| Budget Amount *help |
¥99,060,000 (Direct Cost: ¥76,200,000、Indirect Cost: ¥22,860,000)
Fiscal Year 2012: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2011: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2010: ¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2009: ¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2008: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
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| Research Abstract |
Based on mRNA deadenylation mechanism originally uncovered by us, we have newly identified the following mechanisms of the posttranscriptional gene regulation and RNA quality control. (i) deadenylation mediated by mRNA 3’ UTR cis elements (URE, CPE) and negative regulation of gene expression, (ii) stress-induced global stabilization of mRNA poly(A) tails and formation of stress granules, (iii) mRNA polyadenylation mediated by the non-canonical poly(A) polymerase and positive regulation of gene expression, (iv) quality control of aberrant nonstop mRNA. We also verified quality control mechanism of the nuclear histon mRNA.
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