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Molecular mechanism of nitric oxide/nitrosative stress implicating in onset of neurodegenerative disorders

Planned Research

Project AreaSignaling functions of reactive oxygen species
Project/Area Number 20117011
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOkayama University (2010-2012)
Hokkaido University (2008-2009)

Principal Investigator

UEHARA Takashi  岡山大学, 大学院・医歯薬学総合研究科, 教授 (00261321)

Co-Investigator(Kenkyū-buntansha) NISHIYA Tadashi  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80399831)
Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥71,630,000 (Direct Cost: ¥55,100,000、Indirect Cost: ¥16,530,000)
Fiscal Year 2012: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2011: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2010: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2009: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2008: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Keywords一酸化窒素 / 酸化ストレス / 神経細胞 / アポトーシス / 神経変性疾患 / シグナル伝達 / S-ニトロシル化 / ユビキチン / プロテアソーム / PTEN / Akt / 小胞体 / リガーゼ / ストレス / 基質 / 細胞死 / 質量分析 / スクリーニング / 酸化部位
Research Abstract

We performed antibody-array screening in conjunction with biotin-switch assays to identify the novel S-nitrosylated proteins. Using this assay system, we found that phosphatase with sequence homology to tensin (PTEN) is selectively S-nitrosylated by low concentrations of NO at a specific cysteine residue. In addition, we demonstrated the mechanism of SPSB-mediated iNOS degradation and the relative contributions of different SPSB proteins to iNOS regulation.

Report

(7 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (86 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (20 results) (of which Peer Reviewed: 19 results) Presentation (37 results) (of which Invited: 2 results) Book (17 results) Remarks (12 results)

  • [Journal Article] Participation of metabotropic glutamate receptors in pentetrazol-induced kindled seizure2011

    • Author(s)
      Watanabe, Y., Kaida, Y., Fukuhara, S., Takechi, K., Uehara, T., and Kamei, C
    • Journal Title

      Epilepsia

      Volume: 52 Issue: 1 Pages: 140-150

    • DOI

      10.1111/j.1528-1167.2010.02764.x

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN)2011

    • Author(s)
      Numajiri N., Takasawa K., Nishiya T., Tanaka H., Ohno K., Hayakawa W., Asada M., Matsuda H., Azumi K., Kamata H., Nakamura T., Hara H., Minami M., Lipton S.A., Uehara T.
    • Journal Title

      Proceedings of the National Academy of Sciences, USA

      Volume: 108 Issue: 25 Pages: 10349-10354

    • DOI

      10.1073/pnas.1103503108

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening systems for identification of S-nitrosylated proteins2011

    • Author(s)
      Uehara, T. and Nishiya, T
    • Journal Title

      Nitric Oxide

      Volume: 25 Issue: 2 Pages: 108-111

    • DOI

      10.1016/j.niox.2010.11.002

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The ECS (SPSB) E3 ubiquitin ligase is the master regulator of the lifetime of inducible nitric-oxide synthase. Biochem2011

    • Author(s)
      Matsumoto, K., Nishiya, T., Maekawa, S., Horinouchi, T., Ogasawara, K., Uehara, T., and Miwa, S
    • Journal Title

      Biophys. Res. Commun

      Volume: 409 Issue: 1 Pages: 46-51

    • DOI

      10.1016/j.bbrc.2011.04.103

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SPRY domain-containing SOCS box protein-1 (SPSB1), SPSB2, and SPSB4 are master regulators of proteasome-dependent degradation of iNOS2011

    • Author(s)
      Nishiya, T., Matsumoto, K., Maekawa, S., Horinouchi, T., Fujimuro, M., Ogasawara, K., Uehara, T., and Miwa, S
    • Journal Title

      J. Biol. Chem

      Volume: 286 Issue: 11 Pages: 9009-9019

    • DOI

      10.1074/jbc.m110.190678

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2011

    • Author(s)
      Matsumoto K, Nishiya T, Maekawa S, Horinouchi T, Ogasawara K, Uehara T, Miwa S
    • Journal Title

      Biochem.Biophys.Res.Commun. 印刷中

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article]2011

    • Author(s)
      Nishiya T, Uehara T
    • Journal Title

      Nitric Oxide 印刷中

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article]2011

    • Author(s)
      Nishiya T, Matsumoto K, Maekawa S, Kajita E, Horinouchi T, Fujimuro M, Ogasawara K, Uehara T, Miwa
    • Journal Title

      S.J.Biol.Chem. 286

      Pages: 9009-9019

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article]2011

    • Author(s)
      Watanabe Y, Kaida Y, Fukuhara S, Takechi K, Uehara T, Kamei C.
    • Journal Title

      Epilepsia 52

      Pages: 140-150

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Participation of metabotropic glutamate receptors in pentetrazol-induced kindled seizure.2011

    • Author(s)
      Watanabe, Y.
    • Journal Title

      Epilepsia

      Volume: 52 Pages: 140-150

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SSPRY domain-containing SOCS box protein-1 (SPSB1), SPSB2, and SPSB4 are master regulators of proteasome-dependent degradation of iNOS.2011

    • Author(s)
      Nishiya, T.
    • Journal Title

      J.Biol.Chem.

      Volume: 286 Pages: 9009-9019

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      Katayama T, Sakaguchi E, Komatsu Y, Oguma T, Uehara T, Minami M.
    • Journal Title

      Eur.J. Neurosci. 31

      Pages: 1359-1367

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Sustained activation of ERK signaling in astrocytes is critical for neuronal injury-induced monocyte chemoattractant protein-1 production to rat corticostriatal slice cultures.2010

    • Author(s)
      Katayama, T.
    • Journal Title

      Eur.J.Neurosci.

      Volume: 31 Pages: 1359-1367

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sustained activation of ERK signaling in astrocytes is critical for neuronal injury-induced monocyte chemoattractant protein-1 production in rat cortico-striatal slice cultures2010

    • Author(s)
      Katayama, T., et al.
    • Journal Title

      Eur J Neurosci (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal injury induces cytokine-induced neutrophil chemoattractant-1(CINC-1)production in astrocytes2009

    • Author(s)
      Katayama, T., et al.
    • Journal Title

      J Pharmacol Sci. 109

      Pages: 88-93

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reciprocal regulation of ATPgammaS-induced monocyte chemoattractant protein-1 production by ERK and p38 MAP kinases in rat corticostriatal slice cultures2009

    • Author(s)
      Katayama, T., et al.
    • Journal Title

      J Neurosci Res. 87

      Pages: 1573-1581

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal injury induces cytokine-induced neutrophil chemoattractant-1 (CINC-1) production in astrocytes2009

    • Author(s)
      atayama, T., et.al.
    • Journal Title

      J Pharmacol Sci 109

      Pages: 88-93

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reciprocal regulation of ATPgammaS-induced monocyte chemoattractant protein-1 production by ERK and p38 MAP kinases in rat corticostriatal slice cultures2009

    • Author(s)
      Katayama, T., et.al.
    • Journal Title

      J Neurosci Res 87

      Pages: 1573-1581

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GMEB1, a novel endogenous caspase inhibitor, prevents hypoxia-and oxidative stress-induced neuronal apoptosis2008

    • Author(s)
      Nakagawa, T., et.al.
    • Journal Title

      Neurosci Lett 438

      Pages: 34-37

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening systems for identification of S-nitrosylated proteins.

    • Author(s)
      Uehara, T.
    • Journal Title

      Nitric Oxide

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] タンパク質S-ニトロシル化/酸化を介したによる小胞体ストレス誘導機構2013

    • Author(s)
      柴田万里,西屋 禎,上原 孝
    • Organizer
      日本薬学会第133回年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-03-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] SPSB ファミリー蛋白質を介したCDC14A phosphatase のユビキチン-プロテアソーム依存的分解機構2013

    • Author(s)
      西屋 禎,丸山 拳,松本一馬,小笠原康悦,三輪聡一,上原 孝
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2013-03-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] ガス状分子の神経細胞死に対する作用機構2012

    • Author(s)
      上原 孝
    • Organizer
      第39回日本毒性学会学術年会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2012-07-19
    • Related Report
      2012 Final Research Report
  • [Presentation] ガス状分子の神経細胞死に対する作用機構2012

    • Author(s)
      上原 孝
    • Organizer
      第39回日本毒性学会学術年会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2012-07-19
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] A novel modulatory “on-off”system for PI 3-kinase-Akt signaling through S-nitrosylation of PTEN2012

    • Author(s)
      上原 孝
    • Organizer
      The 33rd Naito Conference on Oxygen Biology
    • Place of Presentation
      Chateraise Gateaux Kingdom Sapporo
    • Year and Date
      2012-06-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] NOによる蛋白質修飾と神経細胞死制御2012

    • Author(s)
      上原 孝
    • Organizer
      第53回日本生化学会 中国・四国支部例会
    • Place of Presentation
      岡山大学
    • Year and Date
      2012-05-18
    • Related Report
      2012 Final Research Report
  • [Presentation] NOによる蛋白質修飾と神経細胞死制御2012

    • Author(s)
      上原 孝
    • Organizer
      第53回日本生化学会 中国・四国支部例会
    • Place of Presentation
      岡山大学
    • Year and Date
      2012-05-18
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] PTENのS-ニトロシル化を介するAktシグナル制御機構2012

    • Author(s)
      上原孝
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] ニトロソ化/酸化ストレスによる小胞体蛋白質の機能不全2012

    • Author(s)
      柴田万里, 西屋禎, 上原孝
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] A novel modulatory 'on-off' system for PI 3-kinase-Akt signaling through S-nitrosylation of PTEN2011

    • Author(s)
      Takashi Uehara
    • Organizer
      41^<st> Annual Meeting Neuroscience 2011
    • Place of Presentation
      Walter E.Washington Convention Center, USA
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 一酸化窒素による細胞死連関シグナル制御機構2011

    • Author(s)
      上原孝
    • Organizer
      第6回小胞体スシレス研究会
    • Place of Presentation
      岡山大学
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] A novel modulatory 'on-off' system for PI 3-kinase-Akt signaling through S-nitrosylation2011

    • Author(s)
      上原 孝
    • Organizer
      第11回日本NO学会学術集会
    • Place of Presentation
      昭和薬科大学
    • Year and Date
      2011-05-14
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel modulatory 'on-off' system for PI 3-kinase-Akt signaling through S-nitrosylation2011

    • Author(s)
      上原孝
    • Organizer
      第11回日本NO学会学術集会
    • Place of Presentation
      昭和薬科大学(招待講演)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 蛋白質S-ニトロシル化による新規シグナリング調節機構2011

    • Author(s)
      上原孝
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡グランシップ
    • Year and Date
      2011-03-29
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 抗体アレイを使用した新規S-ニトロシル化蛋白質の探索2010

    • Author(s)
      上原 孝
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-12-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗体アレイを使用した新規S- ニトロシル化蛋白質の探索2010

    • Author(s)
      上原孝
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化 学会大会 合同大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-12-09
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 抗体アレイを使用した新規S-ニトロシル化蛋白質の探索2010

    • Author(s)
      上原孝
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Elongin B/C,Cu15,Rbx2,及びSPRY domain-containing SOCS box protein(SSB)により構成されるE3ユビキチンリガーゼ複合体(ECS-SSB)は誘導型一酸化窒素合成酵素(iNOS)の分解制御システムである2010

    • Author(s)
      西屋禎
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Detection of oxidized protein-disulfide isomerase with a specific antibody2010

    • Author(s)
      Takashi Uehara
    • Organizer
      40th Annual Meeting Neuroscience 2010
    • Place of Presentation
      サンディエゴコンベンションセンター
    • Year and Date
      2010-11-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 欠神発作に対するアセタゾラミドの抑制効果2010

    • Author(s)
      改田祐子
    • Organizer
      第118回日本薬理学会近畿部会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Detection of oxidized protein-disulfide isomerase with a specific antibody2010

    • Author(s)
      Takashi Uehara
    • Organizer
      40^<th> Annual Meeting Neuroscience 2010
    • Place of Presentation
      San Diego Convention Centre
    • Year and Date
      2010-11-15
    • Related Report
      2012 Final Research Report 2010 Self-evaluation Report
  • [Presentation] NOによる小胞体ストレス惹起機構2010

    • Author(s)
      上原孝
    • Organizer
      第5回小胞体ストレス研究会
    • Place of Presentation
      東京大学薬学部
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] ニトロソ化ストレスを切り口とした神経変性疾患の早期診断/治療薬開発へのアプローチ2010

    • Author(s)
      上原 孝
    • Organizer
      生体機能と創薬シンポジウム 2010京都
    • Place of Presentation
      グランヴィア京都
    • Year and Date
      2010-09-09
    • Related Report
      2012 Final Research Report
  • [Presentation] ニトロソ化ストレスを切り口とした神経変性疾患の早期診断/治療薬開発へのアプローチ2010

    • Author(s)
      上原孝
    • Organizer
      生体機能と創薬シンポジウム2010京都
    • Place of Presentation
      グランビア京都
    • Year and Date
      2010-09-09
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] ニトロソ化ストレスを切り口とした神経変性疾患の早期診断/治療薬開発へのアプローチ2010

    • Author(s)
      上原孝
    • Organizer
      生体機能と創薬シンポジウム 2010京都
    • Place of Presentation
      グランビア京都
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] The SPRY domain-containing SOCS box protein family regulates the lifetime of iNOS by linking iNOS with elongin BC-Cu15-Rbx2 E3 ubiquitin ligase complex.2010

    • Author(s)
      Nishiya, T.
    • Organizer
      The 14th International Congress of Immunology (ICI2010)
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] The life time of iNOS is regulated by the SPRY domain-containing SOCS box protein family linking iNOS to the elongin BC-Cul5-Rbx2 E3 ubiquitin ligase complex2010

    • Author(s)
      Tadashi Nishiya, Satoshi Maekawa, Masahiro Fujimuro, Kouetsu Ogasawara, Takashi Uehara, and Soichi Miwa
    • Organizer
      The 6^<th> International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric oxide
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2010-06-17
    • Related Report
      2012 Final Research Report
  • [Presentation] The life time of iNOS is regulated by the SPRY domain-containing SOCS box protein family linking iNOS to the elongin BC-Cu15-Rbx2 E3 ubiquitin ligase complex2010

    • Author(s)
      Nishiya, T.
    • Organizer
      The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric oxide
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Detection of oxidized ER protein by nitrosative/oxidative stress with a specific antibody2010

    • Author(s)
      Takashi Uehara
    • Organizer
      The 6^<th> International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric oxide
    • Place of Presentation
      京都
    • Year and Date
      2010-06-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Detection of oxidized ER protein by nitrosative/oxidative stress with a specific antibody2010

    • Author(s)
      Uehara, T.
    • Organizer
      The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric oxide
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] ニトロソ化ストレスを介した小胞体機能破綻と神経細胞死2009

    • Author(s)
      上原孝
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪市, 大阪大学蛋白質研究所
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 一酸化窒素による小胞体ストレス惹起機構2009

    • Author(s)
      上原孝
    • Organizer
      第4回小胞体ストレス研究会
    • Place of Presentation
      生駒市, 奈良先端科学技術大学大セミナー室
    • Year and Date
      2009-09-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経細胞死とニトロソ化シグナル2009

    • Author(s)
      上原孝
    • Organizer
      第62回日本酸化ストレス学会学術集会
    • Place of Presentation
      福岡市, 九州大学百年講堂
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生理的条件下におけるS-ニトロシル化蛋白質の網羅的同定と機能解析2008

    • Author(s)
      上原孝
    • Organizer
      第81回日本生化学会大会/第31回日本分子生物学会年会合同大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-12-10
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 生理的条件下におけるS-ニトロシル化蛋白質の網羅的同定と機能解析2008

    • Author(s)
      上原孝
    • Organizer
      第81回日本生化学会大会/第31回日本分子生物学会年会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 一酸化窒素による小胞体機能消失2008

    • Author(s)
      上原孝
    • Organizer
      第51回日本神経化学会(富山)大会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 神経変性疾患発症に関わる一酸化窒素による小胞体ストレス発生機構2008

    • Author(s)
      上原孝
    • Organizer
      第31回日本神経科学学会大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Book] 一酸化窒素(NO)結合性(S-ニトロシル化)タンパク質の網羅的同定,生化学85(1)2013

    • Author(s)
      上原 孝
    • Total Pages
      6
    • Related Report
      2012 Final Research Report
  • [Book] 小胞体内ニトロシル化による神経変性疾患の発症,脳212013

    • Author(s)
      上原 孝
    • Total Pages
      6
    • Publisher
      金芳堂
    • Related Report
      2012 Final Research Report
  • [Book] 脳212013

    • Author(s)
      上原 孝
    • Total Pages
      6
    • Publisher
      金芳堂
    • Related Report
      2012 Annual Research Report
  • [Book] 日本生化学会2013

    • Author(s)
      上原 孝
    • Total Pages
      6
    • Publisher
      生化学
    • Related Report
      2012 Annual Research Report
  • [Book] タンパク質ニトロシル化による細胞生死調節,実験医学30(17)2012

    • Author(s)
      上原 孝
    • Total Pages
      7
    • Publisher
      羊土社
    • Related Report
      2012 Final Research Report
  • [Book] 発癌/神経細胞の生死に関わる細胞内ROSシグナル制御,細胞工学31(2)2012

    • Author(s)
      鎌田英明,上原 孝
    • Total Pages
      6
    • Publisher
      秀潤社
    • Related Report
      2012 Final Research Report
  • [Book] 細胞工学2012

    • Author(s)
      鎌田英明
    • Total Pages
      6
    • Publisher
      秀潤社
    • Related Report
      2012 Annual Research Report
  • [Book] 実験医学2012

    • Author(s)
      上原 孝
    • Total Pages
      7
    • Publisher
      羊土社
    • Related Report
      2012 Annual Research Report
  • [Book] 細胞工学2012

    • Author(s)
      鎌田英明, 上原孝
    • Publisher
      秀潤社
    • Related Report
      2011 Annual Research Report
  • [Book] NOはPI3-キナーゼ-Aktシグナルのスイッチ分子として機能している,実験医学29(18)2011

    • Author(s)
      上原 孝
    • Total Pages
      4
    • Publisher
      羊土社
    • Related Report
      2012 Final Research Report
  • [Book] 実験医学2011

    • Author(s)
      上原孝
    • Publisher
      羊土社
    • Related Report
      2011 Annual Research Report
  • [Book] 実験医学2010

    • Author(s)
      上原孝
    • Total Pages
      2
    • Publisher
      羊土社
    • Related Report
      2009 Annual Research Report
  • [Book] NO・ニトロソ化シグナルと細胞死,実験医学27(15)2009

    • Author(s)
      上原 孝
    • Total Pages
      5
    • Publisher
      羊土社
    • Related Report
      2012 Final Research Report
  • [Book] 実験医学2009

    • Author(s)
      上原孝
    • Total Pages
      5
    • Publisher
      羊土社
    • Related Report
      2010 Self-evaluation Report
  • [Book] 実験医学増刊号「活性酸素シグナルと酸化ストレス研究最前線」2009

    • Author(s)
      上原孝
    • Total Pages
      5
    • Publisher
      羊土社
    • Related Report
      2009 Annual Research Report
  • [Book] 脳212008

    • Author(s)
      上原孝
    • Total Pages
      6
    • Publisher
      金芳堂
    • Related Report
      2008 Annual Research Report
  • [Book] 救急・集中治療2008

    • Author(s)
      上原孝
    • Total Pages
      5
    • Publisher
      総合医学社
    • Related Report
      2008 Annual Research Report
  • [Remarks] (1)平成23年6月7日掲載,山陽新聞(27面)「NO濃度細胞生死の鍵/脳梗塞新薬に期待」

    • Related Report
      2012 Final Research Report
  • [Remarks] (2)平成23年6月7日放送,RSK山陽放送 RSKニュース「脳梗塞に新たな治療の可能性」

    • Related Report
      2012 Final Research Report
  • [Remarks] (3)平成23年6月7日放送,KSB瀬戸内海放送 KSBニュース「脳こうそくの治療に期待 世界初の発見」

    • Related Report
      2012 Final Research Report
  • [Remarks] (4)平成23年6月7日WEB掲載,東京新聞「細胞生死の鍵はNO,治療応用も」

    • Related Report
      2012 Final Research Report
  • [Remarks] (5)平成23年6月7日WEB掲載,福井新聞「細胞生死の鍵はNO,治療応用も」

    • Related Report
      2012 Final Research Report
  • [Remarks] (6)平成23年6月16日掲載,朝日新聞(29面)「一酸化窒素濃度 脳細胞生死の鍵」

    • Related Report
      2012 Final Research Report
  • [Remarks] (7)平成23年6月17日掲載,科学新聞(4面)「細胞生死の鍵握る一酸化窒素 2面性の作用機構解明 ガンなどの新たな治療薬も」

    • Related Report
      2012 Final Research Report
  • [Remarks] (8)平成23年6月19日掲載,読売新聞(31面)「細胞の保護・破壊 濃度次第 一酸化窒素の作用解明」

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.pharm.okayama-u.ac.jp/lab/yakuri/Uehara_Lab/Welcome.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 岡山大学大学院医歯薬学総合研究科薬効解析学分野

    • URL

      http://pharm.okayama-u.ac.jp/lab/yakuri/Uehara_Lab/Welcome.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://web.mac.com/takashi_uehara

    • Related Report
      2011 Annual Research Report
  • [Remarks] ホームページ

    • Related Report
      2010 Self-evaluation Report

URL: 

Published: 2008-04-01   Modified: 2018-03-28  

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