| Budget Amount *help |
¥63,500,000 (Direct Cost: ¥63,500,000)
Fiscal Year 2012: ¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2011: ¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2010: ¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2009: ¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2008: ¥12,700,000 (Direct Cost: ¥12,700,000)
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| Research Abstract |
To elucidate the mechanism regulating the reprogramming of gene expression after fertilization, I investigated the change in the gene expression pattern after fertilization in mice. I identified 4,000 genes which are expressed in the 1-cell stage embryos and found that in this set of genes, there are many genes which were not expressed before fertilization. The analysis for the dynamics of histone variants revealed that H2A and H3 variants are dramatically replaced in the whole genome just after fertilization, which would be involved in the regulation of gene expression reprogramming.
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