Budget Amount *help |
¥99,710,000 (Direct Cost: ¥76,700,000、Indirect Cost: ¥23,010,000)
Fiscal Year 2012: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2011: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2010: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2009: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2008: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
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Research Abstract |
We identified the mRNA-binding protein Nrd1 and demonstrated that Nrd1 binds to and regulates mRNA stability of the Myosin mRNA. We also showed that Pmk1 MAPK, a homologue of ERK in fission yeast regulates the RNA-binding activity of Nrd1 in a phosphorylation-dependent manner. Moreover, Nrd1 translocated to the stress granules in a MAPK-mediated phosphorylation-dependent manner, thereby regulates stress tolerance in fission yeast.
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