| Budget Amount *help |
¥100,100,000 (Direct Cost: ¥77,000,000、Indirect Cost: ¥23,100,000)
Fiscal Year 2024: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2023: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2022: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2021: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2020: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
|
|---|
| Outline of Final Research Achievements |
This study aimed to explore and identify subsets of astrocytes and microglia in the spinal dorsal horn (SDH) and to elucidate their roles in somatosensory processing (particularly in pain). Regarding astrocytes, we identified a Hes5+ astrocyte subset selectively localized in the SDH, demonstrated that this subset plays a critical role in enhancing mechanosensory signaling, and elucidated the underlying mechanisms. We further revealed its involvement in the transformation of physiological stress signals into heightened pain sensitivity. Regarding microglia, we identified a CD11c+ microglial subset that emerges in the SDH after peripheral nerve injury and showed that this subset is indispensable for the spontaneous remission of pain behavior. Collectively, our findings reveal the distinct physiological and pathological roles of glial cell subsets and represent a significant advance in our understanding of glial cell diversity and its functional relevance.
|
