| Budget Amount *help |
¥94,380,000 (Direct Cost: ¥72,600,000、Indirect Cost: ¥21,780,000)
Fiscal Year 2012: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2011: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2010: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2009: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2008: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
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| Research Abstract |
Alternative processing of precursor messenger RNAs (pre-mRNAs) is a major source of protein diversity and plays crucial roles in development, differentiation and diseases in higher eukaryotes. We have been utilizing multi-chromatic fluorescence alternative processing reporter system to visualize tissue-specific and/or developmental alternative processing patterns in living worms and isolated mutants defective in alternative processing regulation. Here we performed transcriptome analysis of the mutant worms, identified many novel target events for the regulators, analyzed their expression patterns in vivo and predicted and experimentally identified cis-elements for the regulators to reveal the "splicing code" in living organisms.
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