| Budget Amount *help |
¥63,500,000 (Direct Cost: ¥63,500,000)
Fiscal Year 2012: ¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2011: ¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2010: ¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2009: ¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2008: ¥12,700,000 (Direct Cost: ¥12,700,000)
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| Research Abstract |
We clarified the mechanism underlying the specification of primordial germ cells (PGCs), the precursors both for spermatozoa and oocytes, in mice. Based on the knowledge obtained, we succeeded in reconstituting mouse germ cell specification pathway in culture by pluripotent stem cells including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). The induced PGC-like cells contributed to spermatozoa and oocytes, and to fertile offspring. We also clarified the role of PRDM14 in the maintenance of pluripotency in mouse ESCs.
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