| Budget Amount *help |
¥81,900,000 (Direct Cost: ¥63,000,000、Indirect Cost: ¥18,900,000)
Fiscal Year 2012: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2011: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2010: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2009: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2008: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
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| Research Abstract |
The present study investigated the effects of chemicals such as polycyclic aromatic hydrocarbons (PAHs) and their derivatives, which are major chemical components in particulate matter (PM), on the immune cells and on the bronchial epithelial cells. First, we detected some biomarkers for the health effects of PM. Cytotoxicity and/or inflammatory responses were induced by some PAH derivatives containing hydroxyl, carbonyl, nitro, or amino groups, indicating that the toxicological and inflammatory effects of chemicals may be related to their structures such as functional group and isomer. We also elucidated the underlying molecular mechanisms for the health effects of these chemicals.
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