| Budget Amount *help |
¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2011: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2009: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Research Abstract |
We investigated the roles of water and ATP in the functional mechanism of ABC transporter and obtained the following conclusions: 1) the hydrolysis energies of ATP and its related compounds all converge to ~10 kcal/mol by the effect of hydration, 2) the main driving force of the protein-ligand complexation is the translational entropy of water (exclusion volume effect), 3) the binding-free energy of ATP can be converted to a power stroke like the dimerization of NBDs, 4) a long-range hydration force of enthalpic origin and the water-mediated attraction of entropic origin drive the NBD dimerization in ABC transporter.
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