| Budget Amount *help |
¥97,240,000 (Direct Cost: ¥74,800,000、Indirect Cost: ¥22,440,000)
Fiscal Year 2012: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2011: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2010: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2009: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2008: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
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| Research Abstract |
We conducted detailed analyses for germ plasm assembly and maintenance, and proposed several new ideas and concepts on RNA regulation. First, our analyses revealed that Edc3, a component of cytoplasmic RNP granules, mediates a dynamic remodeling of RNP components during localization and translation of germ plasm RNAs. We also found that the vesicle trafficking pathway promotes actin remodeling and plays a crucial role in the cortical anchorage of the germ plasm. Furthermore, our results show that the protection of germ plasm RNAs from the miRNA-mediated RNA degradation pathway is an evolutionally conserved process.
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