| Budget Amount *help |
¥161,720,000 (Direct Cost: ¥124,400,000、Indirect Cost: ¥37,320,000)
Fiscal Year 2023: ¥30,940,000 (Direct Cost: ¥23,800,000、Indirect Cost: ¥7,140,000)
Fiscal Year 2022: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2021: ¥29,510,000 (Direct Cost: ¥22,700,000、Indirect Cost: ¥6,810,000)
Fiscal Year 2020: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000)
Fiscal Year 2019: ¥36,010,000 (Direct Cost: ¥27,700,000、Indirect Cost: ¥8,310,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we aimed to characterize the information processing properties of eukaryotic intracellular signaling systems. Using the epithelial growth factor signaling system of cultured mammalian cells and the chemotaxis signaling system of cellular slime mold as research materials, we successfully characterized and quantified the flow of the ligand-receptor-intracellular signaling system. Furthermore, to clarify the principle of encoding diverse ligands by intracellular signaling systems, we focused on the GPCR signaling system and obtained data showing that dynamic fluctuations in downstream signaling encode information. Finally, to demonstrate the link between diverse information and cellular function, we quantified the relationship between signaling and function in cell cycle and chemotaxis signaling in mammalian cells and cellular slime molds, respectively,
|
