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Construction of Densely Packed Hybrid Biointerfase

Planned Research

Project AreaMolecular Soft-Interface Science
Project/Area Number 20106011
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionUniversity of Tsukuba

Principal Investigator

NAGASAKI Yukio  筑波大学, 数理物質系, 教授 (90198309)

Co-Investigator(Kenkyū-buntansha) YOSHIMOTO Keitaro  東京大学, 総合文化研究科, 准教授 (60392172)
堀口 諭吉  筑波大学, 数理物質系, 研究員 (50609758)
原 暁非  筑波大学, 大学院・数理物質科学研究科, 研究員 (60422185)
Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥71,240,000 (Direct Cost: ¥54,800,000、Indirect Cost: ¥16,440,000)
Fiscal Year 2012: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2011: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2010: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2009: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2008: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywordsバイオインターフェース / 酸化ストレス / 活性酸素 / 安定ラジカル / 表面コーティング / ポリエチレングリコール / 細胞分化抑制 / 血液活性化抑 / 血液透析 / PEG / ポリマーブラシ / 密生層 / 分子認識 / センサー / ソフト界面 / PEG混合ブラシ / 抗体 / DNAチップ / ELISA / イムノアッセイ / バイオナノ粒子 / ナノ診断 / 免疫診断 / ナノ酵素 / 表面プラズモン共鳴
Research Abstract

In recent years, improvement of culture technique is desired to achieve effective cellular differentiation of not only cell lines but also stem cells. However, cells are subj ected to various stresses when they attach the culture equipment. Accordingly, it is essential to design a new biointerface, which gives minimum or no damage to cells. In this study, we have fbcused on reactive oxygen species (ROS), which is generated by contact with culture substrates. Because excessively generated ROS tends to increase cellular activation, we designed surface coating materials, which scavenge ROS effectively. ROS-induced-differentiation of leukemic cells which contacted with our polymer surface was investigated in this study.

Report

(7 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (166 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (78 results) (of which Peer Reviewed: 77 results) Presentation (76 results) (of which Invited: 1 results) Book (9 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Enhanced intracellular drug delivery of pH-sensitive doxorubicin/poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells2013

    • Author(s)
      長崎幸夫
    • Journal Title

      Biomaterials Science

      Volume: 1 Issue: 4 Pages: 361-367

    • DOI

      10.1039/c2bm00156j

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate2013

    • Author(s)
      長崎幸夫
    • Journal Title

      Journal of Materials Chemistry B

      Volume: 1 Issue: 4 Pages: 529-535

    • DOI

      10.1039/c2tb00031h

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPAR gamma in breast cancer pathophysiology2013

    • Author(s)
      長崎幸夫
    • Journal Title

      Journal of Drug Targeting

      Volume: 21 Issue: 2 Pages: 161-174

    • DOI

      10.3109/1061186x.2012.736998

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Biocompatible Nanoreactor for Silica/Gold Hybrid Nanoparticles Preparation2013

    • Author(s)
      長崎幸夫
    • Journal Title

      Colloids and Surfaces B: Biointerfaces

      Volume: 102 Pages: 778-782

    • DOI

      10.1016/j.colsurfb.2012.09.034

    • NAID

      120007137069

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Orally Administered Redox Nanoparticle that Accumlates in the Colonic Mucosa and Reduces Colitis in Mice2012

    • Author(s)
      Long Binh Vong, Tsutomu Tomita, Toru Yoshitomi, Hirofumi Matsui, Yukio Nagasaki
    • Journal Title

      Gastroenterology

      Volume: Vol.143, No.4 Issue: 4 Pages: 1027-1036

    • DOI

      10.1053/j.gastro.2012.06.043

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different mechanisms of action of poly(ethylene glycol) and arginine on thermal inactivation of lysozyme and ribonuclease A2012

    • Author(s)
      Shunsuke Tomita
    • Journal Title

      Biotechnology and Bioengineering

      Volume: 109 Issue: 10 Pages: 2543-2552

    • DOI

      10.1002/bit.24531

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Redox Nanoparticle Treatment Protects Against Neurological Deficit in Focused Ultrasound-Induced Intracerebral Hemorrhage2012

    • Author(s)
      Pennapa Chonpathompikunlert, Ching-Hsiang Fan, Yuki Ozaki, Toru Yoshitomi, Chih-Kuang Yeh, Yukio Nagasaki
    • Journal Title

      Nanomedicine

      Volume: Vol.7, No.7 Issue: 7 Pages: 1029-1043

    • DOI

      10.2217/nnm.12.2

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a high-performance immunolatex based on "soft landing" antibody immobilization mechanism2012

    • Author(s)
      Xiaofei Yuan, Dolca Fabregat, Keitaro Yoshimoto and Yukio Nagasaki
    • Journal Title

      Colloid and Surface B: Biointreface

      Volume: Vol.99 Pages: 45-52

    • DOI

      10.1016/j.colsurfb.2011.09.040

    • NAID

      120007137228

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Boron Neutron Capture Therapy Assisted by Boron-conjugated Nanoparticles2012

    • Author(s)
      Shogo Sumitani, Yukio Nagasaki
    • Journal Title

      Polymer Journal

      Volume: Vol.44, No.6 Issue: 6 Pages: 522-530

    • DOI

      10.1038/pj.2012.30

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Design and preparation of a nanoprobe for imaging inflammation sites2012

    • Author(s)
      Toru Yoshitomi, Yukio Nagasaki
    • Journal Title

      Biointerphase

      Volume: 7 Issue: 1 Pages: 7-7

    • DOI

      10.1007/s13758-011-0007-5

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly Stable, pH Responsive Drug Delivery System2012

    • Author(s)
      Masao Kamimura, Jong Oh Kim, Alexander V. Kabanov, Tatiana K. Bronich, and Yukio Nagasaki
    • Journal Title

      Journal of Controlled Release

      Volume: Vol.160 Issue: 3 Pages: 486-494

    • DOI

      10.1016/j.jconrel.2012.04.027

    • NAID

      120007137277

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array2012

    • Author(s)
      Yutaka Ikeda, Tomoko Jomura, Umeko Horiuchi, Junko Saeki, Keitaro Yoshimoto, Takeshi Ikeya, Yukio Nagasaki
    • Journal Title

      Colloid and Surface, B, Biointerface

      Volume: 97 Pages: 97-100

    • DOI

      10.1016/j.colsurfb.2012.04.022

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improved Complementary Polymer Pair System: Switching for Enzyme Activity by PEGylated Polymers2012

    • Author(s)
      Takaaki Kurinomaru, Shunsuke Tomita, Shinpei Kudo, Sumon Ganguli, Yukio Nagasaki, Kentaro Shiraki
    • Journal Title

      Langmuir

      Volume: Vol.28, No.9 Issue: 9 Pages: 4334-4338

    • DOI

      10.1021/la2043312

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amemiya: Dependence of Swelling Behavior of pH-responsive PEG-modified Nanogel on Cross-link Density2012

    • Author(s)
      Goshu Tamura, Yuya Shinohara, Atushi Tamura, Yusuke Sanada, Motoi Oishi, Isamu Akiba, Yukio Nagasaki, Kazuo Sakurai, and Yoshiyuki
    • Journal Title

      Polymer Journal

      Volume: Vol.44,No.3 Issue: 3 Pages: 240-244

    • DOI

      10.1038/pj.2011.123

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] PEGylation Technology in Nanomedicine2012

    • Author(s)
      Yutaka Ikeda, Yukio Nagasaki
    • Journal Title

      Advances in Polymer Science

      Volume: Volume 247, Polymers in Nanomedicine Pages: 115-140

    • DOI

      10.1007/12_2011_154

    • ISBN
      9783642278556, 9783642278563
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetics of core-polymerized, boron-conjugated micell es designed for boron neutron capture therapy for cancer2012

    • Author(s)
      Shogo Sumitani, Motoi Oishi, Tatsuya Yaguchi, Hiroki Murotani, Yukichi, Horiguchi, Minoru Suzuki, Koji Ono, Hironobu Yanagie, Yukio Nagasaki
    • Journal Title

      Biomaterials

      Volume: 33 Issue: 13 Pages: 3568-3577

    • DOI

      10.1016/j.biomaterials.2012.01.039

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Creation of a blood-compatible surface: a novel strategy for suppressing blood activation and coagulation using nitroxide radical-containing polymer with reactive oxygen species scavenging activity2012

    • Author(s)
      Toru Yoshitomi, Yu Yamaguchi, Akihiko Kikuchi, Yukio Nagasaki
    • Journal Title

      Acta Biomaterialia

      Volume: 8 Pages: 1323-1329

    • NAID

      120007130697

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生体適合性ポリエチレングリコール表面の構築2012

    • Author(s)
      長崎幸夫
    • Journal Title

      高分子

      Volume: 61巻、2月号 Pages: 77-82

    • NAID

      10030169568

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] High PEGylation Efficiency of Pentaethylenehexamine-end Poly(ethyleneglycol) (mPEG-N6) for Active-ester Surface2012

    • Author(s)
      Xiaofei Yuan, Dolca Fabregat, Keitaro Yoshimoto and Yukio Nagasaki
    • Journal Title

      Colloid and Surface B: Biointerface

      Volume: 92 Issue: 2 Pages: 25-29

    • DOI

      10.4155/tde.11.153

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Creation of a blood-compatible surface: a novel strategy for suppressing blood activation and coagulation using nitroxide radical-containing polymer with reactive oxygen species scavenging activity2012

    • Author(s)
      Toru Yoshitomi, Yu Yamaguchi, Akihiko Kikuchi, Yukio Nagasaki
    • Journal Title

      Acta Biomaterialia

      Volume: 8 Issue: 3 Pages: 1323-1329

    • DOI

      10.1016/j.actbio.2011.11.029

    • NAID

      120007130697

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High PEGylation Efficiency of Pentaethylenehexamine-end Poly(ethyleneglycol) (mPEG-N6) for Active-ester Surface2012

    • Author(s)
      長崎幸夫
    • Journal Title

      Colloid and Surface B: Biointerface

      Volume: 92 Pages: 25-29

    • DOI

      10.1016/j.colsurfb.2011.11.013

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of Densely Poly(ethylene glycol) Chain Tethered Surface and its Performance2011

    • Author(s)
      Yukio Nagasaki
    • Journal Title

      Polymer Journal

      Volume: 43 Issue: 12 Pages: 949-958

    • DOI

      10.1038/pj.2011.93

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel redox nanomedicine improves gene expression of polyion complex vector2011

    • Author(s)
      KazukoToh, Toru Yoshitomi, Yutaka Ikeda, Yukio Nagasaki
    • Journal Title

      Science and Technology of Advanced Materials

      Volume: 12 Issue: 6 Pages: 65001-65001

    • DOI

      10.1088/1468-6996/12/6/065001

    • NAID

      120007130770

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Highly Dispersible and Tumor-Accumulative, Iron Oxide Nanoparticles -Multi-point Anchoring of PEG-b-poly(4-vinylbenzylphosphonate) Improves Performance Significantly2011

    • Author(s)
      Kodai Ujiie, Naoki Kanayama, Kei Asai, Mikio Kishimoto, Yusuke Ohara, Yoshimasa Akashi, Keiichi Yamada, Shinji Hashimoto, Tatsuya Oda, Nobuhiro Ohkohchi, Hideto Yanagihara, Eiji Kita, Masayuki Yamaguchi, Hirofumi Fujii, Yukio Nagasaki
    • Journal Title

      Colloid and Surface B: Biointreface

      Volume: 88 Pages: 771-778

    • NAID

      120007137385

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Use of Nitroxide Radical-containing Nanoparticles Coupled with Piperine to Protect Neuroblastoma SH-SY5Y cells from Aβ-Induced Oxidative Stress2011

    • Author(s)
      Chonpathompikunlert Pennapa, Toru Yoshitomi, Han Junkyu, Hiroko Isoda, Yukio Nagasaki
    • Journal Title

      Biomaterials

      Volume: 32 Pages: 8605-8612

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The ROS scavenging and renal protective effects of pH-responsive nitroxide radical-containing nanoparticles2011

    • Author(s)
      Toru Yoshitomi, Aki Hirayama, Yukio Nagasaki
    • Journal Title

      Biomaterials

      Volume: 32 Pages: 8021-8028

    • NAID

      120007137437

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Near-infrared (1550nm) In Vivo Bioimaging Based on Rare-earth Doped Ceramic Nanophosphors Modified with PEG-b-poly(4-vinylbenzyl phosphonate)2011

    • Author(s)
      Naoki Kanayama, Kimikazu Tokuzen, Kohei Soga, Yukio Nagasaki
    • Journal Title

      Nanoscale

      Volume: 3 Pages: 3705-3713

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] In Vivo and In Vitro Characteristics of Core-Shell-Type Nanogel Particles: Optimization of Core Cross-Linking Density and Surface PEG Density in PEGylated Nanogels2011

    • Author(s)
      Masato Tamura, Satoshi Ichinohe, Atsushi Tamura, Yutaka Ikeda, Yukio Nagasaki
    • Journal Title

      Acta Biomaterialia

      Volume: 7(9) Pages: 3354-3361

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gd@C_<82> metallofullerenes for neutron capture therapy - Fullerene solubilization by poly(ethylene glycol)-block-poly(2-(N,N-diethylamino)ethyl methacrylate) and resultant efficacy in vitro2011

    • Author(s)
      Yukichi Horiguchi, Shinpei Kudo, Yukio Nagasaki
    • Journal Title

      Science and Technology of Advanced Materials

      Volume: 12 Pages: 44607-44607

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carborane Confined Nanoparticle for Boron Neutron Capture Therapy: -Improved Stability, Blood Circulation Time and Tumor Accumulation-2011

    • Author(s)
      Shogo Sumitani, Motoi Oishi, Yukio Nagasaki
    • Journal Title

      Reactive and Functional Polymers

      Volume: 71(7) Pages: 684-693

    • NAID

      120007130836

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid2011

    • Author(s)
      Hiroto Hatakeyama, Hidetaka Akita, Erika Itoh, Yasuhiro Hayashi, Motoi Oishi, Yukio Nagasaki, R. Danev, K. Nagayama, N. Kaji, H. Kikuchi, Y. Baba, Harashima H
    • Journal Title

      Biomaterials

      Volume: 32(18) Pages: 4306-4316

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of the thermal stability of streptavidin immobilized on magnetic beads by the construction of a mixed poly(ethylene glycol) tethered-chain layer2011

    • Author(s)
      Masaki Kubota, Keitaro Yoshimoto, Yuan Xiaofei, Yukio Nagasaki
    • Journal Title

      Polymer Journal

      Volume: 43 Pages: 493-496

    • NAID

      10028221047

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemical Nanotherapy-Nitroxyl Radical-containing Nanoparticle (RNP) Protects Neuroblastoma SH-SY5Y cells from As-induced Oxidative Stress2011

    • Author(s)
      Chonpathompikunlert Pennapa, Toru Yoshitomi, Han Junkyu, Kazuko Toh, Hiroko Isoda, Yukio Nagasaki
    • Journal Title

      Therapeutic Delivery

      Volume: 2(5) Pages: 585-597

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitroxyl radical-containing nanoparticles for novel nanomedicine against oxidative stress injury2011

    • Author(s)
      Toru Yoshitomi, Yukio Nagasaki
    • Journal Title

      Nanomedicine

      Volume: April, Vol.6, No.3 Pages: 509-518

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Newly Synthesized Radical-containing Nanoparticles (RNP) Enhance Neuroprotection after Cerebral Ischemia-reperfusion Injury2011

    • Author(s)
      Aiki Marushima, Hideo Tsurusima, Toru Yoshitomi, Kazuko Toh, Aki Hirayama, Yukio Nagasaki, Akira Matumura
    • Journal Title

      Neurosurgery

      Volume: 68 Pages: 1418-1426

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Noveloligonucleotide carrier possessing reactive oxygen species scavengingability2011

    • Author(s)
      Yutaka Ikeda, Rie Suzuki, Toru Yoshitomi, Yukio Nagasaki
    • Journal Title

      Macromolecular Bioscience

      Volume: 11 Pages: 344-351

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] TEMPOL Protects Human Neuroblastoma SH-SY5Ycells Against β-amyloid-induced Cell Toxicity2011

    • Author(s)
      Chonpathompikunlert Pennapa, Han Junkyu, Toh Kazuko, Hiroko Isoda,Nagasaki Yukio
    • Journal Title

      European Journal of Pharmacology

      Volume: 650 Pages: 544-549

    • Related Report
      2012 Final Research Report 2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noveloligonucleotide carrier possessing reactive oxygen species scaven gingability2011

    • Author(s)
      Yutaka Ikeda, Rie Suzuki, Toru Yoshitomi, Yukio Nagasaki
    • Journal Title

      Macromolecular Bioscience

      Volume: 11 Issue: 3 Pages: 344-351

    • DOI

      10.1002/mabi.201000305

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Newly Synthesized Radical-containing Nanoparticles (RNP) Enhance Neuroprotection after Cerebral Ischemia-reperfusion Injury2011

    • Author(s)
      Aki Marushima, Hideo Tsurusima, Toru Yoshitomi, Kazuko Toh, Aki Hirayama, Yukio Nagasaki, Akira Matumura
    • Journal Title

      Neurosurgery

      Volume: 68 Pages: 344-351

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of the thermal stability of streptavidin immobilized on magnetic beads by the construction of a mixed poly (ethylene glycol) tethered-chain layer2011

    • Author(s)
      Masaki Kubota, Keitaro Yoshimoto, Yuan Xiaofei, Yukio Nagasaki
    • Journal Title

      Polymer Journal

      Volume: 43 Issue: 5 Pages: 493-496

    • DOI

      10.1038/pj.2011.5

    • NAID

      10028221047

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carborane Confined Nanoparticle for Boron Neutron Capture Therapy : -Improved Stability, Blood Circulation Time and Tumor Accumulation2011

    • Author(s)
      Shogo Sumitani, Motoi Oishi, Yukio Nagasaki
    • Journal Title

      Reactive and Functional Polymers

      Volume: 71(7) Pages: 684-693

    • NAID

      120007130836

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gd@C_<82> metallofullerenes for neutron capture therapy-Fullerene solubilization by poly(ethylene glycol)-block-poly(2-(N,N-diethylamino)ethyl methacrylate) and resultant efficacy in vitro2011

    • Author(s)
      Yukichi Horiguchi, Shinpei Kudo, Yukio Nagasaki
    • Journal Title

      Science and Technology of Advanced Materials

      Volume: 12 Issue: 4 Pages: 44607-44614

    • DOI

      10.1088/1468-6996/12/4/044607

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In Vivo and In Vitro Characteristics of Core-Shell-Type Nanogel Particles : Optimization of Core Cross-Linking Density and Surface PEG Density in PEGylated Nanogels2011

    • Author(s)
      Masato Tamura, Satoshi Ichinohe, Atsushi Tamura, Yutaka Ikeda, Yukio Nagasaki
    • Journal Title

      Acta Biomaterialia

      Volume: 7(9) Pages: 3354-3361

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly (4-vinylbenzylphosphonate)2011

    • Author(s)
      Masao Kamimura, Naoki Kanayama, Kimikazu Tokuzen, Kohei Soga, Yukio Nagasaki
    • Journal Title

      Nanoscale

      Volume: 3 Issue: 9 Pages: 3705-3713

    • DOI

      10.1039/c1nr10466g

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Highly Dispersible and Tumor-Accumulative, Iron Oxide Nanoparticles -Multi-point Anchoring of PEG-b-poly(4-vinylbenzylphosphonate) Improves Performance Significantly, Colloid and Surface B2011

    • Author(s)
      Kodai Ujiie, Naoki Kanayama, Kei Asai, Mikio Kishimoto, Yusuke Ohara, Yoshimasa Akashi, Keiichi Yamada, Shinji Hashimoto, Tatsuya Oda, Nobuhiro Ohkohchi, Hideto Yanagihara, Eiji Kita, Masayuki Yamaguchi, Hirofumi Fujii, Yukio Nagasaki
    • Journal Title

      Biointreface

      Volume: 88 Pages: 771-778

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of the Thermal Stability of Streptavidin Immobilized on Magnetic Beads by the Construction of a Mixed-poly(ethylene glycol) Tethered-chain Layer2011

    • Author(s)
      Kubota Masaki, Yoshimoto Keitaro, Yuan Xiaofei, Nagasaki Yukio
    • Journal Title

      Polymer Journal in press

    • NAID

      10028221047

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Direct Observation of Adsorption-Induced Inactivation of Antibody Fragments Surrounded by Mixed-PEG Layer on a Gold Surface2010

    • Author(s)
      Yoshimoto Keitaro, Nishio Motohiko, Sugasawa Hiroaki, Nagasaki Yukio
    • Journal Title

      Journal of the American Chemical Society 132(23)

      Pages: 7982-7989

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Engineering of poly(ethylene glycol) chain-tethered surfaces to obtain high-performance bionanoparticles2010

    • Author(s)
      Nagasaki Yukio
    • Journal Title

      Science and Technology of Advanced Materials

      Volume: 11(5) Pages: 54505-54514

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enzyme switch by complementary polymer pair system (CPPS)2010

    • Author(s)
      Tomita Shunsuke, Ito Len, Yamaguchi Hiroshi, Konishi Gen-ichi, Nagasaki Yukio, Shiraki Kentaro
    • Journal Title

      Soft Matter

      Volume: 6 Pages: 5320-5326

    • NAID

      120007130810

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple Solid-Phase Synthesis and Biological Properties of Carbohydrate-Oligonucleotide Conjugates Modified at the 3''-Terminus2010

    • Author(s)
      Ikeda Yutaka, Kubota Daisuke, Nagasaki Yukio
    • Journal Title

      Bioconjugate Chemistry

      Volume: 21 Pages: 1685-1690

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PEGylated Polymer Micelle-based Nitric Oxide (NO) Photodonor with NO-mediated Antitumor Activity2010

    • Author(s)
      Kanayama Naoki, Yamaguchi Kazuhiro, Nagasaki Yukio
    • Journal Title

      Chemistry Letter

      Volume: 39(9) Pages: 1008-1009

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Smart siRNA Delivery Systems Based on Polymeric Nano-assemblies and Nanoparticles2010

    • Author(s)
      Tamura Atsushi, Nagasak Yukio
    • Journal Title

      Nanomedicine

      Volume: 5(7) Pages: 1089-1102

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient siRNA Delivery Based on PEGylated and Partially Quaternized Polyamine Nanogels : Enhanced Gene Silencing Activity by the Cooperative Effect of Tertiary and Quaternary Amino Groups in the Core2010

    • Author(s)
      Tamura Atsushi, Oishi Motoi, Nagasaki Yukio
    • Journal Title

      Journal of Controlled Release

      Volume: 146 Pages: 378-387

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct Observation of Adsorption-Induced Inactivation of Antibody Fragments Surrounded by Mixed-PEG Layer on a Gold Surface2010

    • Author(s)
      Yoshimoto Keitaro, Nishio Motohiko, Sugasawa Hiroaki, Nagasaki Yukio
    • Journal Title

      Journal of the American Chemical Society

      Volume: 132(23) Pages: 7982-7989

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improving the Heat Resistance of Ribonuclease A by the Addition of Poly(N,N-diethylaminoethyl methacrylate)-graft-poly(ethylene glycol) (PEAMA-g-PEG)2010

    • Author(s)
      Ganguli Sumon, Keitaro Yoshimoto, Tomita Shunsuke, Sakuma Hiroshi, Matsuoka Tsuneyoshi, Shiraki Kentaro, Nagasaki Yukio
    • Journal Title

      Macromolecular Bioscience

      Volume: 10(8) Pages: 853-859

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Large Payloads of Gold Nanoparticles into the Polyamine Network Core of Stimuli-Responsive PEGylated Nanogels for Selective and Noninvasive Cancer Photothermal Therapy2010

    • Author(s)
      Nakamura Takahito, Tamura Atsushi, Murotani Hiroki, Oishi Motoi, Jinji Yuta, Matsuishi Kiyoto, Nagasaki Yukio
    • Journal Title

      Nanoscale

      Volume: 2(5) Pages: 739-746

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimuli-Responsive Smart Nanogels for Cancer Diagnostics and Therapy2010

    • Author(s)
      Oishi Motoi, Nagasaki Yukio
    • Journal Title

      Nanomedicine

      Volume: 5(3) Pages: 451-468

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation and Molecular Recognition of SERS Probe Based on Gold Nanoparticles Constructed from PEG-Oligoamine Copolymer Possessing a Coumarin Group between PEG and Oligoamine2010

    • Author(s)
      Furusho Hitoshi, Oishi Motoi, Kishi Tetsuo, Yasumori Atsuo, Nagasaki Yukio
    • Journal Title

      Chemistry Letters

      Volume: 39(1) Pages: 52-53

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Inhibition of Interfacial Nonspecific Interaction to Create Practically Utilizable High Ferritin-Response Immunolatex2009

    • Author(s)
      Yuan Xiaofei, Fabregat Dolca, Yoshimoto Keitaro, Nagasaki Yukio
    • Journal Title

      Analytical Chemistry 81

      Pages: 10097-10105

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine] Modified Gold Surfaces Fabricated by the "Grafting to" Method : Comparison of its Protein Resistance with Poly(ethylene glycol)Modified Gold Surfaces.2009

    • Author(s)
      Yoshimoto Keitaro, Hirase Takumi, Madsen Jeppe, Armes Steven P., Nagasaki Yukio
    • Journal Title

      Macromolecular Rapid Communication 30(24)

      Pages: 2136-2140

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Studies on the Adsorption Property and Structure of Polyamine-Ended Poly(ethylene glycol)Derivatives on a Gold Surface by Surface Plasmon Resonance and Angle-resolved X-ray Photoelectron Spectroscopy.2009

    • Author(s)
      Yoshimoto Keitaro, Nozawa Makiko, Matsumoto Shinya, Echigo Takuya, Nemoto Seiko, Hatta Tamao, Nagasaki Yukio
    • Journal Title

      Langmuir 25(20)

      Pages: 12243-12249

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Spheroid Array of Fetal Mouse Liver Cells Constructed on a PEG-gel Micropatterned Surface : Upregulation of Hepatic Functions by Co-Culture with Nonparenchymal Liver Cells.2009

    • Author(s)
      Kojima Ryota, Yoshimoto Keitaro, Miyoshi Hirotoshi, Nagasaki Yukio
    • Journal Title

      Lab on a Chip 9

      Pages: 1991-1993

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Inverted Pattern Formation of Cell Microarrays on Poly(ethylene glycol)(PEG)Gel Patterned Surface and Construction of Hepatocyte Spheroids on Unmodified PEG Gel Microdomains.2009

    • Author(s)
      Yoshimoto Keitaro, Ichino Masahiro, Nagasaki Yukio
    • Journal Title

      Lab on a Chip 9

      Pages: 1286-1289

    • NAID

      120007138167

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] High-performance Immunolatex Possessing A Mixed-PEG/Antibody Co-immobilized Surface : High Sensitive Ferritin Immunodiagnostics.2009

    • Author(s)
      Yuan Xiaofei, Yoshimoto Keitaro, Nagasaki Yukio
    • Journal Title

      Analytical Chemistry 81(4)

      Pages: 1549-1556

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Efficient Inhibition of Interfacial Nonspecific Interaction to Create Practically Utilizable High Ferritin-Response Immunolatex, Analytical Chemistry, 81 10097-10105(2009)2009

    • Author(s)
      長崎幸夫
    • Journal Title

      Analytical Chemistry 81

      Pages: 10097-10105

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine]Modified Gold Surfaces Fabricated by the "Grafting to" Method : Comparison of its Protein Resistance with Poly(ethylene glycol)Modified Gold Surfaces2009

    • Author(s)
      長崎幸夫
    • Journal Title

      Macromolecular Rapid Communications 30

      Pages: 2136-2140

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] pH-Sensitive Radical-Containing-Nanoparticle(RNP)for the L-Band-EPR Imaging of Low pH Circumstances2009

    • Author(s)
      長崎幸夫
    • Journal Title

      Bioconjugate Chemistry 20

      Pages: 1792-1798

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spheroid Array of Fetal Mouse Liver Cells Constructed on a PEG-gel Micropatterned Surface : Upregulation of Hepatic Functions by Co-Culture with Nonparenchymal Liver Cells2009

    • Author(s)
      長崎幸夫
    • Journal Title

      Lab on a Chip 9

      Pages: 1991-1993

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inverted Pattern Formation of Cell Microarrays on Poly(ethylene glycol)(PEG)Gel Patterned Surface and Construction of Hepatocyte Spheroids on Unmodified PEG Gel Microdomains2009

    • Author(s)
      長崎幸夫
    • Journal Title

      Lab on a Chip 9

      Pages: 1286-1289

    • NAID

      120007138167

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of Lysozyme Activity Based on Thermotolerant Protein/Smart Polymer Complex Formation2009

    • Author(s)
      長崎幸夫
    • Journal Title

      Journal of the American Chemical Society 131

      Pages: 6549-6553

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of Core-shell-type Nanoparticles Carrying Stable Radicals in the Core2009

    • Author(s)
      長崎幸夫
    • Journal Title

      Biomacromolecules 10

      Pages: 596-601

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Luminescence-based Colorimetric Discrimination of Single-nucleotide Transversions by the Combined Use of the Derivatives of DOTA-conjugated Naphthyridine and Its Terbium Complex2009

    • Author(s)
      長崎幸夫
    • Journal Title

      Tetrahedron Letter 50

      Pages: 2177-2180

    • NAID

      120007138274

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-performance Immunolatex Possessing A Mixed-PEG/Antibody Co-immobilized Surface : High Sensitive Ferritin Immunodiagnostics2009

    • Author(s)
      長崎幸夫
    • Journal Title

      Analytical Chemistry 81

      Pages: 1549-1556

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Binding Enhancement of Antigen-Functionalized PEGylated Gold Nanoparticles onto Antibody-Immobilized Surface by Increasing the Functionalized Antigen using α-sulfanyl-ω -amino-PEG.2008

    • Author(s)
      Yoshimoto Keitaro, Hoshino Yuki, Ishii Takehiko, Nagasaki Yukio
    • Journal Title

      Chemical Communications

      Pages: 5369-5371

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Facile Construction of Sulfanyl-terminated Poly(ethylene glycol)-brushed Layer on a Gold Surface for Protein Immobilization by the Combined Use of Sulfanyl-Ended Telechelic and Semi-Telechelic Poly(ethylene glycol)s.2008

    • Author(s)
      Yoshimoto Keitaro, Hirase Takumi, Nemoto Seiko, Hatta Tamao, Nagasaki Yukio
    • Journal Title

      Langmuir 24

      Pages: 9623-9629

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] PEG-b-polyamine Stabilized Bionanoparticles for Nanodiagnostics and Nanotherapy2008

    • Author(s)
      長崎幸夫
    • Journal Title

      Chemistry Letter 37

      Pages: 564-569

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and Activity Assay of Nanozymes Prepared by the Coimmobilization of Practically Useful Enzymes and Hydrophilic Blo ck Copolymers on Gold Nanoparticles2008

    • Author(s)
      原暁非、長崎幸夫、他
    • Journal Title

      Langmuir 24

      Pages: 6903-6909

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Completely Dispersible PEGylated Gold Nanoparticles Under Physiolo gical Conditions : Modification of Gold Nanoparticles With Precisely Controlled PEGbnolvamine2008

    • Author(s)
      吉本敬太郎、長崎幸夫、他
    • Journal Title

      Langmuir 24

      Pages: 5010-5017

    • Related Report
      2008 Annual Research Report
  • [Presentation] Novel Redox Injectable Gel for Local Inflammation2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      New Innovations in Polymers And (bio)Materials(NIPAM-80)
    • Place of Presentation
      Ka'anapali, Maui, Hawaii, USA
    • Year and Date
      2012-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] バイオインターフェースの設計2012

    • Author(s)
      長崎幸夫
    • Organizer
      有機エレクトロニクス研究会(OME)
    • Place of Presentation
      沖縄青年会館、那覇
    • Year and Date
      2012-12-05
    • Related Report
      2012 Final Research Report
  • [Presentation] バイオインターフェースの設計2012

    • Author(s)
      長崎幸夫
    • Organizer
      有機エレクトロニクス研究会(OME)(招待講演)
    • Place of Presentation
      沖縄青年会館、那覇
    • Year and Date
      2012-12-05
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ハイブリッドPEG化表面の設計と機能2012

    • Author(s)
      長崎幸夫
    • Organizer
      生物工学フォーラム
    • Place of Presentation
      早稲田大学、東京
    • Year and Date
      2012-12-04
    • Related Report
      2012 Final Research Report
  • [Presentation] アルジェリア産プロポリスに関する化学的研究2012

    • Author(s)
      土屋育未、Benhanifia Mokhtar、長崎幸夫、太田敏郎、細谷孝博、熊澤茂則
    • Organizer
      第3回岐阜薬科大学機能性健康食品研究講演会
    • Place of Presentation
      じゅうろくプラザ、岐阜
    • Year and Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Redox Polymer Therapeutics2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      6th International Symposium, on Nanomedicine, (ISNM2012)
    • Place of Presentation
      Kunibiki Messe, Matsue, Shimane
    • Year and Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] PEG化表面の精密設計と機能2012

    • Author(s)
      長崎幸夫
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台国際センター、仙台
    • Year and Date
      2012-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Design of Biointerface for High-Performance Biodevice2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      23rd 2012 International Symposium on Micro-NanoMechatronics and Human Science (MHS2012)
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2012-11-05
    • Related Report
      2012 Final Research Report
  • [Presentation] レドックスインジェクタブルゲルの設計と評価2012

    • Author(s)
      長崎幸夫
    • Organizer
      第51回電子スピンサイエンス学会年会 (SEST2012)
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Year and Date
      2012-11-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Fullerene as Nanobiomedicine2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      The 6th International Workshop on Advanced Materials Science IWAMSN 2012
    • Place of Presentation
      Halong-Vietnam
    • Year and Date
      2012-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Conjugation chemistries for the development of next generation drugs2012

    • Author(s)
      Yutaka Ikeda Hiromichi Kawasaki Jinya Katamachi Yukio Nagasaki
    • Organizer
      The 6th International Workshop on Advanced Materials Science IWAMSN 2012
    • Place of Presentation
      Halong-Vietnam
    • Year and Date
      2012-10-31
    • Related Report
      2012 Final Research Report
  • [Presentation] Redox Polymer Nanoarchitectonics in vivo -Novel Oral Plymer Therapeutics-2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      PCCP Asian Symposium 2012
    • Place of Presentation
      MANA, NIMS, Tsukuba
    • Year and Date
      2012-10-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 生体適合性分子で高度に安定化されたオリゴ核酸の固相合成法開発2012

    • Author(s)
      池田 豊、河崎弘道、窪田大輔、長崎幸夫
    • Organizer
      第61回高分子学会高分子討論会
    • Place of Presentation
      名古屋工業大学、名古屋
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 高性能な腹膜透析を目指したシリカ含有レドックスナノ粒子の開発2012

    • Author(s)
      吉冨 徹、矢口 達也、平山 暁、植田 敦志、長崎 幸夫
    • Organizer
      第61回高分子学会高分子討論会
    • Place of Presentation
      名古屋工業大学、名古屋
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 局所的酸化ストレス障害の治療効果を高める新規ニトロキシドラジカル含有インジェクタブルハイドロゲルの開発2012

    • Author(s)
      プアミンリー、ペナパーションパトンピクンラット、吉冨徹、長崎幸夫
    • Organizer
      第61回高分子学会高分子討論会
    • Place of Presentation
      名古屋工業大学、名古屋
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Design of Redox Polymer Nanotherapy2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      The Saudi International, Biotechnology Conference 2012
    • Place of Presentation
      Ryado, Saudi Arabia
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 経口投与によるレドックスポリマードラッグの開発2012

    • Author(s)
      長崎幸夫
    • Organizer
      日本バイオマテリアル学会第2回九州地区講演会
    • Place of Presentation
      九州大学、福岡
    • Year and Date
      2012-09-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Design of Boron-containing Nanoparticle for High Performance BNCT2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      15th International Congress on Neutron Capture Therapy(15-ICNCT)
    • Place of Presentation
      Tsukuba, Japan
    • Year and Date
      2012-09-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Polymer nanoparticle-based nitric oxide(NO) photodonor for novel therapeutics2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      SPIE2012 Nanosystem(the international society for optics and photonics)
    • Place of Presentation
      Incheon, Korea
    • Year and Date
      2012-09-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Hybrid chemistry for nanomedicine2012

    • Author(s)
      Yutaka Ikeda
    • Organizer
      Nanobio Seattle
    • Place of Presentation
      Seattle, U.S.A.
    • Year and Date
      2012-07-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Redox Nanomedicine for Cancer Chemotherapy2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      Nanobio Seattle
    • Place of Presentation
      Seattle, U.S.A.
    • Year and Date
      2012-07-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Self-organizing Redox Polymer Therapy2012

    • Author(s)
      Yutaka Ikeda
    • Organizer
      First Workshop between UdeM-MANA on Nano-life
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2012-07-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel PEGylation technologies of biomolecules for drug, developments2012

    • Author(s)
      Yutaka Ikeda
    • Organizer
      First Workshop between UdeM-MANA on Nano-life
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2012-07-19
    • Related Report
      2012 Final Research Report
  • [Presentation] ハイブリッドバイオインターフェースの設計と機能2012

    • Author(s)
      長崎幸夫
    • Organizer
      新学術領域研究合同公開シンポジウム
    • Place of Presentation
      小柴ホール、東京大学、東京20120710
    • Year and Date
      2012-07-10
    • Related Report
      2012 Final Research Report
  • [Presentation] フラーレンによる先進治療への展開2012

    • Author(s)
      長崎幸夫
    • Organizer
      第6回ナノ・バイオメディカル学会大会
    • Place of Presentation
      産総研、つくば、日本
    • Year and Date
      2012-07-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Nanobio-interface, Panel Symposium in English: "Polymer, Photonics and Lithography Technologies in Nanobiotechnology"2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      29th International Conference of Photopolymer Science and Technology (ICPST-29)
    • Place of Presentation
      Chiba, Japan
    • Year and Date
      2012-06-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Self-assembling Redox Polymer as Novel Nanoimaging and Therapy2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      2nd Nanosymposium on Nanomaterials Organizational Summary
    • Place of Presentation
      Adam Mickiewicz University, Poznan, Poland
    • Year and Date
      2012-06-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 自己組織化能を有するレドックスポリマードラッグによる新しいナノ治療2012

    • Author(s)
      長崎幸夫
    • Organizer
      第49回(2012年)薬剤学懇談会研究討論会
    • Place of Presentation
      兵庫県南あわじ市
    • Year and Date
      2012-06-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Self Assembled Polymer Drug2012

    • Author(s)
      Yukio Nagasaki,
    • Organizer
      9th International Symposium on Polymer Therapeutics (ISPT)
    • Place of Presentation
      Centro de Investigacion principe Felipe, Valencia, Spain
    • Year and Date
      2012-05-28
    • Related Report
      2012 Final Research Report
  • [Presentation] ピンポイント治療のためのナノ粒子設計2012

    • Author(s)
      長崎幸夫
    • Organizer
      第51会日本生体医工学会大会
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2012-05-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Nanotherapy of kidney Ischemia-reperfusion Injury by pH-sensitive Redox Nanoparticle2012

    • Author(s)
      Toru Yoshitomi, Aki Hirayama, Yukio Nagasaki
    • Organizer
      International Advanced Drug Delivery System(IADDS)
    • Place of Presentation
      Industrial Technology Research Institute, Hsinchum, Taiwan
    • Year and Date
      2012-04-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Oral Nanotherapy by Redox Polymer Nanoparticle2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      International Advanced Drug Delivery System(IADDS)
    • Place of Presentation
      Industrial Technology Research Institute, Hsinchum, Taiwan
    • Year and Date
      2012-04-26
    • Related Report
      2012 Final Research Report
  • [Presentation] PEGナノ粒子の調製と診断・治療材料への応用2012

    • Author(s)
      長崎幸夫
    • Organizer
      第62回医用高分子研究会【医用高分子研究会40周年記念】
    • Place of Presentation
      東京理科大学森戸記念会館、東京
    • Year and Date
      2012-03-09
    • Related Report
      2012 Final Research Report
  • [Presentation] ガドリニウムフラーレンによる中性子捕捉療法2012

    • Author(s)
      長崎幸夫
    • Organizer
      第42回 フラーレン・ナノチューブ・グラフェン, 総合シンポジウム
    • Place of Presentation
      東京大学、東京
    • Year and Date
      2012-03-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Anticancer redox-nanotherapy2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      MANA International Symposium 2012
    • Place of Presentation
      Tsukuba, Japan
    • Year and Date
      2012-03-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel Redox-active Polymer Nanotherapy, -Cancer, Ischemia-reperfusion, Inflammatory Bowel Disease-2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      APA International Congress on Advances in Human Healthcare Systems
    • Place of Presentation
      New Delhi, India
    • Year and Date
      2012-02-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 大気圧プラズマによるバイオ表面設計2012

    • Author(s)
      長崎幸夫
    • Organizer
      仙台"プラズマフォーラム"平成23年度東北大学電気通信研究所共同プロジェクト研究会, 「プラズマナノバイオトロニクスの基礎研究」共催
    • Place of Presentation
      秋保温泉岩沼屋、宮城
    • Year and Date
      2012-02-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 高い認識能を有するバイオセンシング界面の設計2012

    • Author(s)
      長崎幸夫
    • Organizer
      有機エレクトロニクス研究会
    • Place of Presentation
      産総研九州センター 、鳥栖
    • Year and Date
      2012-02-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Oral Redox Nanotherapy2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      Biomimetic Materials Processing
    • Place of Presentation
      Nagoya University, Nagoya, Japan
    • Year and Date
      2012-01-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Construction of Biointerface by Block Copolymer Possessing Poly(ethylene glycol) as one of Segments and Multi-anchoring Groups as Side Chain of the Other Segments2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      IACIS2012
    • Place of Presentation
      Sendai International Center, Sendai, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Redox nanoparticle therapy for ischemic reperfusion injuries2012

    • Author(s)
      Yukio Nagasaki
    • Organizer
      UK-Japan Research Symposium:, Molecular Mechanisms of Stress Response in Disease
    • Place of Presentation
      Tsukuba Science Information Center,Tsukuba, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] SELF-ASSEMBLING REDOX POLYMER DRUG FOR ANTI-OXIDATIVE STRESS INJURY2011

    • Author(s)
      長崎幸夫
    • Organizer
      2nd International School-Nano2011. Nanomaterials and Nanotechnologies in Living Systems. Safety and Nanomedicine
    • Place of Presentation
      Moscow, Russia(招待講演)
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Design of antibody/PEG hybrid biointerface for obtaining high-performance immunolatex2010

    • Author(s)
      Xiaofei Yuan, Dolca Fabregat, Keitaro Yoshimoto, Yukio Nagasaki
    • Organizer
      Gordon Research Conferences(GRC)-Biointerface Science
    • Place of Presentation
      Les Diablerets, Switzerland.
    • Year and Date
      2010-09-08
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Surface engineering of antibody/PEG hybrid for design of high-performance immunolatex2010

    • Author(s)
      Xiaofei Yuan, Dolca Fabregat, Keitaro Yoshimoto, Yukio Nagasaki
    • Organizer
      IVC-18/ICN+T2010/ICSS-14/VASSCAA-5
    • Place of Presentation
      Beijing, China.
    • Year and Date
      2010-08-26
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 高密度PEG化ナノゲルの合成と評価2010

    • Author(s)
      長崎幸夫
    • Organizer
      第21回 高分子ゲル研究討論会
    • Place of Presentation
      東京大学
    • Year and Date
      2010-01-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Novel Nanoparticles Functionalized for Anti-Oxidative Stress2010

    • Author(s)
      Nagasaki Yukio
    • Organizer
      NanoDDS'10
    • Place of Presentation
      Omaha, Nbraska USA(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Reformulations of Enzyme Surface by PEAMA-g-PEG with the Improvementof Heat-resistant Property2009

    • Author(s)
      長崎幸夫
    • Organizer
      19th Symposium of MRS-Japan
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2009-12-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hybridization of synthetic polymers and biopolymers for creation of high-performance biointerface2009

    • Author(s)
      Nagasaki Yukio
    • Organizer
      Nano Europe 2009
    • Place of Presentation
      Rapperswil, Switzerland
    • Year and Date
      2009-11-25
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Hybridization of synthetic polymers and biopolymers for creation of high-performance biointerface2009

    • Author(s)
      長崎幸夫
    • Organizer
      NanoEurope 2009
    • Place of Presentation
      Rapperswil, Switzerland
    • Year and Date
      2009-11-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体適合性金ナノ粒子を利用した診断技術2009

    • Author(s)
      長崎幸夫
    • Organizer
      第六回コロイド・界面新領域創造講座
    • Place of Presentation
      日本化学会館5階会議室
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Spheroid array chip of fetal liver cells on micropatterned PEG-gel surface for culture technique to regenerative medicine in liver : up regulation of liver function by co-culture's cell-cell contact2009

    • Author(s)
      長崎幸夫
    • Organizer
      The 4th International Symposium on Atomic Technology(ISAT-4)
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Prevention of Heat-induced Inactivation of Enzymes Through Complexation with PEAMA-g-PEG2009

    • Author(s)
      長崎幸夫
    • Organizer
      The 4th International Symposium on Atomic Technology(ISAT-4)
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2009-11-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synthesis and Characterization of Highly PEGylated Nanogel2009

    • Author(s)
      長崎幸夫
    • Organizer
      The 4th International Symposium on Atomic Technology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2009-11-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Noncovalent Modification of Enzyme Based on Thermotolerant Enzyme/Smart Polymer Complex Formation : Implications in Modulating Protein Function2009

    • Author(s)
      長崎幸夫
    • Organizer
      The 1st FAPS Polymer Congress
    • Place of Presentation
      Nagoya
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of PEAMA-g-PEG on the Heat-induced Inactivation of Enzymes Based on Enzyme/Polymer Complex Formation2009

    • Author(s)
      長崎幸夫
    • Organizer
      TSAMS
    • Place of Presentation
      Epochal Tsukuba, Japan
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Modulation of Lysozyme Activity Based on Protein/Polymer Complex Formation2009

    • Author(s)
      長崎幸夫
    • Organizer
      ソフトインターフェースの分子科学 第二回公開シンポジウム
    • Place of Presentation
      理化学研究所 和光キャンパス
    • Year and Date
      2009-09-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] バイオ環境を制御するナノゲルの設計2009

    • Author(s)
      長崎幸夫
    • Organizer
      ゲルワークショップ イン 熊本
    • Place of Presentation
      ホテル法華クラブ熊本
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 金表面上に固定化した抗体フラグメントの抗原認識能に対するPEG密生層の役割2009

    • Author(s)
      長崎幸夫
    • Organizer
      第58回 高分子討論会
    • Place of Presentation
      熊本大学 工学部 黒髪キャンパス
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体内安定性を目指した高密度PEGナノゲルの構築2009

    • Author(s)
      長崎幸夫
    • Organizer
      ゲルワークショップ イン 熊本
    • Place of Presentation
      ホテル法華クラブ熊本
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高感度免疫診断粒子の設計―実用化を目指したPEG/抗体密生層の表面構築2009

    • Author(s)
      長崎幸夫
    • Organizer
      第58回 高分子討論会
    • Place of Presentation
      熊本大学
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] ナノリアクターとして機能するPEG化ナノゲル粒子によるナノ治療・診断2009

    • Author(s)
      長崎幸夫
    • Organizer
      第58回 高分子討論会
    • Place of Presentation
      熊本大学 工学部 黒髪キャンパス
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Formulation a highly ferritin-responding immunolatex by construction of antiferritin/mixed-PEG coimmobilized soft surface onto polystyrene nanospheres2009

    • Author(s)
      長崎幸夫
    • Organizer
      238th ACS National Meeting & Exposition
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2009-08-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] PEGポリアミングラフト共重合体との耐熱性ポリイオンコンプレックス形成に基づくリゾチームの酵素活性制御2009

    • Author(s)
      長崎幸夫
    • Organizer
      第19回バイオ・高分子シンポジウム
    • Place of Presentation
      東京大学先端科学技術研究センター
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] マイクロパターン化PEGゲルチップを用いた胎生肝細胞スフェロイドアレイの構築と機能評価2009

    • Author(s)
      長崎幸夫
    • Organizer
      第38回医用高分子シンポジウム
    • Place of Presentation
      東京大学先端科学技術研究センター
    • Year and Date
      2009-07-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Spheroid array chip of fetal liver cells for regenerative medicine constructed on micropatterned PEG-gel surface : control of liver cell spheroids functions by hetero co-culture system2009

    • Author(s)
      長崎幸夫
    • Organizer
      Gordon Research Conference, Biomaterials : Biocompatibility
    • Place of Presentation
      Tissue Engineering. Holderness School Holderness, NH United states of America
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 環境変化に応答するナノ粒子の設計とナノメディシンへの展開2009

    • Author(s)
      長崎幸夫
    • Organizer
      徳島大学大学院ソシオテクノサイエンス研究部セミナー
    • Place of Presentation
      徳島大学
    • Year and Date
      2009-07-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] バイオナノ粒子の魅力2009

    • Author(s)
      長崎幸夫
    • Organizer
      ナノ科学・材料研究センター(N2RC)セミナー
    • Place of Presentation
      大阪府立大
    • Year and Date
      2009-07-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] プラズマプロセスによるナノ生体機能材料の創成2009

    • Author(s)
      長崎幸夫
    • Organizer
      日本学術振興会プラズマ材料科学第153委員会
    • Place of Presentation
      弘済会館
    • Year and Date
      2009-05-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高度分子認識を目指した生体分子と合成分子のなす超構造界面生層の構築-PEGゲルマイクロパタン上における肝細胞スフェロイドの構築と評価-2009

    • Author(s)
      長崎幸夫
    • Organizer
      ソフトインターフェースの分子科学第, 二回領域会議
    • Place of Presentation
      九州大学
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] ポリエチレングリコール誘導体を修飾した界面を利用する生体高分子の分子認識能および酵素活性制御2009

    • Author(s)
      長崎幸夫
    • Organizer
      ソフトインターフェースの分子科学 第二回領域会議
    • Place of Presentation
      九州大学
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] PEG密生層形成による固定化ストレプトアビジンの熱変性抑制効果2009

    • Author(s)
      長崎幸夫
    • Organizer
      ソフトインターフェースの分子科学 第二回領域会議
    • Place of Presentation
      九州大学
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Novel Nanoparticle Therapy2009

    • Author(s)
      長崎幸夫
    • Organizer
      ISAP2009
    • Place of Presentation
      Keio University
    • Year and Date
      2009-04-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Smart Nanomedicine Based on Stimuli-Responsive PEGylated Nanogels for Cancer Diagnosis and Therapy2009

    • Author(s)
      長崎幸夫
    • Organizer
      3^<rd> ISIMSBMS-2009
    • Place of Presentation
      筑波大学
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Function of Poly(ethylene glycol)Modified Layers Prepared by "Grafting to" Method on Gold Surface2009

    • Author(s)
      長崎幸夫
    • Organizer
      3^<rd> ISIMSBMS-2009
    • Place of Presentation
      筑波大学
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Prevention of Heat-induced Inactivation of Lysozyme Using PEAMA-g-PEG2009

    • Author(s)
      長崎幸夫
    • Organizer
      SIMSBMS
    • Place of Presentation
      University of Tsukuba
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Materials design for functional bionanoparticles2008

    • Author(s)
      長崎幸夫
    • Organizer
      2008 Prague Meetings on Macromolecules
    • Place of Presentation
      Plague, Czech Republic
    • Year and Date
      2008-07-21
    • Related Report
      2008 Annual Research Report
  • [Book] ナノ粒子アシスト型がん化学療法の開発、癌と人2012

    • Author(s)
      長崎幸夫
    • Publisher
      公益財団法人大阪癌研究会
    • Related Report
      2012 Final Research Report
  • [Book] PEGylation Technology in Nanomedicine, Advances in Polymer Scienc 2472012

    • Author(s)
      Yutaka Ikeda, Yukio Nagasaki
    • Publisher
      Polymer s in Nanomedicine
    • Related Report
      2012 Final Research Report
  • [Book] ガドリニウムフラーレンによる中性子捕捉療法、2013ナノカーボン技術大全2012

    • Author(s)
      長崎幸夫
    • Total Pages
      5
    • Publisher
      Electric Journal
    • Related Report
      2012 Annual Research Report
  • [Book] ナノゲルによるピンポイント治療・診断システムへの展開、先端バイオマテリアルハンドブック2012

    • Author(s)
      長崎幸夫
    • Total Pages
      6
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2012 Annual Research Report
  • [Book] ナノ粒子アシスト型がん化学療法の開発2012

    • Author(s)
      長崎幸夫
    • Total Pages
      7
    • Publisher
      公益財団法人大阪癌研究会
    • Related Report
      2012 Annual Research Report
  • [Book] 高分子材料が一番わかる2011

    • Author(s)
      長崎幸夫
    • Total Pages
      20
    • Publisher
      技術評論社
    • Related Report
      2011 Annual Research Report
  • [Book] Design of Highly Functional Antiferritin-Immunolatex by Hybridization of Antiferritin/Mixed-PEG Polymers onto Polystyrene Submicroparticles2010

    • Author(s)
      Xiaofei Yuan, Dolca Fabregat, Keitaro Yoshimoto, Yukio Nagasaki
    • Total Pages
      15
    • Publisher
      Biomaterials : ACS Symposium Series
    • Related Report
      2010 Annual Research Report
  • [Book] 高分子ミセル、「ソフトマスター分子設計・キャラクタリゼーションから機能性材料まで」、高原淳, 栗原和江, 前田瑞夫共編2009

    • Author(s)
      長崎幸夫
    • Total Pages
      8
    • Publisher
      丸善
    • Related Report
      2009 Annual Research Report
  • [Book] "Block Copolymer Synthesis of Nanoscale Drug and Gene Delivery", in Nanotechnology in Drug Delivery, Ed. by Melgaradt M. de Villiers, Pornanong Aramwit, Glen S. Kwon2008

    • Author(s)
      長崎幸夫、他
    • Publisher
      Springer, New York, 2008
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.ims.tsukuba.ac.jp/~nagasaki_lab/index.htm

    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 免疫ラテックス粒子及びその製造方法2009

    • Inventor(s)
      長崎幸夫, 吉本敬太郎, 原暁非, Dolca Fabrigat
    • Industrial Property Rights Holder
      筑波大学
    • Filing Date
      2009-01-16
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 混合ポリエチレングリコールと抗体が共固定化された表面を所有する免疫ラテックス粒子及びその製造方法2009

    • Inventor(s)
      長崎幸夫, 原暁非, 吉本敬太郎
    • Industrial Property Rights Holder
      筑波大学
    • Filing Date
      2009-01-16
    • Related Report
      2010 Self-evaluation Report

URL: 

Published: 2008-04-01   Modified: 2018-03-28  

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