| Budget Amount *help |
¥51,350,000 (Direct Cost: ¥39,500,000、Indirect Cost: ¥11,850,000)
Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2011: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2010: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2009: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Research Abstract |
Dendrimer immobilized interfaces were prepared, and the material properties were investigate in terms of the regular and oriented molecular assemblies.
First, the glycodendrimer interfaces were prepared as sugar array, and the sugar-protein interactions were investigated. Since the glycodendrimer with higher generation displayed the dense saccharide structure, the glycodendrimer was a suitable tool to investigate the sugar-protein interaction. The multivalent dendrimer sugar arrays were also prepared with a sulfonated sugar. The glycodendrimer arrays with a sulfonated sugar showed the interaction with Alzheimer amyloid β peptide. Amyloid β formed fibril with low toxicity on the monovalent sugar interface, and formed spherical objects with high toxicity on the divalent and trivalent sugar interface.
The self-assembled monolayers (SAMs) of polyamidoamine (PAMAM) dendrimer with carboxylate terminal showed the strong wettability due to the densely packed hydrophilic group and the large surface area. In addition, the SAMs of PAMAM with higher generation showed the inert properties to protein adsorption because of molecular repulsion.
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