| Co-Investigator(Renkei-kenkyūsha) |
HAYASHI Yoshiki 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 助教 (30508817)
SATO Masanao 基礎生物学研究所, 発生遺伝学研究部門, 助教 (20517693)
KITADATE Yu 基礎生物学研究所, 生殖細胞研究部門, 助教 (10455214)
ABE Kuniya 独立行政法人理化学研究所, 動物変異動態解析技術開発チーム, チームリーダー (40240915)
|
|---|
| Budget Amount *help |
¥206,830,000 (Direct Cost: ¥159,100,000、Indirect Cost: ¥47,730,000)
Fiscal Year 2012: ¥39,780,000 (Direct Cost: ¥30,600,000、Indirect Cost: ¥9,180,000)
Fiscal Year 2011: ¥39,780,000 (Direct Cost: ¥30,600,000、Indirect Cost: ¥9,180,000)
Fiscal Year 2010: ¥39,780,000 (Direct Cost: ¥30,600,000、Indirect Cost: ¥9,180,000)
Fiscal Year 2009: ¥39,780,000 (Direct Cost: ¥30,600,000、Indirect Cost: ¥9,180,000)
Fiscal Year 2008: ¥47,710,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥11,010,000)
|
|---|
| Research Abstract |
In this study, we have been trying to clarify the mechanisms regulating "GSC Niche System" in Drosophila. We found that 1) heparan sulphate proteoglycans (HSPG) are deeply involved in GSC maintenance by restricting the function of growth factors in a narrow region (Niche field) around "Niche cells", 2) Notch, Sevenless and Egfr signaling are required for proper formation of "Niche cells" in the anterior region of male embryonic gonads, and that 3) maternal Ovo and Sxl are required for germline-specific gene expression and sex determination of primordial germ cells, respectively.
|
