| Budget Amount *help |
¥107,500,000 (Direct Cost: ¥107,500,000)
Fiscal Year 2012: ¥21,500,000 (Direct Cost: ¥21,500,000)
Fiscal Year 2011: ¥21,500,000 (Direct Cost: ¥21,500,000)
Fiscal Year 2010: ¥21,500,000 (Direct Cost: ¥21,500,000)
Fiscal Year 2009: ¥21,500,000 (Direct Cost: ¥21,500,000)
Fiscal Year 2008: ¥21,500,000 (Direct Cost: ¥21,500,000)
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| Research Abstract |
Spermatozoa must have fertilizing ability other than to have sperm specific shape and moving ability. We clarified that Spesp1, Calsperin, Pdilt and Tex101 are all essentially required for spermatozoa to establish their fertilizing ability by making gene-manipulated animals. We also revealed the precise mechanism of sperm dynamics in female reproductive tract using these gene-manipulated animals and live-imaging systems. Furthermore, miR-200b and miR-429 were shown to be essential for female ovulation by gene-disruption experiments.
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