グリア・神経ネットワークの統合による脳内エネルギー代謝機構

• Project Area: Glia decoding: deciphering information critical for brain-body interactions
• Project/Area Number: 20H05896
• Research Category: Grant-in-Aid for Transformative Research Areas (A)
• Allocation Type: Single-year Grants
• Review Section: Transformative Research Areas, Section (III)
• Research Institution: Keio University
• Principal Investigator: 田中 謙二 慶應義塾大学, 医学部(信濃町), 教授 (30329700)
• Co-Investigator(Kenkyū-buntansha): 松井 広 東北大学, 生命科学研究科, 教授 (20435530)
• Project Period (FY): 2020-11-19 – 2025-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥103,220,000 (Direct Cost: ¥79,400,000、Indirect Cost: ¥23,820,000); Fiscal Year 2024: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2023: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2022: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2021: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2020: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
• Keywords: アストロサイト / 血管 / シナプス / 小脳 / てんかん / グリア神経相互作用 / ファイバーフォトメトリー / 血流 / ノイズ / オプトジェネティクス / 神経-血管機能連関 / 末梢-中枢機能連関 / 血管オプトジェネティクス / 神経活動 / 自由行動 / 神経－血管機能連環 / 末梢－中枢脳機能連環 / 末梢中枢機能連関 / 神経－血管機能連関 / 末梢中枢脳機能連関

Outline of Research at the Start

本研究の概要は、神経回路、グリア細胞、血管等の複数の異なる脳内機能要素間を統合するメカニズムを探索する研究である。また、脳内エネルギー代謝は、脳のサバイバルを担うに留まらず、神経回路を流れる情報そのものの特性を左右する存在であることを明らかにする。さらに、本研究では、末梢から中枢へと伸びる迷走神経を、生来の中枢へのアクセスルートとして人為的に活用し、脳内環境を遠隔操作することにも挑戦する。グリア細胞を起点とするエネルギーのスマート供給システムを調整し、神経・精神疾患の治療原理を開拓する。

Outline of Annual Research Achievements

ファイバーフォトメトリー法で計測される蛍光シグナルは、局所血流量と細胞内のpHに強く影響を受ける。そこで計測シグナルから、目的検出分子（Ca2+等）の濃度、細胞内pH、局所脳血流量の変動を分離して推定する方法を編み出した（Ikoma et al 2023a）。この手法を用いて解析したところ、レム睡眠時に視床下部アストロサイトが酸性化（Ikoma et al 2023b）、マウス同士のケンカが解散する時には小脳グリア細胞のCa2+濃度が増加（Asano et al 2024）、不安な状態のマウスの手綱核アストロサイトのpHは酸性化する（Tan et al 2024）ことが示された。また、小脳バーグマングリア細胞の機能をChR2やArchTで光操作したところ、小脳運動学習のトレーニング中に生じるオンライン学習とトレーニング後の休憩中に生じるオフライン学習があり、グリア機能操作はオンライン学習だけに作用することが示された（Kanaya et al 2023）。さらに、自発的なてんかん様神経発振が生じるマウスでのモデルを作製したところ、海馬アストロサイトでのCa2+濃度上昇がてんかん様神経発振に先立つことが示された（Araki et al 2024）。また、脳へのエネルギー循環を担う血管動態を観察したところ、ゆっくりと水平方向に振れる縞模様の視覚刺激に対し、周期も位相も完全に同調した脳全体の血管の拡張・収縮運動が生じることが示された（Sasaki et al 2024）。このような血管運動による脳内エネルギー動態への影響を探る上で、これまで、血管径を光操作するオプトジェネティクスを開発してきたが、今回、血管平滑筋ではなくペリサイトのみを光操作してみたところ、ペリサイトにも収縮能があることが示唆された（Iba et al 2023）。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

ファイバーフォトメトリーを用いた細胞内カルシウム計測が多くのラボで行われているが、そのデータに隠された情報、すなわち血流量と細胞内pHを推測する方法を明らかにしたことは意義がある。これは、脳内エネルギー代謝と神経活動を同時にモニターできるようになったことと同義であり、脳内エネルギー分配の仕組みを明らかにする研究を有利に進められる。

Strategy for Future Research Activity

神経活動、血流、エネルギー代謝、行動を同時に評価できるモデルを用い、グリア・神経・血管の相互作用を明らかにしていく。

Research Products

• [Int'l Joint Research] Bonn University(ドイツ)
• [Int'l Joint Research] Icahn School of Medicine at Mount Sinai/Harvard University(米国)
• [Int'l Joint Research] University of Texas, Austin(米国)
• [Int'l Joint Research] Hangzhou Normal University(中国)
• [Int'l Joint Research] University of Strathclyde(英国)
• [Int'l Joint Research] University of Texas, Austin/University of Washington(米国)
• [Int'l Joint Research] University Dusseldorf/University of Bonn/Max-Planck-Institute(ドイツ)
• [Journal Article] Plastic vasomotion entrainment (2024)
  • Author(s): Sasaki Daichi、Imai Ken、Ikoma Yoko、Matsui Ko
  • Journal Title: eLife Volume: 13
  • DOI: 10.7554/elife.93721.3
  • Peer Reviewed / Open Access
• [Journal Article] Anxiety control by astrocytes in the lateral habenula (2024)
  • Author(s): Tan Wanqin、Ikoma Yoko、Takahashi Yusuke、Konno Ayumu、Hirai Hirokazu、Hirase Hajime、Matsui Ko
  • Journal Title: Neuroscience Research Volume: - Pages: 1-15
  • DOI: 10.1016/j.neures.2024.01.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glial tone of aggression (2024)
  • Author(s): Asano Y, Sasaki D, Ikoma Y, Matsui K
  • Journal Title: Neuroscience Research Volume: N/A Pages: 39-51
  • DOI: 10.1016/j.neures.2023.11.008
  • Peer Reviewed / Open Access
• [Journal Article] Optogenetic demonstration of the involvement of SMA-negative mural cells in the regulation of cerebral blood flow (2023)
  • Author(s): Iba Chisato、Abe Yoshifumi、Tanaka Kenji F.
  • Journal Title: Frontiers in Physiology Volume: 14 Pages: 1322250-1322250
  • DOI: 10.3389/fphys.2023.1322250
  • Peer Reviewed / Open Access
• [Journal Article] Acceleration of the Development of Microcirculation Embolism in the Brain due to Capillary Narrowing (2023)
  • Author(s): Murata Juri、Unekawa Miyuki、Kudo Yuya、Kotani Maho、Kanno Iwao、Izawa Yoshikane、Tomita Yutaka、Tanaka Kenji F.、Nakahara Jin、Masamoto Kazuto
  • Journal Title: Stroke Volume: 54 Issue: 8 Pages: 2135-2144
  • DOI: 10.1161/strokeaha.122.042416
  • Peer Reviewed / Open Access
• [Journal Article] Glial modulation of the parallel memory formation (2023)
  • Author(s): Kanaya Teppei、Ito Ryo、Morizawa Yosuke M.、Sasaki Daichi、Yamao Hiroki、Ishikane Hiroshi、Hiraoka Yuichi、Tanaka Kohichi、Matsui Ko
  • Journal Title: Glia Volume: 71 Issue: 10 Pages: 2401-2417
  • DOI: 10.1002/glia.24431
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Properties of REM sleep alterations with epilepsy (2023)
  • Author(s): Ikoma Yoko、Takahashi Yusuke、Sasaki Daichi、Matsui Ko
  • Journal Title: Brain Volume: N/A Issue: 6 Pages: 2431-2442
  • DOI: 10.1093/brain/awac499
  • Peer Reviewed / Open Access
• [Journal Article] Serotonergic neurons control cortical neuronal intracellular energy dynamics by modulating astrocyte-neuron lactate shuttle (2023)
  • Author(s): Natsubori Akiyo、Hirai Shinobu、Kwon Soojin、Ono Daisuke、Deng Fei、Wan Jinxia、Miyazawa Momoka、Kojima Takashi、Okado Haruo、Karashima Akihiro、Li Yulong、Tanaka Kenji F.、Honda Makoto
  • Journal Title: iScience Volume: 26 Issue: 1 Pages: 105830-105830
  • DOI: 10.1016/j.isci.2022.105830
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse Using a Recurrent Neural Network (2023)
  • Author(s): Kobayashi Goh、Tanaka Kenji F.、Takata Norio
  • Journal Title: The Keio Journal of Medicine Volume: 72 Issue: 2 Pages: 44-59
  • DOI: 10.2302/kjm.2022-0020-OA
  • ISSN: 0022-9717, 1880-1293
  • Peer Reviewed / Open Access
• [Journal Article] Slow‐rising and fast‐falling dopaminergic dynamics jointly adjust negative prediction error in the ventral striatum (2023)
  • Author(s): Shikano Yu、Yagishita Sho、Tanaka Kenji F.、Takata Norio
  • Journal Title: European Journal of Neuroscience Volume: in press Issue: 12 Pages: 4502-4522
  • DOI: 10.1111/ejn.15945
  • Peer Reviewed
• [Journal Article] Local brain environment changes associated with epileptogenesis (2022)
  • Author(s): Ikoma Yoko、Sasaki Daichi、Matsui Ko
  • Journal Title: Brain Volume: 146 Issue: 2 Pages: 576-586
  • DOI: 10.1093/brain/awac355
  • Peer Reviewed
• [Journal Article] Downregulation of Bdnf Expression in Adult Mice Causes Body Weight Gain (2022)
  • Author(s): Suzuki Toru、Tanaka Kenji F.
  • Journal Title: Neurochemical Research Volume: 47 Issue: 9 Pages: 2645-2655
  • DOI: 10.1007/s11064-021-03523-7
  • Peer Reviewed
• [Journal Article] A gradual temporal shift of dopamine responses mirrors the progression of temporal difference error in machine learning (2022)
  • Author(s): Amo Ryunosuke、Matias Sara、Yamanaka Akihiro、Tanaka Kenji F.、Uchida Naoshige、Watabe-Uchida Mitsuko
  • Journal Title: Nature Neuroscience Volume: 25 Issue: 8 Pages: 1082-1092
  • DOI: 10.1038/s41593-022-01109-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice (2022)
  • Author(s): Takahashi A, Durand-de Cuttoli R, Flanigan ME, Hasegawa E, Tsunematsu T, Aleyasin H, Cherasse Y, Miya K, Okada T, Keino-Masu K, Mitsui K, Li L, Patel V, Blitzer RD, Lazarus M, Tanaka KF, Yamanaka A, Sakurai T, Ogawa S, Russo SJ
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 4039-4039
  • DOI: 10.1038/s41467-022-31728-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oscillatory Population-Level Activity of Dorsal Raphe Serotonergic Neurons Is Inscribed in Sleep Structure (2022)
  • Author(s): Kato Tomonobu、Mitsukura Yasue、Yoshida Keitaro、Mimura Masaru、Takata Norio、Tanaka Kenji F.
  • Journal Title: The Journal of Neuroscience Volume: 42 Issue: 38 Pages: 7244-7255
  • DOI: 10.1523/jneurosci.2288-21.2022
  • Peer Reviewed
• [Journal Article] Separate optogenetic manipulation of Nerve/glial antigen 2 (NG2) glia and mural cells using the NG2 promoter. (2022)
  • Author(s): Oishi M, Stefan P, Yamazaki Y, Unekawa M, Adachi R, Yamada M, Imayoshi I, Abe Y, Steinhauser C, Tanaka KF
  • Journal Title: Glia Volume: 71 Issue: 2 Pages: 317-333
  • DOI: 10.1002/glia.24273
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Synaptic pruning through glial synapse engulfment upon motor learning (2022)
  • Author(s): Morizawa Yosuke M.、Matsumoto Mami、Nakashima Yuka、Endo Narumi、Aida Tomomi、Ishikane Hiroshi、Beppu Kaoru、Moritoh Satoru、Inada Hitoshi、Osumi Noriko、Shigetomi Eiji、Koizumi Schuichi、Yang Guang、Hirai Hirokazu、Tanaka Kohichi、Tanaka Kenji F.、Ohno Nobuhiko、Fukazawa Yugo、Matsui Ko
  • Journal Title: Nature Neuroscience Volume: 25 Issue: 11 Pages: 1458-1469
  • DOI: 10.1038/s41593-022-01184-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Mlc1 Promoter Directs M?ller Cell-specific Gene Expression in the Retina (2022)
  • Author(s): Danjo Yosuke、Shinozaki Youichi、Natsubori Akiyo、Kubota Yuto、Kashiwagi Kenji、Tanaka Kenji F.、Koizumi Schuichi
  • Journal Title: Translational Vision Science & Technology Volume: 11 Issue: 1 Pages: 25-25
  • DOI: 10.1167/tvst.11.1.25
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Optogenetic stimulus-triggered acquisition of seizure resistance (2022)
  • Author(s): Shimoda Yoshiteru、Beppu Kaoru、Ikoma Yoko、Morizawa Yosuke M.、Zuguchi Satoshi、Hino Utaro、Yano Ryutaro、Sugiura Yuki、Moritoh Satoru、Fukazawa Yugo、Suematsu Makoto、Mushiake Hajime、Nakasato Nobukazu、Iwasaki Masaki、Tanaka Kenji F.、Tominaga Teiji、Matsui Ko
  • Journal Title: Neurobiology of Disease Volume: 163 Pages: 105602-105602
  • DOI: 10.1016/j.nbd.2021.105602
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sustained ErbB Activation Causes Demyelination and Hypomyelination by Driving Necroptosis of Mature Oligodendrocytes and Apoptosis of Oligodendrocyte Precursor Cells (2021)
  • Author(s): Hu Xu、Xiao Guanxiu、He Li、Niu Xiaojie、Li Huashun、Lou Tianjie、Hu Qianqian、Yang Youguang、Xu Qi、Wei Zhengdong、Qiu Mengsheng、Tanaka Kenji F.、Shen Ying、Tao Yanmei
  • Journal Title: The Journal of Neuroscience Volume: 41 Issue: 48 Pages: 9872-9890
  • DOI: 10.1523/jneurosci.2922-20.2021
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Optogenetic activation of DRN 5-HT neurons induced active wakefulness, not quiet wakefulness. (2021)
  • Author(s): Moriya R, Kanamaru M, Okuma N, Yoshikawa A, Tanaka KF, Hokari S, Ohshima Y, Yamanaka A, Honma M, Onimaru H, Kikuchi T, Izumizaki M.
  • Journal Title: Brain Res Bull. Volume: 177 Pages: 129-142
  • DOI: 10.1016/j.brainresbull.2021.09.019
  • Peer Reviewed / Open Access
• [Journal Article] Oligodendrocytic Na+-K+-Cl- co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain (2021)
  • Author(s): Yamazaki Yoshihiko、Abe Yoshifumi、Fujii Satoshi、Tanaka Kenji F.
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 5146-5146
  • DOI: 10.1038/s41467-021-25488-5
  • Peer Reviewed / Open Access
• [Journal Article] Optical manipulation of local cerebral blood flow in the deep brain of freely moving mice (2021)
  • Author(s): Abe Yoshifumi、Kwon Soojin、Oishi Mitsuhiro、Unekawa Miyuki、Takata Norio、Seki Fumiko、Koyama Ryuta、Abe Manabu、Sakimura Kenji、Masamoto Kazuto、Tomita Yutaka、Okano Hideyuki、Mushiake Hajime、Tanaka Kenji F.
  • Journal Title: Cell Reports Volume: 36 Issue: 4 Pages: 109427-109427
  • DOI: 10.1016/j.celrep.2021.109427
  • Peer Reviewed / Open Access
• [Journal Article] Mice with reduced glutamate transporter GLT1 expression exhibit behaviors related to attention-deficit/hyperactivity disorder (2021)
  • Author(s): Hiraoka Yuichi、Sugiyama Kaori、Nagaoka Daiki、Tsutsui-Kimura Iku、Tanaka Kenji F.、Tanaka Kohichi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 567 Pages: 161-165
  • DOI: 10.1016/j.bbrc.2021.06.057
  • Peer Reviewed
• [Journal Article] Ninjin’yoeito, a traditional Japanese Kampo medicine, suppresses the onset of anhedonia induced by dysfunction in the striatal dopamine receptor type 2-expressing medium spiny neurons (2021)
  • Author(s): Oizumi Hiroaki、Imai Ryota、Suzuki Toru、Omiya Yuji、Tanaka Kenji F、Mimura Masaru、Mizoguchi Kazushige
  • Journal Title: NeuroReport Volume: 32 Issue: 10 Pages: 869-874
  • DOI: 10.1097/wnr.0000000000001667
  • Peer Reviewed / Open Access
• [Journal Article] Region-Specific and State-Dependent Astrocyte Ca²⁺ Dynamics during the Sleep-Wake Cycle in Mice (2021)
  • Author(s): Tsunematsu Tomomi、Sakata Shuzo、Sanagi Tomomi、Tanaka Kenji F.、Matsui Ko
  • Journal Title: The Journal of Neuroscience Volume: 41 Issue: 25 Pages: 5440-5452
  • DOI: 10.1523/jneurosci.2912-20.2021
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differential pial and penetrating arterial responses examined by optogenetic activation of astrocytes and neurons (2021)
  • Author(s): Hatakeyama N., Unekawa M., Tomita Y. Suzuki N. Nakahara J. Takuwa H., Kanno I., Matsui K., Tanaka K.F., Masamoto K.
  • Journal Title: J Cereb Blood Flo Metab Volume: - Issue: 10 Pages: 2676-2689
  • DOI: 10.1177/0271678x211010355
  • Peer Reviewed / Open Access
• [Journal Article] Chronic social defeat stress impairs goal-directed behavior through dysregulation of ventral hippocampal activity in male mice (2021)
  • Author(s): Yoshida Keitaro、Drew Michael R.、Kono Anna、Mimura Masaru、Takata Norio、Tanaka Kenji F.
  • Journal Title: Neuropsychopharmacology Volume: 46 Issue: 9 Pages: 1606-1616
  • DOI: 10.1038/s41386-021-00990-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Flexible annotation atlas of the mouse brain: combining and dividing brain structures of the Allen Brain Atlas while maintaining anatomical hierarchy (2021)
  • Author(s): Takata Norio、Sato Nobuhiko、Komaki Yuji、Okano Hideyuki、Tanaka Kenji F.
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 6234-6234
  • DOI: 10.1038/s41598-021-85807-0
  • Peer Reviewed / Open Access
• [Journal Article] Exacerbation of Epilepsy by Astrocyte Alkalization and Gap Junction Uncoupling (2021)
  • Author(s): Mariko Onodera, Jan Meyer, Kota Furukawa, Yuichi Hiraoka, Tomomi Aida, Kohichi Tanaka, Kenji F. Tanaka, Christine R. Rose and Ko Matsui
  • Journal Title: Journal of Neuroscience Volume: 41 Issue: 10 Pages: 2106-2118
  • DOI: 10.1523/jneurosci.2365-20.2020
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nitric oxide‐mediated signal transmission in bladder vasculature underlies the therapeutic actions of PDE5 inhibitors in the rat (2021)
  • Author(s): Tanaka Hidekazu、Mitsui Retsu、Oishi Mitsuhiro、Passlick Stefan、Jabs Ronald、Steinh?user Christian、Tanaka Kenji F.、Hashitani Hikaru
  • Journal Title: British Journal of Pharmacology Volume: 178 Issue: 5 Pages: 1073-1094
  • DOI: 10.1111/bph.15342
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Astrocytic cAMP modulates memory via synaptic plasticity (2021)
  • Author(s): Zhou Zhiwen、Okamoto Kazuki、Onodera Junya、Hiragi Toshimitsu、Andoh Megumi、Ikawa Masahito、Tanaka Kenji F.、Ikegaya Yuji、Koyama Ryuta
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 118 Issue: 3 Pages: 2016584118-2016584118
  • DOI: 10.1073/pnas.2016584118
  • Peer Reviewed / Open Access
• [Journal Article] Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice. (2021)
  • Author(s): Miyata S, Kakizaki T, Fujihara K, Obinata H, Hirano T, Nakai J, Tanaka M, Itohara S, Watanabe M, Tanaka KF, Abe M, Sakimura K, Yanagawa Y.
  • Journal Title: Mol Brain Volume: 14 Issue: 1 Pages: 5-5
  • DOI: 10.1186/s13041-020-00713-2
  • Peer Reviewed / Open Access
• [Journal Article] Activation of ventral CA1 hippocampal neurons projecting to the lateral septum during feeding (2021)
  • Author(s): Kosugi Kenzo、Yoshida Keitaro、Suzuki Toru、Kobayashi Kenta、Yoshida Kazunari、Mimura Masaru、Tanaka Kenji F.
  • Journal Title: Hippocampus Volume: 31 Issue: 3 Pages: 294-304
  • DOI: 10.1002/hipo.23289
  • Peer Reviewed / Open Access
• [Journal Article] Direct Impact of Motor Cortical Stimulation on the Blood Oxygen-level Dependent Response in Rats (2021)
  • Author(s): Xin Zonghao、Abe Yoshifumi、Liu Shuang、Tanaka Kenji F.、Hosomi Koichi、Saitoh Youichi、Sekino Masaki
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 20 Issue: 1 Pages: 83-90
  • DOI: 10.2463/mrms.mp.2019-0156
  • NAID: 130007993616
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Glial amplification of synaptic signals (2021)
  • Author(s): Beppu Kaoru、Kubo Naoko、Matsui Ko
  • Journal Title: The Journal of Physiology Volume: 599 Issue: 7 Pages: 2085-2102
  • DOI: 10.1113/jp280857
  • Peer Reviewed
• [Journal Article] Serotonergic projections to the orbitofrontal and medial prefrontal cortices differentially modulate waiting for future rewards (2020)
  • Author(s): Miyazaki K, Miyazaki KW, Sivori G, Yamanaka A, Tanaka KF, Doya K
  • Journal Title: Science Advances Volume: 6 Issue: 48 Pages: 7246-7246
  • DOI: 10.1126/sciadv.abc7246
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain (2020)
  • Author(s): Kawamura Atsuki、Abe Yoshifumi、Seki Fumiko、Katayama Yuta、Nishiyama Masaaki、Takata Norio、Tanaka Kenji F.、Okano Hideyuki、Nakayama Keiichi I.
  • Journal Title: Molecular Brain Volume: 13 Issue: 1 Pages: 160-160
  • DOI: 10.1186/s13041-020-00699-x
  • Peer Reviewed / Open Access
• [Journal Article] Varying perivascular astroglial endfoot dimensions along the vascular tree maintain perivascular‐interstitial flux through the cortical mantle (2020)
  • Author(s): Wang Marie Xun、Ray Lori、Tanaka Kenji F.、Iliff Jeffrey J.、Heys Jeffrey
  • Journal Title: Glia Volume: 69 Issue: 3 Pages: 715-728
  • DOI: 10.1002/glia.23923
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep-wake states (2020)
  • Author(s): A. Natsubori, T. Tsunematsu, A. Karashima, H. Imamura, N. Kabe, A. Trevisiol, J. Hirrlinger, T. Kodama, T. Sanagi, K. Masamoto, N. Takata, K-A Nave, K. Matsui, K.F. Tanaka, M. Honda
  • Journal Title: Communications Biology Volume: 3 Issue: 1 Pages: 491-491
  • DOI: 10.1038/s42003-020-01215-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Diffusion functional MRI reveals global brain network functional abnormalities driven by targeted local activity in a neuropsychiatric disease mouse model (2020)
  • Author(s): Abe Yoshifumi、Takata Norio、Sakai Yuki、Hamada Hiro Taiyo、Hiraoka Yuichi、Aida Tomomi、Tanaka Kohichi、Bihan Denis Le、Doya Kenji、Tanaka Kenji F
  • Journal Title: NeuroImage Volume: 223 Pages: 117318-117318
  • DOI: 10.1016/j.neuroimage.2020.117318
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Opposing Ventral Striatal Medium Spiny Neuron Activities Shaped by Striatal Parvalbumin-Expressing Interneurons during Goal-Directed Behaviors. (2020)
  • Author(s): Yoshida K, Tsutsui-Kimura I, Kono A, Yamanaka A, Kobayashi K, Watanabe M, Mimura M, *Tanaka KF.
  • Journal Title: Cell Rep Volume: 31 Issue: 13 Pages: 107829-107829
  • DOI: 10.1016/j.celrep.2020.107829
  • Peer Reviewed / Open Access
• [Journal Article] Compartmentalized Input?Output Organization of Lugaro Cells in the Cerebellar Cortex (2020)
  • Author(s): Miyazaki Taisuke、Yamasaki Miwako、Tanaka Kenji F.、Watanabe Masahiko
  • Journal Title: Neuroscience Volume: in press Issue: 20 Pages: 30332-30325
  • DOI: 10.1016/j.neuroscience.2020.05.026
  • Peer Reviewed / Open Access
• [Journal Article] Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model (2020)
  • Author(s): Abe Y, Ikegawa N, Yoshida K, Muramatsu K, Hattori S, Kawai K, Murakami M, Tanaka T, Goda W, Goto Zm, Yamamoto T, Hashimoto T, Yamada K, Shibata T, Misawa H, Mimura M, Tanaka KF, Miyakawa T, Iwatsubo T, Hata J, Niikura T, Yasui M
  • Journal Title: Acta Neuropathologica Communications Volume: 8 Issue: 1 Pages: 67-67
  • DOI: 10.1186/s40478-020-00936-3
  • Peer Reviewed / Open Access
• [Presentation] Rejuvenation of oligodendrocytes restores plasticity in the adult mouse brain (2023)
  • Author(s): 田中謙二
  • Organizer: THE 50th NAITO CONFERENCE ON Glia World
  • Int'l Joint Research / Invited
• [Presentation] オプトジェネティクス概論：医学生物学分野への応用 (2023)
  • Author(s): 田中謙二
  • Organizer: 第127回日本眼科学会総会
  • Invited
• [Presentation] Metaplasticity augmentation by acid glia in cerebellar motor learning. (2023)
  • Author(s): 松井 広
  • Organizer: The 10th FAOPS congress
  • Int'l Joint Research
• [Presentation] 脳内pH変化の秘めたる役割：アストロサイトpHとてんかん (2023)
  • Author(s): 松井 広
  • Organizer: 第56回日本てんかん学会学術集会
• [Presentation] Dual synaptic plasticity differentially controlled by glia (2023)
  • Author(s): 松井 広
  • Organizer: THE 50th NAITO CONFERENCE ON Glia World
  • Int'l Joint Research / Invited
• [Presentation] Glial control of functional and structural synaptic plasticity. (2023)
  • Author(s): 松井 広
  • Organizer: The 16th Annual Meeting of Chinese Neuroscience Society & The 2nd CJK International Meeting
  • Int'l Joint Research
• [Presentation] Optical signal detection of local brain environmental changes in epilepsy and sleep (2023)
  • Author(s): 松井 広
  • Organizer: Cold Spring Harbor Asia Meetings
  • Int'l Joint Research / Invited
• [Presentation] Vascular optogenetics (2023)
  • Author(s): 田中謙二
  • Organizer: U.S.-Japan Joint Workshop on the Neurovascular Unit 2023
  • Int'l Joint Research / Invited
• [Presentation] 薬理学と神経化学で展開する形態学 (2022)
  • Author(s): 田中謙二
  • Organizer: 第96回日本薬理学会年会・第43回日本臨床薬理学会学術総会
• [Presentation] 血管オプトジェネティクス (2022)
  • Author(s): 田中謙二
  • Organizer: Neurovascular Unit 研究会2022
  • Invited
• [Presentation] Vascular optogenetics (2021)
  • Author(s): 田中謙二
  • Organizer: 第64回日本神経化学会大会
• [Presentation] Opposing ventral striatal medium spiny neuron activities are shaped by striatal Pvalb-expressing interneurons during goal-directed behaviors (2021)
  • Author(s): 田中謙二
  • Organizer: 第126回日本解剖学会・第98回日本生理学会 合同大会
• [Presentation] in vivo glial pH in epilepsy (2021)
  • Author(s): 松井広
  • Organizer: 第126回日本解剖学会・第98回日本生理学会 合同大会
• [Presentation] in vivo glial pH in epilepsy (2021)
  • Author(s): 生駒葉子、松井広
  • Organizer: 第126回日本解剖学会・第98回日本生理学会 合同大会
• [Presentation] Glial contribution to the early phase of the parallel memory formation process. (2021)
  • Author(s): 金谷哲平、佐々木大地、伊東諒、山尾啓熙、別府薫、松井広
  • Organizer: 第126回日本解剖学会・第98回日本生理学会 合同大会
• [Presentation] Generation of the epileptic focus by glia. (2021)
  • Author(s): 荒木峻、伊東諒、松井広
  • Organizer: 第126回日本解剖学会・第98回日本生理学会 合同大会
• [Presentation] Energizing epilepsy. (2021)
  • Author(s): 古川孝太、松井広
  • Organizer: 第126回日本解剖学会・第98回日本生理学会 合同大会
• [Presentation] Glial switch of fear memory formation. (2021)
  • Author(s): 山尾啓熙、松井広
  • Organizer: 第126回日本解剖学会・第98回日本生理学会 合同大会
• [Presentation] 血管壁細胞の光操作 (2020)
  • Author(s): 田中謙二
  • Organizer: 第63回 日本脳循環代謝学会
• [Remarks] プレスリリース（東北大学）
  • URL: https://www.lifesci.tohoku.ac.jp/research/results/detail---id-49856.html
• [Remarks] プレスリリース（東北大学）
  • URL: https://www.lifesci.tohoku.ac.jp/research/results/detail---id-49826.html