| Budget Amount *help |
¥64,610,000 (Direct Cost: ¥49,700,000、Indirect Cost: ¥14,910,000)
Fiscal Year 2023: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2022: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2021: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2020: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2019: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Outline of Final Research Achievements |
Based on information thermodynamics, we have developed a theoretical framework that integrates various biological functions: chemical reaction systems, cellular information processing, learning, and evolution. For intracellular reactions, a general theory of equilibrium and non-equilibrium chemical thermodynamics was established based on the Hessian geometry, which was applied to analyze the thermodynamics of self-replication. For single-cell information processing, bacterial chemotaxis was formalized using theories of optimal filtering and control to elucidate its optimality. For the multicellular phenomena, we constructed theories for populational information processing by cells, reinforcement learning of adaptive immunity, and evolution with learning agents. These results significantly advance the establishment of a theory for information physics that captures diverse adaptive phenomena in living systems.
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