| Budget Amount *help |
¥53,300,000 (Direct Cost: ¥41,000,000、Indirect Cost: ¥12,300,000)
Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2011: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2010: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2009: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
We demonstrated an ability of stimuli-responsive polymer gels as nano-interfaces enabling a FET-based, but nonetheless virtually “Debye length-free” universal molecular detection. The FET gate has been modified with stimuli-responsive polymer gels that are called “smart gel”. As a key property of the volume phase transition of the smart gels, the property changes commencing from the gel/outer aqueous media interface can geometrically propagate across a macroscopic thickness of the gel layer. On extension of this approach, we further investigated feasibility of using linear polymer brush to replace the gel matrix. In the case of the cross-linked network (or gel), the rate of response is determined by the rate of relaxation of the polymer chains (involving cooperative diffusion of polymer network) during the change in hydration, which typically takes hours. Therefore, for a potential advantage, the linear polymer brush surfaces offer dramatically improved response time. To prove this concept, phenylboronate-based linear polymers were brushed onto gold electrodes, either by grafting-from or grafting-to methods, and were assessed for the capability of transducing the target signals in a mode of the change in permittivity during hydration. It was clearly demonstrated that these non-cross-linked surfaces enable the signal transduction in a similar fashion to those observed for the cross-linked systems. It was clearly demonstrated that these non-cross-linked surfaces enable the signal transduction in a similar fashion to those observed for the cross-linked systems.
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