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Mechanisms of epigenomic regulation in gametogenesis and genomic imprinting

Planned Research

Project AreaThe germline: its developmental cycle and epigenome network
Project/Area Number 20062010
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyushu University (2010-2012)
National Institute of Genetics (2008-2009)

Principal Investigator

SASAKI Hiroyuki  九州大学, 生体防御医学研究所, 教授 (30183825)

Co-Investigator(Kenkyū-buntansha) HATA Kenichiro  国立成育医療センター研究所, 周産期病態研究部, 部長 (60360335)
Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥210,000,000 (Direct Cost: ¥210,000,000)
Fiscal Year 2012: ¥42,000,000 (Direct Cost: ¥42,000,000)
Fiscal Year 2011: ¥42,000,000 (Direct Cost: ¥42,000,000)
Fiscal Year 2010: ¥42,000,000 (Direct Cost: ¥42,000,000)
Fiscal Year 2009: ¥42,000,000 (Direct Cost: ¥42,000,000)
Fiscal Year 2008: ¥42,000,000 (Direct Cost: ¥42,000,000)
Keywords発生・分化 / 発現制御 / 生殖細胞 / エピゲノム / ゲノム刷込み / ゲノム刷り込み
Research Abstract

In mammalian germ cell development, many epigenetic events including genomic imprinting occur. The changes in the epigenome affect the progression of meiosis and, after fertilization, the developmental potential of the embryo. In this study, we discovered the existence of endogenous siRNA in mouse oocytes, which regulated expression of transposons and genes. We also found that the biogenesis of piRNA in male germ cells requires a phospholipase/nuclease family protein called MitoPLD, and that piRNA is involved in de novo DNA methylation of transposons and a certain imprinted gene(s). Based on the results, we proposed a model in which piRNA-mediated DNA methylation involves nascent noncoding RNA complimentary to the piRNA. Lastly, we developed a method to visualize the DNA methylation status in individual cells.

Report

(7 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (129 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (62 results) (of which Peer Reviewed: 58 results) Presentation (54 results) Book (7 results) Remarks (6 results)

  • [Journal Article] Mouse oocyte methylomes at base resolution reveal genome- wide accumulation of non-CpG methylation and role of DNA methyltransferases2013

    • Author(s)
      Shirane K, Toh H, Kobayashi H, Miura F, Chiba H, Ito T, Kono T, Sasaki H
    • Journal Title

      PLoS Genet

      Volume: 9(4) Issue: 4 Pages: 303-306

    • DOI

      10.1371/journal.pgen.1003439

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus2013

    • Author(s)
      Yamamoto Y,Watanabe T,Hoki Y, Shirane K, Li Y, Ichiiyanagi K, Kuramochi-Miyagawa S, Toyoda A, Fujiyama A, Oginuma M, Suzuki H, Sado T, Nakano T, Sasaki H
    • Journal Title

      Genome Res

      Volume: 23 Issue: 2 Pages: 292-299

    • DOI

      10.1101/gr.137224.112

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development. Nucl2013

    • Author(s)
      Ichiyanagi, T., Ichiyanagi, K., Miyake, M. & Sasaki, H
    • Journal Title

      Acids Res

      Volume: 41 Issue: 2 Pages: 738-745

    • DOI

      10.1093/nar/gks1117

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases.2013

    • Author(s)
      Shirane, K., et al
    • Journal Title

      PLoS Genet.

      Volume: (in press)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An atomic model of ZFP57 recognition of CpG methylation within a specific DNA sequence2012

    • Author(s)
      Liu, Y., Toh, H., Sasaki, H., Zhang, X. & Cheng, X
    • Journal Title

      Genes Dev

      Volume: 26 Issue: 21 Pages: 2374-2379

    • DOI

      10.1101/gad.202200.112

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice2012

    • Author(s)
      Takahashi, T., Matsuzaki, H., Tomizawa, S., Okamura, E., Ichiyanagi, T., Fukamizu, A., Sasaki, H. & Tanimoto, K
    • Journal Title

      Gene

      Volume: 508 Issue: 1 Pages: 26-34

    • DOI

      10.1016/j.gene.2012.07.062

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genomic imprinting and its relevance to congenital disease, infertility, molar pregnancy and induced pluripotent stem cells2012

    • Author(s)
      Tomizawa, S. & Sasaki, H
    • Journal Title

      J. Hum. Genet

      Volume: 57 Issue: 2 Pages: 84-91

    • DOI

      10.1038/jhg.2011.151

    • NAID

      10030711407

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Active role of small non-coding RNAs derived from SINE/B1 retrotransposon during early mouse development2012

    • Author(s)
      Ohnishi, Y., Totoki, Y., Toyoda, A., Watanabe, T., Yamamoto, Y., Tokunaga, K., Sakaki, Y., Sasaki, H. & Hohjoh, H
    • Journal Title

      Mol. Biol. Rep

      Volume: 39 Issue: 2 Pages: 903-909

    • DOI

      10.1007/s11033-011-0815-1

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Re-investigation and RNA sequencing-based identification of genes with placenta-specific imprinted expression2012

    • Author(s)
      Hiroaki Okae, et al
    • Journal Title

      Human Molecular Genetics

      Volume: 21 Issue: 3 Pages: 548-558

    • DOI

      10.1093/hmg/ddr488

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Locus- and domain-dependent control of DNA methylation at mouse B1 retrotransposons during male germ cell development2011

    • Author(s)
      Ichiyanagi, T., Fukuda, K., Kitayama, J., Yamamoto, Y., Kuramochi-Miyagawa, S., Nakano, T., Yabuta, Y., Seki, Y., Saitou, M., & Sasaki, H
    • Journal Title

      Genome Res

      Volume: 21 Issue: 12 Pages: 2058-2066

    • DOI

      10.1101/gr.123679.111

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus2011

    • Author(s)
      Watanabe, T., Tomizawa, S., Mitsuya, K., Totoki, Y., Yamamoto, Y., Kuramochi-Miyagawa, S., Iida, N., Hoki, Y., Murphy, P.J., Toyoda, A., Gotoh, K., Hiura, H., Arima, T., Fujiyama, A., Sado, T., Shibata, T., Nakano, T., Lin, H., Ichiyanagi, K., Soloway, P.D., Sasaki, H
    • Journal Title

      Science

      Volume: 332 Issue: 6031 Pages: 848-52

    • DOI

      10.1126/science.1203919

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic imprinting in mammals: its life cycle, molecular mechanisms and reprogramming2011

    • Author(s)
      Li, Y. & Sasaki, H
    • Journal Title

      Cell Res

      Volume: 21 Issue: 3 Pages: 466-473

    • DOI

      10.1038/cr.2011.15

    • NAID

      120004951578

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] MitoPLD Is a Mitochondrial Protein Essential for Nuage Formation and piRNA Biogenesis in the Mouse Germline2011

    • Author(s)
      Watanabe T, et al
    • Journal Title

      Dev Cell

      Volume: 20 Issue: 3 Pages: 364-375

    • DOI

      10.1016/j.devcel.2011.01.005

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic stage-specific changes of imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes2011

    • Author(s)
      Tomizawa, S., Kobayashi, H., Watanabe, T., Andrews, S., Hata, K., Kelsey, G. & Sasaki, H
    • Journal Title

      Development

      Volume: 138 Issue: 5 Pages: 811-820

    • DOI

      10.1242/dev.061416

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] MitoPLD is a mitochondrialprotein essential for nuage formationand piRNA biogenesis in the mousegermline2011

    • Author(s)
      Watanabe, T, Chuma, S, Yamamoto, Y, Kuramochi-Miyagawa, S, Totoki, Y, Toyoda, A, Hoki, Y, Fujiyama, A, Shibata, T, Sado, T, Noce, T, Nakano, T, Nakatsuji, N, Lin, H, Sasaki, H.
    • Journal Title

      Dev Cell 20

      Pages: 364-375

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Dynamic stage-specific changes of imprinted differentially methylated regions during early mammalian development and prevalence of non-CpGmethylation in oocytes.2011

    • Author(s)
      Tomizawa, S, Kobayashi, H, Watanabe, T, Andrews, S, Hata, K, Kelsey, G, Sasaki, H.
    • Journal Title

      Development 138

      Pages: 811-829

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Genomic imprinting in mammals : its life cycle, molecular mechanisms and reprogramming.2011

    • Author(s)
      Li, Y., Sasaki, H.
    • Journal Title

      Cell Res

      Volume: 21 Pages: 466-473

    • NAID

      120004951578

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic stage-specific changes of imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes.2011

    • Author(s)
      Tomizawa, S., et al
    • Journal Title

      Development

      Volume: 138 Pages: 811-829

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MitoPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.2011

    • Author(s)
      Watanabe, T., et al
    • Journal Title

      Dev.Cell

      Volume: 20 Pages: 364-375

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targets and dynamics of promoter DNA methylation during early mouse development2010

    • Author(s)
      Borgel, J., Guibert, S., Li, Y., Chiba, H., Schuebeler, D., Sasaki, H., Forne, T. & Weber, M
    • Journal Title

      Nat. Genet

      Volume: 42 Issue: 12 Pages: 1093-1100

    • DOI

      10.1038/ng.708

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development. Nucl2010

    • Author(s)
      Ohnishi, Y., Totoki, Y., Toyoda, A., Watanabe, T., Yamamoto, Y., Tokunaga, K., Sakaki, Y., Sasaki, H. & Hohjoh, H
    • Journal Title

      Acids Res

      Volume: 38 Issue: 15 Pages: 5141-5151

    • DOI

      10.1093/nar/gkq229

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip2010

    • Author(s)
      Hiura, H., Sugawara, A., Ogawa, H., John, R., Miyauchi, N., Miyanari, Y., Horiike, T., Li, Y., Yaegashi, N., Sasaki, H., Kono, T. & Arima, T
    • Journal Title

      Nucl. Acids Res

      Volume: 38 Issue: 15 Pages: 4929-4945

    • DOI

      10.1093/nar/gkq200

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] MVH in piRNA processing and gene silencing of retrotransposons2010

    • Author(s)
      Kuramochi-Miyagawa, S., Watanabe, T., Gotoh, K., Takamatsu, K., Chuma, S., Kojima-Kita, K., Shiromoto, Y., Asada, N., Kimura, T., Nakatsuji, N., Noce, T., Sasaki, H. & Nakano, T
    • Journal Title

      Genes Dev

      Volume: 24 Issue: 9 Pages: 887-892

    • DOI

      10.1101/gad.1902110

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic evidence for Dnmt3a-dependent imprinting during oocyte growth obtained by conditional knockout with Zp3-Cre and complete exclusion of Dnmt3b by chimera formation2010

    • Author(s)
      Kaneda, M., Hirawasa, R., Chiba, H., Okano, M., Li, E. & Sasaki, H
    • Journal Title

      Genes Cells

      Volume: 15 Pages: 169-179

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targets and dynamics of promoter DNA methylation during early mouse development.2010

    • Author(s)
      Borgel, J, Guibert, S, Li, Y, Chiba, H, Schuebeler, D, Sasaki, H, Forne, T, Weber, M.
    • Journal Title

      Nat Genet 42

      Pages: 1093-1100

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] MVH in piRNA processing and gene silencing of retrotransposons2010

    • Author(s)
      Kuramochi-Miyagawa, S, Watanabe, T, Gotoh, K, Takamatsu, K, Chuma, S, Kojima-Kita, K, Shiromoto, Y, Asada, N, Kimura, T, Nakatsuji, N, Noce, T, Sasaki, H, Nakano, T.
    • Journal Title

      Genes Dev 24

      Pages: 887-892

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] MVH in piRNA processing and gene silencing of retrotransposons.2010

    • Author(s)
      Kuramochi-Miyagawa, S., et al
    • Journal Title

      Genes Dev

      Volume: 24 Pages: 887-892

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted do main on mouse chromosome 1 identified by meDIP-on-chip.2010

    • Author(s)
      Hiura, H., et al
    • Journal Title

      Nucl.Acids Res

      Volume: 38 Pages: 4929-4945

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development.2010

    • Author(s)
      Ohnishi, Y., et al
    • Journal Title

      Nucl.Acids Res

      Volume: 38 Pages: 5141-5151

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targets and dynamics of promoter DNA methylation during early mouse development.2010

    • Author(s)
      Borgel, J., et al
    • Journal Title

      Nat.Genet

      Volume: 42 Pages: 1093-1100

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MVH in piRNA processing and gene silencing of retrotransposons2010

    • Author(s)
      Kuramochi-Miyagawa, S.et al
    • Journal Title

      Genes Dev. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic evidence for Dnmt3a-dependent imprinting during oocyte growth obtained by conditional knockout with Zp3-Cre and complete exclusion of Dnmt3b by chimera formation2010

    • Author(s)
      Kaneda, M.et al
    • Journal Title

      Genes Cells (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline2009

    • Author(s)
      Shoji, M., Tanaka, T., Hosokawa, M., Reuter, M., Stark, A., Kato, Y., Kondoh, G., Okawa, K., Chujo, T., Suzuki, T., Hata, K., Martin, S.L., Noce, T., Kuramochi-Miyagawa, S., Nakano, T., Sasaki, H., Pillai, R.S., Nakatsuji, N. & Chuma, S
    • Journal Title

      Dev. Cell

      Volume: 17 Pages: 775-787

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conditional knockdown of Nanog induces apoptotic cell death in mouse migrating primordial germ cells2009

    • Author(s)
      Yamaguchi, S., Kurimoto, K., Yabuta, Y., Sasaki, H., Nakatsuji, N., Saitou, M. & Tada, T
    • Journal Title

      Development

      Volume: 136 Issue: 23 Pages: 4011-4020

    • DOI

      10.1242/dev.041160

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal DNA methyltransferase expression in mouse germline Stem Cells results in spermatogenic defects2009

    • Author(s)
      Takashima, S.,Takehashi, M.,Lee, J., Chuma, S., Okano, M., Hata, K., Suetake, I., Nakatsuji, N.,Miyoshi, H., Tajima, S., Sasaki, H., Kanatsu-Shinohara, M. and Shinohara, T
    • Journal Title

      Biol. Reprod

      Volume: 81 Issue: 1 Pages: 155-164

    • DOI

      10.1095/biolreprod.108.074708

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 22009

    • Author(s)
      Kobayashi H, Yamada K, Morita S, Hiura H, Fukuda A, Kagami M, Ogata T, Hata K, Sotomaru Y, Kono T
    • Journal Title

      Genomics

      Volume: 93(5) Issue: 5 Pages: 461-47

    • DOI

      10.1016/j.ygeno.2008.12.012

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histone methylation is mechanistically linked to DNA methylation at imprinting control regions in mammals2009

    • Author(s)
      Henckel, A., Nakabayashi, K., Sanz, LA., Feil, R., Hata, K. & Arnaud, P
    • Journal Title

      Hum Mol Genet

      Volume: 18 Issue: 18 Pages: 3375-83

    • DOI

      10.1093/hmg/ddp277

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic transition of Dnmt3b expression in mouse pre- and early post-implantation embryos2009

    • Author(s)
      Hirasawa, R. & Sasaki, H
    • Journal Title

      Gene Expr. Patt

      Volume: 9 Issue: 1 Pages: 27-30

    • DOI

      10.1016/j.gep.2008.09.002

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mousemale germline2009

    • Author(s)
      Shoji, M, Tanaka, T, Hosokawa, M, Reuter, M, Stark, A, Kato, Y, Kondoh, G, Okawa, K, Chujo, T, Suzuki, T, Hata, K, Martin, SL, Noce, T, Kuramochi-Miyagawa, S, Nakano, T, Sasaki, H, Pillai, RS, Nakatsuji, N, Chuma, S.
    • Journal Title

      Dev Cell 17

      Pages: 775-787

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline2009

    • Author(s)
      Shoji, M.et al
    • Journal Title

      Dev.Cell 17

      Pages: 775-787

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conditional knockdown of Nanog induces apoptotic cell death in mouse migrating primordial germ cells2009

    • Author(s)
      Yamaguchi, S.et al
    • Journal Title

      Development 136

      Pages: 4011-4020

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects2009

    • Author(s)
      Takashima, S.et al
    • Journal Title

      Biol Reprod. 81

      Pages: 155-164

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline2009

    • Author(s)
      Shoji, M.et al
    • Journal Title

      Dev Cell. 17

      Pages: 775-787

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 22009

    • Author(s)
      Kobayashi, H.et al
    • Journal Title

      Genomics. 93

      Pages: 461-472

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone methylation is mechanistically linked to DNA methylation at imprinting control regions in mammals2009

    • Author(s)
      Henckel, A.et al
    • Journal Title

      Hum Mol Genet. 18

      Pages: 3375-3383

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 哺乳類のエピジェネティクス2009

    • Author(s)
      佐渡敬, ほか
    • Journal Title

      生物の科学:遺伝 63

      Pages: 65-70

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Dynamic transition of Dnmt3b expression in mouse pre-and early post implantation embryos2009

    • Author(s)
      Hirasawa, R., et.al.
    • Journal Title

      Gene Expr. Patt. 9

      Pages: 27-30

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenesis defects2009

    • Author(s)
      Takashima, S., et.al.
    • Journal Title

      Biol. Reprod. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes2008

    • Author(s)
      Chiba, H., Hirasawa, R., Kaneda, M., Amakawa, Y., Li, E., Sado, T. & Sasaki, H
    • Journal Title

      Genesis

      Volume: 46 Issue: 12 Pages: 768-774

    • DOI

      10.1002/dvg.20496

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development2008

    • Author(s)
      Hirasawa, R., Chiba, H., Kaneda, M., Tajima, S., Li, E., Jaenisch, R. & Sasaki, H
    • Journal Title

      Genes Dev

      Volume: 22 Issue: 12 Pages: 1607-1616

    • DOI

      10.1101/gad.1667008

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes2008

    • Author(s)
      Watanabe, T., Totoki, Y., Toyoda, A., Kaneda, M., Kuramochi-Miyagawa, S., Obata, Y., Chiba, H., Kohara, Y., Kono, T., Nakano, T., Surani, M.A., Sakaki, Y. & Sasaki, H
    • Journal Title

      Nature

      Volume: 453 Pages: 539-543

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes2008

    • Author(s)
      Kuramochi-Miyagawa, S., Watanabe, T., Gotoh, K., Totoki, Y., Toyoda, A., Ikawa, M., Asada, N., Kojima, K., Yamaguchi, Y., Ijiri, T., Hata, K., Li, E., Matsuda, Y., Kimura, T., Okabe, M., Sakaki, Y., Sasaki, H. & Nakano, T
    • Journal Title

      Genes Dev

      Volume: 22 Issue: 7 Pages: 908-917

    • DOI

      10.1101/gad.1640708

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Maternal and zygotic Dnmt1 are necessaryand sufficient for the maintenance of DNA methylation imprints during preimplantation development.2008

    • Author(s)
      Hirasawa, R, Chiba, H, Kaneda, M, Tajima, S, Li, E, Jaenisch, R, Sasaki, H.
    • Journal Title

      Genes Dev 22

      Pages: 1607-1616

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Endogenous siRNAs from naturally for medds RNAs regulate transcripts in mouse oocytes.2008

    • Author(s)
      Watanabe, T, Totoki, Y, Toyoda, A, Kaneda, M, Kuramochi-Miyagawa, S, Obata, Y, Chiba, H, Kohara, Y, Kono, T, Nakano, T, Surani, MA, Sakaki, Y, Sasaki, H.
    • Journal Title

      Nature 453

      Pages: 539-543

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes.2008

    • Author(s)
      Kuramochi-Miyagawa, S, Watanabe, T, Gotoh, K, Totoki, Y, Toyoda, A, Ikawa, M, Asada, N, Kojima, K, Yamaguchi, Y, Ijiri, T, Hata, K, Li, E, Matsuda, Y, Kimura, T, Okabe, M, Sakaki, Y, Sasaki, H, Nakano, T.
    • Journal Title

      Genes Dev 22

      Pages: 908-917

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes2008

    • Author(s)
      Kuramochi-Miyagawa, S., et.al.
    • Journal Title

      Genes Dev. 22

      Pages: 908-917

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes2008

    • Author(s)
      Watanabe, T., et.al.
    • Journal Title

      Nature 453

      Pages: 539-543

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development2008

    • Author(s)
      Hirasawa, R., et.al.
    • Journal Title

      Genes Dev. 22

      Pages: 1607-1616

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes2008

    • Author(s)
      Chiba, H., et.al.
    • Journal Title

      Genesis 46

      Pages: 768-774

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ゲノムインプリンティング2008

    • Author(s)
      平澤竜太郎ほか
    • Journal Title

      生体の科学(増大特集)現代医学・生物学の仮説・学説2008 59

      Pages: 402-403

    • Related Report
      2008 Annual Research Report
  • [Journal Article] カレントトピックス : マウス卵子において内在性siRNAは自然に形成される二本鎖RNAから作られ、転写物を制御している2008

    • Author(s)
      渡部聡朗
    • Journal Title

      実験医学 26

      Pages: 2109-2111

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus.

    • Author(s)
      Watanabe, T, Tomizawa, S, Mitsuya, K, Totoki, Y, Yamamoto, Y, Kuramochi-Miyagawa, S, Iida, N, Hoki, Y, Murphy, PJ, Toyoda, A, Gotoh, K, Hiura, H, Arima, T, Fujiyama, A, Sado, T, Shibata, T, Nakano, T, Lin, H, Ichiyanagi, K, Soloway, PD, Sasaki, H.
    • Journal Title

      Science in press

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Presentation] 次世代遺伝子解析技術を用いた生殖発生異常のゲノム研究2012

    • Author(s)
      秦健一郎
    • Organizer
      第30回日本受精着床学会学術講演会
    • Place of Presentation
      大阪国際会議場(グランキューブ大阪)(招待講演)
    • Year and Date
      2012-08-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] The regulatory network of small RNAs and DNA methylation in mouse germ cells revealed by high-throughput sequencing combined with genetic studies2012

    • Author(s)
      Sasaki, H.
    • Organizer
      Computational Biology Research Center Workshop 2011, AIST
    • Place of Presentation
      産業技術総合研究所(東京)(招待講演)
    • Year and Date
      2012-01-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNAメチル化と小分子RNAの網羅的解析がもたらす新発見2011

    • Author(s)
      佐々木裕之
    • Organizer
      第34回日本分子生物学会年会バイオテクノロジーセミナー
    • Place of Presentation
      パシフィコ横浜(神奈川)(招待講演)
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNAメチル化に依らないゲノムインプリンティング2011

    • Author(s)
      千葉初音, 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of small RNAs in shaping the epigenome of germ cells for genome defense and imprinting2011

    • Author(s)
      Sasaki, H.
    • Organizer
      第27回国際生物学賞記念シンポジウム
    • Place of Presentation
      京都ガーデンパレス(京都)(招待講演)
    • Year and Date
      2011-11-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] The regulatory network of small RNAs and DNA methylation in mouse germ cells2011

    • Author(s)
      Sasaki, H.
    • Organizer
      EpiGeneSys 1st Annual Meeting, IMBA
    • Place of Presentation
      Institute fur Molekulare Biotechnologie GmbH, Vienna, Austria(招待講演)
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Germline small RNA and imprinting2011

    • Author(s)
      Sasaki, H.
    • Organizer
      ICC on Genomic Imprinting and Beyond 2011
    • Place of Presentation
      Institut d'Estudis Catalans, Barcelona, Spain(招待講演)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of small RNAs in shaping the epigenome of germ cells for genome defense and imprinting2011

    • Author(s)
      Sasaki, H.
    • Organizer
      KEY Forum in Developmental Biology and Regenerative Medicine
    • Place of Presentation
      熊本大学工学部百周年記念館(熊本)(招待講演)
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 哺乳類生殖細胞の小分子RNAとエピゲノム制御Small RNA and epigenomic regulation in mammalian germ cells2011

    • Author(s)
      佐々木裕之
    • Organizer
      第3回日本RNAi研究会
    • Place of Presentation
      グランドプリンスホテル広島(広島)(招待講演)
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mammalian germline small RNAs and epigenetic programming. Gordon Research Conference (Epigenetics)2011

    • Author(s)
      Sasaki, H
    • Organizer
      Easton
    • Place of Presentation
      MA, USA
    • Year and Date
      2011-08-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Mammalian germline small RNAs and epigenetic programming2011

    • Author(s)
      Sasaki, H.
    • Organizer
      Gordon Research Conferences (Epigenetics)
    • Place of Presentation
      Stonehill College, Easton, MA (USA)(招待講演)
    • Year and Date
      2011-08-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of epigenetics and small RNAs in genome defense and developmental control in mammalian germ cell2011

    • Author(s)
      Sasaki, H.
    • Organizer
      The 6^<th> International Symposium of InstituteNetwork and the 10^<th> Surugadai International Symposium, Joint Usage/Research Program of Medical Research Institute International Symposium
    • Place of Presentation
      東京医科歯科大学鈴木章夫記念講堂(東京)(招待講演)
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of Small RNAs in Shaping the Epigenome of Germ Cells for Genome Defense and Imprinting2011

    • Author(s)
      Sasaki, H.
    • Organizer
      6th Asian Epigenomics Meeting
    • Place of Presentation
      KKRホテル熊本(熊本)(招待講演)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生殖細胞のエピゲノムと小分子RNA2010

    • Author(s)
      佐々木裕之
    • Organizer
      第4回 がん・エピゲノム研究会
    • Place of Presentation
      仙台
    • Year and Date
      2010-12-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生殖細胞のエピゲノムと小分子RNA2010

    • Author(s)
      佐々木裕之
    • Organizer
      エピゲノム研究の最先端
    • Place of Presentation
      東京
    • Year and Date
      2010-11-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role for Piwi-interacting RNA and a novel noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus in the germline.2010

    • Author(s)
      Sasaki, H., Watanabe, T.
    • Organizer
      Cold Spring Harbor Asia Meeting on Epigenetics, Chromatin & Transcription.
    • Place of Presentation
      Suzhou, China.
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Role for Piwi-interacting RNA and a novel noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus in the germline2010

    • Author(s)
      Sasaki, H., Watanabe, T.
    • Organizer
      Epigenetics, Chromatin & Transcription
    • Place of Presentation
      Suzhou, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role for Piwi-interacting RNA and a novel noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus in the germline2010

    • Author(s)
      Sasaki, H.
    • Organizer
      第43回 日本発生生物学会年会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] Epigenetics and small RNA systems in mammalian male germ cells2010

    • Author(s)
      Sasaki, H.
    • Organizer
      11th International Symposium on Spermatology
    • Place of Presentation
      Okinawa
    • Related Report
      2010 Annual Research Report
  • [Presentation] Epigenetics in human disorder2010

    • Author(s)
      佐々木裕之
    • Organizer
      第16回 日本遺伝子治療学会学術集会
    • Place of Presentation
      宇都宮
    • Related Report
      2010 Annual Research Report
  • [Presentation] 哺乳類生殖細胞のエピジェネティクスと小分子RNA2010

    • Author(s)
      佐々木裕之
    • Organizer
      第6回 日本先天代謝異常学会セミナー
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] Small RNAs, retrotransposons and genomic imprinting in the mammalian germline2010

    • Author(s)
      Sasaki, H., Watanabe, T.
    • Organizer
      The 20th hot Spring Harbor Symposium and joint with the 6th Global COE International Symposium
    • Place of Presentation
      Fukuoka
    • Related Report
      2010 Annual Research Report
  • [Presentation] 哺乳類生殖細胞のエピジェネティクスと小分子RNA2010

    • Author(s)
      佐々木裕之
    • Organizer
      第5回 認識と形成研究会
    • Place of Presentation
      阿蘇
    • Related Report
      2010 Annual Research Report
  • [Presentation] 哺乳類生殖細胞におけるゲノムインプリンティング制御2010

    • Author(s)
      佐々木裕之
    • Organizer
      日本遺伝学会 第82回大会
    • Place of Presentation
      札幌
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genomic imprinting and small RNAs in mammalian germ cells2010

    • Author(s)
      Sasaki, H.
    • Organizer
      The 16th International Conference of the International Society of Differentiation
    • Place of Presentation
      Nara
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genomic imprinting, DNA methylation and small RNA in male germ cell development2010

    • Author(s)
      Sasaki, H., Watanabe, T.
    • Organizer
      International Symposium on "Epigenome Network, Development and Reprogramming of Germ Cells
    • Place of Presentation
      Fukuoka
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genomic imprinting and small RNAs in the mammalian germ cells2010

    • Author(s)
      Sasaki, H.
    • Organizer
      第33回日本分子生物学会年会,第83回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] The epigenome and functional small RNAs2010

    • Author(s)
      佐々木裕之
    • Organizer
      Korea-Japan Chromatin & Epigenetics Joint Symposlum 2010
    • Place of Presentation
      Hoengseong Gun, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] 哺乳類生殖細胞のエピジェネティクスと小分子RNA2009

    • Author(s)
      佐々木裕之
    • Organizer
      第7回RCGMフロンティアシンポジウム"未来医療のためのゲノム医学研究"
    • Place of Presentation
      埼玉
    • Year and Date
      2009-11-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roles of genomic imprinting in reproduction2009

    • Author(s)
      秦健一郎
    • Organizer
      The 7th Conference of the Pacific Rim Society for Fertility and Sterility
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2009-08-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胎児・胎盤分化発育異常のエピジェネティクス-網羅的ゲノム・エピゲノム解析の試み-2009

    • Author(s)
      秦健一郎
    • Organizer
      日本周産期新生児学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-07-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] エピジェネティクスが拓く生命科学2009

    • Author(s)
      佐々木裕之
    • Organizer
      2009 Millipore Asia BioForum 幹細胞およびエピジェネティクス研究の最前線
    • Place of Presentation
      東京
    • Year and Date
      2009-06-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Epigenetics and small RNAs in mammalian germ cells2009

    • Author(s)
      佐々木裕之
    • Organizer
      TriRhena Chromatin/Transcription Club Meeting, Freiburg
    • Place of Presentation
      Freiburg, Germany
    • Year and Date
      2009-05-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genomic imprinting, DNA methylation and small RNAs in mammalian germ cells2009

    • Author(s)
      Sasaki, H.
    • Organizer
      Gordon Research Conference "Epigenetics- The Role of the Environment and Epigenetic Mechanisms in Bahavior, Health, and Disease", Holderness
    • Place of Presentation
      NH, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Imprinting, DNA methylation and small RNA in germ cells2009

    • Author(s)
      Sasaki, H
    • Organizer
      Cold Spring Harbor Laboratory/Wellcome Trust Joint Conference "Mouse Genetics & Genomics: Development & Disease"
    • Place of Presentation
      Hinxton, UK
    • Related Report
      2012 Final Research Report
  • [Presentation] Genomic imprinting, DNA methylation and small RNAs in mammaliangerm cells.2009

    • Author(s)
      Sasaki, H.
    • Organizer
      Gordon Research Conferenceon Epigenetics-The Role of the Environment and Epigenetic Mechanisms
    • Place of Presentation
      Holderness, NH, USA.
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] The epigenome and small RNA repertoire in mammalian germ cells.2009

    • Author(s)
      Sasaki, H.
    • Organizer
      EMBO Conference Series on Chromatin and Epigenetics
    • Place of Presentation
      Heidelberg, Germany.
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] The epigenome and small RNA repertoire in mammalian germ cells2009

    • Author(s)
      佐々木裕之
    • Organizer
      EMBO Conference Series on Chromatin and Epigenetics
    • Place of Presentation
      Heidelberg, Germany
    • Related Report
      2009 Annual Research Report
  • [Presentation] The epigenome and small RNA repertoire in mammalian germ cells2009

    • Author(s)
      佐々木裕之
    • Organizer
      The 24th Naito Conference on Nuclear Dynamics and RNA[II]
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] 発生・成長におけるエピジェネティクス2009

    • Author(s)
      佐々木裕之
    • Organizer
      第13回小児分子内分泌研究会
    • Place of Presentation
      函館
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生殖細胞のエピゲノムと機能性RNA2009

    • Author(s)
      佐々木裕之
    • Organizer
      第33回阿蘇シンポジウム生命科学のフロントランナー
    • Place of Presentation
      熊本
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genomic imprinting, DNA methylation and small RNAs in mammalian germ cells2009

    • Author(s)
      佐々木裕之
    • Organizer
      Gordon Research Conference "Epigenetics-The Role of the Environment and Epigenetic Mechanisms in Behavior, Health, and Disease"
    • Place of Presentation
      Holderness, NH, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Imprinting, DNA methylation and small RNA in germ cells2009

    • Author(s)
      佐々木裕之
    • Organizer
      Cold Spring Harbor Laboratory/Wellcome Trust Joint Conference "Mouse Genetics & Genomics : Development & Disease"
    • Place of Presentation
      Hinxton, UK.
    • Related Report
      2009 Annual Research Report
  • [Presentation] 次世代シークエンサーによる機能性小分子RNAの網羅的解析2009

    • Author(s)
      佐々木裕之
    • Organizer
      日本遺伝学会第81回大会
    • Place of Presentation
      松本
    • Related Report
      2009 Annual Research Report
  • [Presentation] ゲノムインプリンティングのエピゲノム機構に関する研究2009

    • Author(s)
      佐々木裕之
    • Organizer
      日本人類遺伝学会第54回大会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] シンポジウム "Emerging power of epigenomics in life science"2009

    • Author(s)
      佐々木裕之
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Endogenous siRNAs derived from naturally formed dsRNAs regulate transcripts in mouse oocytes2008

    • Author(s)
      佐々木裕之ほか
    • Organizer
      第60回日本細胞生物学会大会シンポジウム「分化とepigenetic制御」
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Endogenous siRNAs derived from naturally formed dsRNAs regulate coding-transcripts and retrotransposons in mouse oocytes2008

    • Author(s)
      Sasaki, H.
    • Organizer
      The 2nd Shanghai Symposium on Epigenetics in Development and Diseases/the 3rd Annual Meeting of Asian Epigenome Alliance
    • Place of Presentation
      Shanghai
    • Related Report
      2008 Annual Research Report
  • [Presentation] Endogenous siRNAs derived from naturally formed dsRNAs regulate coding-transcripts and retrotransposons in mouse oocytes2008

    • Author(s)
      Sasaki, H.
    • Organizer
      International Conference on Epigenetics 2008
    • Place of Presentation
      Berlin
    • Related Report
      2008 Annual Research Report
  • [Presentation] 内在性siRNAはマウスの卵子において自然に形成される二本鎖RNAから作られ、遺伝子やレトロトランスポゾンを制御する2008

    • Author(s)
      佐々木裕之ほか
    • Organizer
      日本遺伝学会第80回大会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gametogenesis and imprinting in mice2008

    • Author(s)
      Sasaki, H.
    • Organizer
      EMBO Workshop on Genomic Imprinting
    • Place of Presentation
      Singapore
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生殖細胞の発生・リプログラミングとエピジェネティクス2008

    • Author(s)
      佐々木裕之
    • Organizer
      日本人類遺伝学会第53回大会
    • Place of Presentation
      横浜(シンポジウム)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 哺乳類の生殖細胞系列におけるゲノムインプリンティングのプログラム機構2008

    • Author(s)
      佐々太裕之
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸(シンポジウム)
    • Related Report
      2008 Annual Research Report
  • [Presentation] The epigenome and small RNA repertoire in mammalian germ cells2008

    • Author(s)
      Sasaki, H.
    • Organizer
      International Symposium Decoding Epigenetic Code
    • Place of Presentation
      Tokyo
    • Related Report
      2008 Annual Research Report
  • [Book] 卵子学2011

    • Author(s)
      佐々木裕之
    • Publisher
      京都大学学術出版会
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Book] 4章.ゲノムの高度活用戦術-エピジェネティクス.現代生物科学入門1ゲノム科学の基礎2009

    • Author(s)
      佐々木裕之
    • Publisher
      岩波書店
    • Related Report
      2012 Final Research Report
  • [Book] Genomic imprinting and X chromosome inactivation in germ cell development. Genetic and Epinenetic Control of Mammalian Germ Cell Development and Function (ed. Nozaki, M)2009

    • Author(s)
      Kaneda, M. & Sasaki, H.
    • Publisher
      Research Signopost
    • Related Report
      2012 Final Research Report
  • [Book] 現代生物科学入門-1ゲノム科学の基礎(浅島誠, 黒岩常祥, 小原雄治編)(4章ゲノムの高度活用戦略-エピジェネティクス)2009

    • Author(s)
      佐々木裕之
    • Publisher
      岩波書店
    • Related Report
      2010 Self-evaluation Report
  • [Book] 4章.ゲノムの高度活用戦略-エピジェネティクス. 現代生物科学入門1ゲノム科学の基礎(浅島誠, 黒岩常祥, 小原雄治編)2009

    • Author(s)
      佐々木裕之
    • Publisher
      岩波書店
    • Related Report
      2009 Annual Research Report
  • [Book] Genomic imprinting and X chromosome inactivation in germ cell development. Genetic and Epigenetic Control of Mammalian Germ Cell Development and Function(ed.Nozaki, M.)2009

    • Author(s)
      Kaneda, M.et al
    • Publisher
      Research Signpost
    • Related Report
      2009 Annual Research Report
  • [Book] 生殖細胞分化とエピジェネティクス.転写制御の分子生物学-ゲノムデコードに向けて(加藤茂明編)2008

    • Author(s)
      平澤竜太郎ほか
    • Publisher
      南山堂
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.bioreg.kyushu-u.ac.jp/labo/epigenome/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.brc.riken.go.jp/lab/mcd/germline/index.html#

    • Related Report
      2012 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.bioreg.kyushu-u.ac.jp/labo/epigenome/

    • Related Report
      2011 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.bioreg.kyushu-u.ac.jp/labo/epigenome/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.nig.ac.jp/labs/HumGen/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.nig.ac.jp/labs/HumGen/index.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2019-07-29  

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