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Epigenetic Regulation and small RNAs in Spermatogenesis

Planned Research

Project AreaThe germline: its developmental cycle and epigenome network
Project/Area Number 20062007
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOsaka University

Principal Investigator

NAKANO Toru  大阪大学, 生命機能研究科, 教授 (00172370)

Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥112,500,000 (Direct Cost: ¥112,500,000)
Fiscal Year 2012: ¥22,500,000 (Direct Cost: ¥22,500,000)
Fiscal Year 2011: ¥22,500,000 (Direct Cost: ¥22,500,000)
Fiscal Year 2010: ¥22,500,000 (Direct Cost: ¥22,500,000)
Fiscal Year 2009: ¥22,500,000 (Direct Cost: ¥22,500,000)
Fiscal Year 2008: ¥22,500,000 (Direct Cost: ¥22,500,000)
Keywords遺伝子発現制御 / 小分子RNA / 非コードRNA / エピジェネティクス / piRNA / 生殖細胞 / DNAメチル化 / small RNA / 精子形成 / エピジェネティック制御 / 幹細胞 / PIWI / PIWIファミリー / ピストン修飾 / MILI / MIWI / TDRD1
Research Abstract

We analyzed the molecular functions of two mouse PIWI family members, MILI (mouse piwi like) and MIWI2 (mouse piwi 2) and revealed that these two proteins were crucial for the biogenesis of germ cell specific small RNAs, piRNAs (piwi interacting RNA). We also exhibited that MILI and MIWI2 played pivotal roles in de novo DNA methylation of retrotransposon genes in embryonic male germ cells presumably through piRNA. In addition, we showed the molecular functions of MVH (mouse vasa homologue), a germ cell specific RNA helicase and glycerol-3-phosphate acyltransferase 2 (GPAT2) in piRNA-genesis.

Report

(7 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (69 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (40 results) (of which Peer Reviewed: 38 results) Presentation (28 results) (of which Invited: 4 results) Remarks (1 results)

  • [Journal Article] Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus2013

    • Author(s)
      Yamamoto Y,Watanabe T,Hoki Y, Shirane K, Li Y, Ichiiyanagi K, Kuramochi-Miyagawa S, Toyoda A, Fujiyama A, Oginuma M, Suzuki H, Sado T, Nakano T, Sasaki H
    • Journal Title

      Genome Res

      Volume: 23 Issue: 2 Pages: 292-299

    • DOI

      10.1101/gr.137224.112

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GPAT2, a Mitochondrial Outer Membrane Protein in piRNA Biogenesis in Germline Stem Cells2013

    • Author(s)
      Shiromoto Y, Kuramochi-Miyagawa S, Daiba A, Chuma S, Katanaya A, Nishimura K, Ohtaka M, Nakanishi M, Nakamura T, Yoshinaga K, Asada N, Nakamura S, Yasunaga T, Kojima-Kita K, Itou D, Kimura T, Nakano T
    • Journal Title

      RNA

      Volume: 19 Issue: 6 Pages: 803-810

    • DOI

      10.1261/rna.038521.113

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Dppa3 on DNA methylation dynamics during primordial germ cell development2013

    • Author(s)
      Nakashima H, Kimura T, Kaga Y. Nakatani T, Seki Y, Nakamura T, Nakano T
    • Journal Title

      Biol Rep

      Volume: 88 Issue: 5 Pages: 1-9

    • DOI

      10.1095/biolreprod.112.105932

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GPAT2, a Mitochondrial Outer Membrane Protein, in piRNA Biogenesis in Germline Stem Cells2013

    • Author(s)
      Shiromoto Y, Kuramochi-Miyagawa S, Daiba A, Chuma S, Katanaya A, Nishimura K, Ohtaka M, Nakanishi M, Nakamura T, Yoshinaga K, Asada N, Nakamura S, Yasunaga T, Kojima-Kita K, Itou D, Kimura T, Nakano T
    • Journal Title

      RNA

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A forward genetic screen to study mammalian RNA interference - essential role of RNase IIIa domain of Dicer1 in 3' strand cleavage of dsRNA in vivo2012

    • Author(s)
      Ohishi K, Nakano T
    • Journal Title

      FEBS J.

      Volume: 279 Issue: 5 Pages: 832-43

    • DOI

      10.1111/j.1742-4658.2012.08474.x

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of DPPA3 for chromatin condensation in mouse oocytogenesis2012

    • Author(s)
      Liu YJ, Nakamura T, Nakano T
    • Journal Title

      Biol Rep

      Volume: 86 Issue: 2 Pages: 1-8

    • DOI

      10.1095/biolreprod.111.095018

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PGC7 binds histone H3K9me2 to protect against conversion of 5MeC to 5HmC in early embryos2012

    • Author(s)
      Nakamura, T., Liu, Y.U., Nakashima, H., Umehara, H., Inoue, K., Matoba, S., Tachibana, M., Ogura, A., Shinkai, Y., Nakano, T
    • Journal Title

      Nature

      Volume: 486 Issue: 7403 Pages: 415-419

    • DOI

      10.1038/nature11093

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MitoPLD Is a Mitochondrial Protein Essential for Nuage Formation and piRNA Biogenesis in the Mouse Germline2011

    • Author(s)
      Watanabe T, et al
    • Journal Title

      Dev Cell

      Volume: 20 Issue: 3 Pages: 364-375

    • DOI

      10.1016/j.devcel.2011.01.005

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus2011

    • Author(s)
      Watanabe, T., Tomizawa, S., Mitsuya, K., Totoki, Y., Yamamoto, Y., Kuramochi-Miyagawa, S., Iida, N., Hoki, Y., Murphy, P.J., Toyoda, A., Gotoh, K., Hiura, H., Arima, T., Fujiyama, A., Sado, T., Shibata, T., Nakano, T., Lin, H., Ichiyanagi, K., Soloway, P.D., Sasaki, H
    • Journal Title

      Science

      Volume: 332 Issue: 6031 Pages: 848-52

    • DOI

      10.1126/science.1203919

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis2011

    • Author(s)
      Tanaka T, et al
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108 Issue: 26 Pages: 10579-10584

    • DOI

      10.1073/pnas.1015447108

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metastable primordial germ cell-like state induced from mouse embryonic stem cells .by Akt activation2010

    • Author(s)
      Yamano N, Kimura T, Watanabe S, Shinohara T, Nakano T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 392 Pages: 311-316

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] MVH in piRNA processing and gene silencing of retrotransposons2010

    • Author(s)
      Kuramochi-Miyagawa S, Watanabe T, Kimura T, Nakatsuji N, Noce T, Sasaki H, Nakano T, et al
    • Journal Title

      Genes Dev

      Volume: 24 Pages: 887-892

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disabled-2 is required for mesoderm differentiation of murine embryonic stem cells2010

    • Author(s)
      Huang CL, Cheng JC, Kitajima K, Nakano T, Yeh CF, Chong KY, Tseng CP
    • Journal Title

      J Cell Physiol

      Volume: 225 Pages: 92-105

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MVH in piRNA processing and gene silencing of retrotransposons2010

    • Author(s)
      Kuramochi-Miyagawa S, Nakano T, et al
    • Journal Title

      Genes and Development

      Volume: 24 Pages: 887-892

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metastable primordial germ cell-like state induced from mouse embryonic stem cells by Akt activation2010

    • Author(s)
      Yamano N, Nakano T, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 392 Pages: 311-316

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MVH in piRNA processing and gene silencing of retrotransposons2010

    • Author(s)
      Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Takamatasu K, Chuma S, Kojima-Kita K, Shiromoto Y, Asada N, Toyoda A, Fujiyama A, Totoki Y, Shibata T, Kimura T, Nakatsuji N, Noce T, Sasaki H, Nakano T.
    • Journal Title

      Genes Dev 24

      Pages: 887-892

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Associations between PIWI proteins and TDRD1/MTR-1 are critical for integrated subcellular localization in murine male germ cells2009

    • Author(s)
      Kojima K, Nakano T, et al
    • Journal Title

      Genes to Cells

      Volume: 14 Pages: 1155-1165

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increase of hematopoietic progenitor and suppression of endothelial gene expression by Runx1 expression during in vitro ES differentiation2009

    • Author(s)
      Sakai E, Kitajima K, Sato A, Nakano T
    • Journal Title

      Experimental Hematology

      Volume: 37 Pages: 334-345

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline2009

    • Author(s)
      Shoji M, Nakano T, et al
    • Journal Title

      Developmental Cell

      Volume: 17 Pages: 775-787

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gtsf1/Cue110. a gene encoding a protein with two copies of a CHHC Zn-finger motif. is involved in spermatogenesis and retrotransposon suppression in murine testes2009

    • Author(s)
      Yoshimura T, Nakano T, Miyazaki J, et al
    • Journal Title

      Developmental Biology

      Volume: 335 Pages: 216-227

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] MILI. a piRNA binding protein. is required for germline stem cell self-renewal and appears to positively regulate translation2009

    • Author(s)
      Unhavaithaya Y, Nakano T, Lin H, et al
    • Journal Title

      Journal of Biological Chemistry

      Volume: 284 Pages: 6507-6519

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] MILI, a piRNA binding protein, is required for germline stem cell self-renewal and appears to positively regulate translation.2009

    • Author(s)
      Unhavaithaya Y, Hao Y, Beyret E, Yin H, Kuramochi-Miyagawa S, Nakano T, Lin H.
    • Journal Title

      J Biol Chem 284

      Pages: 6507-6519

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline2009

    • Author(s)
      Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, Kondoh G, Okawa K, Chujo, Suzuki T, Hata K, Martin S, Noce T, Kuramochi-Miyagawa S, Nakano T, Sasaki H, Pillai RS, Nakatsuji N, Chuma S.
    • Journal Title

      Dev Cell 17

      Pages: 775-787

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Associations between PIWI proteins and TDRD1/MTR-1 are critical for integrated subcellular localization in murine male germ cells2009

    • Author(s)
      Kojima K, (5名), Nakano T
    • Journal Title

      Genes to Cells 14

      Pages: 1155-1165

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increase of hematopoietic progenitor and suppression of endothelial gene expressi on by Runxl expression during in vitro ES differentiation2009

    • Author(s)
      Sakai E, Kitajima K, Sato A, Nakano T
    • Journal Title

      Experimental Hematology 37

      Pages: 334-345

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silening in the mouse male germline2009

    • Author(s)
      Shoji M, (13名), Nakano T, (4名)
    • Journal Title

      Developmental Cell 17

      Pages: 775-787

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-fingermotif, is involved in spermatogenesis and retrotransposon suppression in murine testes2009

    • Author(s)
      Yoshimura T, (6名), Nakano T, Miyazaki J
    • Journal Title

      Developmental Biology 335

      Pages: 216-227

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MILI, a piRNA binding protein, is required for germline stem cell self-renewal and appears to positively regulate translation2009

    • Author(s)
      Unhavaithaya Y, (4名), Nakano T, Lin H
    • Journal Title

      Journal of Biological Chemistry 284

      Pages: 6507-6519

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes2009

    • Author(s)
      Watanabe T, Totoki Y, Toyoda A, Kaneda M, Kuramochi-Miyagawa S, Obata Y, Chiba H, Kohara Y, Kono T, Nakano T, Surani MA, Sakaki Y, Sasaki H
    • Journal Title

      Nature 453

      Pages: 539-543

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increase of hematopoietic progenitor and suppression of endothelial gene expression by Runxl expression during in vitro ES differentiation2009

    • Author(s)
      Sakai E, Kitajima K, Sato A, Nakano T
    • Journal Title

      Exp Hematol 37

      Pages: 334-345

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Akt signaling on nuclear reprogramming2009

    • Author(s)
      Nakamura T, Inoue K, Ogawa S, Umehara H, Ogonuki N, Miki H, Kimura T, Ogura A, Nakano T
    • Journal Title

      Genes Cells (in press)

    • Related Report
      2008 Annual Research Report
  • [Journal Article] MILl, a piRNA binding protein, is required for germline stem cell self-renewal and appears to positively regulate translation2009

    • Author(s)
      Unhavaithaya Y, Hao Y, Beyret E, Yin H, Kuramochi-Miyagawa S, Nakano T, Lin H
    • Journal Title

      J Biol Chem (in press)

    • Related Report
      2008 Annual Research Report
  • [Journal Article] DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes.2008

    • Author(s)
      Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Totoki Y, Toyoda A, Ikawa M, Asada N, Kojima K, Yamaguchi Y, Ijiri T, Hata K, Li E, Matsuda Y, Kimura T, Okabe M, Sakaki Y, Sasaki H, Nakano T
    • Journal Title

      Genes Dev 22

      Pages: 918-930

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes2008

    • Author(s)
      Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Totoki Y, Toyoda A, Ikawa M, Asada N, Kojima K, Yamaguchi Y, Ijiri T, Hata K, Li E, Matsuda Y, Kimura T, Okabe M, Sakaki Y, Sasaki H, Nakano T
    • Journal Title

      Genes Dev 22

      Pages: 918-930

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Akt signaling promotes derivation of embryonic germ cells from primordial germ cell2008

    • Author(s)
      Kimura T, Tomooka M, Yamano N, Murayama K, Matoba S, Umehara H, Kanai Y, Nakano T
    • Journal Title

      Development 135

      Pages: 869-879

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential context-dependent effects of FOG-1 on mast cell development and differentiation2008

    • Author(s)
      Sugiyama D, Tanaka M, Kitajima K, Zheng J, Yen H, Murotani T, Yamatodani A, Nakano T
    • Journal Title

      Blood 111

      Pages: 1924-1932

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calyculin A retraction of mature megakaryocytes proplatelets from embryonic stem cells2008

    • Author(s)
      Tamaru S, Kitajima K, Nakano T, Eto K, Yazaki A, Kobayashi T, Matsuinoto T, Wada H, Katayama N, Nishikawa M
    • Journal Title

      Biochem Biophys Res Commun 366

      Pages: 763-768

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PI3K/Akt signaling as a key regulatory pathway for chondrocyte terminal differentiation2008

    • Author(s)
      Kita K, Kimura T, Nakamura N, Yoshikawa H, Nakano T
    • Journal Title

      Genes Cells 13

      Pages: 839-850

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MVH in piRNA processing and gene silencing of retrotransposons

    • Author(s)
      Kuramochi-Miyagawa S, (15名), Nakano T
    • Journal Title

      Genes and Development (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metastable primordial germ cell-like state induced from mouse embryonic stem cells by Akt activation

    • Author(s)
      Yamano N, (3名), Nakano T
    • Journal Title

      Biochem Biophys Res Commun (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Artilicial Incluction of Germ Cell Specific liene Sileucing through piRNA pathway2013

    • Author(s)
      仲野 徹
    • Organizer
      Small RNAs to Stem Cells & Epigenetic Reprogramming Asia-2013
    • Place of Presentation
      東京大学、東京
    • Year and Date
      2013-11-25
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Artificial Induction of Germ Cell Specific Gene Silencing tnrough piRNA pathway2013

    • Author(s)
      仲野 徹
    • Organizer
      8th Annual Conference of Asia Epigenome Alliance
    • Place of Presentation
      台北(台湾)
    • Year and Date
      2013-11-06
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Artificial Induction of Germ cell Specific Gene Silencing tnrouga piRNA pathway2013

    • Author(s)
      仲野 徹
    • Organizer
      Recent Advances in Stem Cell Biology
    • Place of Presentation
      九州大学、博多
    • Year and Date
      2013-11-04
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] DMメチル化と発生・発がん2013

    • Author(s)
      仲野 徹
    • Organizer
      日本病理学会
    • Place of Presentation
      札幌
    • Year and Date
      2013-06-07
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] piRNA産生システムの解析2012

    • Author(s)
      仲野 徹
    • Organizer
      22nd HCS 4th JARI Joint International Symposium
    • Place of Presentation
      広島市
    • Year and Date
      2012-08-30
    • Related Report
      2012 Final Research Report
  • [Presentation] piRNA産生システムの解析2012

    • Author(s)
      仲野徹
    • Organizer
      22nd HCS 4th JARI Joint International Symposium
    • Place of Presentation
      広島
    • Year and Date
      2012-08-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] piRNA and Spermatogenesis2012

    • Author(s)
      仲野 徹
    • Organizer
      2nd SKLRB Symposia
    • Place of Presentation
      北京・中国
    • Year and Date
      2012-05-07
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] DNA Methylation in Cell Differentiation and Transformation2012

    • Author(s)
      仲野 徹
    • Organizer
      Shanghai International Conference of Epigenetics in Development and Disease
    • Place of Presentation
      上海・中国
    • Year and Date
      2012-04-21
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] piRNA産生システムの解析2011

    • Author(s)
      仲野 徹
    • Organizer
      特定領域研究 生殖サイクル 公開シンポジウム
    • Place of Presentation
      大阪市
    • Year and Date
      2011-11-17
    • Related Report
      2012 Final Research Report
  • [Presentation] DNA methylation control by PGC7/Stella2010

    • Author(s)
      仲野 徹
    • Organizer
      BMB 2010
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] DNA methylation control by PGC7/Stella2010

    • Author(s)
      仲野徹
    • Organizer
      BMB 2010
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細胞分化・がん化におけるエピジェネティクス制御2010

    • Author(s)
      仲野 徹
    • Organizer
      JDDW2010
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞分化・がん化におけるエピジェネティクス制御2010

    • Author(s)
      仲野徹
    • Organizer
      JDDW2010
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 幹細胞の未分化性とシグナル2010

    • Author(s)
      仲野 徹
    • Organizer
      第69回日本癌学会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 幹細胞の未分化性とシグナル2010

    • Author(s)
      仲野徹
    • Organizer
      第69回日本癌学会
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNA methylation in Early Embryogenesis2010

    • Author(s)
      仲野 徹
    • Organizer
      Epigenetics : New horizons in Japan and Scandinavia
    • Place of Presentation
      ストックホルム・スウェーデン
    • Year and Date
      2010-09-06
    • Related Report
      2012 Final Research Report
  • [Presentation] DNA methylation in Early Embryogenesis2010

    • Author(s)
      仲野徹
    • Organizer
      Epigenetics : New horizons in Japan and Scandinavia
    • Place of Presentation
      ストックホルム スウェーデン(招待講演)
    • Year and Date
      2010-09-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発生・分化におけるエピジェネティクス制御2009

    • Author(s)
      仲野 徹
    • Organizer
      日本免疫学会
    • Place of Presentation
      大阪市
    • Year and Date
      2009-12-03
    • Related Report
      2012 Final Research Report 2009 Annual Research Report
  • [Presentation] Epigenetic gene regulation and GATA factors2009

    • Author(s)
      仲野 徹
    • Organizer
      International Society of Experimental Hematology
    • Place of Presentation
      アテネ・ギリシャ
    • Year and Date
      2009-09-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Epigenetic gene regulation and GATA factors2009

    • Author(s)
      仲野徹
    • Organizer
      International Society of Experimental Hematology
    • Place of Presentation
      アテネ、ギリシャ
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] DNA methylation in early embryogenesis2009

    • Author(s)
      仲野 徹
    • Organizer
      From Imprinting to the Epigenome
    • Place of Presentation
      ケンブリッジ・イギリス
    • Year and Date
      2009-09-04
    • Related Report
      2012 Final Research Report
  • [Presentation] DNA methylation in early embryogenesis2009

    • Author(s)
      仲野徹
    • Organizer
      From Imprinting to the Epigenome
    • Place of Presentation
      ケンブリッジ、英国
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] DNA methylation in early embryogenesis2009

    • Author(s)
      仲野 徹
    • Organizer
      日本発生生物学会
    • Place of Presentation
      新潟市
    • Year and Date
      2009-05-29
    • Related Report
      2012 Final Research Report 2009 Annual Research Report
  • [Presentation] Small RNA and Gene Silencing in Spermatogenesis2009

    • Author(s)
      仲野徹
    • Organizer
      9th International Congress of Andrology
    • Place of Presentation
      バルセロナ、スペイン
    • Year and Date
      2009-03-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] DNA methylation in early embryogenesis2008

    • Author(s)
      仲野徹
    • Organizer
      Decoding Epigenetic Code
    • Place of Presentation
      東京
    • Year and Date
      2008-12-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulation of Stem Cell Systems by PI3K/Akt Signaling2008

    • Author(s)
      Nakano T
    • Organizer
      The 5th Nikko International Symposium : Stem Cells and Cancer
    • Place of Presentation
      Tochigi
    • Year and Date
      2008-10-25
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] DNA methylation in early embryogenesis2008

    • Author(s)
      仲野徹
    • Organizer
      Royan International Twin Congress
    • Place of Presentation
      テヘラン、イラン
    • Year and Date
      2008-08-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] DNAメチル化制御とsmall RNA2008

    • Author(s)
      仲野徹
    • Organizer
      第二回エピジェネティクス研究会
    • Place of Presentation
      三島、静岡県
    • Year and Date
      2008-05-09
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.fbs.osaka-u.ac.jp/labs/nakano/researches.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2019-07-29  

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