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Integrated Synthesis of Glycans Using Microfluidic and Solid-phase Methods

Planned Research

Project AreaOrganic Synthesis based on Integration of Chemical Reactions. New Methodologies and New Materials
Project/Area Number 21106008
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionOsaka University

Principal Investigator

FUKASE Koichi  大阪大学, 理学(系)研究科(研究院), 教授 (80192722)

Project Period (FY) 2009-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥41,080,000 (Direct Cost: ¥31,600,000、Indirect Cost: ¥9,480,000)
Fiscal Year 2013: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2012: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2009: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywordsマイクロフロー / 固相合成 / N-グリカン / 自然免疫リガンド / グリコシル化 / マイクロフローリアクター / 糖鎖合成 / マイクロフロー合成 / 合成化学 / デンドリマー / マイクロアレイ / シアリル化 / N-結合型糖タンパク質糖鎖 / リポ多糖 / ペプチドグリカン / 糖タンパク質 / 効率合成
Outline of Final Research Achievements

We have investigated the synthesis of various glycans from both animals and microbes in order to investigate their biological functions. The former targets are the N-glycans containing core fucose, bisecting glucosamine or bis-sialylated motif. The key issues for the synthesis were stereoselective glycosylation reactions and we developed highly efficient methods by using microfluidic conditions. We then achieved the solid-phase synthesis of sialylated N-glycan.
Microbial glycoconjugates such as partial structures of lipopolysaccharide (LPS) and peptidoglycan (PGN) from bacteria as well as inositol phospholipids from Entamoeba histolytica were also synthesized. For the synthesis of E. histolytica phospholipids, we developed new synthetic methods including regioselective phosphorylation and synthesis of the long-chain fatty acids by Ni catalyzed sp3-sp3 cross coupling reaction. We also adopted a new protecting group strategy utilizing allyl group as the permanent protecting group.

Report

(6 results)
  • 2014 Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (200 results)

All 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article (37 results) (of which Peer Reviewed: 37 results,  Acknowledgement Compliant: 4 results,  Open Access: 1 results) Presentation (146 results) (of which Invited: 9 results) Book (14 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Facile Preparation of 1,5-Diazacyclooctanes from Unsaturated Imines: Effects of the Hydroxyl Groups on [4+4] Dimerization2014

    • Author(s)
      Tanaka, K., Matsumoto, R., Pradipta, A. R., Kitagawa, Y., Okumura, M. Manabe. Y., Fukase, K.
    • Journal Title

      Synlett

      Volume: 25 Issue: 07 Pages: 1026-1030

    • DOI

      10.1055/s-0033-1340859

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct Guanylation of Amino Groups by Cyanamide in Water: Catalytic Generation and Activation of Unsubstituted Carbodiimide by Scandium(III) Triflate2014

    • Author(s)
      Tsubokura, K., Iwata, T., Taichia, M., Kurbangalieva, A., Fukase, K., Nakao, Y., Tanaka, K.
    • Journal Title

      Synlett

      Volume: 25 Issue: 09 Pages: 1302-1306

    • DOI

      10.1055/s-0033-1341080

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imino [4+4] cycloaddition products as exclusive and biologically relevant acrolein-amine conjugates are intermediates of 3-formyl-3,4-dehydropiperidine (FDP), an acrolein biomarker.2014

    • Author(s)
      Takamatsu, M., Fukase, K., Kurbangalieva, A., Tanaka, K.
    • Journal Title

      Bioorg Med Chem.

      Volume: 22 Issue: 22 Pages: 6380-6386

    • DOI

      10.1016/j.bmc.2014.09.045

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Solid-phase Synthesis of Bacterial Cell Wall Peptidoglycan Fragments.2014

    • Author(s)
      Kadonaga, Y., Wang, N., Fujimoto, Y., Fukase, K.
    • Journal Title

      Chem. Lett.

      Volume: 43 Issue: 9 Pages: 1461-1463

    • DOI

      10.1246/cl.140400

    • NAID

      130004427171

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Revisiting the bromination of C-H bonds with molecular bromine by using a photo-microflow system.2014

    • Author(s)
      Manabe, Y., Kitawaki, Y., Nagasaki, M., Fukase, K., Matsubara, H., Hino, Y., Fukuyama, T., Ryu, I.
    • Journal Title

      Chem. Eur. J.

      Volume: 20 Issue: 40 Pages: 12750-12753

    • DOI

      10.1002/chem.201402303

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Efficient Glycosylation Using In(OTf)<sub>3</sub> as a Lewis Acid: Activation of <i>N</i>-Phenyltrifluoroacetimidate or Thioglycosides with Halogenated Reagents or PhIO2014

    • Author(s)
      Salmasan, R. M., Manabe, Y., Kitawaki, Y., Chang, T.-C., Fukase, K.
    • Journal Title

      Chemistry Letters

      Volume: 43 Issue: 6 Pages: 956-958

    • DOI

      10.1246/cl.140167

    • NAID

      130004868149

    • ISSN
      0366-7022, 1348-0715
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Practical and Efficient Method for α-Sialylation with an Azide Sialyl Donor Using a Microreactor.2014

    • Author(s)
      Uchinashi, Y., Tanaka, K., Manabe, Y., Fujimoto, Y., Fukase, K.
    • Journal Title

      Journal of carbohydrate chemistry

      Volume: 33 Issue: 2 Pages: 55-67

    • DOI

      10.1080/07328303.2014.880116

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] One-pot synthesis of N-acetyl- and N-glycolylneuraminic Acid capped trisaccharides and evaluation of their influenza a(h1 n1) inhibition.2014

    • Author(s)
      Hsu, Y., Ma, HH., Lico, LS., Jan, JT., Fukase, K., Uchinashi, Y., Zulueta, MM., Hung, SC.
    • Journal Title

      Angew Chem Int Ed

      Volume: 53 Issue: 9 Pages: 2413-2416

    • DOI

      10.1002/anie.201309646

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole-body imaging of tumor cells by azaelectrocyclization: Visualization of metastasis dependence on glycan structure2013

    • Author(s)
      Tanaka, K., Moriwaki, K., Yokoi, S., Koyama, K., Miyoshi, E., Fukase, K.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 21(5) Issue: 5 Pages: 614-621

    • DOI

      10.1016/j.bmc.2013.01.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycan Sequence-Dependent Nod2 Activation Investigated by Using a Chemically Synthesized Bacterial Peptidoglycan Fragment Library2013

    • Author(s)
      Ning Wang, Cheng-yuan Huang, Mizuho Hasegawa, Naohiro Inohara, Yukari Fujimoto, Koichi Fukase
    • Journal Title

      ChemBioChem

      Volume: 14 Issue: 4 Pages: 482-488

    • DOI

      10.1002/cbic.201200655

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A conformationally fixed analog of the peptide mimic Grb2-SH2 domain: synthesis and evaluation against the A431 cancer cell2013

    • Author(s)
      T. Iwata, K. Tanaka, T. Tahara, S. Kozaki, H. Onoe, Y. Watanabe, K. Fukase
    • Journal Title

      Molecular BioSystems

      Volume: 9 Issue: 5 Pages: 1019-1025

    • DOI

      10.1039/c3mb25462c

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Innate immunomodulation by lipophilic termini of lipopolysaccharide; synthesis of lipid A from Porphyromonas gingivalis and other bacteria and their immunomodulative response2013

    • Author(s)
      Fujimoto, Y., Shimoyama, A., Saeki, A., Kitayama, N., Kasamatsu, C., Tsutsui, H., Fukase, K.
    • Journal Title

      Mol. BioSyst.

      Volume: 9 Issue: 5 Pages: 987-996

    • DOI

      10.1039/c3mb25477a

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ni-Butadiene Catalytic System for the Cross-Coupling of Bromoalkanoic Acids with Alkyl Grignard Reagents : A Practical and Versatile Method for Preparing Fatty Acids2013

    • Author(s)
      Takanori Iwasaki
    • Journal Title

      Chemistry A European Journal

      Volume: 19 Issue: 9 Pages: 2956-2960

    • DOI

      10.1002/chem.201204222

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bio-imaging and cancer targeting with glycoproteins and N-glycans2012

    • Author(s)
      Fukase, K., Tanaka, K.
    • Journal Title

      Curr. Opin. Chem. Biol.

      Volume: 16(5-6) Issue: 5-6 Pages: 614-621

    • DOI

      10.1016/j.cbpa.2012.09.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient synthesis of 2, 6, 9-triazabicyclo[3.3.1] =====s through a=ine-=ediated for=al [4+4] reaction of unsaturated i=ines2012

    • Author(s)
      K. Tanaka, E. R. 0. Siwu、S. Hirosaki, T. Iwata, R. Matsumoto, Y. Kitagawa, A. R. Pradipta, M. Okumura, K. Fukase
    • Journal Title

      Tetrahedron Letters

      Volume: 53 Issue: 44 Pages: 5899-5902

    • DOI

      10.1016/j.tetlet.2012.08.081

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell surface biotinylation by azaelectrocyclization: Easy-handling and versatile approach for living cell labeling.2012

    • Author(s)
      Tanaka,K., Yokoi, S., Morimoto, K., Iwata, T., Nakamoto, Y., Nakayama, K., Koyama, K., Fujiwara, T., Fukase, K.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 20 Issue: 6 Pages: 1865-1868

    • DOI

      10.1016/j.bmc.2011.12.043

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and immunomodulatory activities of Helicobacter pylori lipophilic terminus of lipopolysaccharide including lipid A2012

    • Author(s)
      Fujimoto, Y., Shimoyama, A., Suda, Y., Fukase, K.
    • Journal Title

      Carbohydrate Research

      Volume: 356 Pages: 37-43

    • DOI

      10.1016/j.carres.2012.03.013

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Azaelectrocyclization-Based Labeling and Application to Noninvasive Imaging and Targeting Using N-Glycan Derivatives ―In pursuit of N-Glycan Functions on Proteins, Dendrimers, and Living Cells―2012

    • Author(s)
      Tanaka, K.; Fukase, K.
    • Journal Title

      Trends in Glycoscience and Glycotechnology

      Volume: 24 (136) Pages: 47-64

    • NAID

      10030975689

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and immunomodulatory activities of Helicobacter pylori lipophilic terminus of lipopolysaccharide including lipid A2012

    • Author(s)
      Fujimoto, Y., Shimoyama, A., Suda, Y., Fukase, K
    • Journal Title

      Carbohydrate Research

      Volume: (未定)(accepted)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auxiliary-directed oxidation of ursolic acid by 'Ru'-porphyrins : chemical modulation of cytotoxicity against tumor cell lines2012

    • Author(s)
      Tanaka, K., Mazumder, K., Siwu, E.R.O., Nozaki, Satoshi, Watanabe, Y., Fukase, K.
    • Journal Title

      Tetrahedron Lett.

      Volume: 53 Issue: 14 Pages: 1756-1759

    • DOI

      10.1016/j.tetlet.2012.01.107

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Bacterial Glycoconjugates and Their Bio-functional Studies in Innate Immunity2012

    • Author(s)
      Fukase, K., Fujimoto, Y., Shimoyama, A., Tanaka, K
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 70 Issue: 2 Pages: 113-130

    • DOI

      10.5059/yukigoseikyokaishi.70.113

    • NAID

      10030481197

    • ISSN
      0037-9980, 1883-6526
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity Effects of Glycan Clusters on Microarrays and Dendrimers2011

    • Author(s)
      K.Tanaka
    • Journal Title

      Trends in Glycoscience and Glycotechnology

      Volume: 23 Issue: 131 Pages: 155-157

    • DOI

      10.4052/tigg.23.155

    • NAID

      10029583041

    • ISSN
      0915-7352, 1883-2113
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical synthesis of Helicobacter pylori lipopolysaccharide partial structures and their selective proinflammatory response2011

    • Author(s)
      Shimoyama, A., Saeki, A., Tanimura, N., Tsutsui, H., Miyake, K., Suda, Y., Fujimoto, Y., Fukase, K.
    • Journal Title

      Chem.--Eur.J.

      Volume: 17 Issue: 51 Pages: 14464-14474

    • DOI

      10.1002/chem.201003581

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reinvestigation of the C5-Acetamide Sialic Acid Donor for a-Selective Sialylation : Practical Procedure under Microfluidic Conditions2011

    • Author(s)
      Uchinashi, Y., Nagasaki, M., Zhou, J., Tanaka, K., Fukase, K.
    • Journal Title

      Org.Biomol.Chem.

      Volume: 9 Issue: 20 Pages: 7243-7248

    • DOI

      10.1039/c1ob06164j

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective glycosylation of 3-deoxy-D-manno-2-octulosomc acid (Kdo) with batch and microfluidic methods2011

    • Author(s)
      Shimoyama, A., Fujimoto, Y., Fukase. K.
    • Journal Title

      Synlett

      Volume: 16 Issue: 16 Pages: 2359-2362

    • DOI

      10.1055/s-0030-1260313

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exploring a unique reactivity of 6II-azaelectrocyclization to enzyme inhibition, natural products synthesis, and molecular imaging : an approach to chemical biology by synthetic chemists2011

    • Author(s)
      Tanaka, K., Fukase, K., Katsumura, S.
    • Journal Title

      Synlett

      Volume: 15 Issue: 15 Pages: 2115-2139

    • DOI

      10.1055/s-0030-1261192

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Widely applicable deprotection method of 2,2,2-trichloroethoxy carbonyl (Troc) group using tetrabutylammonium fluoride2010

    • Author(s)
      Huang, C-y., Fukase, K., et al.
    • Journal Title

      J.Carbohydr.Chem.

      Volume: 29 Pages: 1-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noninvasive imaging of dendrimer-type N-glycan clusters : in vivo dynamics dependence on oligosaccharide structure.2010

    • Author(s)
      Tanaka, K., Fukase, K., et al.
    • Journal Title

      Angew.Chem..Int.Ed.

      Volume: 49 Pages: 8195-8200

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New strategy in synthetic biology : from enzyme inhibition and natural products synthesis to PET imaging by 6π-azaelectrocyclization2010

    • Author(s)
      Tanaka, K., Fukase, K., et al.
    • Journal Title

      The Chemical Record

      Volume: 10 Pages: 119-139

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A combined 6p-azaelectrocyclization/staudinger approach to protein & cell engineering : non-invasive tumor targeting by N-Glycan-engineered lymphocytes2010

    • Author(s)
      Tanaka, K., Fukase, K., et al.
    • Journal Title

      J.Carbohydr.Chem.

      Volume: 29 Pages: 118-132

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Probe design and synthesis of Galβ(1→3)[NeuAcα(2→6)]GlcNAcβ(1→2)Man motif of N-glycan.2010

    • Author(s)
      Bao, G.-m., Fukase, K., et al.
    • Journal Title

      Bioorg.Med.Chem.

      Volume: 18 Pages: 3760-3766

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrocyclization-based labeling allows efficient in Vivo imaging of cellular trafficking2010

    • Author(s)
      Tanaka, K., Fukase, K., et al.
    • Journal Title

      ChemMedChem

      Volume: 5 Pages: 841-845

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acid-Mediated Reactions under Microfluidic Conditions : A New Strategy for Practical Synthesis of Biofunctional Natural Products2010

    • Author(s)
      Tanaka, K.
    • Journal Title

      Journal of Organic Chemistry (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Practical Synthesis of Manβ(1-4)GlcNTroc Fragment via Microfluidic β-Mannosylation2009

    • Author(s)
      Tanaka, K.
    • Journal Title

      J.Carbohydr.Chem. 28

      Pages: 1-11

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Library-directed Synthesis of N-Glycans : Synthesis of Sialic Acid-containing Complex-type N-Glycan on Solid-supports2009

    • Author(s)
      Tanaka, K.
    • Journal Title

      Chem.Asian J. 4

      Pages: 574-580

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical N-Glycosylation by Asparagine under Combined Microfluidic/Batch Conditions2009

    • Author(s)
      Tanaka, K.
    • Journal Title

      Synlett 10

      Pages: 1571-1574

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Renaissance of Traditional Organic Reactions under Microfluidic Conditions : A New Paradigm for Natural Products Synthesis2009

    • Author(s)
      Tanaka, K.
    • Journal Title

      Org.Process Res.Dev. 13

      Pages: 983-990

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ageladine A誘導体のワンポット合成と神経分化促進活性2015

    • Author(s)
      岩田隆幸・大塚悟史・新井大祐・深瀬浩一・中尾洋一・田中克典
    • Organizer
      日本化学会第95回春季年会
    • Place of Presentation
      千葉
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2013 Annual Research Report
  • [Presentation] 酸性シリカゲルを用いたフロー系でのフィッシャーグリコシル化2015

    • Author(s)
      増井誠二、真鍋良幸、下山敦史、福山高英、柳日馨、深瀬浩一
    • Organizer
      日本化学会第95回春季年会
    • Place of Presentation
      千葉
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2013 Annual Research Report
  • [Presentation] 免疫調節作用を有する原虫由来イノシトールリン脂質の合成と生物活性2015

    • Author(s)
      相羽俊彦、末原紗英、佐藤昌紀、田中慎二、北村雅人、BERNIN, Hannah、LOTTER, Hanna、井貫晋輔、深瀬浩一、藤本ゆかり
    • Organizer
      日本化学会第95回春季年会
    • Place of Presentation
      千葉
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2013 Annual Research Report
  • [Presentation] アクロレインによる生体内での8員環化合物の生成とその酸化ストレスマーカーへの変換2015

    • Author(s)
      高松正之・深瀬浩一・田中克典
    • Organizer
      日本化学会第95回春季年会
    • Place of Presentation
      千葉
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2013 Annual Research Report
  • [Presentation] スルホン酸修飾シリカゲルを用いたフロー系でのアルコールの脱水反応:プリスタン合成への応用2015

    • Author(s)
      古田章宏、広部勇輝、福山高英、柳日馨、真鍋良幸、深瀬浩一
    • Organizer
      日本化学会第95回春季年会
    • Place of Presentation
      千葉
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2013 Annual Research Report
  • [Presentation] Synthesis of Inositol Phospholipids as an NKT Cell Modulator2014

    • Author(s)
      Toshihiko Aiba, Masaki Sato, Daichi Umegaki, Shou Nakagawa, Shinji Tanaka, Masato Kitamura, Shinsuke Inuki, Koichi Fukase, Yukari Fujimoto
    • Organizer
      Joint Meeting of the Society for Glycobiology (SFG) and the Japanese Society of Carbohydrate Research (JSCR) (SFG-JSCR 2014)
    • Place of Presentation
      Honolulu Hawaii
    • Year and Date
      2014-11-16 – 2014-11-19
    • Related Report
      2013 Annual Research Report
  • [Presentation] High throughput screening and synthetic study of Fut8 inhibitors2014

    • Author(s)
      Satomi Kasahara, Yoshiyuki Manabe, Shinji Takamatsu, Eiji Miyoshi, Koichi Fukase
    • Organizer
      Joint Meeting of the Society for Glycobiology (SFG) and the Japanese Society of Carbohydrate Research (JSCR) (SFG-JSCR 2014)
    • Place of Presentation
      Honolulu Hawaii
    • Year and Date
      2014-11-16 – 2014-11-19
    • Related Report
      2013 Annual Research Report
  • [Presentation] Efficient Glycosylation Using In(OTf)3 as an Acid Catalyst for The Activation of N-Phenyltrifluoroacetimidate or Thioglycosides2014

    • Author(s)
      Yuriko Kitawaki, Yoshiyuki Manabe, Regina M. Salmasan, Tsung-Che Chang, Koichi Fukase
    • Organizer
      he Ninth International Symposium on Integrated Synthesis(ISIS9)
    • Place of Presentation
      Hyogo, Japan
    • Year and Date
      2014-11-14 – 2014-11-15
    • Related Report
      2013 Annual Research Report
  • [Presentation] An Efficient Synthesis of α-Gal epitope2014

    • Author(s)
      Kento Tokunaga, Yoshiyuki Manabe and Koichi Fukase
    • Organizer
      he Ninth International Symposium on Integrated Synthesis(ISIS9)
    • Place of Presentation
      Hyogo, Japan
    • Year and Date
      2014-11-14 – 2014-11-15
    • Related Report
      2013 Annual Research Report
  • [Presentation] One-Pot Total Synthesis of Ageladine A Inspired by Arginine Post-Translational Modification and its Application to Bioactivity Remodeling2014

    • Author(s)
      Takayuki Iwata, Koichi Fukase, Katsunori Tanaka
    • Organizer
      第5回大津会議
    • Place of Presentation
      滋賀県
    • Year and Date
      2014-10-20 – 2014-10-21
    • Related Report
      2013 Annual Research Report
  • [Presentation] アルギニンの翻訳後修飾に学ぶ血管新生阻害剤ageladine Aのワンポット全合成と活性リモデリング分子の創製2014

    • Author(s)
      岩田隆幸、大塚悟史、坪倉一輝、新井大祐、深瀬浩一、中尾洋一、田中克典
    • Organizer
      第56回天然有機化合物討論会
    • Place of Presentation
      高知県
    • Year and Date
      2014-10-15 – 2014-10-17
    • Related Report
      2013 Annual Research Report
  • [Presentation] NKT細胞刺激作用を有するイノシトールリン脂質の合成2014

    • Author(s)
      相羽俊彦 , 佐藤昌紀 , 梅垣大地 , 中川翔 , 田中慎二 , 北村雅人 , 深瀬浩一 , 藤本ゆかり
    • Organizer
      第56回天然有機化合物討論会
    • Place of Presentation
      高知県
    • Year and Date
      2014-10-15 – 2014-10-17
    • Related Report
      2013 Annual Research Report
  • [Presentation] イリジウム触媒によるヒドロキシ基の直接的アミノ化反応を用いた効率的アミノ糖合成法の開発2014

    • Author(s)
      増井誠二、藤本ゆかり、真鍋良幸、藤田健一、深瀬浩一
    • Organizer
      第4回CSJ化学フェスタ2014
    • Place of Presentation
      東京
    • Year and Date
      2014-10-14 – 2014-10-16
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多様性指向型合成によるフコシルトランスフェラーゼ8阻 害剤の探索2014

    • Author(s)
      笠原里実、真鍋良幸、深瀬浩一
    • Organizer
      第4回CSJ化学フェスタ2014
    • Place of Presentation
      東京
    • Year and Date
      2014-10-14 – 2014-10-16
    • Related Report
      2013 Annual Research Report
  • [Presentation] マイクロフロー系を用いたベンジル位の選択的光臭素化法の開発2014

    • Author(s)
      北脇夕莉子、真鍋良幸、深瀬浩一、福山高英、柳 日馨
    • Organizer
      第4回CSJ化学フェスタ2014
    • Place of Presentation
      東京
    • Year and Date
      2014-10-14 – 2014-10-16
    • Related Report
      2013 Annual Research Report
  • [Presentation] alpha-Galエピトープの効率合成法の開発 - One-potグリコシル化とマイクロフロー系への適用2014

    • Author(s)
      徳永健斗、真鍋良幸、深瀬浩一
    • Organizer
      第4回CSJ化学フェスタ2014
    • Place of Presentation
      東京
    • Year and Date
      2014-10-14 – 2014-10-16
    • Related Report
      2013 Annual Research Report
  • [Presentation] Challenge for immunoregulation with synthetic innate immune receptor ligands2014

    • Author(s)
      K. Fukase
    • Organizer
      COST Conference
    • Place of Presentation
      Napoli, Italy
    • Year and Date
      2014-10-13 – 2014-10-14
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] One-Pot Total Synthesis and Bioactivity Remodeling of Ageladine A2014

    • Author(s)
      Takayuki Iwata, Koichi Fukase, Katsunori Tanaka
    • Organizer
      Swiss Japanese Chemical Biology Symposium
    • Place of Presentation
      Bern, Switzerland
    • Year and Date
      2014-10-02 – 2014-10-04
    • Related Report
      2013 Annual Research Report
  • [Presentation] コアフコース及びバイセクティンググルコサミン含有N-結合型糖鎖の化学合成2014

    • Author(s)
      長崎政裕、源 直也、真鍋良幸、田中克典、深瀬浩一
    • Organizer
      第33回日本糖質学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-08-10 – 2014-08-12
    • Related Report
      2013 Annual Research Report
  • [Presentation] HTSと多様性指向型合成を併用したフコシルトランスフェラーゼ8阻 害剤の探索2014

    • Author(s)
      笠原里実,真鍋良幸,高松真二,三善英知,深瀬浩一
    • Organizer
      第33回日本糖質学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-08-10 – 2014-08-12
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腸球菌Enterococcus faecalis由来ペプチドグリカン部分構 造の合成研究2014

    • Author(s)
      長谷川弘毅、王 寧、藤本 ゆかり、深瀬 浩一
    • Organizer
      第33回日本糖質学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-08-10 – 2014-08-12
    • Related Report
      2013 Annual Research Report
  • [Presentation] 時空間制御反応による機能集積分子の創製を目指して2014

    • Author(s)
      深瀬浩一
    • Organizer
      第34回有機合成若手セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2014-08-05
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] In(III)を用いた温和なグリコシル化法の開発2014

    • Author(s)
      北脇夕莉子, 真鍋良幸, Regina M. Salmasan, Tsung-Che Chang, 深瀬浩一
    • Organizer
      第34回有機合成若手セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2014-08-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新規がん免疫療法を目指したα-Galエピトープの効率合成2014

    • Author(s)
      徳永健斗、真鍋良幸、深瀬浩一
    • Organizer
      第34回有機合成若手セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2014-08-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] 蛍光偏光法を用いたHigh Throughput ScreeningによるFut8阻害剤の探索2014

    • Author(s)
      笠原里実,真鍋良幸,高松真二,三善英知,深瀬浩一
    • Organizer
      日本ケミカルバイオロジー学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] Synthetic study of glycans and glycoconjugates toward immune regulation2014

    • Author(s)
      Koichi Fukase
    • Organizer
      Asia-Canada Glycoscience Satellite Meeting
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2014-05-31 – 2014-06-01
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] NKT細胞刺激作用を有するイノシトールリン脂質の合成2014

    • Author(s)
      相羽俊彦、佐藤昌紀、梅垣大地、中川 翔、田中慎二、北村雅人、藤本ゆかり、深瀬浩一
    • Organizer
      第15回関西グライコサイエンスフォーラム
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-24
    • Related Report
      2013 Annual Research Report
  • [Presentation] マイクロリアクターを利用した反応制御と糖鎖合成2013

    • Author(s)
      深瀬浩一
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀県草津 立命館大学びわこ・くさつキャンパス
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 細菌細胞壁ペプチドグリカンのフラグメント構造ライブラリ/アレイ作成と認識タンパク質による被認識構造の探索2013

    • Author(s)
      王 寧、平田晃義、軒原清史、藤本ゆかり、深瀬浩一
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] アルギニン翻訳後修飾に学ぶ2-アミノイミダゾール誘導体のワンポット合成2013

    • Author(s)
      岩田隆幸、深瀬浩一、田中克典
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] GlcN3N 構造を有するリピド A の合成研究2013

    • Author(s)
      増井誠二、生地哲平、藤本ゆかり、深瀬浩一
    • Organizer
      日本化学会第93春季年会(2013)
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] 効率的αシアリル化反応を利用したジシアリル化<I>N</I>結合型糖鎖の合成研究2013

    • Author(s)
      周 家洲、真鍋良幸、田中克典、深瀬浩一
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] グリコシルアスパラギン中間体を用いた新経路によるコアフコース含有<I>N</I>- 結合型糖鎖の合成研究2013

    • Author(s)
      長崎政裕、源 直也、真鍋良幸、田中克典、深瀬浩一
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] Entamoeba histolytica 由来NKT 細胞刺激作用を有するイノシトールリン脂質合成2013

    • Author(s)
      相羽俊彦、佐藤昌紀、梅垣大地、岩﨑孝紀、神戸宣明、藤本ゆかり、深瀬浩一
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] N-結合型糖鎖の汎用的合成を目指したバイセクティング型糖鎖の合成研究2013

    • Author(s)
      源直也、長崎政裕、真鍋良幸、田中克典、深瀬浩一
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] マイクロフローを用いた光反応性官能基共存下でのベンジル位の選択的光臭素化反応2013

    • Author(s)
      北脇 夕莉子、真鍋良幸、深瀬浩一
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthesis of regulatory molecules and probes for innate immunity and glyco-imaging2013

    • Author(s)
      Koichi Fukase
    • Organizer
      The 7th Glycan Forum Berlin 2013
    • Place of Presentation
      nhow Hotel, Berlin, Germany
    • Year and Date
      2013-03-20
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] (11) Comprehensive Approaches for New Antitumor Agents and Immunoregulatory Molecules, Regulation of Innate Immune Responses and Signal Transductions2013

    • Author(s)
      Koichi Fukase
    • Organizer
      First International Symposium on Pharmaceutical Sciences: A Global Approach
    • Place of Presentation
      Department of Pharmacy, University of Science & Technology, Chittagong,
    • Related Report
      2012 Annual Research Report
  • [Presentation] Nanyang Technological University (Singapore) Library-oriented Synthetic Study of N-Glycans2012

    • Author(s)
      Yoshiyuki Manabe, Masahiro Nagasaki, Naoya Minamoto, Regina Salmasan, Katsunori Tanaka, Koichi Fukase
    • Organizer
      The 7th international conference on cutting-edge organic chemistry in Asia / The 3rd new phase international conference on cutting-edge organic chemistry (ICCEOCA-7 / NICCEOCA-3)
    • Place of Presentation
      (13) Nanyang Technological University (Singapore)
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthesis and Biofunctions of Nod1/Nod2 ligands from peptidoglycan; Innate Immunostimulatory glycoconjugates of bacteria2012

    • Author(s)
      Y. Fujimoto, A. R. Pradipta, N. Wang, A. Kawasaki, Y. Kadonaga, M. Hasegawa, N. Inohara, K. Fukase
    • Organizer
      The Twelfth International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-12)
    • Place of Presentation
      Rihga Royal Hotel Kyoto
    • Year and Date
      2012-11-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] Library Oriented Synthetic Study of N-Glycans2012

    • Author(s)
      Yoshiyuki Manabe, Masahiro Nagasaki, Naoya Minamoto, Regina Salmasan, Katsunori Tanaka, Koichi Fukase
    • Organizer
      The Twelfth International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-12)
    • Place of Presentation
      Rihga Royal Hotel Kyoto
    • Year and Date
      2012-11-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthesis of peptidoglycan fragment library for analysis of receptor recognitionSynthesis of peptidoglycan fragment library for analysis of receptor recognition2012

    • Author(s)
      Ning Wang, Cheng-yuan Huang, Yukari, Fujimoto, Koichi, Fukase
    • Organizer
      The Twelfth International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-12)
    • Place of Presentation
      Rihga Royal Hotel Kyoto
    • Year and Date
      2012-11-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] Practical Microfluidic Procedures for a(alpha)-Sialylation2012

    • Author(s)
      Yosuke Uchinashi, Katsunori Tanaka, Koichi Fukase
    • Organizer
      The Twelfth International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-12)
    • Place of Presentation
      Rihga Royal Hotel Kyoto
    • Year and Date
      2012-11-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] 標的タンパク質への選択的アザ電子環状反応による蛍光スイッチオン標識2012

    • Author(s)
      北谷方嵩、田中克典、深瀬浩一
    • Organizer
      第49回ペプチド討論会
    • Place of Presentation
      鹿児島県民交流センター
    • Year and Date
      2012-11-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] Immunoactivation and immunomodulation using synthetic PRR ligands2012

    • Author(s)
      Koichi Fukase
    • Organizer
      The 1st International Symposium on Chemical Biology of Natural Products Target ID and Regulation of Bioactivity
    • Place of Presentation
      Kyoto Century Hotel
    • Year and Date
      2012-10-31
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Immunoactivation and immunomodulation using synthetic PRR ligands2012

    • Author(s)
      Koichi Fukase
    • Organizer
      International Endotoxin and Innate Immunity Society Meeting 2012 (IEIIS2012)
    • Place of Presentation
      National Institute of Informatics, Tokyo
    • Year and Date
      2012-10-23
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 有機合成とイメージングを基盤とする生物活性分子の機能解析と創製:新しい抗腫瘍療法を目指して2012

    • Author(s)
      深瀬浩一
    • Organizer
      大塚 有機合成シンポジウム
    • Place of Presentation
      大塚製薬 能力開発研究所(徳島)
    • Year and Date
      2012-10-15
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 鋳型誘起反応を用いたリン酸化タンパク質認識ペプチドの転写合成法の開発とその選択的な癌増殖抑制作用2012

    • Author(s)
      田中克典, 岩田隆幸, 白坏早苗, 影山知佳, 田原強, 野崎聡, Eric R. O. Siwu, 田村理, 道家駿佑, 村上啓寿, 尾上浩隆, 渡辺恭良, 深瀬浩一
    • Organizer
      第54回天然有機化合物討論会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2012-09-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規アスパラギン結合型中間体を経由するN-結合型糖鎖フラグメントの合成2012

    • Author(s)
      長崎政裕、源直也、Regina Salmasan、真鍋良幸、田中克典、深瀬浩一
    • Organizer
      第31回日本糖質学会年会
    • Place of Presentation
      鹿児島市民文化ホール
    • Year and Date
      2012-09-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthesis of bacterial glycoconjugates for regulation of immune system2012

    • Author(s)
      Koichi Fukase
    • Organizer
      5th Baltic Meeting on Microbial Carbohydrates
    • Place of Presentation
      Suzdal, Russia
    • Year and Date
      2012-09-02
    • Related Report
      2012 Annual Research Report
  • [Presentation] リン酸基を標的とした鋳型誘起合成の開発と癌増殖抑制ペプチドの創製2012

    • Author(s)
      岩田隆幸, 白坏早苗, 影山知佳, 田原 強, 野崎 聡, 田村 理, 渡辺恭良, 田中克典, 深瀬浩一
    • Organizer
      第44回若手夏のペプチド勉強会
    • Place of Presentation
      大阪・ロッジ舞洲
    • Year and Date
      2012-08-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] 標的タンパク質へのアザ電子環状反応による蛍光スイッチオン標識2012

    • Author(s)
      北谷方嵩、田中克典、深瀬浩一
    • Organizer
      第44回若手夏のペプチド勉強会
    • Place of Presentation
      大阪・ロッジ舞洲
    • Year and Date
      2012-08-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] 末端シアル酸とコアフコースを含むN-結合型糖タンパク質糖鎖の合成研究2012

    • Author(s)
      長崎政裕、内梨洋介、真鍋良幸、田中克典、深瀬浩一
    • Organizer
      第47回天然物化学談話会
    • Place of Presentation
      阿蘇プラザホテル
    • Year and Date
      2012-07-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] 免疫活性物質ペプチドグリカンフラグメントの新規固相合成法の開発2012

    • Author(s)
      角永悠一郎、藤本ゆかり、深瀬浩一
    • Organizer
      第47回天然物化学談話会
    • Place of Presentation
      阿蘇プラザホテル
    • Year and Date
      2012-07-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthesis of bis-sialylated motifs of N-glycan and application to molecular probes2012

    • Author(s)
      Jiazhou Zhou, Yosuke Uchinashi, Masahiro Nagasaki, Yoshiyuki Manabe, Katsunori Tanaka and Koichi Fukase
    • Organizer
      第47回天然物化学談話会
    • Place of Presentation
      阿蘇プラザホテル
    • Year and Date
      2012-07-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] Entamoeba histolytica由来NKT細胞刺激作用を有するイノシトールリン脂質の合成研究2012

    • Author(s)
      相羽俊彦、佐藤昌紀、梅垣大地、 藤本ゆかり、深瀬浩一
    • Organizer
      第47回天然物化学談話会
    • Place of Presentation
      阿蘇プラザホテル
    • Year and Date
      2012-07-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] Solid Supported Synthesis of N-Glycans: N-Glycosylation and Cleavage2012

    • Author(s)
      Regina Salmasan・Masahiro Nagasaki・Yoshiyuki Manabe・Katsunori Tanaka・Koichi Fukase
    • Organizer
      The Second Asian Chemical Biology Conference ACBC2012
    • Place of Presentation
      Southern Beach Hotel & Resort, Okinawa Japan
    • Year and Date
      2012-07-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] Microfluidic glycosylation for efficient synthesis of biofucntional glycans2012

    • Author(s)
      Koichi Fukase, Katsunori Tanaka, Yukari Fujimoto, Yosuke Uchinashi, Atsushi Shimoyama
    • Organizer
      The 26th International Carbohydrate Symposium (ICS2012)
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2012-06-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] Noninvasive imaging of glycan-dependent tumor metastasis through live cell labeling by azaelectrocyclization2012

    • Author(s)
      Katsunorti Tanaka, Kenta Moriwaki, Tsutomu Nakagawa, Satomi Yokoi, Koichi Koyama, Eiji Miyoshi, Koichi Fukase
    • Organizer
      The 26th International Carbohydrate Symposium (ICS2012)
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2012-06-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] アザ電子環状反応を用いた標的タンパク質選択的ならびに位置選択的蛍光スイッチオン標識2012

    • Author(s)
      谷方嵩、田中克典、深瀬浩一
    • Organizer
      日本ケミカルバイオロジー学会 第7回年会
    • Place of Presentation
      京都大学
    • Year and Date
      2012-06-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] 化学合成で糖鎖の生物機能に迫る2012

    • Author(s)
      深瀬浩一
    • Organizer
      第15回機能性分子シンポジウム
    • Place of Presentation
      茨城県、筑波大学(招待講演)
    • Year and Date
      2012-01-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 有機合成を基盤とする生物活性分子の機能解析と創製2012

    • Author(s)
      深瀬浩一
    • Organizer
      ヘテロ原子部会平成24年度第2回懇話会
    • Place of Presentation
      京都大学・宇治おうばくプラザ
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ペプチドグリカン・フラグメントライブラリ構築と受容体認識解析2012

    • Author(s)
      王 寧、黄 正元、藤本ゆかり、深瀬浩一
    • Organizer
      第32回有機合成若手セミナー「明日の有機合成を担う人のために」
    • Place of Presentation
      神戸薬科大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] (1) Entamoeba histoly1ca由来NKT細胞刺激作用を有するイノシトールリン脂質の合成研究2012

    • Author(s)
      相羽俊彦、佐藤昌紀、梅垣大地、藤本ゆかり、深瀬浩一
    • Organizer
      第39回有機反応懇談会
    • Place of Presentation
      吹田・関西大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 水酸基が活性化する共役イミンの新奇[4+4]反応2012

    • Author(s)
      松本梨沙、田中克典、深瀬浩一
    • Organizer
      第39回有機反応懇談会
    • Place of Presentation
      吹田・関西大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] バイセクティング型糖鎖の合成研究:N‐型糖鎖の汎用的ライブラリー合成を目指して2012

    • Author(s)
      源 直也、真鍋良幸、田中克典、深瀬浩一
    • Organizer
      第39回有機反応懇談会
    • Place of Presentation
      吹田・関西大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 認識タンパク質探索・解析を目指した細菌細胞壁ペプチドグリカン・フラグメントライブラリ構築2012

    • Author(s)
      王 寧、黄 正元、藤本ゆかり、深瀬浩一
    • Organizer
      第13回関西グライコサイエンスフォーラム
    • Place of Presentation
      堺・大阪府立大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 自然免疫活性化物質と発酵食品2012

    • Author(s)
      PRADIPTA Ambara Rachmat、藤本ゆかり、橋本雅仁、管慎太郎、重久浩、深瀬浩一
    • Organizer
      日本化学会第92春季年会(2012)
    • Place of Presentation
      神奈川県、慶應義塾大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] ペプチドグリカン・フラグメントライブラリ構築と受容体認識解析2012

    • Author(s)
      王寧、黄正元、藤本ゆかり、深瀬浩一
    • Organizer
      日本化学会第92春季年会(2012)
    • Place of Presentation
      神奈川県、慶應義塾大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] ペプチドグリカンの新規固相合成法の開発2012

    • Author(s)
      角永悠一郎、藤本ゆかり、深瀬浩一
    • Organizer
      日本化学会第92春季年会(2012)
    • Place of Presentation
      神奈川県、慶應義塾大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] N-結合型糖鎖の固相合成研究:固相上でのN-グリコシル化反応と糖鎖切断の検討2012

    • Author(s)
      Regina Salmasan、長崎政裕、田中克典、深瀬浩一
    • Organizer
      日本化学会第92春季年会(2012)
    • Place of Presentation
      神奈川県、慶應義塾大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] N-結合型糖鎖のモノおよびビスシアリル化構造の合成とプローブ化2012

    • Author(s)
      周家洲、鮑光明、田中克典、深瀬浩一
    • Organizer
      日本化学会第92春季年会(2012)
    • Place of Presentation
      神奈川県、慶應義塾大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] 単糖のデンドリマー型クラスターの合成とPETイメージング2012

    • Author(s)
      李昊晟、Eric R.O.Siwu、岩田隆幸、野崎聡、長谷川功紀、渡辺恭良、田中克典、深瀬浩一
    • Organizer
      日本化学会第92春季年会(2012)
    • Place of Presentation
      神奈川県、慶應義塾大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] アミンやアルコール求核剤が媒介する共役イミンの[4+4]反応2012

    • Author(s)
      松本梨沙、田中克典、深瀬浩一
    • Organizer
      日本化学会第92春季年会(2012)
    • Place of Presentation
      神奈川県、慶應義塾大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] マイクロフロー経路内における古典的α-シアリル化反応の再開拓2011

    • Author(s)
      長崎政裕、内梨洋介、周家州、田中克典、深瀬浩一
    • Organizer
      第38回有機反応懇談会
    • Place of Presentation
      大阪府立大学
    • Year and Date
      2011-08-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Glycoimaging of whole-body system : application to glycoproteins, glycan denderimers, and glycan-engineered cells2011

    • Author(s)
      Koichi Fukase, Katsunori Tanaka
    • Organizer
      43rd IUPAC World Chemistry Congress "Balancing Life with Glycoconjugates"
    • Place of Presentation
      Puerto Rico Convention Center, Puerto Rico
    • Year and Date
      2011-08-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 有機合成で糖鎖機能を探る2011

    • Author(s)
      深瀬浩一
    • Organizer
      天然物化学の新展開
    • Place of Presentation
      高知大学(招待講演)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 有機合成と生体イメージングを用いて糖鎖の生物機能を解明する2011

    • Author(s)
      深瀬浩一
    • Organizer
      第4回生体分子科学シンポジウム
    • Place of Presentation
      大阪府立大学理学系研究科(招待講演)
    • Year and Date
      2011-03-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Integrated Synthesis of Bioactive Glycans and Heterocycles2011

    • Author(s)
      K.Fukase
    • Organizer
      10th International Symposium on Organic Reactions (ISOR10)
    • Place of Presentation
      神奈川県、Faculty of Science and Technology, Keio University(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Syntheis of lipopolysaccharide partial structures of parasitic bacteria ; elucidation of their immunomudulating function2011

    • Author(s)
      K.Fukase, A.Shimoyama, A.Saeki, N.Kitayama, C.Kasamatsu, Y.Fujimoto
    • Organizer
      The 3rd Asian Communications on Glycobiology and Glycotechnology
    • Place of Presentation
      Shanghai Institute of Organic Chemistry, Shanghai, China
    • Related Report
      2011 Annual Research Report
  • [Presentation] Glyco-imaging for glycan dynamics study2011

    • Author(s)
      K.Fukase
    • Organizer
      The 71st Okazaki Conference "New perspectives on molecular science of glycoconjugates"
    • Place of Presentation
      愛知県、Osakazaki Conference Center(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 免疫調節作用制御を目指した寄生性細菌由来リポ多糖部分構造の集積的合成法の開発と機能解析2011

    • Author(s)
      下山敦史、佐伯昭典、来山直弘、笠松千郁、藤本ゆかり、深瀬浩一
    • Organizer
      第53回天然有機化合物討論会
    • Place of Presentation
      大阪国際交流センター
    • Related Report
      2011 Annual Research Report
  • [Presentation] Solid-phase synthesis of glycoconjugates2011

    • Author(s)
      Y.Kadonaga, Y.Fujimoto, K.Fukase
    • Organizer
      The Seventh International Symposium on Integrated Synthesis (ISIS-7)
    • Place of Presentation
      兵庫県、Seaside Hotel Maiko Villa, Kobe
    • Related Report
      2011 Annual Research Report
  • [Presentation] Synthesis of Mono- and Di-sialylation N-glycan Motifs as Molecular Probes for Biological Evalution2011

    • Author(s)
      J.Zhou, G.Bao, K.Tanaka, K.Fukase
    • Organizer
      The Seventh International Symposium on Integrated Synthesis (ISIS-7)
    • Place of Presentation
      兵庫県、Seaside Hotel Maiko Villa, Kobe
    • Related Report
      2011 Annual Research Report
  • [Presentation] Reinvestigation of α-Sialylation under Microfluidic Conditions2011

    • Author(s)
      M.Nagasaki, Y.Uchinashi, J.Zhou, K.Tanaka, K.Fukase
    • Organizer
      The Seventh International Symposium on Integrated Synthesis (ISIS-7)
    • Place of Presentation
      兵庫県、Seaside Hotel Maiko Villa, Kobe
    • Related Report
      2011 Annual Research Report
  • [Presentation] N5-Acシアル酸糖供与体を用いた実践的α-シアリル化反応2011

    • Author(s)
      内梨洋介、長崎政裕、周家州、田中克典、深瀬浩一
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      新潟県、長岡リリックホール
    • Related Report
      2011 Annual Research Report
  • [Presentation] 複合糖質合成を指向した新規固相合成法の開発2011

    • Author(s)
      角永悠一郎、藤本ゆかり、深瀬浩一
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      新潟県、長岡リリックホール
    • Related Report
      2011 Annual Research Report
  • [Presentation] 認識タンパク質探索・解析を目指したペプチドグリカン・フラグメントライブラリ構築2011

    • Author(s)
      王寧、黄正元、藤本ゆかり、深瀬浩一
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      新潟県、長岡リリックホール
    • Related Report
      2011 Annual Research Report
  • [Presentation] 寄生性細菌由来リポ多糖部分構造群の網羅的合成と機能2011

    • Author(s)
      下山敦史、佐伯昭典、来山直弘、藤本ゆかり、深瀬浩一
    • Organizer
      第46回天然物化学談話会
    • Place of Presentation
      静岡県、熱川ハイツ
    • Related Report
      2011 Annual Research Report
  • [Presentation] 糖タンパク質、糖鎖クラスター、細胞のグライコイメージング2011

    • Author(s)
      深瀬浩一
    • Organizer
      第6回日本分子イメージング学会
    • Place of Presentation
      兵庫県、神戸国際会議場
    • Related Report
      2011 Annual Research Report
  • [Presentation] New functional analysis of glycans based on chemical synthesis and bio-imaging2011

    • Author(s)
      Koichi Fukase
    • Organizer
      Frontiers of Chemical Biology
    • Place of Presentation
      Peking University, China
    • Related Report
      2011 Annual Research Report
  • [Presentation] 標的指向型ライブラリー構築と生命科学への貢献2011

    • Author(s)
      深瀬浩一
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 精密有機合成と生体イメージングを基盤とする生物活性複合糖質の機能解明2011

    • Author(s)
      深瀬浩一
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 免疫制御を指向したケミカルグリコバイオロジー2011

    • Author(s)
      深瀬浩一
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] コアフコースを持つ複合型N-結合型糖鎖の合成研究2011

    • Author(s)
      宮川卓也、深瀬浩一
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] Isolation and Cytotoxicity of Ursolic Acid Derivatives from Bangladeshi Medicinal Plants, Saurauja roxburghii2011

    • Author(s)
      M.Kishor, K.Fukase
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] N5-Acシアル酸糖供与体を用いた実践的α-シアリル化反応2011

    • Author(s)
      内梨洋介、深瀬浩一
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] 基質隣接効果による初めての"head-to-head"イミン二量化反応:縮環1,2-ジアゼチジンの直接的[2+2]合成2010

    • Author(s)
      広崎真司、深瀬浩一
    • Organizer
      第37回有機反応懇談会
    • Place of Presentation
      京都大学宇治キャンパス
    • Year and Date
      2010-08-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Azaelectrocyclization-Based Labelling and Bioconjugation of Proteins and Living Cells : Application to Imaging of N-Glycans and Lymphocytes2010

    • Author(s)
      K.Fukase
    • Organizer
      The 4th HiPep-Okinawa International Workshp
    • Place of Presentation
      Okinawa Industry Support Center(招待講演)
    • Year and Date
      2010-07-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロフローシステムを用いた実用的なa-シアリル化反応の開発とポリシアル酸合成への展開2010

    • Author(s)
      内梨洋介、深瀬浩一
    • Organizer
      第11回関西グライコサイエンスフォーラム
    • Place of Presentation
      大阪市立大学学術情報総合センター
    • Year and Date
      2010-05-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthetic approach for in vivo functional studies of glycans : Application of PET imaging2010

    • Author(s)
      K.Fukase
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
    • Place of Presentation
      Honolulu, USA(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Study of microfluidic reactions toward production of biofunctional molecules : Application to glycan synthesis2010

    • Author(s)
      K.Fukase
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
    • Place of Presentation
      Honolulu, USA(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Unprecedented [2+2]-Condensation of Imines : Remarkable Substituent Effects and Synthetic Applications2010

    • Author(s)
      K.Tanaka, K.Fukase
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cytotoxic Ursolic Acid Derivatives from Bangladeshi Medicinal Plants, Sauragja roxburghii2010

    • Author(s)
      K, Mazumder, K.Fukase
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthesis of a-Sialosides under Microfluidic Conditions2010

    • Author(s)
      Y.Uchinashi, K.Fukase
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthetic Approach for Elucidating Glycan Codes2010

    • Author(s)
      K.Fukase
    • Organizer
      The 5th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-5)/The 1st New phase International Conference on Cutting-Edge Organic Chemistry in Asia (NICCEOCA-1)
    • Place of Presentation
      Hsinchu, Taiwan(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthetic Approach for Elucidation of Biological Relevance of Glycans2010

    • Author(s)
      K.Fukase
    • Organizer
      The Sixth International Symposium on Integrated Synthesis (ISIS-6)
    • Place of Presentation
      Seaside Hotel Maiko Villa Kobe (Hyogo)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Microfluidic Procedures in Oligosaccharides Synthesis : Innovative Chemical Transformation to Sialoglycans2010

    • Author(s)
      Y.Uchinashi, K.Fukase
    • Organizer
      International Symposium on Environmentally Benign Synthesis
    • Place of Presentation
      Osaka Univ.Nakanoshima Center
    • Related Report
      2010 Annual Research Report
  • [Presentation] 共役イミン誘導体の初めての[2+2]反応によるワンポット1,2-ジアゼチジン合成2010

    • Author(s)
      田中克典、深瀬浩一
    • Organizer
      第40回複素環化学討論会
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] アザ電子環状反応を基盤とするタンパク質および細胞表層の高速標識化とN-結合型糖鎖の"生きている動物内"でのイメージング2010

    • Author(s)
      田中克典、深瀬浩一
    • Organizer
      第52回天然有機化合物討論会
    • Place of Presentation
      グランシップ(静岡県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] アスパラギン結合型糖タンパク質糖鎖の合成を指向したマイクロフロー/バッチ混合系でのN-グリコシル化反応の開発2010

    • Author(s)
      宮川卓也、深瀬浩一
    • Organizer
      第27回有機合成化学セミナー
    • Place of Presentation
      シーサイドホテル舞子ビラ神戸(兵庫県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthesis of α-Sialosides under Microfluidic Conditions2010

    • Author(s)
      K.Fukase
    • Organizer
      Sialoglyco 2010
    • Place of Presentation
      Potsdam, Germany
    • Related Report
      2010 Annual Research Report
  • [Presentation] Practical Microfluidic Procedures for a-Sialylation2010

    • Author(s)
      K.Tanaka, K.Fukase
    • Organizer
      The 25th International Carbohydrate Symposium (ICS 2010)
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] イメージングを利用した糖鎖の新しい機能探索2010

    • Author(s)
      深瀬浩一
    • Organizer
      平成22年度生理学研究所研究会
    • Place of Presentation
      生理学研究所(愛知県)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロフロー系反応を活用したシアル酸含有糖鎖の実用的合成と分子イメージングへの展開2010

    • Author(s)
      内梨洋介、深瀬浩一
    • Organizer
      日本ケミカルバイオロジー学会第5回年会
    • Place of Presentation
      慶応大学日吉キャンパス(神奈川県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthetic Approach for In Vivo Functional Studies of Glycans2010

    • Author(s)
      K.Fukase
    • Organizer
      The 21st French-Japanese Symposium on Medicinal and Fine Chemistry (FJS2010)
    • Place of Presentation
      Kyoto Garden Palace(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Unprecedented [2+2]-Condensation of Imines : Simulataneous C-C & N-N Bond Formations to 1,2-Diazetidenes2010

    • Author(s)
      K.Tanaka, K.Fukase
    • Organizer
      The 21st French-Japanese Symposium on Medicinal and Fine Chemistry (FJS2010)
    • Place of Presentation
      Kyoto Garden Palace
    • Related Report
      2010 Annual Research Report
  • [Presentation] Isolation and Cytotoxic Activity of Ursolic Acid Derivatives from Bangladeshi Medicinal Plants, Saurauja roxburghii2010

    • Author(s)
      K.Mazumder, K.Fukase
    • Organizer
      The 21st French-Japanese Symposium on Medicinal and Fine Chemistry (FJS2010)
    • Place of Presentation
      Kyoto Garden Palace
    • Related Report
      2010 Annual Research Report
  • [Presentation] Practical Microfluidic Procedures for a-Sialylation2010

    • Author(s)
      Y.Uchinashi, K.Fukase
    • Organizer
      International Symposium on Organelle Networks :Interface among Infection-Immunity, Cell Biology and Glycobiology
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府)
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロフローシステムを用いたグリコシル重合反応の制御2010

    • Author(s)
      中薮愛子
    • Organizer
      第90回日本化学会春季年会
    • Place of Presentation
      近畿大学(大阪)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 広幅経路のマイクロミキサーを活用した実用的α-シアリル化反応2010

    • Author(s)
      内梨洋介
    • Organizer
      第90回日本化学会春季年会
    • Place of Presentation
      近畿大学(大阪)
    • Related Report
      2009 Annual Research Report
  • [Presentation] マイクロフロー/バッチ混合系を用いたN-グリコシル化反応2010

    • Author(s)
      宮川卓也
    • Organizer
      第90回日本化学会春季年会
    • Place of Presentation
      近畿大学(大阪)
    • Related Report
      2009 Annual Research Report
  • [Presentation] イミン誘導体の形式的[2+2]反応と合成的展開2010

    • Author(s)
      田中克典
    • Organizer
      第90回日本化学会春季年会
    • Place of Presentation
      近畿大学(大阪)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Integrated Microfluidic/Batch Conditions for Practical Glycosylation2010

    • Author(s)
      Miyagawa, T.
    • Organizer
      11^<th> International Conference on Microreaction Technology (IMRET11)
    • Place of Presentation
      Kyoto Research Park (Kyoto)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Acid-Mediated Reactions under Microfluidic Conditions : A New Strategy for Practical Synthesis of Biofunctional Natural Products2010

    • Author(s)
      Tanaka, K.
    • Organizer
      11^<th> International Conference on Microreaction Technology (IMRET11)
    • Place of Presentation
      Kyoto Research Park (Kyoto)
    • Related Report
      2009 Annual Research Report
  • [Presentation] マイクロ系内でのグリコシルカチオンの制御に基づく実用的フロー糖鎖合成2009

    • Author(s)
      中薮愛子
    • Organizer
      第29回有機合成若手セミナー
    • Place of Presentation
      甲南大学ポートアイランド(神戸)
    • Year and Date
      2009-11-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 集積型合成を目指したマイクロフロー合成研究2009

    • Author(s)
      深瀬浩一
    • Organizer
      フロー・マイクロ合成研究会 第21回公開講演会
    • Place of Presentation
      大阪科学技術センター(大阪)
    • Year and Date
      2009-08-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] マイクロフロー/バッチ混合系を用いたN-グリコシル化反応の開発2009

    • Author(s)
      宮川卓也
    • Organizer
      第36回有機反応懇談会
    • Place of Presentation
      関西学院大学 三田(神戸)
    • Year and Date
      2009-08-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synthetic approach for in vivo functional studies of glycans : application of PET imaging2009

    • Author(s)
      Koichi Fukase.
    • Organizer
      Korean Society for Glycoscience
    • Place of Presentation
      Daejeon, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] Glycosylation in Microfluidic and on Solid Supports : Synthesis of Sialic Acid-Containing Complex-type N-Glycan2009

    • Author(s)
      Nakayabu, A.
    • Organizer
      The Eleventh International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-11)
    • Place of Presentation
      Kyoto Royal Hotel (Kyoto)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synthesis of Peptidoglycan Fragments with a New Disaccharide Building Block2009

    • Author(s)
      C.Huang
    • Organizer
      The Eleventh International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-11)
    • Place of Presentation
      Kyoto Royal Hotel (Kyoto)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Investigation of α-Sialylation Reactivity under Batch vs Various Microfluidic Conditions2009

    • Author(s)
      Uchinashi, Y.
    • Organizer
      5^<th> Spanish-Portuguese-Japanese Organic Chemistry Symposium
    • Place of Presentation
      Osaka Univ.(Osaka)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synthesis of Glycans by Integration of Solid-phase and Microfluidic Methods2009

    • Author(s)
      Fukase, K.
    • Organizer
      5^<th> Spanish-Portuguese-Japanese Organic Chemistry Symposium
    • Place of Presentation
      Osaka Univ.(Osaka)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synthetic studies of glycans and glyco-probes for chemical glycobiology2009

    • Author(s)
      Koichi Fukase
    • Organizer
      Simposium Nasional Kimia Bahan Alam XVII
    • Place of Presentation
      Semarang, Indonesia
    • Related Report
      2009 Annual Research Report
  • [Presentation] Convergent Synthesis of N-linked Glycan through Microfluidic & Solid-supported Glycocsylation2009

    • Author(s)
      Tanaka, K.
    • Organizer
      Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
    • Place of Presentation
      Senri Life Science Center (Osaka)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Integrated Microfluidic/Batch Conditions for Practical N-Glycosylation and β-Mannosylation2009

    • Author(s)
      Tanaka, K.
    • Organizer
      Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
    • Place of Presentation
      Senri Life Science Center (Osaka)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synthesis of new probes for chemical glycobiology : application to PET and fluorescent imaging of glycoproteins, glycoclusters, and living cells2009

    • Author(s)
      Koichi Fukase
    • Organizer
      The Second International Symposium on Combinatorial Sciences in Chemistry, Biology, Catalysts and Materials (SCS09)
    • Place of Presentation
      Beijin, China
    • Related Report
      2009 Annual Research Report
  • [Presentation] Study of microfluidic reactions toward production of biofunctional molecules : application to glycan synthesis2009

    • Author(s)
      Koichi Fukase
    • Organizer
      GRATAMA WORKSHOP 2009
    • Place of Presentation
      Delft, Netherlands
    • Related Report
      2009 Annual Research Report
  • [Presentation] 有機合成で生物機能に迫る:マイクロフロー合成と固相合成による糖鎖構築と糖鎖の新機能解析2009

    • Author(s)
      深瀬浩一
    • Organizer
      第29回日本糖質学会年会
    • Place of Presentation
      世界生活文化センター(高山)
    • Related Report
      2009 Annual Research Report
  • [Presentation] マイクロフロー/バッチ混合系を用いたグリコシル化反応の開発2009

    • Author(s)
      宮川卓也
    • Organizer
      第29回日本糖質学会年会
    • Place of Presentation
      世界生活文化センター(高山)
    • Related Report
      2009 Annual Research Report
  • [Presentation] In Vivo Imaging of N-Glycan Dendrimers by Fluorescence and Positron Emission Tomography (PET)2009

    • Author(s)
      Eric R.O.Siwu
    • Organizer
      第29回日本糖質学会年会
    • Place of Presentation
      世界生活文化センター(高山)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖鎖の合成とin vivo生体分子科学2009

    • Author(s)
      深瀬浩一
    • Organizer
      第44回天然物化学談話会
    • Place of Presentation
      つくばグランドホテル(つくば)茨城
    • Related Report
      2009 Annual Research Report
  • [Presentation] マイクロフロー/バッチ混合系を用いたN-グリコシル化反応の開発とN-結合型糖鎖固相合成への応用2009

    • Author(s)
      宮川卓也
    • Organizer
      第44回天然物化学談話会
    • Place of Presentation
      つくばグランドホテル(つくば)茨城
    • Related Report
      2009 Annual Research Report
  • [Presentation] Convergent Synthesis of N-linked Sialoglycan on Solid-Supports2009

    • Author(s)
      Bao, G.-m
    • Organizer
      International Workshop of Biofunctional Chemistry for Young Scientists
    • Place of Presentation
      Awaji Yumebutai (Awaji)兵庫
    • Related Report
      2009 Annual Research Report
  • [Presentation] Practical α-Sialylation under Microfluidic Conditions2009

    • Author(s)
      Uchinashi, Y.
    • Organizer
      International Workshop of Biofunctional Chemistry for Young Scientists
    • Place of Presentation
      Awaji Yumebutai (Awaji)兵庫
    • Related Report
      2009 Annual Research Report
  • [Presentation] Tilton, NH2009

    • Author(s)
      Koichi Fukase
    • Organizer
      Gordon Research Conferences, Carbohydrates
    • Place of Presentation
      Tilton, NH
    • Related Report
      2009 Annual Research Report
  • [Book] 糖鎖の生体内イメージング2012

    • Author(s)
      田中克典、深瀬浩一
    • Total Pages
      209
    • Publisher
      化学同人
    • Related Report
      2012 Annual Research Report
  • [Book] 実験医学2012

    • Author(s)
      深瀬浩一、田中克典
    • Total Pages
      225
    • Publisher
      羊土社
    • Related Report
      2012 Annual Research Report
  • [Book] Oligosaccharide Synthesis on Solid, Soluble Polymer and Tag Supports in Solid-Phase Organic Synthesis Book2011

    • Author(s)
      K.Tanaka, K.Fukase
    • Publisher
      Wiley
    • Related Report
      2011 Annual Research Report
  • [Book] マイクロフローシステムを用いた生理活性天然物の実用的合成戦略in月刊未来材料,解説Review2011

    • Author(s)
      田中克典, 深瀬浩一
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2011 Annual Research Report
  • [Book] マイクロ経路内および固相上での効率的グリコシル化反応を基盤としたN-結合型糖タンパク質糖鎖のライブラリー指向型合成in月刊ファインケミカル特集糖鎖合成の発展と最新応用研究2011

    • Author(s)
      田中克典, 深瀬浩一
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Annual Research Report
  • [Book] Methods in Enzymology2010

    • Author(s)
      Fujimoto, Y., Fukase, K.
    • Publisher
      Glycomics
    • Related Report
      2010 Annual Research Report
  • [Book] 創薬研究への分子イメージング応用2010

    • Author(s)
      田中克典、深瀬浩一
    • Publisher
      メディカルドゥ
    • Related Report
      2010 Annual Research Report
  • [Book] 生体の科学(糖鎖のかかわる病気)2010

    • Author(s)
      田中克典, 深瀬浩一
    • Publisher
      (財)金原一郎記念医学医療振興財団/医学書院
    • Related Report
      2010 Annual Research Report
  • [Book] 第三の生命鎖「糖鎖」を活用・制御するケミカルバイオロジー、月刊バイオインダストリー2010

    • Author(s)
      田中克典、深瀬浩一
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Annual Research Report
  • [Book] 生体の科学(糖鎖のかかわる病気)2010

    • Author(s)
      田中克典, 深瀬浩一
    • Publisher
      (財)金原一郎記念医学医療振興財団/医学書院(In press)
    • Related Report
      2009 Annual Research Report
  • [Book] Glycoscience : Chemistry and Chemical Biology I-III(2^<nd> ed., B.O.Fraser-Reid, K.Tatsuta, J.Thiem, eds., Polymer-supported and Tag-assisted Methods in Oligosaccharide Synthesis)2010

    • Author(s)
      Tanaka, K.; Fukase, K.
    • Publisher
      Springer(In press)
    • Related Report
      2009 Annual Research Report
  • [Book] Glycoscience : Chemistry and Chemical Biology I-III(2^<nd> ed., B.O.Fraser-Reid, K.Tatsuta, J.Thiem, eds.) Combinatorial Methods in Oligosaccharide Synthesis2010

    • Author(s)
      Tanaka, K.; Fujimoto, Y.; Tanaka, S.; Mori, Y.; Fukase, K.
    • Publisher
      Springer(In press)
    • Related Report
      2009 Annual Research Report
  • [Book] 複合糖質の化学と最新応用技術(糖鎖のインビボバイオイメージング)2009

    • Author(s)
      田中克典, 深瀬浩一
    • Related Report
      2009 Annual Research Report
  • [Book] 月刊BIO INDUSTRY(第三の生命鎖「糖鎖」を活用・制御するケミカルバイオロジー)2009

    • Author(s)
      田中克典, 深瀬浩一
    • Publisher
      シーエムシー出版
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/fukase/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.chem.sci.osaka-u.ac..jp/lab/fukase/

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 水不溶性担体及びエンドトキシン吸着材2011

    • Inventor(s)
      深瀬浩一
    • Industrial Property Rights Holder
      深瀬浩一
    • Industrial Property Rights Type
      特許
    • Patent Publication Number
      2012-143707
    • Filing Date
      2011-01-12
    • Acquisition Date
      2012-08-02
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2018-03-28  

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