| Budget Amount *help |
¥31,460,000 (Direct Cost: ¥24,200,000、Indirect Cost: ¥7,260,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2011: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Research Abstract |
Replacement of intemucleoside phosphodiester linkages ofDNA or RNA with non-natUral structUres would generate intriguing oligonucleotides with fUnctions that could explore the field of medicinal chemistry, chemical biology and materials science. The Nature's choice of phosphine for the intemucleoside linkage is so divine that allows the connection and cleavage of the oligonucleotides at will. We developed non-natUral oligonucleotides with an intenlucleosidic modification. Adopting an effective reaction from the click chemistry, copper-catalyzed Huisgen cycloaddition, we designed and synthesized the new analogues, triazole-linked DNA and RNA(^<TL>DNA/^<TL>RNA). The robust synthesis supported the concise synthesis of oligonucleotides with triazole-linkages and the development of their functions in bioorganic and materials chemistry.
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