Planned Research
Grant-in-Aid for Scientific Research on Priority Areas
We have analyzed gene expression profiles and DNA methylation profiles of cells belong to the cell lineage from pluripotent cells in the blastocyst to primordial germ cells to spermatogonia or oocytes in the mouse. We also investigated changes in X chromosome inactivation status of female cells in this lineage or changes in nuclear architecture during development of these cells. Through these analyses, we gained comprehensive understanding of genes functioning in this cell lineage, and identified developmental transition points in this lineage revealed by large scale changes in gene expression and epigenetic states. We also identified large DNA domains hypomethylated specifically in male germ cells possibly involved in expression regulation of genes contained in these domains. Using a spontaneous developmental mutant affecting one of developmental transitions in this lineage, we found that Vps52 is the essential gene required for growth and differentiation of primitive ectoderm. To achieve the research described above, we developed novel experimental technologies and research resources, which have facilitated active collaborations between research groups belong to this Priority Area.
All 2013 2012 2011 2010 2009 2008 Other
All Journal Article (50 results) (of which Peer Reviewed: 48 results) Presentation (31 results) Book (3 results) Remarks (6 results)
Nature Communications
Volume: 4 Issue: 1 Pages: 1754-1754
10.1038/ncomms2780
genesis
Volume: (in press)
J. Repord. Dev.
10031184751
PLoS Genet.
Volume: Vol.9 Issue: 2 Pages: 1-17
10.1371/journal.pgen.1003204
Cell Reports
Volume: Vol.2 Issue: 5 Pages: 1363-1374
10.1016/j.celrep.2012.10.004
Genes Dev.
Volume: Vol.26 Pages: 2477-2482
Genes & Development
Volume: 26 Issue: 22 Pages: 2477-2482
10.1101/gad.202242.112
Proc Natl Acad Sci USA
Volume: 108 Issue: 51 Pages: 20621-20626
10.1073/pnas.1112664108
Development
Volume: Vol.138 Pages: 2649-2659
Nucleic Acids Res
Volume: Vol.39 Pages: 2649-2657
Mech.Dev.
Volume: 128 Issue: 1-2 Pages: 129-140
10.1016/j.mod.2010.11.005
Volume: 138 Issue: 13 Pages: 2649-2659
10.1242/dev.061226
BMC Med.Genomics
Volume: 4 Issue: 1 Pages: 42-42
10.1186/1755-8794-4-42
Nucleic Acids Res.
Volume: 39 Issue: 7 Pages: 2649-2657
10.1093/nar/gkq1201
モデル動物利用マニュアル;生命科学研究モデルの作製と利用
Volume: (In press)
Volume: Vol.37 Pages: 4159-4169
Science
Volume: Vol.330 Pages: 496-499
Genomics
Volume: Vol.96 Pages: 333-341
Molecular Reproduction and Development
Volume: Vol.77 Pages: 802-811
Volume: Vol.38 Pages: 3672-3681
domestication.Proc.Natl.Acad.Sci, USA 107
Pages: 6412-6417
Nucleic Acids Res 38
Pages: 3672-3681
cloning.Science 330
Pages: 496-499
Development 37
Pages: 4159-4169
Reproduction and Development 77
Pages: 802-811
Nucleic Acids Res. 39
Pages: 2649-2657
Volume: 38-11 Pages: 3672-3681
Cell.
Volume: 141-6 Pages: 956-969
Mol Reprod Dev.
Volume: 77-9 Pages: 802-811
Genomics.
Volume: 96-6 Pages: 333-341
Science.
Volume: 330-6003 Pages: 496-499
Development.
Volume: 137-24 Pages: 4159-4169
BMC Genomics
Volume: Vol.10 Issue: 1 Pages: 392-392
10.1186/1471-2164-10-392
PLoS genetics
Volume: Vol5 Issue: 12 Pages: e1000756-e1000756
10.1371/journal.pgen.1000756
PLoS One
Volume: 4(3) Issue: 3 Pages: e4943-e4943
10.1371/journal.pone.0004943
Int. J. Dev. Biol.
Volume: Vol.53 Pages: 605-613
BMC Genomics 10:392
Pages: 1471-2164
Int J Dev Biol. 53-4
Pages: 605-613
PLoS Genet. 5-12
実験医学増刊号「細胞核-遺伝情報制御と疾患」 27-17
Pages: 2767-2773
Neurosci Res.
Volume: Vol.62 Pages: 236-239
Genes to cells
Volume: Vol.13 Pages: 863-877
Human Mol. Genet
Volume: Vol.17 Pages: 1631-1640
Hum Mol Genet. 17-11
Pages: 1631-1640
Genes to cells 13-8
Pages: 863-77
Int.J.Dev.Biol. (in press)
http://www.brc.riken.jp/lab/mcd/mcd2/
http://www.brc.riken.jp/lab/mcd/germline/index.html
http://www.brc.riken.go.jp/lab/mcd/germline/index.html
http://www.brc.riken.jp/lab/mcd/germline/index.thml