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Mathematical modeling of virtual human

Planned Research

Project AreaScience for virtual human development: Organ(s)-on-a-chips reveal systemic metabolic networks
Project/Area Number 20H05743
Research Category

Grant-in-Aid for Transformative Research Areas (B)

Allocation TypeSingle-year Grants
Review Section Transformative Research Areas, Section (II)
Research InstitutionTokyo Medical University

Principal Investigator

Masahiro Sugimoto  東京医科大学, 医学部, 教授 (30458963)

Co-Investigator(Kenkyū-buntansha) 斎藤 輪太郎  慶應義塾大学, 政策・メディア研究科(藤沢), 特任教授 (40348842)
前田 和勲  九州工業大学, 大学院情報工学研究院, 助教 (50631230)
Project Period (FY) 2020-10-02 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥51,480,000 (Direct Cost: ¥39,600,000、Indirect Cost: ¥11,880,000)
Fiscal Year 2022: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2021: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Keywords生体医工学関連 / バイオ機能応用およびバイオプロセス工学関連 / 生体医工学 / 生物物理学関連
Outline of Research at the Start

本研究は、生体内の細胞・臓器・個体レベルで起きる様々な分子レベルの相互作用を数理モデル化して、その動態を包括的に理解することを目指す。多臓器にわたる全身性疾患の再現や、実証実験による精度検証したモデル化の研究例は少ない。そこで、本研究では、代謝をモデル化し、臓器内で起きる空間的局在や細胞間の物質収支を考慮したヘテロな環境を再現する。多臓器臓器モデル培養系を利用して臓器間の相互作用のモデル化・検証も行う。臓器間連動の再現やそのメカニズムの理解、特に生化学的な合理性の解明を目指す。

Outline of Final Research Achievements

In this study, we implemented mathematical models of the dynamic changes in living systems. To develop and evaluate models related to metabolism, we also performed metabolomic analyses of biological samples in collaboration with other groups. As a model of metabolism at the molecular level, we modeled the interaction of drugs and energy metabolism in hepatocytes. The hepatocytes showed different metabolic patterns based on the zone, i.e., the metabolism of the hepatocytes in the portal vein and the centration vein were different. We also implemented an agent-oriented model of liver fibrosis. Various cells interact to detect dead cells damaged by the toxic compounds and produced collagens. This simulation model was validated by mouse-based experiments. We also modeled the physical and chemical properties of tumor-induced angiogenesis. We added angiopoietins and successfully reproduced the temporal reduction of the new vessels.

Academic Significance and Societal Importance of the Research Achievements

【研究成果の学術的意義】本研究では既知の知見をボトムアップ的に積み上げて数理モデルを開発し、生体内の現象で複雑な要素の定量的な関係性を明らかにすることができた。数理モデルによるシミュレーションで十分なバリデーションを行うことができれば、様々な仮想的な実験を行うことができる。ただし従来のモデル化の方法では、1細胞の精緻化が主体的であったため、本研究では同一細胞でも環境に応じて異なる動態を示すことや、組織レベルで様々な細胞が相互作用することなどを実装した。
【社会的意義】本研究はシステムズ・バイオロジーが目指す数理モデルによる生体の理解を実践した具体的な事例を研究成果として創出することができた。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (76 results)

All 2023 2022 2021 2020 2019 Other

All Journal Article (55 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 54 results,  Open Access: 51 results) Presentation (20 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Remarks (1 results)

  • [Journal Article] Relationship between Urinary Metabolomic Profiles and Depressive Episode in Antarctica2023

    • Author(s)
      Kasuya Kazuhiko、Imura Satoshi、Ishikawa Takashi、Sugimoto Masahiro、Inoue Takeshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 2 Pages: 943-943

    • DOI

      10.3390/ijms24020943

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Salivary Polyamines Help Detect High-Risk Patients with Pancreatic Cancer: A Prospective Validation Study2023

    • Author(s)
      Nose Daisuke、Sugimoto Masahiro、Muta Tsuneo、Miura Shin-Ichiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 3 Pages: 2998-2998

    • DOI

      10.3390/ijms24032998

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biomarkers for Alzheimer’s Disease in the Current State: A Narrative Review2022

    • Author(s)
      Gunes Serafettin、Aizawa Yumi、Sugashi Takuma、Sugimoto Masahiro、Rodrigues Pedro Pereira
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 9 Pages: 4962-4962

    • DOI

      10.3390/ijms23094962

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Salivary Metabolomics for Oral Cancer Detection: A Narrative Review2022

    • Author(s)
      Panneerselvam Karthika、Ishikawa Shigeo、Krishnan Rajkumar、Sugimoto Masahiro
    • Journal Title

      Metabolites

      Volume: 12 Issue: 5 Pages: 436-436

    • DOI

      10.3390/metabo12050436

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a highly sensitive Prussian-blue-based enzymatic biosensor for l-carnitine employing the thiol/disulfide exchange reaction2022

    • Author(s)
      Tango Ryota、Koeda Aya、Nagamine Kuniaki、Tokito Shizuo、Niwa Osamu、Ishikawa Shigeo、Sugimoto Masahiro
    • Journal Title

      Analytical Sciences

      Volume: 38 Issue: 7 Pages: 963-968

    • DOI

      10.1007/s44211-022-00122-6

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salivary metabolomics with machine learning for colorectal cancer detection2022

    • Author(s)
      Kuwabara Hiroshi、Katsumata Kenji、Iwabuchi Atsuhiro、Udo Ryutaro、Tago Tomoya、Kasahara Kenta、Mazaki Junichi、Enomoto Masanobu、Ishizaki Tetsuo、Soya Ryoko、Kaneko Miku、Ota Sana、Enomoto Ayame、Soga Tomoyoshi、Tomita Masaru、Sunamura Makoto、Tsuchida Akihiko、Sugimoto Masahiro、Nagakawa Yuichi
    • Journal Title

      Cancer Science

      Volume: 113 Issue: 9 Pages: 3234-3243

    • DOI

      10.1111/cas.15472

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-Term Mastication Changed Salivary Metabolomic Profiles2022

    • Author(s)
      Saeki Yoji、Takenouchi Akane、Otani Etsuyo、Kim Minji、Aizawa Yumi、Aita Yasuko、Tomita Atsumi、Sugimoto Masahiro、Matsukubo Takashi
    • Journal Title

      Metabolites

      Volume: 12 Issue: 7 Pages: 660-660

    • DOI

      10.3390/metabo12070660

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor metabolic alterations after neoadjuvant chemoradiotherapy predict postoperative recurrence in patients with pancreatic cancer2022

    • Author(s)
      Wada Yukiko、Okano Keiichi、Sato Kiyotoshi、Sugimoto Masahiro、Shimomura Ayaka、Nagao Mina、Matsukawa Hiroyuki、Ando Yasuhisa、Suto Hironobu、Oshima Minoru、Kondo Akihiro、Asano Eisuke、Kishino Takayoshi、Kumamoto Kensuke、Kobara Hideki、Kamada Hideki、Masaki Tsutomu、Soga Tomoyoshi、Suzuki Yasuyuki
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 52 Issue: 8 Pages: 887-895

    • DOI

      10.1093/jjco/hyac074

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Computational simulation of liver fibrosis dynamics2022

    • Author(s)
      Yoshizawa Misa、Sugimoto Masahiro、Tanaka Minoru、Sakai Yusuyuki、Nishikawa Masaki
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 14112-14112

    • DOI

      10.1038/s41598-022-18123-w

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simulation of the crosstalk between glucose and acetaminophen metabolism in a liver zonation model2022

    • Author(s)
      Maeda Kazuhiro、Hagimori Shuta、Sugimoto Masahiro、Sakai Yasuyuki、Nishikawa Masaki
    • Journal Title

      Frontiers in Pharmacology

      Volume: 13 Pages: 995597-995597

    • DOI

      10.3389/fphar.2022.995597

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Underwater Exercise on Salivary Metabolites of Older Persons With Disability2022

    • Author(s)
      TAMURA NOBUAKI、MIZUNO KAZU、SUZUKI RYUICHIRO、SUGIMOTO MASAHIRO、ENOMOTO AYAME、OTA SANA、KANEKO MIKU、SAKAGAMI HIROSHI、TAKESHIMA HIROSHI
    • Journal Title

      In Vivo

      Volume: 36 Issue: 6 Pages: 2678-2688

    • DOI

      10.21873/invivo.13003

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolomic Profiling of Plasma, Urine, and Saliva of Kidney Transplantation Recipients2022

    • Author(s)
      Iwamoto Hitoshi、Okihara Masaaki、Akashi Isao、Kihara Yu、Konno Osamu、Kawachi Shigeyuki、Sunamura Makoto、Sugimoto Masahiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 22 Pages: 13938-13938

    • DOI

      10.3390/ijms232213938

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeted Metabolomic Profiling of Plasma Samples in Gastric Cancer by Liquid Chromatography-Mass Spectrometry2022

    • Author(s)
      Matsumoto Taisuke、Fukuzawa Masakatsu、Itoi Takao、Sugimoto Masahiro、Aizawa Yumi、Sunamura Makoto、Kawai Takashi、Koyama Yohei、Madarame Akira、Morise Takashi、Yamaguchi Hayato、Sugimoto Akihiko、Yamauchi Yoshiya、Kono Shin、Naito Sakiko
    • Journal Title

      Digestion

      Volume: 104 Issue: 2 Pages: 97-108

    • DOI

      10.1159/000526864

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Breast cancer detection using volatile compound profiles in exhaled breath via selected ion-flow tube mass spectrometry2022

    • Author(s)
      Nakayama Yoshie、Hanada Mariko、Koda Hiroshi、Sugimoto Masahiro、Takada Masahiro、Toi Masakazu
    • Journal Title

      Journal of Breath Research

      Volume: 17 Issue: 1 Pages: 016006-016006

    • DOI

      10.1088/1752-7163/aca696

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Preliminary Pilot Study: Metabolomic Analysis of Saliva in Oral Candidiasis2022

    • Author(s)
      Adachi Takuya、Kawanishi Norishige、Ichigaya Narumi、Sugimoto Masahiro、Hoshi Noriyuki、Kimoto Katsuhiko
    • Journal Title

      Metabolites

      Volume: 12 Issue: 12 Pages: 1294-1294

    • DOI

      10.3390/metabo12121294

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolic profiling of charged metabolites in association with menopausal status in Japanese community-dwelling midlife women: Tsuruoka Metabolomic Cohort Study.2022

    • Author(s)
      Watanabe K, Iida M, Harada S, Kato S, Kuwabara K, Kurihara A, Takeuchi A, Sugiyama D, Okamura T, Suzuki A, Amano K, Hirayama A, Sugimoto M, Soga T, Tomita M, Kobayashi Y, Banno K, Aoki D, Takebayashi T.
    • Journal Title

      Maturitas

      Volume: 155 Pages: 54-62

    • DOI

      10.1016/j.maturitas.2021.10.004

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Salivary Metabolomics for Prognosis of Oral Squamous Cell Carcinoma2022

    • Author(s)
      Ishikawa Shigeo、Sugimoto Masahiro、Konta Tsuneo、Kitabatake Kenichiro、Ueda Shohei、Edamatsu Kaoru、Okuyama Naoki、Yusa Kazuyuki、Iino Mitsuyoshi
    • Journal Title

      Frontiers in Oncology

      Volume: 11 Pages: 789248-789248

    • DOI

      10.3389/fonc.2021.789248

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation of Urinary Charged Metabolite Profiles in Colorectal Cancer Using Capillary Electrophoresis-Mass Spectrometry2022

    • Author(s)
      Sakurai Toru、Katsumata Kenji、Udo Ryutaro、Tago Tomoya、Kasahara Kenta、Mazaki Junichi、Kuwabara Hiroshi、Kawakita Hideaki、Enomoto Masanobu、Ishizaki Tetsuo、Nemoto Yukako、Osaka Yoshiaki、Nagakawa Yuichi、Sugimoto Masahiro、Tsuchida Akihiko
    • Journal Title

      Metabolites

      Volume: 12 Issue: 1 Pages: 59-59

    • DOI

      10.3390/metabo12010059

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The usefulness of sparse k-means in metabolomics data: An example from breast cancer data2022

    • Author(s)
      Goudo Misa、Sugimoto Masahiro、Hiwa Satoru、Hiroyasu Tomoyuki
    • Journal Title

      bioRxiv

      Volume: - Pages: 1-1

    • DOI

      10.1101/2022.02.05.479235

    • Related Report
      2021 Annual Research Report
    • Open Access
  • [Journal Article] Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin2022

    • Author(s)
      K Miyajima, Y Sudo, S Sanechika, Y Hara, M Horiguchi, F Xu, M Suzuki, S Hara, K Tanda, K Inoue, M Takada, N Yoshioka, H Takebayashi, M Mori-Kojima, M Sugimoto, C Sumi-Ichinose, K Kondo, K Takao, T Miyakawa, H Ichinose
    • Journal Title

      J Neurochemistry

      Volume: 161(2) Issue: 2 Pages: 129-145

    • DOI

      10.1111/jnc.15600

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Machine learning techniques for breast cancer diagnosis and treatment: a narrative review2021

    • Author(s)
      Sugimoto Masahiro、Hikichi Shiori、Takada Masahiro、Toi Masakazu
    • Journal Title

      Annals of Breast Surgery

      Volume: 0 Pages: 0-0

    • DOI

      10.21037/abs-21-63

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reliability of urinary charged metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry2021

    • Author(s)
      Ishibashi Yoshiki、Harada Sei、Takeuchi Ayano、Iida Miho、Kurihara Ayako、Kato Suzuka、Kuwabara Kazuyo、Hirata Aya、Shibuki Takuma、Okamura Tomonori、Sugiyama Daisuke、Sato Asako、Amano Kaori、Hirayama Akiyoshi、Sugimoto Masahiro、Soga Tomoyoshi、Tomita Masaru、Takebayashi Toru
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 7407-7407

    • DOI

      10.1038/s41598-021-86600-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cognitive Dysfunction in a Mouse Model of Cerebral Ischemia Influences Salivary Metabolomics2021

    • Author(s)
      To Masahiro、Sugimoto Masahiro、Saruta Juri、Yamamoto Yuko、Sakaguchi Wakako、Kawata Akira、Matsuo Masato、Tsukinoki Keiichi
    • Journal Title

      Journal of Clinical Medicine

      Volume: 10 Issue: 8 Pages: 1698-1698

    • DOI

      10.3390/jcm10081698

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quality Assessment of Untargeted Analytical Data in a Large-Scale Metabolomic Study2021

    • Author(s)
      Saito Rintaro、Sugimoto Masahiro、Hirayama Akiyoshi、Soga Tomoyoshi、Tomita Masaru、Takebayashi Toru
    • Journal Title

      Journal of Clinical Medicine

      Volume: 10 Issue: 9 Pages: 1826-1826

    • DOI

      10.3390/jcm10091826

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multi-Omics Analysis of Anti-Inflammatory Action of Alkaline Extract of the Leaves of Sasa sp.2021

    • Author(s)
      Sakagami Hiroshi、Nakatani Sachie、Enomoto Ayame、Ota Sana、Kaneko Miku、Sugimoto Masahiro、Horiuchi Misaki、Toeda Kazuki、Oizumi Takaaki
    • Journal Title

      Journal of Clinical Medicine

      Volume: 10 Issue: 10 Pages: 2100-2100

    • DOI

      10.3390/jcm10102100

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optimization of prediction methods for risk assessment of pathogenic germline variants in the Japanese population2021

    • Author(s)
      Senda Noriko、Ogawa Seishi, et al.
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 8 Pages: 3338-3348

    • DOI

      10.1111/cas.14986

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Kernel weighted least square approach for imputing missing values of metabolomics data2021

    • Author(s)
      Kumar Nishith、Hoque Md. Aminul、Sugimoto Masahiro
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 11108-11108

    • DOI

      10.1038/s41598-021-90654-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Correlation of Plasma Amino Acid and Anthropometric Profiles with Brown Adipose Tissue Density in Humans2021

    • Author(s)
      Kuroiwa Miyuki、Hamaoka-Fuse Sayuri、Sugimoto Masahiro、Kurosawa Yuko、Aita Yasuko、Tomita Atsumi、Anjo Mikiko、Tanaka Riki、Endo Tasuki、Kime Ryotaro、Hamaoka Takafumi
    • Journal Title

      Journal of Clinical Medicine

      Volume: 10 Issue: 11 Pages: 2339-2339

    • DOI

      10.3390/jcm10112339

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Time-Course of Salivary Metabolomic Profiles during Radiation Therapy for Head and Neck Cancer2021

    • Author(s)
      Wakako Yatsuoka, Takao Ueno, Kanako Miyano, Ayame Enomoto, Sana Ota, Masahiro Sugimoto, Yasuhito Uezono
    • Journal Title

      Journal of clinical medicine

      Volume: 10(12) Issue: 12 Pages: 2631-2631

    • DOI

      10.3390/jcm10122631

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TGF-β-dependent reprogramming of amino acid metabolism induces epithelial?mesenchymal transition in non-small cell lung cancers2021

    • Author(s)
      Nakasuka Fumie, Tabata Sho, Sakamoto Takeharu, Hirayama Akiyoshi, Ebi Hiromichi, Yamada Tadaaki, Umetsu Ko, Ohishi Maki, Ueno Ayano, Goto Hisatsugu, Sugimoto Masahiro, Nishioka Yasuhiko, Yamada Yasuhiro, Tomita Masaru, Sasaki Atsuo T, Yano Seiji, Soga Tomoyoshi
    • Journal Title

      Communications Biology

      Volume: 4 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s42003-021-02323-7

    • NAID

      120007178465

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feiyanning Formula Induces Apoptosis of Lung Adenocarcinoma Cells by Activating the Mitochondrial Pathway2021

    • Author(s)
      Zhu Li-Min、Shi Hai-Xia、Sugimoto Masahiro、Bandow Kenjiro、Sakagami Hiroshi、Amano Shigeru、Deng Hai-Bin、Ye Qing-Yu、Gai Yun、Xin Xiao-Li、Xu Zhen-Ye
    • Journal Title

      Frontiers in Oncology

      Volume: 11 Pages: 690878-690878

    • DOI

      10.3389/fonc.2021.690878

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High-throughput screening of salivary polyamine markers for discrimination of colorectal cancer by multisegment injection capillary electrophoresis tandem mass spectrometry2021

    • Author(s)
      Igarashi Kaori、Ota Sana、Kaneko Miku、Hirayama Akiyoshi、Enomoto Masanobu、Katumata Kenji、Sugimoto Masahiro、Soga Tomoyoshi
    • Journal Title

      Journal of Chromatography A

      Volume: 1652 Pages: 462355-462355

    • DOI

      10.1016/j.chroma.2021.462355

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Impact of m1A Methylation Modification Patterns on Tumor Immune Microenvironment and Prognosis in Oral Squamous Cell Carcinoma2021

    • Author(s)
      Gao Li、Chen Ru、Sugimoto Masahiro、Mizuta Masanobu、Kishimoto Yo、Omori Koichi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 19 Pages: 10302-10302

    • DOI

      10.3390/ijms221910302

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine.2021

    • Author(s)
      Chen C, Yamanaka Y, Ueda K, Li P, Miyagi T, Harada Y, Tezuka S, Narumi S, Sugimoto M, Kuroda M, Hayamizu Y, Kanekura K.
    • Journal Title

      J Cell Biol.

      Volume: 220 Issue: 11

    • DOI

      10.1083/jcb.202103160

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The RNA Methylation Modification 5-Methylcytosine Impacts Immunity Characteristics, Prognosis and Progression of Oral Squamous Cell Carcinoma by Bioinformatics Analysis2021

    • Author(s)
      Gao Li、Chen Ru、Sugimoto Masahiro、Mizuta Masanobu、Zhou Lei、Kishimoto Yo、Huang Xinsheng、Omori Koichi
    • Journal Title

      Frontiers in Bioengineering and Biotechnology

      Volume: 9 Pages: 760724-760724

    • DOI

      10.3389/fbioe.2021.760724

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Differential diagnosis of lung cancer and benign lung lesion using salivary metabolites: A preliminary study2021

    • Author(s)
      Takamori Satoshi、Ishikawa Shigeo、Suzuki Jun、Oizumi Hiroyuki、Uchida Tetsuro、Ueda Shohei、Edamatsu Kaoru、Iino Mitsuyoshi、Sugimoto Masahiro
    • Journal Title

      Thoracic Cancer

      Volume: 13 Issue: 3 Pages: 460-465

    • DOI

      10.1111/1759-7714.14282

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between Standard Uptake Values of Positron Emission Tomography/Computed Tomography and Salivary Metabolites in Oral Cancer: A Pilot Study2020

    • Author(s)
      Ishikawa Shigeo、Hiraka Toshitada、Kirii Kazukuni、Sugimoto Masahiro、Shimamoto Hiroaki、Sugano Ayako、Kitabatake Kenichiro、Toyoguchi Yuuki、Kanoto Masafumi、Nemoto Kenji、Soga Tomoyoshi、Tomita Masaru、Iino Mitsuyoshi
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 12 Pages: 3958-3958

    • DOI

      10.3390/jcm9123958

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum Metabolomic Profiling of Patients with Non-Infectious Uveitis.2020

    • Author(s)
      Shimizu H, Usui Y, Asakage M, Nezu N, Wakita R, Tsubota K, Sugimoto M, Goto H.
    • Journal Title

      J Clin Med

      Volume: 9 Issue: 12 Pages: 3955-3955

    • DOI

      10.3390/jcm9123955

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Urinary charged metabolite profiling of colorectal cancer using capillary electrophoresis-mass spectrometry2020

    • Author(s)
      Udo Ryutaro、Katsumata Kenji、Kuwabara Hiroshi、Enomoto Masanobu、Ishizaki Tetsuo、Sunamura Makoto、Nagakawa Yuichi、Soya Ryoko、Sugimoto Masahiro、Tsuchida Akihiko
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 21057-21057

    • DOI

      10.1038/s41598-020-78038-2

    • NAID

      120007017518

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Salivary metabolomics for cancer detection2020

    • Author(s)
      Sugimoto Masahiro
    • Journal Title

      Expert Review of Proteomics

      Volume: 17 Issue: 9 Pages: 639-648

    • DOI

      10.1080/14789450.2020.1846524

    • NAID

      40021850352

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolomic profiling of tumor-infiltrating macrophages during tumor growth2020

    • Author(s)
      Naoki Umemura, Masahiro Sugimoto, Yusuke Kitoh, Masanao Saio, Hiroshi Sakagami
    • Journal Title

      Cancer immunology, immunotherapy

      Volume: Nor 69(11) Issue: 11 Pages: 2357-2369

    • DOI

      10.1007/s00262-020-02622-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantification of Salivary Charged Metabolites using Capillary Electrophoresis Time-of-flight-mass Spectrometry2020

    • Author(s)
      Sugimoto Masahiro、Ota Sana、Kaneko Miku、Enomoto Ayame、Soga Tomoyoshi
    • Journal Title

      BIO-PROTOCOL

      Volume: 10 Issue: 20

    • DOI

      10.21769/bioprotoc.3797

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electrochemical enzyme biosensor for carnitine detection based on cathodic stripping voltammetry2020

    • Author(s)
      Zhang Zixin、Niwa Osamu、Shiba Shunsuke、Tokito Shizuo、Nagamine Kuniaki、Ishikawa Shigeo、Sugimoto Masahiro
    • Journal Title

      Sensors and Actuators B: Chemical

      Volume: 321 Pages: 128473-128473

    • DOI

      10.1016/j.snb.2020.128473

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells2020

    • Author(s)
      Sho Tanosaki, Shugo Tohyama, Jun Fujita, Hiroki Nakanishi, Takayo Ohto-Nakanishi, Tomohiko Akiyama, Yuika Morita, Yoshikazu Kishino, Marina Okada, Hidenori Tani, Yusuke Soma, Kazuaki Nakajima, Hideaki Kanazawa, Masahiro Sugimoto, Minoru S.H. Ko, Makoto Suematsu, Keiichi Fukuda
    • Journal Title

      iScience

      Volume: 23 Issue: 9 Pages: 101535-101535

    • DOI

      10.1016/j.isci.2020.101535

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity2020

    • Author(s)
      Sakaguchi Wakako、Kubota Nobuhisa、Shimizu Tomoko、Saruta Juri、Fuchida Shinya、Kawata Akira、Yamamoto Yuko、Sugimoto Masahiro、Yakeishi Mayumi、Tsukinoki Keiichi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 17 Pages: 6000-6000

    • DOI

      10.3390/ijms21176000

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of hydroxyproline via EGLN/HIF1A is associated with distant metastasis in pancreatic cancer2020

    • Author(s)
      Naokazu Chiba, Makoto Sunamura, Masashi Nakagawa, Itsuki Koganezawa, Kei Yokozuka, Toshimichi Kobayashi, Kosuke Hikita, Yosuke Ozawa, Masaaki Okihara, Toru Sano, Koichi Tomita, Rina Tsutsui, Masahiro Sugimoto, and Shigeyuki Kawachi
    • Journal Title

      American Journal of Cancer Research

      Volume: 10 Pages: 2570-2581

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of in vitro Metabolic Zonation in Primary Hepatocytes Requires Both Near-Physiological Oxygen Concentration and Flux2020

    • Author(s)
      Scheidecker Benedikt、Shinohara Marie、Sugimoto Masahiro、Danoy Mathieu、Nishikawa Masaki、Sakai Yasuyuki
    • Journal Title

      Frontiers in Bioengineering and Biotechnology

      Volume: 8 Pages: 524-524

    • DOI

      10.3389/fbioe.2020.00524

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Correlation-centred variable selection of a gene expression signature to predict breast cancer metastasis2020

    • Author(s)
      Hikichi Shiori、Sugimoto Masahiro、Tomita Masaru
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 7923-7923

    • DOI

      10.1038/s41598-020-64870-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adenosine leakage from perforin-burst extracellular vesicles inhibits perforin secretion by cytotoxic T-lymphocytes2020

    • Author(s)
      Tadokoro Hiroko、Hirayama Akiyoshi、Kudo Ryuhei、Hasebe Masako、Yoshioka Yusuke、Matsuzaki Juntaro、Yamamoto Yusuke、Sugimoto Masahiro、Soga Tomoyoshi、Ochiya Takahiro
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 4 Pages: e0231430-e0231430

    • DOI

      10.1371/journal.pone.0231430

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Promoter-level transcriptome identifies stemness associated with relatively high proliferation in pancreatic cancer cells.2020

    • Author(s)
      Ru Chen, Aiko Sugiyama, Naoyuki Kataoka, Masahiro Sugimoto, Shoko Yokoyama, Akihisa Fukuda, Shigeo Takaishi, Hiroshi Seno
    • Journal Title

      Frontiers in Oncology,

      Volume: 10 Pages: 1-14

    • DOI

      10.3389/fonc.2020.00316

    • NAID

      120006826695

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationships between plasma lipidomic profiles and brown adipose tissue density in humans2020

    • Author(s)
      Fuse Sayuri、Sugimoto Masahiro、Kurosawa Yuko、Kuroiwa Miyuki、Aita Yasuko、Tomita Atsumi、Yamaguchi Eri、Tanaka Riki、Endo Tasuki、Kime Ryotaro、Hamaoka Takafumi
    • Journal Title

      International Journal of Obesity

      Volume: - Issue: 6 Pages: 1387-1396

    • DOI

      10.1038/s41366-020-0558-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sensory properties and metabolomic profiles of dry-cured ham during the ripening process2020

    • Author(s)
      Sugimoto Masahiro、Sugawara Tetsuya、Obiya Shinichi、Enomoto Ayame、Kaneko Miku、Ota Sana、Soga Tomoyoshi、Tomita Masaru
    • Journal Title

      Food Research International

      Volume: 129 Pages: 108850-108850

    • DOI

      10.1016/j.foodres.2019.108850

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Abstract P2-10-12: Relationship between predicted risks of carrying breast cancer susceptibility genes and the presence of germline variants in Japanese patients with primary breast cancer2020

    • Author(s)
      Senda Noriko、Kawaguchi-Sakita Nobuko、Kawashima Masahiro、Inagaki-Kawata Yukiko、Yoshida Kenichi、Nishimura Tomomi、Takada Masahiro、Suzuki Eiji、Kataoka Yuki、Sato Fumiaki、Matsumoto Yoshiaki、Torii Masae、Yoshibayashi Hiroshi、Yamagami Kazuhiro、Tsuyuki Shigeru、Sugimoto Masahiro、Ogawa Seishi、Toi Masakazu
    • Journal Title

      Poster Session Abstracts

      Volume: 80 Issue: 4_Supplement Pages: P2-10-12-P2-10-12

    • DOI

      10.1158/1538-7445.sabcs19-p2-10-12

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer.2020

    • Author(s)
      Kawashima M, Tokiwa M, Nishimura T, Kawata Y, Sugimoto M, Kataoka TR, Sakurai T, Iwaisako K, Suzuki E, Hagiwara M, Harris AL, Toi M.
    • Journal Title

      Br J Cancer.

      Volume: 122 Issue: 2 Pages: 245-257

    • DOI

      10.1038/s41416-019-0662-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Discrimination of oral squamous cell carcinoma from oral lichen planus by salivary metabolomics2019

    • Author(s)
      Ishikawa Shigeo、Sugimoto Masahiro、Edamatsu Kaoru、Sugano Ayako、Kitabatake Kenichiro、Iino Mitsuyoshi
    • Journal Title

      Oral Diseases

      Volume: 26 Issue: 1 Pages: 35-42

    • DOI

      10.1111/odi.13209

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] メタボローム解析によるリキッドバイオプシーの開発2023

    • Author(s)
      杉本昌弘
    • Organizer
      第7回 Liquid Biopsy 研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] メタボローム解析を用いた癌関連疲労バイオマーカーの探索2022

    • Author(s)
      沖中 勇輝、後藤 俊志、片岡 洋祐、相澤 有美、杉本 昌弘、影山 進、河内 明宏
    • Organizer
      第18回日本疲労学会総会・学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 肝臓のヘテロな代謝と線維化における動的変化2022

    • Author(s)
      杉本昌弘
    • Organizer
      第16回メタボロームシンポジウム
    • Related Report
      2022 Annual Research Report
  • [Presentation] 唾液から見える全身の代謝2022

    • Author(s)
      杉本昌弘
    • Organizer
      第57回神奈川歯科大学学会総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] サリバテクノロジーシンポジウム 唾液と癌検査2022

    • Author(s)
      杉本昌弘
    • Organizer
      第1回日本唾液ケア研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] MPSと数理モデルを用いた生体ネットワークの理解に向けて2022

    • Author(s)
      杉本昌弘
    • Organizer
      細胞アッセイ研究会シンポジウム2021
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 仮想人体構築のための数理モデル化2022

    • Author(s)
      杉本昌弘
    • Organizer
      第21回日本再生医療学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] メタボロミクスを用いた眼内リンパ腫と眼サルコイドーシスにおける血清代謝物の解析2021

    • Author(s)
      脇田遼、杉本昌弘
    • Organizer
      第125回日本眼科学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] データ駆動型サイエンスとメタボロミクス2021

    • Author(s)
      杉本昌弘
    • Organizer
      第28回クロマトグラフィーシンポジウム(CS28)
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] LC-MS を用いた水溶性代謝物の一斉分析法 による眼関連疾患のメタボローム解析2021

    • Author(s)
      相田泰子、富田淳美、脇田遼、相澤有美、杉本昌弘、臼井嘉彦、後藤浩
    • Organizer
      第28回クロマトグラフィーシンポジウム(CS28)
    • Related Report
      2021 Annual Research Report
  • [Presentation] Metabolomics and machine learning for ophthalmic diseases2021

    • Author(s)
      Masahiro Sugimoto、Hiroyuki Shimizu、Yumi Aizawa、Ryo Wakita、Yoshihiko Usui、Hiroshi Goto
    • Organizer
      METABOLOMICS 2021 ONLINE
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 筋痛性脳脊髄炎/慢性疲労症候群におけるメタボロミクス研究2021

    • Author(s)
      山野恵美、杉本昌弘、曽我朋義、渡辺恭良、片岡洋祐
    • Organizer
      第17回日本疲労学会総会・学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ヒト全身代謝シミュレーションの最前線2021

    • Author(s)
      倉田博之、松崎芙美子、羽賀雅俊、川西潤、吉澤美沙、前田和勲、杉本昌弘
    • Organizer
      2021年日本バイオインフォマティクス学年年会・第10回生命医薬情報学連合大会(IIBMP2021)
    • Related Report
      2021 Annual Research Report
  • [Presentation] 機械学習と代謝プロファイルを用いたIgG4関連眼疾患と眼窩MALTリンパ腫の識別2021

    • Author(s)
      杉本昌弘、富田淳美、相田泰子、脇田遼、臼井嘉彦、後藤浩
    • Organizer
      第15回メタボロームシンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] 数理モデルと生体模倣システム(MPS)による仮想人体構築に向けた取り組み2021

    • Author(s)
      杉本昌弘
    • Organizer
      CBI学会 2021年大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] AI(General), AI(Radiology), AI(Pathology)2021

    • Author(s)
      Eiji Aramaki、Masako Kataoka、Yosiaki Matsumoto、Kazunori Kubota、Ichiro Maeda、Masahiro Sugimoto
    • Organizer
      Best of SABCS Kyoto
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 酵母の胞子形成の時系列マイクロアレイデータに対する効果的な非階層的クラスタリング手法開発の検討2020

    • Author(s)
      谷葵衣, 杉本昌弘, 佐々木貴規
    • Organizer
      第58回日本生物物理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ディープラーニング及びオートエンコーダーを用いた乳癌組織中の DEGs からの特徴抽出と予後予測2020

    • Author(s)
      水越優介, 杉本昌弘, 佐々木貴規
    • Organizer
      第58回日本生物物理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 遺伝子発現データからの幾何学的特徴抽出を用いたアトピー性皮膚炎発症における関連遺伝子群の調査2020

    • Author(s)
      長谷部拓弥, 杉本昌弘, 佐々木貴規
    • Organizer
      第58回日本生物物理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Machine learning enabled breast cancer detection using salivary metabolomics.2020

    • Author(s)
      Sugimoto Masahiro
    • Organizer
      Annual Congress on Advances in Biotechnology
    • Related Report
      2020 Annual Research Report
  • [Remarks] 仮想人体構築学

    • URL

      https://www.kasojintai.com/

    • Related Report
      2020 Annual Research Report

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Published: 2020-10-30   Modified: 2024-01-30  

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