| Budget Amount *help |
¥72,280,000 (Direct Cost: ¥55,600,000、Indirect Cost: ¥16,680,000)
Fiscal Year 2012: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2011: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2010: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2009: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2008: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
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| Research Abstract |
The major focus of this project is to elucidate the effects of NO, particularly through S-nitrosylation of the target protein, transmitted through the plasma membrane of juxtaposed cells. NO reacts with cysteine to convert itself to membrane transferrable molecule, CysNO, which in tern can travel through the amino acid transporter to the juxtaposed cells. The intracellular decomposition enzyme for CysNO works to prevent excess influx of NO signal into the cell resulting in the formation of pathophysiological conditions.
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