| Budget Amount *help |
¥84,500,000 (Direct Cost: ¥65,000,000、Indirect Cost: ¥19,500,000)
Fiscal Year 2012: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2011: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2010: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2009: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2008: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
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| Research Abstract |
Neuronal circuits that generate locomotion in mammals are not well understood. In this study, we studied locomotor circuits in larval zebrafish, by using a number of transgenic zebrafish expressing fluorescent protein in a particular class of neurons. We have revealed the followings: (1) a specialized class of commissural inhibitory neurons play a critical role for determining the direction of an escape behavior, (2) multiple types of V0 neurons are produced by two distinct mechanisms; from heterogeneous p0 progenitors and from the same p0 progenitor, but in a time-dependent manner, (3) Chx10-expressing neurons in the hindbrain play an essential role for providing excitation to the spinal locomotor circuits during zebrafish swimming.
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