| Budget Amount *help |
¥84,500,000 (Direct Cost: ¥65,000,000、Indirect Cost: ¥19,500,000)
Fiscal Year 2012: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2011: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2010: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2009: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2008: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
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| Research Abstract |
Drosophila is an ideal animal model to investigate molecular and physiological function of memory-related genes. In this study, using Drosophila, we demonstrate following results. 1) Mg2+ block of NMDA receptors is specifically required for long-term memory (LTM) formation through inhibiting expression of suppressor isoform of CREB. 2) increase in cell adhesion molecule, Klingon (Klg) after induction of LTM is an essential for LTM formation and is dependent on Notch. 3) PKA has an inhibitory function in memory consolidation. 4) mild starvation enhance LTM formation via activating CRTC/CREB transcriptional pathway. Regarding memory disorders we show following results. 5) acute inhibition of PKA can ameliorate memory impairment in aged flies. 6) age-related memory impairment (AMI) is not caused by age-related increase in oxidative stress in Drosophila. 7) insulin signaling-dependent developmental defects causes mental retardation. 8) long-term enhancement (LTE) formed in the mushroom bodies of cultured isolated brain is a cellular model of olfactory associative memory.
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