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Studies on developmental programs of embryonic stem cells and germ cells in mice

Planned Research

Project AreaThe germline: its developmental cycle and epigenome network
Project/Area Number 20062013
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

ABE Kuniya  独立行政法人理化学研究所, 動物変異動態解析技術開発チーム, チームリーダー (40240915)

Co-Investigator(Kenkyū-buntansha) MISE Natan  独立行政法人理化学研究所, 動物変異動態解析技術開発チーム, 開発研究員 (00360644)
SUGIMOTO Michihiko  独立行政法人理化学研究所, 動物変異動態解析技術開発チーム, 開発研究員 (10373317)
FUCHIKAMI Takuya  独立行政法人理化学研究所, 動物変異動態解析技術開発チーム, 開発研究員 (00392100)
Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥100,000,000 (Direct Cost: ¥100,000,000)
Fiscal Year 2012: ¥20,000,000 (Direct Cost: ¥20,000,000)
Fiscal Year 2011: ¥20,000,000 (Direct Cost: ¥20,000,000)
Fiscal Year 2010: ¥20,000,000 (Direct Cost: ¥20,000,000)
Fiscal Year 2009: ¥20,000,000 (Direct Cost: ¥20,000,000)
Fiscal Year 2008: ¥20,000,000 (Direct Cost: ¥20,000,000)
Keywords始原生殖細胞 / ゲノム再プログラム化 / 遺伝子発現 / エピゲノム / DNA メチル化 / 癌精巣抗原遺伝子 / DNAメチル化 / Cancer Testis Antigen / 幹細胞 / エピジェネティクス / 細胞分化 / 多能性幹細胞 / 胚性幹細胞 / 再プログラム化 / X染色体不活性化 / 初期発生 / ES細胞
Research Abstract

We have analyzed gene expression profiles and DNA methylation profiles of cells belong to the cell lineage from pluripotent cells in the blastocyst to primordial germ cells to spermatogonia or oocytes in the mouse. We also investigated changes in X chromosome inactivation status of female cells in this lineage or changes in nuclear architecture during development of these cells. Through these analyses, we gained comprehensive understanding of genes functioning in this cell lineage, and identified developmental transition points in this lineage revealed by large scale changes in gene expression and epigenetic states. We also identified large DNA domains hypomethylated specifically in male germ cells possibly involved in expression regulation of genes contained in these domains. Using a spontaneous developmental mutant affecting one of developmental transitions in this lineage, we found that Vps52 is the essential gene required for growth and differentiation of primitive ectoderm. To achieve the research described above, we developed novel experimental technologies and research resources, which have facilitated active collaborations between research groups belong to this Priority Area.

Report

(7 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (90 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (50 results) (of which Peer Reviewed: 48 results) Presentation (31 results) Book (3 results) Remarks (6 results)

  • [Journal Article] Max is a repressor of germ-cell-related gene expression in mouse embryonic stem cells2013

    • Author(s)
      Maeda, I., Okamura, D., Tokitake, Y., Ikeda, M, Kawaguchi, H., Mise, N., Abe, K., Noce, T., Okuda, A, Matsui, Y
    • Journal Title

      Nature Communications

      Volume: 4 Issue: 1 Pages: 1754-1754

    • DOI

      10.1038/ncomms2780

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Generation of a novel germline stem cell line expressing a germline-specific reporter in the mouse.2013

    • Author(s)
      Shiura, H., Ikeda, R., Lee, J., Sato, T., Ogonuki, N., Hirose, M., Ogura, A., Ogawa, T., Abe, K.
    • Journal Title

      genesis

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] RNAi-mediated knockdown of Xist does not rescue the impaired development of female cloned mouse embryos.2013

    • Author(s)
      Oikawa. M. Matoba, S., Inoue, K., Kamimura, S., Hirose, M., Ogonuki, N., Shiura, H., Sugimoto, M., Abe, K., Ishino, F. and Ogura, A.
    • Journal Title

      J. Repord. Dev.

      Volume: (in press)

    • NAID

      10031184751

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] RNAi-mediated knockdown of Xist does not rescue the impaired development of female cloned mouse embryos.2013

    • Author(s)
      Oikawa. M., et al.
    • Journal Title

      J. Repord. Dev.

      Volume: (in press)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ectopic expression of Ptf1a induces spinal defects, urogenital defects and anorectal malformations in Danforth's short tail mice.2012

    • Author(s)
      Semba, K., Araki, K., Matsumoto, K.-I., Suda, H., Ando, T. Sei, A., Mizuta, H., Takagi, K., Nakahara, M., Muta, M., Yamada, G., Nakagata, N., Iida, A., Ikegawa, Y., Araki, M., Abe, K. and Yamamura, K.
    • Journal Title

      PLoS Genet.

      Volume: Vol.9 Issue: 2 Pages: 1-17

    • DOI

      10.1371/journal.pgen.1003204

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular identification of t^<w5>: Vps52 promotes pluripotential cell differentiation through cell-cell interactions.2012

    • Author(s)
      Sugimoto, M., Kondo, M., Hirose, M., Suzuki, M., Mekada, K., Abe, T., Kiyonari, H., Ogura, A., Takagi, N., Artzt, K. and Abe, K.
    • Journal Title

      Cell Reports

      Volume: Vol.2 Issue: 5 Pages: 1363-1374

    • DOI

      10.1016/j.celrep.2012.10.004

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell-cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells.2012

    • Author(s)
      Okamura, D., Maeda, I., Taniguchi, H., Tokitake, Y., Ikeda, M., Ozato, K., Mise, N., Abe, K., Noce, T., Belmonte, J.C.I.,Matsui, Y.
    • Journal Title

      Genes Dev.

      Volume: Vol.26 Pages: 2477-2482

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell-cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells2012

    • Author(s)
      Okamura, D., Maeda, I., Taniguchi, H., Tokitake, Y., Ikeda, M., Ozato, K., Mise, N., Abe, K., Noce, T., Izpisua Belmonte, J. C. and Matsui, Y
    • Journal Title

      Genes & Development

      Volume: 26 Issue: 22 Pages: 2477-2482

    • DOI

      10.1101/gad.202242.112

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos2011

    • Author(s)
      Matoba S, et al
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108 Issue: 51 Pages: 20621-20626

    • DOI

      10.1073/pnas.1112664108

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse.2011

    • Author(s)
      Hoki, Y., Ikeda, R., Mise, N., Sakata, Y., Ohhata, T., Sasaki, H., Abe, K., Sado, T.
    • Journal Title

      Development

      Volume: Vol.138 Pages: 2649-2659

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Highly parallel SNP genotyping reveals high-resolution landscape of mono-allelic Ube3a expression associated with locus-wide antisense transcription.2011

    • Author(s)
      Numata, K., Kohama, C., Abe, K., Kiyosawa, H.
    • Journal Title

      Nucleic Acids Res

      Volume: Vol.39 Pages: 2649-2657

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The floor plate is sufficient for development of the sclerotome and spine without notochord2011

    • Author(s)
      Ando, A., et al
    • Journal Title

      Mech.Dev.

      Volume: 128 Issue: 1-2 Pages: 129-140

    • DOI

      10.1016/j.mod.2010.11.005

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse2011

    • Author(s)
      Hoki, Y., et al
    • Journal Title

      Development

      Volume: 138 Issue: 13 Pages: 2649-2659

    • DOI

      10.1242/dev.061226

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive expressional analyses of antisense transcripts in colon cancer tissues using artificial antisense probes2011

    • Author(s)
      Saito, R., et al
    • Journal Title

      BMC Med.Genomics

      Volume: 4 Issue: 1 Pages: 42-42

    • DOI

      10.1186/1755-8794-4-42

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly parallel SNP genotyping reveals high-resolution landscape of mono-allelic Ube3a expression associated with locus-wide antisense transcription2011

    • Author(s)
      Numata K., et al
    • Journal Title

      Nucleic Acids Res.

      Volume: 39 Issue: 7 Pages: 2649-2657

    • DOI

      10.1093/nar/gkq1201

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新しいリサーチツールとしてのバイオイメージング(蛍光イメージングを中心に)2011

    • Author(s)
      阿部訓也
    • Journal Title

      モデル動物利用マニュアル;生命科学研究モデルの作製と利用

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Initiation of trophectoderm lineage specification in mouse embryos is independent of Cdx2.2010

    • Author(s)
      Wu, G., Gentile, L., Fuchikami, T., Sutter, J., Psathaki, K., Esteves, T., Arauzo-Bravo, M.J., Ortmeier, C., Verberk, G., Abe, K., Scholer, H.R.
    • Journal Title

      Development

      Volume: Vol.37 Pages: 4159-4169

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impeding Xist expression from the active X chromosome improves mouse somatic cell cloning.2010

    • Author(s)
      Inoue, K., Kohda, T., Sugimoto, M., Sado, T., Ogonuki, N., Matoba, S., Shiura, H., Ikeda, R., Mochida, K., Fujii, T., Sawai, K., Otte, A.P., Tian, X.C., Yang, X., Ishino, F., Abe, K. and Ogura, A.
    • Journal Title

      Science

      Volume: Vol.330 Pages: 496-499

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide analysis of expression modes and DNA methylation status at sense-antisense transcript loci in mouse.2010

    • Author(s)
      Watanabe, Y., Numata, K., Murata, S., Osada, Y., Saito, R., Nakaoka, H., Yamamoto, N., Watanabe, K., Kato, H., Abe, K. and Kiyosawa, H.
    • Journal Title

      Genomics

      Volume: Vol.96 Pages: 333-341

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of primordial germ cells from mouse induced pluripotent stem cells derived from adult hepatocytes.2010

    • Author(s)
      Imamura, M., Aoi, T., Tokumasu, A., Mise, N., Abe, K., Yamanaka, S., and Noce, T.
    • Journal Title

      Molecular Reproduction and Development

      Volume: Vol.77 Pages: 802-811

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The X-linked imprinted gene family Fthl17 shows predominantly female expression following the two-cell stage in mouse embryos.2010

    • Author(s)
      Kobayashi, S., Fujihara, Y. Mise, N., Kaseda, K., Abe, K., Ishino, F., Okabe, M.
    • Journal Title

      Nucleic Acids Res.

      Volume: Vol.38 Pages: 3672-3681

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variation of melatonin productivity in laboratory mice under2010

    • Author(s)
      Kasahara, T., Abe, K., Mekada, K., Yoshiki, A., Kato, T.
    • Journal Title

      domestication.Proc.Natl.Acad.Sci, USA 107

      Pages: 6412-6417

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] The X-linked imprinted gene family Fth117 shows predominantly female expression following the two-cell stage in mouse embryos2010

    • Author(s)
      Kobayashi, S., Fujihara, Y.Mise, N., Kaseda, K., Abe, K., Ishino, F., Okabe, M.
    • Journal Title

      Nucleic Acids Res 38

      Pages: 3672-3681

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Impeding Xist expression from the active X chromosome improves mouse somatic cell2010

    • Author(s)
      Inoue, K., Kohda, T., Sugimoto, M., Sado, T., Ogonuki, N., Matoba, S., Shiura, H., Ikeda, R., Mochida, K., Fujii, T., Sawai, K., Otte, A.P., Tian, X.C., Yang, X., Ishino, F., Abe, K., Ogura, A.
    • Journal Title

      cloning.Science 330

      Pages: 496-499

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Initiation of trophectoderm lineage specification in mouse embryos is independent of Cdx22010

    • Author(s)
      Wu, G., Gentile, L., Fuchikami, T., Sutter, J., Psathaki, K., Esteves, T., Arauzo-Bravo, M.J., Ortmeier, C., Verberk, G., Abe, K., Scholer, H.R.
    • Journal Title

      Development 37

      Pages: 4159-4169

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Induction of primordial germ cells from mouse induced pluripotent stem cells derived from adult hepatocytes.Molecular2010

    • Author(s)
      Imamura, M., Aoi, T., Tokumasu, A., Mise, N., Abe, K., Yamanaka, S., Noce, T.
    • Journal Title

      Reproduction and Development 77

      Pages: 802-811

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Highly parallel SNP genotyping reveals high-resolution landscape of mono-allelic Ube3a expression associated with locus-wide antisense transcription2010

    • Author(s)
      Numata, K., Kohama, C., Abe, K., Kiyosawa, H.
    • Journal Title

      Nucleic Acids Res. 39

      Pages: 2649-2657

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] The X-linked imprinted gene family Fthl17 shows predominantly female expression following the two-cell stage in mouse embryos.2010

    • Author(s)
      Kobayashi S., et al.
    • Journal Title

      Nucleic Acids Res.

      Volume: 38-11 Pages: 3672-3681

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation.2010

    • Author(s)
      Chow JC., et al.
    • Journal Title

      Cell.

      Volume: 141-6 Pages: 956-969

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of primordial germ cells from mouse induced pluripotent stem cells derived from adult hepatocytes.2010

    • Author(s)
      Imamura M., et al.
    • Journal Title

      Mol Reprod Dev.

      Volume: 77-9 Pages: 802-811

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide analysis of expression modes and DNA methylation status at sense-antisense transcript loci in mouse.2010

    • Author(s)
      Watanabe Y., et al.
    • Journal Title

      Genomics.

      Volume: 96-6 Pages: 333-341

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer.2010

    • Author(s)
      Inoue K., et al.
    • Journal Title

      Science.

      Volume: 330-6003 Pages: 496-499

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Initiation of trophectoderm lineage specification in mouse embryos is in dependent of Cdx2.2010

    • Author(s)
      Wu G., et al.
    • Journal Title

      Development.

      Volume: 137-24 Pages: 4159-4169

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly parallel SNP genotyping reveals high-resolution landscape of mono-allelic Ube3a expression associated with locus-wide antisense transcription.2010

    • Author(s)
      Numata K., et al.
    • Journal Title

      Nucleic Acids Res.

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel endogenous antisense transcripts by DNA microarray analysis targeting complementary strand of annotated genes.2009

    • Author(s)
      Numata, K., Osada, Y., Okada, Y., Saito, R., Hiraiwa, N., Nakaoka, H., Yamamoto, N., Watanabe, K., Okubo, K., Kohama, C., Kanai, A., Abe, K., Kiyosawa, H.
    • Journal Title

      BMC Genomics

      Volume: Vol.10 Issue: 1 Pages: 392-392

    • DOI

      10.1186/1471-2164-10-392

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice.2009

    • Author(s)
      Cao, L., Shitara, H., Sugimoto, M., Hayashi, J.=I., Abe, K., Yonekawa, H.
    • Journal Title

      PLoS genetics

      Volume: Vol5 Issue: 12 Pages: e1000756-e1000756

    • DOI

      10.1371/journal.pgen.1000756

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A high-speed congenic strategy using first-wave male germ cells.2009

    • Author(s)
      Ogonuki N, Inoue K, Hirose M, Miura I, Mochida K, Sato T, Mise N, Mekada K, Yoshiki A, Abe K, Kurihara H, Wakana S, Ogura A
    • Journal Title

      PLoS One

      Volume: 4(3) Issue: 3 Pages: e4943-e4943

    • DOI

      10.1371/journal.pone.0004943

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Large-scale production of growing oocytes from neonatal mouse ovaries.2009

    • Author(s)
      Honda, A., Hirose, M., Inoue, K., Hiura, H., Miki, H., Ogonuki, N., Sugimoto, M., Abe, K., Kanatsu-Shinohara, M., Kono, T., Shinohara, T., Ogura, A.
    • Journal Title

      Int. J. Dev. Biol.

      Volume: Vol.53 Pages: 605-613

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel endogenous antisense transcripts by DNA microarray analysis targeting complementary strand of annotated genes2009

    • Author(s)
      Koji Numata, et.al.
    • Journal Title

      BMC Genomics 10:392

      Pages: 1471-2164

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Large-scale production of growing oocytes in vitro from neonatal mouse ovaries2009

    • Author(s)
      Honda A, et.al.
    • Journal Title

      Int J Dev Biol. 53-4

      Pages: 605-613

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondriaL DNA content in early primordial germ cells of mice2009

    • Author(s)
      Cao L et.al.
    • Journal Title

      PLoS Genet. 5-12

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肺性肝細胞・生殖細胞の発生分化と核内構造動態2009

    • Author(s)
      阿部訓也
    • Journal Title

      実験医学増刊号「細胞核-遺伝情報制御と疾患」 27-17

      Pages: 2767-2773

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Natural antisense transcripts are co-expressed with sense mRNAs in synaptoneurosomes of adult mouse forebrain.2008

    • Author(s)
      Smalheiser, N.R., Lugli, G., Torvik, V.I., Mise, N., Ikeda, R., Abe, K.
    • Journal Title

      Neurosci Res.

      Volume: Vol.62 Pages: 236-239

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences and similarities in the developmental status of embryo-derived stem cells and primordial germ cells revealed by global expression profiling.2008

    • Author(s)
      Mise, N., Fuchikami, T., Sugimoto, M., Kobayakawa, S., Ike, F., Ogawa, T., Tada, T., Kanaya, S., Noce, T. and Abe, K.
    • Journal Title

      Genes to cells

      Volume: Vol.13 Pages: 863-877

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative expression analysis uncovers novel features of endogenous antisense transcription.2008

    • Author(s)
      Okada, Y., Tashiro, C., Numata, K., Watanabe, K., Nakaoka, H., Yamamoto, N., Okubo, K., Ikeda, R., Saito, R., Kanai, A., Abe, K., Tomita, M., Kiyosawa, H.
    • Journal Title

      Human Mol. Genet

      Volume: Vol.17 Pages: 1631-1640

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative expression analysis uncovers novel features of endogenous antisense transcription.2008

    • Author(s)
      Okada Y., et al.
    • Journal Title

      Hum Mol Genet. 17-11

      Pages: 1631-1640

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences and similarities in the developmental status of embryo-derived stem cells and primordial germ cells revealed by global expression profiling.2008

    • Author(s)
      Mise, N., et al.
    • Journal Title

      Genes to cells 13-8

      Pages: 863-77

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High resolution intravital imaging of subcellular structures of mouse abdominal organs using a microstage device

    • Author(s)
      Cao L., et al
    • Journal Title

      PLoS One

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse

    • Author(s)
      Hoki, Y., Ikeda, R., Mise, N., Sakata, Y., Ohhata, T., Sasaki, H., Abe, K., Sado, T.
    • Journal Title

      Development

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Large-scale production of growing oocytes from neonatal mouse ovaries

    • Author(s)
      Honda, A., et al.
    • Journal Title

      Int.J.Dev.Biol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Xist 発現から見たマウス着床期における細胞リプログラミング2012

    • Author(s)
      志浦寛相
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Xist発現から見たマウス着床期における細胞リプログラミング2012

    • Author(s)
      志浦寛相, 阿部訓也
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス生殖細胞で発現するX連鎖遺伝子群に見出された特徴的なエピジェネティック修飾2012

    • Author(s)
      池田理恵子
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-09-25
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス生殖細胞で発現するX連鎖遺伝子群に見出された特徴的なエピジェネティック修飾2012

    • Author(s)
      池田理恵子、志浦寛相、沼田興治、細川美穂子、近藤昌代、中馬新一郎、阿部訓也
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      九州大学百年講堂(福岡市)
    • Year and Date
      2012-09-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] t^<w5>変異マウスの解析で明らかになったり瓩認夐伝子の多能性幹細胞分化制御因子としての役割2012

    • Author(s)
      杉本道彦、近藤昌代、阿部訓也
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      九州大学百年講堂(福岡市)
    • Year and Date
      2012-09-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] Region-wide DNA methylation and gene expression of the X-linked genes in mouse germ line.2011

    • Author(s)
      Rieko Ikeda
    • Organizer
      50 Years of X Inactivation Research - 3rd X-inactivation meeting, Oxford 2011
    • Place of Presentation
      Oxford (UK)
    • Related Report
      2012 Final Research Report
  • [Presentation] Dynamics of epigenomic changes during development of early embryos and primordial germ cells in mice.2011

    • Author(s)
      Kuniya Abe
    • Organizer
      50 Years of X Inactivation Research - 3rd X-inactivation meeting, Oxford 2011
    • Place of Presentation
      Oxford (UK)
    • Related Report
      2012 Final Research Report
  • [Presentation] Dynamics of epigenomic changes during development of early embryos and primordial germ cells in mice2011

    • Author(s)
      Abe K., et al
    • Organizer
      50 Years of X Inactivation Research-3rd X-inactivation meeting, Oxford 2011
    • Place of Presentation
      Oxford, UK
    • Related Report
      2011 Annual Research Report
  • [Presentation] Region-wide DNA methylation and gene expression of the X-linked genes in mouse germ line2011

    • Author(s)
      Ikeda R., et al
    • Organizer
      50 Years of X Inactivation Research-3rd X-inactivation meeting, Oxford 2011
    • Place of Presentation
      Oxford, UK
    • Related Report
      2011 Annual Research Report
  • [Presentation] Gene expression in embryonic pluripotential cells and germ cells in mice2010

    • Author(s)
      Abe K., et al.
    • Organizer
      International Symposium on"Epigenome Network, Development and Reprogramming of Germ Cells"
    • Place of Presentation
      福岡
    • Year and Date
      2010-11-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウスIgf2r 遺伝子の刷り込み型発現制御の成立に関わるDNA メチル化のES 細胞を用いた解析2010

    • Author(s)
      三瀬名丹
    • Organizer
      遺伝学会第82回大会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス初期胚・生殖細胞発生におけるエピゲノム動態解析2010

    • Author(s)
      阿部訓也
    • Organizer
      遺伝学会第82回大会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-20
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 多能性胚細胞(エピブラスト)の増殖・分化を制御するtw5 遺伝子の同定と機能解析2009

    • Author(s)
      阿部訓也
    • Organizer
      文部科学省科学研究費補助金・特定領域研究「生殖系列の世代サイクルとエピゲノムネットワーク」第2回公開シンポジウム
    • Place of Presentation
      品川
    • Year and Date
      2009-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Establishment of in vitro system for analysis of genomic imprinting using newly isolated ES/EG cell lines.2009

    • Author(s)
      Nathan Mise
    • Organizer
      The 24th Naito Conference on Nuclear Dynamics and RNA [II]
    • Place of Presentation
      Sapporo (Japan)
    • Year and Date
      2009-06-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Establishment of in vitro system for analysis of genomic imprinting using newly isolated ES/EG cell lines2009

    • Author(s)
      Nathan Mise et.al.
    • Organizer
      The 24th Naito Conference on Nuclear Dynamics and RNA[II]
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ(北海道札幌市)
    • Year and Date
      2009-06-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dynamics of the X chromosome activity and the DNA methylation status of X-linked genes during X reactivation in mouse female embryos2009

    • Author(s)
      Michihiko Sugimoto et.al.
    • Organizer
      The 24th Naito Conference on Nuclear Dynamics and RNA[II]
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ(北海道札幌市)
    • Year and Date
      2009-06-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice.2009

    • Author(s)
      Liqin Cao
    • Organizer
      6th Conference of Asian Society for Mitochondrial Research and Medicine
    • Place of Presentation
      台北(中華民国)
    • Related Report
      2012 Final Research Report
  • [Presentation] CpG island周辺のDNAメチル化に影響を及ぼす内在性アンチセンス転写産物の解析2008

    • Author(s)
      渡邊豊, ほか6名
    • Organizer
      第31回日本分子生物学会年会/第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 微量化HELP法によるゲノムワイドDNAメチル化解析2008

    • Author(s)
      池田理恵子、三瀬名丹、阿部訓也
    • Organizer
      第31回日本分子生物学会年会/第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] マイクロアレイをもちいた内在性アンチセンスRNAの検出と乳がんモデルマウスへの適用2008

    • Author(s)
      沼田興治, ほか6名
    • Organizer
      第31回日本分子生物学会年会/第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生殖細胞特異的にVenusを発現する新規TgマウスとES細胞を用いた生殖細胞発生過程の研究2008

    • Author(s)
      三瀬名丹, ほか6名
    • Organizer
      第31回日本分子生物学会年会/第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス多能性胚細胞, 生殖細胞系譜における遺伝子発現ダイナミクス2008

    • Author(s)
      阿部訓也
    • Organizer
      文部科学省化学研究費補助金・特定領域研究「性分化機構の解明」第5回、「生殖系列の世代サイクルとエピゲノムネットワーク」第1回合同領域会議
    • Place of Presentation
      熊本
    • Year and Date
      2008-11-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Essential role of Nanos3 for acquisition of germ cell identity in mice.2008

    • Author(s)
      Kuniya Abe
    • Organizer
      22nd International Mammalian Genome Conference
    • Place of Presentation
      Prague (Czech Republic)
    • Year and Date
      2008-11-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Essential role of Nanos3 for acquisition of germ cell identity in mice2008

    • Author(s)
      Kobayakawa S., Sage Y., and Abe K.
    • Organizer
      22nd International Mammalian Genome Conference
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2008-11-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] DNAのメチル化に影響を与える内在性アンチセンス転写産物のスクリーニング2008

    • Author(s)
      渡邊豊, ほか6名
    • Organizer
      日本遺伝学会第80回大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] DNA のメチル化に影響を与える内在性アンチセンス転写産物のスクリーニング2008

    • Author(s)
      渡邊豊
    • Organizer
      日本遺伝学会第80回大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-04
    • Related Report
      2012 Final Research Report
  • [Presentation] ES/EG 細胞試験管内分化系を用いた生殖細胞研究:新規レポーターES/EG細胞の樹立とその分化能の解析2008

    • Author(s)
      三瀬名丹
    • Organizer
      日本遺伝学会第80回大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 雌マウスPGC におけるX 染色体再活性化のタイミングとDNA メチレーションの変化2008

    • Author(s)
      杉本道彦
    • Organizer
      日本遺伝学会第80回大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 雌マウスPGCにおけるX染色体再活性化のタイミングとDNAメチレーションの変化2008

    • Author(s)
      杉本道彦、佐渡敬、阿部訓也
    • Organizer
      日本遺伝学会第80回大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] ES/EG細胞試験管内分化系を用いた生殖細胞研究 : 新規レポーターES/EG細胞の樹立とその分化能の解析2008

    • Author(s)
      三瀬名丹、近藤昌代、中野かおる、阿部訓也
    • Organizer
      日本遺伝学会第80回大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Essential role of Nanos3 for acquisition of germ cell identity in mice2008

    • Author(s)
      Kobayakawa S., Saga Y., and Abe K.
    • Organizer
      The Germ Cell Meeting
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Related Report
      2008 Annual Research Report
  • [Book] 「新しいリサーチツールとしてのバイオイメージング(蛍光イメージングを中心に)」モデル動物利用マニュアル 生物機能モデルと新しいリソース・リサーチツール2011

    • Author(s)
      阿部訓也
    • Publisher
      エル・アイ・シー
    • Related Report
      2012 Final Research Report
  • [Book] 論文ができてしまう!疾患モデルマウス表現型解析指南2011

    • Author(s)
      太田聡史、阿部訓也、沼田興治
    • Publisher
      中山書店
    • Related Report
      2011 Annual Research Report
  • [Book] 「胚性幹細胞・生殖細胞の発生分化と核内構造動態」実験医学増刊号「細胞核ー遺伝情報制御と疾患」2009

    • Author(s)
      阿部訓也
    • Publisher
      羊土社
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.brc.riken.jp/lab/mcd/mcd2/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.brc.riken.jp/lab/mcd/germline/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.brc.riken.jp/lab/mcd/mcd2/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.brc.riken.go.jp/lab/mcd/germline/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.brc.riken.jp/lab/mcd/mcd2/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.brc.riken.jp/lab/mcd/germline/index.thml

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2019-07-29  

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