133,640,000 (Direct Cost: ¥102,800,000、Indirect Cost: ¥30,840,000)
Fiscal Year 2023: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2022: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2021: ¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2020: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2019: ¥30,290,000 (Direct Cost: ¥23,300,000、Indirect Cost: ¥6,990,000)
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| Outline of Final Research Achievements |
Our purpose of this study is to develop a "chemical photo-control method" that enables high-speed molecular movies of proteins that are inherently insensitive to light, by leveraging chemical biology techniques. We developed photo-control technologies tailored to various time domains to elucidate the structural changes and elementary enzymatic reactions of proteins occurring over a broad temporal range, from nanoseconds to milliseconds. In this research, we succeeded in developing novel caged compounds. We also developed photoswitching ligands targeting the adenosine A2A receptor using azobenzene. Through a collaborative study with the Iwata group, we succeeded in determining the X-ray crystal structure of the photoswitching ligand bound to the adenosine A2A receptor.
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