| Budget Amount *help |
¥109,000,000 (Direct Cost: ¥109,000,000)
Fiscal Year 2012: ¥24,200,000 (Direct Cost: ¥24,200,000)
Fiscal Year 2011: ¥24,200,000 (Direct Cost: ¥24,200,000)
Fiscal Year 2010: ¥20,200,000 (Direct Cost: ¥20,200,000)
Fiscal Year 2009: ¥20,200,000 (Direct Cost: ¥20,200,000)
Fiscal Year 2008: ¥20,200,000 (Direct Cost: ¥20,200,000)
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| Research Abstract |
The germ cell genome can acquire totipotency, the genomic state of early fertilized embryos. To obtain clues to understanding the mechanisms of acquisition of totipotency by the germ cells, the epigenetic characteristics in the embryos reconstructed with different donor cell nuclei during the life cycle were analyzed using the mouse as the model. The results indicated that mature MII oocytes could reprogram all the epigenetic modifications with only some exceptions including a certain histone tail methylation.
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