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Measurement of brain activity related to qualia structure and pharmacological load manipulation to elucidate causal relationships

Planned Research

Project AreaUnderstanding the relationship between the structure of qualia and the structure of information processing extracted from brain activity
Project/Area Number 20H05711
Research Category

Grant-in-Aid for Transformative Research Areas (B)

Allocation TypeSingle-year Grants
Review Section Transformative Research Areas, Section (I)
Research InstitutionNational Institutes for Quantum Science and Technology

Principal Investigator

Yamada Makiko  国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 上席研究員 (50557444)

Project Period (FY) 2020-10-02 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥35,880,000 (Direct Cost: ¥27,600,000、Indirect Cost: ¥8,280,000)
Fiscal Year 2022: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2021: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2020: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywordsクオリア / 意識 / 脳イメージング / 脳機能 / 認知神経科学 / fMRI
Outline of Research at the Start

本研究は、認知脳科学手法を用いてヒトにおける精密な脳活動の測定と薬理負荷による操作の二側面から、クオリアと脳活動パターンの因果的な関係性を明らかにすることを目標とする。まず、fMRI計測により、クオリア類似度報告課題中の被験者の脳活動を測定し、意識的な類似度判断と相関する脳活動部位を明らかにする。さらに、薬理負荷操作法によってクオリアと脳活動の因果関係を明らかにする。

Outline of Final Research Achievements

The purpose of this study was to identify brain regions corresponding to qualia structures based on the similarity of their brain activity patterns. First, color-qualia similarity reports were conducted in all visual fields, and then color-qualia structures based on subjective reports were evaluated. We found that color qualia based on subjective reports had equivalent structures in both central and peripheral visual fields. Furthermore, we successfully extracted qualia structures from brain activity data by performing a color-qualia similarity reporting task during fMRI imaging, and established a methodology that enables the mapping of color qualia structures to brain activity. Furthermore, we conducted PET measurements targeting monoamine neurotransmitters and clarified the relationship between dopamine and serotonin and subjectivity.

Academic Significance and Societal Importance of the Research Achievements

クオリアの構造がわかると、他の感覚意識(痛み、匂い、感情)への手法の一般化や、他人のクオリアとの比較、人間以外の生物が持っているかもしれないクオリアの理解など、意識研究の重要な基盤構築に繋がる。社会的還元としては、例えば、盲人に触覚・聴覚を通して視覚入力を行う「感覚代行」の技術の洗練化や、言語コミュニケーションの取れない脳損傷患者や未熟児などとのコミュニケーションを可能にする技術にもつながり、臨床・工学・社会への応用が期待できる。意識の質を明らかにする測定技術とデータ解析法の開発は、情報表現やネットワーク解析などの他分野へ広く波及すると期待できる。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (29 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (1 results) Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 6 results) Presentation (14 results) (of which Int'l Joint Research: 6 results,  Invited: 12 results) Funded Workshop (1 results)

  • [Int'l Joint Research] Monash University(オーストラリア)

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Are Color Experiences the Same across the Visual Field?2023

    • Author(s)
      Zeleznikow-Johnston Ariel、Aizawa Yasunori、Yamada Makiko、Tsuchiya Naotsugu
    • Journal Title

      Journal of Cognitive Neuroscience

      Volume: 35 Issue: 4 Pages: 509-542

    • DOI

      10.1162/jocn_a_01962

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Machine learning unveils latent architecture of superiority illusion that predicts visual illusion perception and metacognitive performance2022

    • Author(s)
      Matsuyoshi Daisuke、Isato Ayako、Yamada Makiko
    • Journal Title

      bioRxiv

      Volume: - Pages: 513462-513462

    • DOI

      10.1101/2022.10.24.513462

    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] Measurement of Striatal Dopamine Release Induced by Neuropsychological Stimulation in Positron Emission Tomography With Dual Injections of [11C]Raclopride2022

    • Author(s)
      Ikoma Yoko、Kimura Yasuyuki、Yamada Makiko、Obata Takayuki、Suhara Tetsuya、Ito Hiroshi
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13 Pages: 811136-811136

    • DOI

      10.3389/fpsyt.2022.811136

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Resting-state functional connectivity relates to interindividual variations in positive memory2022

    • Author(s)
      Isato Ayako、Yokokawa Keita、Higuchi Makoto、Suhara Tetsuya、Yamada Makiko
    • Journal Title

      Behavioural Brain Research

      Volume: 419 Pages: 113663-113663

    • DOI

      10.1016/j.bbr.2021.113663

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brain 5-HT2A receptor binding and its neural network related to behavioral inhibition system2022

    • Author(s)
      Kojima Kazuho、Hirano Shigeki、Kimura Yasuyuki、Seki Chie、Ikoma Yoko、Takahata Keisuke、Ito Takehito、Yokokawa Keita、Hashimoto Hiroki、Kawamura Kazunori、Zhang Ming-Rong、Ito Hiroshi、Higuchi Makoto、Kuwabara Satoshi、Suhara Tetsuya、Yamada Makiko
    • Journal Title

      Brain Imaging and Behavior

      Volume: - Issue: 3 Pages: 1337-1348

    • DOI

      10.1007/s11682-021-00609-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neural network of superiority illusion predicts the level of dopamine in striatum.2022

    • Author(s)
      Yahata N, Isato A, Kimura Y, Yokokawa K, Zhang MR, Ito H, Suhara T, Higuchi M, Yamada M.
    • Journal Title

      bioRxiv.

      Volume: -

    • DOI

      10.1101/2022.02.01.478593

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 意識していることへの意識:意識の再帰性を考える2022

    • Author(s)
      山田 真希子
    • Journal Title

      生体の科学

      Volume: 73 Pages: 7-12

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Resting-state brain activity can predict target-independent aptitude in fMRI-neurofeedback training2021

    • Author(s)
      Nakano Takashi、Takamura Masahiro、Nishimura Haruki、Machizawa Maro G.、Ichikawa Naho、Yoshino Atsuo、Okada Go、Okamoto Yasumasa、Yamawaki Shigeto、Yamada Makiko、Suhara Tetsuya、Yoshimoto Junichiro
    • Journal Title

      NeuroImage

      Volume: 245 Pages: 118733-118733

    • DOI

      10.1016/j.neuroimage.2021.118733

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pharmacokinetic and pharmacodynamic assessment of histamine H3 receptor occupancy by enerisant: a human PET study with a novel H3 binding ligand, [11C]TASP4572021

    • Author(s)
      Kimura Yasuyuki、Takahata Keisuke、Shimazaki Toshiharu、Kitamura Soichiro、Seki Chie、Ikoma Yoko、Ichise Masanori、Kawamura Kazunori、Yamada Makiko、Zhang Ming-Rong、Higuchi Makoto、Nishino Izumi、Suhara Tetsuya
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 49 Issue: 4 Pages: 1127-1135

    • DOI

      10.1007/s00259-021-05571-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 無意識の優越感が抑うつ症状に果たす役割.2021

    • Author(s)
      山田 真希子, 伊里 綾子
    • Journal Title

      臨床精神医学

      Volume: 50(5) Pages: 475-481

    • NAID

      40022616996

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serotonergic neural network related to behavioral inhibition system2021

    • Author(s)
      Kojima Kazuho、Hirano Shigeki、Kimura Yasuyuki、Seki Chie、Ikoma Yoko、Takahata Keisuke、Ito Takehito、Yokokawa Keita、Hashimoto Hiroki、Kawamura Kazunori、Zhang Ming-Rong、Ito Hiroshi、Higuchi Makoto、Kuwabara Satoshi、Suhara Tetsuya、Yamada Makiko
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2021.07.09.451787

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Resting-state brain activity can predict target-independent aptitude in fMRI-neurofeedback training2021

    • Author(s)
      Nakano Takashi、Takamura Masahiro、Nishimura Haruki、Machizawa Maro、Ichikawa Naho、Yoshino Atsuo、Okada Go、Okamoto Yasumasa、Yamawaki Shigeto、Yamada Makiko、Suhara Tetsuya、Yoshimoto Junichiro
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2021.02.08.430334

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Enhancing Multi-Center Generalization of Machine Learning-Based Depression Diagnosis From Resting-State fMRI2020

    • Author(s)
      Nakano Takashi、Takamura Masahiro、Ichikawa Naho、Okada Go、Okamoto Yasumasa、Yamada Makiko、Suhara Tetsuya、Yamawaki Shigeto、Yoshimoto Junichiro
    • Journal Title

      Frontiers in Psychiatry

      Volume: 11

    • DOI

      10.3389/fpsyt.2020.00400

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] Neuroimaging of colour qualia and beyond2022

    • Author(s)
      Makiko Yamada
    • Organizer
      学術変革領域会議
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] "How can we measure the quality of consciousness? "2022

    • Author(s)
      Makiko Yamada
    • Organizer
      Quantum Innovation 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neural bases of color qualia structure2022

    • Author(s)
      Makiko Yamada
    • Organizer
      「人工知能と脳科学国際シンポジウム2022」
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] クオリア構造の脳活動2021

    • Author(s)
      山田 真希子
    • Organizer
      CBI学会2021年大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Brain activity measurements on qualia structure2021

    • Author(s)
      Makiko Yamada
    • Organizer
      Neuro2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 思考の癖の脳メカニズム-認知バイアスの脳科学-2021

    • Author(s)
      山田 真希子
    • Organizer
      日本サイコオンコロジー総会 大会長企画
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 痛み共感と向社会行動2021

    • Author(s)
      山田 真希子
    • Organizer
      日本サイコオンコロジー総会 WG企画
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 量子確率論の認知神経科学への応用に向けて2021

    • Author(s)
      山田 真希子
    • Organizer
      認知科学学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Empirical verification of the violation of temporal Bell inequality in bistable perception.2021

    • Author(s)
      Aizawa Y, Tsuchiya N, Pothos E, Busemeyer J, Bruza P, Yamada M.
    • Organizer
      Quantum Innovation 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Do neural activities of binocular rivalry follow a quantum probability model? A test of temporal bell inequalities.2021

    • Author(s)
      Hirao T, Tsuchiya N, Pothos E, Busemeyer J, Bruza P, Yamada M.
    • Organizer
      Quantum Innovation 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 量子確率論の脳科学への応用 ~脳と心の生成原理解明に向けて~2021

    • Author(s)
      山田真希子
    • Organizer
      バイオインダストリー協会企画講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 認知バイアスから見た 脳とこころのメカニズム2021

    • Author(s)
      山田真希子
    • Organizer
      2020年度応用脳科学アカデミー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 認知バイアスの脳科学;思考の癖の脳メカニズム2020

    • Author(s)
      山田真希子
    • Organizer
      第14回 行動科学セミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 脳イメージングが映し出す心の世界2020

    • Author(s)
      山田真希子
    • Organizer
      GTRセミナー / 第8回NLSセミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Funded Workshop] 学術変革領域会議2022

    • Related Report
      2022 Annual Research Report

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Published: 2020-10-30   Modified: 2024-01-30  

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