| Budget Amount *help |
¥127,530,000 (Direct Cost: ¥98,100,000、Indirect Cost: ¥29,430,000)
Fiscal Year 2024: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2023: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2022: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2021: ¥33,280,000 (Direct Cost: ¥25,600,000、Indirect Cost: ¥7,680,000)
Fiscal Year 2020: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
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| Outline of Final Research Achievements |
In this study, we elucidated the structure, physical properties, and functional expression mechanisms of DNA at the cell-nucleus scale from a soft-matter physics perspective using DNA nanostructures based on nanoscale sequence information: quantitative analysis of surface tension and viscosity by designing adhesive ends of DNA droplets, dynamic control of droplets by photo-responsive molecules We have achieved understanding and reconstruction of the physical properties of hierarchical and non-equilibrium DNA through the realization of DNA aggregation behavior in molecularly crowded environments and transcription and translation reactions in liposomes. This has laid a new foundation for the physical control of cellular nuclear functions.
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